Clinical trials: Dry Eye Syndromes
Sjogren's Syndrome
Sjogren's Mini-Pill Oral and Gut Microbiome Study
The goal of this observational study is to characterize and compare region-specific gastrointestinal, stool, oral, and periodontal microbiomes in adults with Sjögren's disease and healthy controls using ingestible mini-pill…
- Trial name
- NCT07732582
- Testing
- Mini-Pill
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tufts University
Rheumatic Diseases, Lupus Erythematosus, Systemic
Pain Phenotyping of Rheumatic Diseases - An Observational Study
Background: Rheumatic diseases can affect the joints, ligaments, tendons, bones, muscles, and skin. They can also cause inflammation, damage body tissues, and change nerve signals in the brain.
- Conditions
- Rheumatic Diseases, Lupus Erythematosus, Systemic, Lupus Vasculitis, Central Nervous System, Arthritis
- Trial name
- NCT07829497
- Testing
- Bedside quantitative sensory testing
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Dry Eye Disease
Comparison of Mucin Levels at the Ocular Surface of Visual Display Users With and Without Dry Eye Disease
The study aimed to evaluate 1) if levels of the glycocalyx membrane mucins, including MUC1, MUC4, MUC16 and MUC20, are altered in conjunctival cells of visual display users With and Without Dry Eye Disease, and 2) if mucin levels…
- Trial name
- NCT05604651
- Testing
- no intervention
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Systemic Lupus, Rheumatoid Arthritis
Yellow Fever Vaccine in Patients With Rheumatic Diseases
According to World Health Organization (WHO), since December 2016, Brazil is showing a significant increase in cases of yellow fever in humans.
- Conditions
- Systemic Lupus, Rheumatoid Arthritis, Spondyloarthritis, Inflammatory Myopathy
- Trial name
- NCT03430388
- Testing
- Yellow Fever vaccine (17D)
- Where
- Brazil
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Dry Eye
Evaluation of Onefit Scleral Lenses in the Mangement of Dry Eye
This study is being conducted to determine if scleral lenses treated with Hydra-PEG improve comfort and dryness.
- Trial name
- NCT05973409
- Testing
- scleral lens
- Where
- Canada
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- CooperVision International Limited (CVIL)
Dry Eye Syndromes
Comparison Of Blue Light Filter Feature and Blue Blocking Lenses in Digital Device Users With Dry Eye Patients
Comparing Blue Light Filter feature and Blue Blocking Lenses for Dry Eye Patients Prolonged screen time can exacerbate dry eye symptoms.
- Trial name
- NCT06913504
- Testing
- Blue cut filter, blue cut glasses
- Where
- Pakistan
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Superior University
Dry Eye Disease, Meibomian Gland Disease
Treating Meibomian Gland Disease in a Pediatric Population
Dry Eye Disease (DED) is commonly encountered among eye care professionals. DED is a disease of the tears and ocular surface that is multi-factorial resulting in a wide range of symptoms and signs with potentially damaging…
- Trial name
- LLLT in Peds (NCT07229001)
- Testing
- Low level light treatment, warm compress and artificial tear
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Illinois College of Optometry
Autologous Serum Eye Drops, Dry Eye Syndrome
Autologous Serum Eye Drops in Dry Eye Syndrome
This study aims to evaluate the clinical efficacy and safety of autologous serum eye drops (ASEDs) in patients with moderate-to-severe dry eye syndrome who are refractory to conventional artificial tear therapy.
- Trial name
- NCT07295691
- Testing
- Autologous Serum Eye Drop
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- The General Authority for Teaching Hospitals and Institutes
Dry Eye Disease
Efficacy of 0.05% Cyclosporine A Eye Drops Combined With Absorbable Tear Duct Plugs in the Treatment of Dry Eye in Sjögren's Syndrom
To study the effectiveness of 0.05% cyclosporine A eye drops in combination with smart plug absorbable lacrimal duct plugs in the monotherapy of cyclosporine for SSDE.
- Trial name
- NCT07171710
- Testing
- 0.05% Cyclosporine Eye Drops, Smart plug absorbable lacrimal duct plugs
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Tianjin Eye Hospital
Dry Eye Syndrome
Evaluation of Tear Osmolarity Over Time With Sustained Use of Thera Tears Lubricating Drops
The objective of the study is to demonstrate a change in osmolarity over time when moderate to severe dry eye subjects are treated with TheraTears lubricating drops.
