Clinical trials: Drug-drug Interaction
Drug-Drug Interaction, HIV Infection
Dihydroartemisinin-Piperaquine in the Context of Antiretroviral Therapy
Open-label prospective intensive pharmacokinetic study of dihydroartemisinin-piperaquine (DP) in HIV-infected children on efavirenz (EFV)-, lopinavir/ritonavir (LPV/r)-, or dolutegravir (DTG)-based antiretroviral therapy (ART)…
- Trial name
- DPART (NCT04487145)
- Testing
- Dihydroartemisinin-piperaquine
- Where
- 2 sites in Uganda
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Drug Interaction
Risk Factors for Potential Drug -Drug Interactions: Study in Surgical Intensive Care Unit -Zagazig University Hospitals.
Drug drug interactions is frequent in critically ill patients due to polypharmacy, different drug groups and prolonged ICU or hospital stay
- Trial name
- NCT04078620
- Testing
- Survey for drug drug interactions on medscape and lexicomp applications
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Elevated Lipoprotein(a), Cardiovascular Diseases
Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Warfarin
This is a single center, open label, single sequence, two-treatment, two-period drug-drug interaction study to evaluate the effect of multiple doses of ISIS 681257 on the pharmacokinetics of a single dose of warfarin.
- Trial name
- NCT03426033
- Testing
- ISIS 681257, Warfarin
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Akcea Therapeutics
Drug-Drug Interactions
DDI Effectiveness and Clinical Awareness
The DECART study will determine if primary care physicians, including internists and family physicians, are able to identify and address drug-drug interactions among simulated patients and whether those physicians, when given…
- Trial name
- DECART (NCT03581994)
- Testing
- DDI Test Report
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Opioid-Related Disorders, Substance-Related Disorders
Effects of Combined Alcohol and Nitrous Oxide Intake - 15
The purpose of this study is to determine the effects of combined alcohol and nitrous oxide intake on mood, psychomotor performance, and the pain response in healthy volunteers.
- Trial name
- NCT00000263
- Testing
- 30% Nitrous oxide, 0.25 g/Kg ethanol, 0.5 g/KG ethanol
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Osteoporosis
A Study Of SB-751689, Atorvastatin, Ketoconazole, And Rosuvastatin In Health Postmenopausal Women.
The first purpose of this study is to determine if taking SB-751689 along with Rosuvastatin (CRESTOR) or Atorvastatin (LIPITOR) will change how Rosuvastatin or Atorvastatin are absorbed and eliminated from the body.
- Trial name
- NCT00388596
- Testing
- SB-751689
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Effects of Kava on the Body's Elimination of Caffeine and Dextromethorphan
This study will examine how kava-a widely used herbal remedy-may affect the body's elimination of other medicines. Many people take kava to reduce anxiety or cause sedation.
- Trial name
- NCT00009542
- Testing
- kava (Piper methysticum)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Drug Dose
Pediatric Drug Dose Calculation
This study is a randomized controlled trial that aimed to investigate the effect of a web-supported interactive learning program on the knowledge level of nursing students about pediatric drug dose calculation.
- Trial name
- NCT07305233
- Testing
- Study Group
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Ege University
Adolescent Health, Adolescent Problem Behavior
The Seattle Social Development Project: An Implementation of the Raising Healthy Children Intervention
The Seattle Social Development Project (SSDP) included a three-part intervention for teachers, parents, and students in grades 1 to 6.
- Trial name
- SSDP (NCT04075019)
- Testing
- The Raising Healthy Children intervention, including teacher training, child skill development, and parent training
- Volunteers
- 808 people, healthy volunteers welcome
- Sponsor
- University of Washington
Substance Abuse, Risk Reduction
First Years Away From Home: Letting Go and Staying Connected
Alcohol abuse is the leading cause of death and serious injury among college students, and students also experience significant harms from other types of substance misuse and risk behaviors.
- Conditions
- Substance Abuse, Risk Reduction, RIsky Sexual Behavior
- Trial name
- FYAH:LGSC (NCT03227809)
- Testing
- Handbook condition, Handbook plus condition
- Where
- United States
- Volunteers
- 910 people, healthy volunteers welcome
- Sponsor
- Washington State University
HIV Infection, Healthy
The Effect of Milk Thistle on the Pharmacokinetics of Indinavir
Complementary and alternative medicines are widely used in the HIV-infected population. Recent data have shown serious drug interactions between certain complementary medicines and protease inhibitors.
- Trial name
- NCT00011635
- Testing
- Silymarin (milk thistle)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Substance Use
Interactive Technology for Media Literacy Drug Prevention in Community Groups
This Phase II STTR will evaluate an interactive, self-paced, e-learning media literacy intervention, REAL media, to prevent youth substance use among youth in the 4-H organization.
- Trial name
- NCT03157700
- Testing
- REAL media curriculum
- Where
- United States
- Volunteers
- 642 people, healthy volunteers welcome
- Sponsor
- Real Prevention, LLC
Overweight, Glucose Metabolism Disorders
The Physical Activity and Nutrition in Children (PANIC) Study
The Physical Activity and Nutrition in Children (PANIC) Study is a single-centre controlled trial on the effects of a combined physical activity and dietary intervention on cardiometabolic risk factors and other health outcomes…
- Conditions
- Overweight, Glucose Metabolism Disorders, Lipid Metabolism Disorders, Blood Pressure
- Trial name
- PANIC (NCT01803776)
- Testing
- lifestyle counseling
- Where
- Finland
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Healthy
Investigation of Pharmacokinetic Drug-drug Interaction of BI 409306 and Donepezil in Healthy Male and Female Subjects
Part I: To investigate whether and to what extent donepezil affects single dose pharmacokinetics of BI 409306 Part II: To investigate whether and to what extent BI 409306 affects the single dose pharmacokinetics of donepezil
- Trial name
- NCT02635750
- Testing
- BI 409306, Donepezil
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Healthy
Effect of Ginkgo Biloba on Phenytoin Elimination
This study will examine how the herbal remedy ginkgo biloba may affect the body's elimination of other medicines. Many people take ginkgo biloba to improve memory, mental alertness and overall feeling of well being.
- Trial name
- NCT00011063
- Testing
- Ginkgo Biloba
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections, Contraception
Kuwa Free! - Live Free!
The study investigators are conducting foundational pharmacokinetic (PK) and qualitative studies, among 15-24 years old (inclusive) adolescent girls and young women living with HIV (AGYWLHIV) already on oral antiretroviral…
- Conditions
- HIV Infections, Contraception, Drug-drug Interaction
- Trial name
- NCT05044962
- Testing
- Cabotegravir/ Rilpivirine, Etonogestrel (ETG) implant, Intramuscular depo-medroxyprogesterone acetate (IM DMPA)
- Where
- Kenya
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Artificial Intelligence (AI), Clinical Reasoning
Teaching Doctors in Training to Reason With Artificial Intelligence
The purpose of the TEACH-AI study is to assess whether a brief, structured workshop on artificial intelligence can improve the performance of medicine doctors in training (i.e.
- Conditions
- Artificial Intelligence (AI), Clinical Reasoning, Clinical Decision-making, Medical Education
- Trial name
- TEACH-AI (NCT07813754)
- Testing
- Workshop-First
- Where
- 4 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Healthy
Drug Interaction Study of Tegretol (Carbamazepine) and St. John's Wort in Normal Volunteers
St. John's Wort is a popular dietary supplement that many patients-including those with epilepsy or seizures-take in addition to their regular medicines to elevate mood or relieve stress.
- Trial name
- NCT00006395
- Testing
- St. John's Wort
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)