Clinical trials: Drug-Drug Interactions
HCV Infection
Drug-Drug Intercations and Direct Acting Antiviral Agents Against HCV
Background: Currently used direct-acting antivirals (DAA) share pharmacokinetic pathways with many comedications commonly used in patients with chronic hepatitis C virus (HCV) infection, therefore drug-drug interactions (DDI)…
- Trial name
- NCT06928259
- Where
- 4 sites in Spain
- Volunteers
- 728 people
- Sponsor
- University of Seville
Sarcoma, Kaposi, HIV Infections
The Safety and Effectiveness of Interferon Alfa-2B Plus Didanosine in Patients With Kaposi's Sarcoma
Primary: To evaluate the safety, toxicity, and antitumor activity of two doses of interferon alfa-2b (IFN-alpha) combined with a fixed dose of didanosine (ddI) in patients with Kaposi's sarcoma associated with HIV infection.
- Trial name
- NCT00001114
- Testing
- Interferon alfa-2b, Didanosine
- Where
- 13 sites in United States, Puerto Rico
- Volunteers
- 90 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Dysbiosis
Interactions Between Skincare Product Ingredients and the Skin Microbiome
This is a study of the influence of skincare products containing chemicals such as parabens and phthalates on the skin microbiome.
- Trial name
- NCT04476732
- Testing
- Paraben-free skincare product, Paraben-containing skincare product
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Tuberculosis, HIV
Rifampin and Nevirapine Interactions in Young Children
Nevirapine is the preferred nonnucleoside reverse transcriptase inhibitor (NNRTI) for treatment of HIV in children younger than 3 years old who have tuberculosis (TB) coinfection.
- Trial name
- NCT01699633
- Where
- Ghana
- Volunteers
- 58 people
- Sponsor
- The Miriam Hospital
Coronary Heart Disease, Acute Coronary Syndrome
Cohort Study of Clopidogrel and Proton Pump Inhibitors
Patients who have experienced and survived non-ST segment elevation acute coronary syndromes are often prescribed a combination of aspirin and clopidogrel to thin the blood and prevent further acute coronary episodes.
- Conditions
- Coronary Heart Disease, Acute Coronary Syndrome, Drug Interactions, Clopidogrel
- Trial name
- NCT01231867
- Where
- United Kingdom
- Volunteers
- 24,471 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Children
Reduction in MACbar of Sevoflurane by Dexmedetomidine in Children
The study was designed to define the interaction of intravenous infusion of dexmedetomidine, an a2-adrenergic agonist, and sevoflurane in children having surgery by using the minimum alveolar concentration which can block…
- Trial name
- NCT02261675
- Testing
- dexmedetomidine
- Volunteers
- 63 people
- Sponsor
- Cai Li
HIV
Polypharmacy and Clinically Significant Drug Interactions Among HIV-Infected Patients Receiving Antiretroviral Therapy
This will be a cross-sectional population-based study carried out in the region of Madrid (6,468,322 inhabitants according to current census) to quantify the number of Co-meds in HIV-infected individuals on ART in the region of…
- Trial name
- PODIUM (NCT03123575)
- Volunteers
- 1,000 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Dementia, Cognitive Impairment
Use of Alternative Medicine in Patients With Dementia and Mild Cognitive Dysfunction
So far, no drugs have shown to stop or delay the pathological processes of dementia. Available pharmacological treatment includes a small number of drugs; cholinesterase inhibitors like donepezil, galantamine and rivastigmine…
- Trial name
- NCT01554475
- Where
- Norway
- Volunteers
- 151 people
- Sponsor
- University Hospital of North Norway
Thyroid Cancer
The Effect of Thyroid Hormone on Drug Elimination in Cancer Patients
This study will examine whether and how levothyroxine (Synthroid, a synthetic thyroid hormone) affects the way the body handles other drugs.
- Trial name
- NCT00080574
- Testing
- Skin Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Dementia
Improving Well-being and Health for People With Dementia
800,000 people in the United Kingdom (UK)have dementia, of which 250,000 are living in care homes. These individuals have complex mental health problems, disabilities and social needs, which if unmet will continue to adversely…
- Trial name
- WHELD (NCT01855152)
- Testing
- Optimised WHELD intervention, Treatment as usual
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- professor Clive Ballard
HIV Infection, Healthy
The Effect of Milk Thistle on the Pharmacokinetics of Indinavir
Complementary and alternative medicines are widely used in the HIV-infected population. Recent data have shown serious drug interactions between certain complementary medicines and protease inhibitors.
- Trial name
- NCT00011635
- Testing
- Silymarin (milk thistle)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV, Tuberculosis
Rifampin and Efavirenz Interactions in Older Children
Efavirenz is an essential component of HIV treatment in children aged 3 years or older on anti-tuberculosis (anti-TB) treatment. However, the appropriate efavirenz dose during anti-TB treatment remains unclear.
- Trial name
- NCT01704144
- Where
- Ghana
- Volunteers
- 160 people
- Sponsor
- The Miriam Hospital
HIV Infections
Antiviral Activity of and Resistance to Lamivudine in Combination With Zidovudine, Stavudine, or Didanosine
To evaluate the efficacy, safety, and pharmacokinetics of lamivudine (3TC) combined with zidovudine (AZT), stavudine (d4T), or didanosine (ddI) in comparison with d4T or ddI monotherapy in HIV-infected patients with no prior…
- Trial name
- NCT00000838
- Testing
- Lamivudine, Stavudine, Zidovudine
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 256 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mycobacterium Avium-intracellulare Infection, HIV Infections
The Safety and Effectiveness of Clarithromycin Plus Zidovudine or Dideoxyinosine in the Treatment of Mycobacterium Avium Complex (MAC) Infections in Children With AIDS
To evaluate three doses of clarithromycin in children with AIDS and Mycobacterium avium complex (MAC) infection who are receiving concurrent antiretroviral therapy.
- Trial name
- NCT00000971
- Testing
- Clarithromycin, Zidovudine, Didanosine
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Abbott
Sarcoma, Kaposi, HIV Infections
A Study of Chemotherapy Plus ddI or ddC in the Treatment of AIDS-Related Kaposi's Sarcoma
To determine the toxicity and response to treatment with cytotoxic chemotherapy using doxorubicin (Adriamycin), bleomycin, and vincristine (DBV) for advanced AIDS-related Kaposi's sarcoma in combination with either didanosine…
- Trial name
- NCT00000954
- Testing
- Bleomycin sulfate, Vincristine sulfate, Doxorubicin hydrochloride
- Where
- 14 sites in United States
- Volunteers
- 72 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Safety, Tolerability, Drug Interactions, and Antiviral Activity of Rilpivirine in Antiretroviral-Naive HIV-Infected Children Less Than 12 Years of Age
Development of tolerable and effective antiretroviral (ARV) drugs for use in children and adolescents remains a high priority. First-line therapy with non-nucleoside reverse transcriptase inhibitors (NNRTIs) has proven to be…
- Trial name
- NCT01975012
- Testing
- Rilpivirine
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Ductus Arteriosis, Patent, Bacterial Infections and Mycoses
Safety of Fluconazole Treatment of Premature and Full-term Newborn Infants
This study will investigate pharmacological interventions between fluconazole and ibuprofen when they are given to premature newborn babys.
- Trial name
- NCT02079298
- Testing
- Treatment with fluconazole., 2. Treatment with both fluconazole and Ibuprofen., 3. Treatment with ibuprofen.
- Where
- Sweden
- Volunteers
- 80 people
- Sponsor
- Anders Rane, MD, PhD, Senior professor
HAART Non-Adherence, HIV
Cell Phone Reminders Intervention
This study will use a longitudinal, experimental design. Participants will be randomized to either the intervention or the control group.
- Conditions
- HAART Non-Adherence, HIV, HIV Infections
- Trial name
- NCT01049568
- Testing
- Cell Phone Intervention
- Where
- 5 sites in United States
- Volunteers
- 43 people
- Sponsor
- University of North Carolina, Chapel Hill
HIV Infections
A Phase I Trial to Evaluate the Safety and Pharmacokinetics of 1592U89
To assess the safety of single oral doses of 1592U89 (abacavir succinate, ABC) administered to HIV-positive individuals. To determine the pharmacokinetics of 1592U89 after single oral doses.
- Trial name
- NCT00002141
- Testing
- Abacavir sulfate
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Burroughs Wellcome
ALL, Childhood, Pediatric Cancer
Pharmacogenomic Association Study in Indian Children With Acute Lymphoblastic Leukemia
A five-year prospective observational cohort study. The study is focused on observing the relation between static germline variants and therapeutic response in Indian children with acute lymphoblastic leukemia (ALL).
- Conditions
- ALL, Childhood, Pediatric Cancer, Toxicity, Drug, Adverse Drug Event
- Trial name
- MPGx-INDALL (NCT05512169)
- Where
- 2 sites in India
- Volunteers
- 556 people
- Sponsor
- University of Geneva, Switzerland