- Trial name
- AKORN (NCT02758327)
- Testing
- TheraTears Lubricating Eye Drops
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Koffler Vision Group
Dry Eye Syndromes
Mask-associated Dry Eye Symptoms in China
To review the relationship of increased face mask usage arising from lockdown measures instituted during the COVID-19 pandemic with dry eye symptoms on Chinese people, and make recommendations for mitigating potential detrimental…
- Trial name
- NCT04744805
- Testing
- face mask or not
- Volunteers
- 6,262 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Juvenile Open Angle Glaucoma, Dry Eye Disease (DED)
Supplementary Kelulut Honey Therapy in Juvenile Open-Angle Glaucoma: Effects on IL-6, RNFL and Dry Eye
The goal of this clinical trial is to evaluate the effects of stingless bee honey (Kelulut honey) in juvenile open-angle glaucoma patients.
- Conditions
- Juvenile Open Angle Glaucoma, Dry Eye Disease (DED), Interleukin 6, Retinal Nerve Fiber Layer Thickness
- Trial name
- HONEY-JOAG (NCT07396441)
- Testing
- Stingless bee honey (Kelulut)
- Where
- 4 sites in Malaysia
- Volunteers
- 60 people
- Sponsor
- Universiti Sains Malaysia
Leukodystrophy, White Matter Disease
The Myelin Disorders Biorepository Project
The Myelin Disorders Biorepository Project (MDBP) seeks to collect and analyze clinical data and biological samples from leukodystrophy patients worldwide to support ongoing and future research projects.
- Conditions
- Leukodystrophy, White Matter Disease, Leukoencephalopathies, 4H Syndrome
- Trial name
- MDBP (NCT03047369)
- Where
- 23 sites in United States
- Volunteers
- 12,000 people
- Sponsor
- Children's Hospital of Philadelphia
Sjogren's Syndrome, Dry Eye
Assessment of Inflammatory and Functional Changes in the Ocular Surface Associated With Dry Eye Disease
This project will examine the similarities and differences of the ocular surface and tear film in patients with Sjogren's syndrome related to dry eye, severe dry eye and those who do not have dry eye.
- Trial name
- JADE (NCT00809003)
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Dry Eye
Lipid Layer Thickness Pre and Post Lid Scrubs With Cliradex
Tears play a vital role in vision. A thin layer of tears is always present to cover the surface of the eye for optimal comfort and vision.
- Trial name
- HONDA (NCT02493244)
- Testing
- Cliradex
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Dry Eye
Effects of 3% Diquafosol on Tear Film and Vision-related Quality of Life in Orthokeratology Lens Related Dry Eye
Investigate the effect of 3% Diquafosol on tear film and vision-related quality of life in dry eye patients wearing orthokeratology lenses(OK lens), and to provide reference for clinical treatment.This prospective, open label…
- Trial name
- NCT06537349
- Testing
- 3% Diquafosol tetrasodium
- Volunteers
- 30 people
- Sponsor
- He Eye Hospital
Graft Vs Host Disease
Cyclosporine Implant for Ocular Graft-Versus-Host Disease
Graft-vs.-Host Disease (GVHD) is a major complication of allogeneic hematopoietic stem cell transplantation (SCT) commonly affecting the skin, liver, gastrointestinal tract, and eye.
- Trial name
- NCT00102583
- Testing
- Subconjunctival Cyclosporine Implant
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Eye Institute (NEI)
Dry Eye Syndromes
Treatment Regimens in Meibomian Gland Dysfunction
This study seeks to explore the relevance of inflammation in dry eye patients with MGD and compare the efficacy of LipiFlow treatment followed by lid hygiene and lubricant treatment with Systane Ultra or LipiFlow treatment…
- Trial name
- NCT05594745
- Testing
- Lifitegrast Ophthalmic, Systane Free, Lipiflow
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tauber Eye Center
Dry Eye Disease
Effectiveness of Dry Eye Treatment With Diquafosol Sodium 3% After Phaco Surgery
The goal of this observational study is to evaluate the effectiveness of diquafosol sodium 3% in patients undergoing phacoemulsification surgery and having dry eye 1 week after the surgery.
- Trial name
- NCT07122635
- Testing
- Diquafosol Sodium 3%
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Le Xuan Cung
Pterygium, Dry Eye
Using Impression Cytology to Observe the Cytological Changes of Ocular Surface Cells in Various Ocular Surface Disorders
Currently, due to the advantage of noninvasive, localized, rapid, painless and easily repeatable of impression specimens, the technique is an ideal method of investigating ocular surface disorders when the diagnosis is not…
- Conditions
- Pterygium, Dry Eye, Tumor
- Trial name
- NCT01387971
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital