Clinical trials: Dysfunction
Peripartum Cardiomyopathy
Peripartum Cardiomyopathy in Nigeria Registry
Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality, and Nigeria probably has the highest burden of the disease in the world.
- Trial name
- PEACE (NCT03081949)
- Testing
- Oral Sodium Selenite 200 µg/day for 3 months
- Where
- 2 sites in Nigeria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aminu Kano Teaching Hospital
Temporomandibular Dysfunction
Temporomandibular Dysfunction and Cervical Posture
The aim of this research was to determine the existence of a correlation between the degree of temporomandibular dysfunction and cervical posture in different occlusal classes in adolescents.
- Trial name
- NCT01331538
- Where
- Brazil
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Emotional Dysfunction, Early Life Stress
Dyadic Neurofeedback for Emotion Regulation in Youth With Maternal Adversity
This study will examine the effect of a real-time functional magnetic resonance imaging (fMRI) dyadic neurofeedback protocol with mothers and their adolescent daughters.
- Trial name
- NCT04964726
- Testing
- Real-time fMRI dyadic neurofeedback
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Stem Cell Transplant, Late Effect
Monitoring Neurocognitive Dysfunction and the Impact of Metabolism and Physical Capacity After Paediatric HSCT
Today the overall survival of childhood cancers has increased to above 85%. This increase is partially caused by treatment with bone marrow transplantation.
- Conditions
- Stem Cell Transplant, Late Effect, Neurocognitive Dysfunction, Paediatric Patients
- Trial name
- MindMe (NCT07140445)
- Where
- Denmark
- Volunteers
- 175 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Left Ventricular Dysfunction
Insulin Cardioplegia for Poor Left Ventricular Function
The purpose of this investigation is to develop a means to improve the recovery of cardiac metabolism and ventricular function following coronary artery bypass surgery (CABG) in patients with poor preoperative ventricular…
- Trial name
- NCT00188994
- Testing
- Insulin Cardioplegia
- Where
- Canada
- Volunteers
- 800 people
- Sponsor
- University Health Network, Toronto
Sickle Cell Disease, Cognitive Impairment
Cognitive Remediation Intervention to Prepare for Transition of Care
Randomized Controlled Trial (RTC) testing the efficacy of a telehealth adaptation of the Cognitive-Remediation of Executive and Adaptive Deficits in Youth (C-READY) intervention to prepare adolescents with sickle cell disease for…
- Conditions
- Sickle Cell Disease, Cognitive Impairment, Adolescent Behavior, Self Efficacy
- Trial name
- NCT05336201
- Testing
- CREADY (Cognitive-Remediation of Executive and Adaptive Deficits in Youth)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
Infant Nutrition Disorders, Gastrointestinal Dysfunction
Post-market Surveillance Study of an Infant Formula Containing Moderately Hydrolyzed Protein and Low Lactose
The study is a before-after trial to evaluate whether the study formula containing moderately hydrolyzed protein and low lactose will be able to improve mild gastrointestinal disorders (MGDs) in infants.
- Trial name
- NCT04112056
- Testing
- Drink the study formula (NAN Comfort producted by Nestle Deutschland AG)
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Peking University
Dementia, Mild Cognitive Impairment
Video Games to Track Cognitive Health
The purpose of this study is to assess cognitive function using a rapid, portable, computerized neurocognitive testing device in a wide variety of clinical settings.
- Conditions
- Dementia, Mild Cognitive Impairment, Cognitive Impairment, Cognitive Decline
- Trial name
- NCT03608722
- Testing
- SLUMS, MMSE, MoCA
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- BrainCheck, Inc.
Eyelid Diseases
Evaluation of Satisfaction Regarding Patient's Management of Ocular Surface Diseases
Multicentric study, open label, uncontrolled phase IV in 30 patients with meibomian glands dysfunction . Its objective is to Collect information from patients and ophthalmologists specialized in ocular surface and eyelids to…
- Trial name
- ESPOIR (NCT01091311)
- Testing
- Blephasteam
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Laboratoires Thea
Vaginismus
Spinal Anesthesia Facilitated Sexual Intercourse As A Treatment Option For Vaginismus
Painful sex continues to be a relationship issue and can lead to marital dys-harmony. Other consequences include infertility, low self-esteem, depression and anxiety.Our study shows that spinal anesthesia is an effective last…
- Trial name
- NCT04436172
- Testing
- spinal anesthesia
- Volunteers
- 20 people
- Sponsor
- Karachi Medical and Dental College
Stunting, Malnutrition; Protein
Protein Plus: Improving Infant Growth Through Diet and Enteric Health
This cluster-randomized controlled trial is designed to address linear growth faltering in 6-12-mo-old Bangladesh infants through a proof-of-concept package of interventions to a) increase intake of high quality protein and b)…
- Conditions
- Stunting, Malnutrition; Protein, Enteric Pathogens, Campylobacter Infections
- Trial name
- JiVitA-6 (NCT03683667)
- Testing
- Azithromycin Oral Product, Protein Supplement, Isocaloric Supplement
- Where
- Bangladesh
- Volunteers
- 5,283 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Eye Abnormalities, Arrythmia
Relation Between Oculocardiac Reflex and Laryngospasm
The aim of this study is to evaluate whether there is a significant relation between various arrhythmias during the surgeon's stretching the eye muscles and laryngospasm and emergence agitation in strabismus surgeries
- Trial name
- NCT05339880
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- TC Erciyes University
Acute Renal Failure, Gastroenteritis
Cystatin C as a Marker for Detecting Early Renal Dysfunction in a Pediatric Emergency Department
Acute renal failure (ARF) is a rare but serious complication of gastroenteritis and dehydration, the most common reason for pediatric emergency visits. Renal function is determined by the glomerular filtration rate (GFR).
- Conditions
- Acute Renal Failure, Gastroenteritis, Dehydration
- Trial name
- CARING (NCT00462527)
- Where
- Canada
- Volunteers
- 464 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
HIV, Endothelial Dysfunction
Use of EndoPAT for Measurements of Endothelial Dysfunction in HIV Infected Children and Healthy Controls
Our objective is to determine whether HIV infected youth have higher level of endothelial dysfunction, as measured by Peripheral Arterial Tonometry, when compared to age matched healthy controls.
- Trial name
- NCT02324179
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Cancer, Cardiovascular Disease
NCGENES: North Carolina Clinical Genomic Evaluation by NextGen Exome Sequencing
This study is part of a larger consortium project investigating the validity and best use of next-generation sequencing (in particular, whole exome sequencing, or WES) in clinical care.
- Conditions
- Cancer, Cardiovascular Disease, Neurologic Dysfunction, Congenital Abnormalities
- Trial name
- NCGENES (NCT01969370)
- Testing
- Experimental
- Where
- United States
- Volunteers
- 645 people
- Sponsor
- University of North Carolina, Chapel Hill
Myelomeningocele, Brain Malformation
The Role of CSF in Chiari II Brain Malformation
Spina bifida, particularly its most severe form known as open spina bifida (myelomeningocele), is a significant congenital disorder that results in profound neurological impairments, including Chiari II malformation.
- Conditions
- Myelomeningocele, Brain Malformation, Chiari Malformation Type 2
- Trial name
- NCT06560788
- Testing
- collection of cerebrospinal fluid
- Volunteers
- 18 people
- Sponsor
- University College, London
Neurocognitive Dysfunction, Language Development
Can Singing Kangaroo Improve Outcome of Preterm Infants
To assess whether a musical intervention (maternal/paternal singing) during the skin-to-skin sessions (Kangaroo care) would improve the language development of the preterm infant.
- Trial name
- SingKang (NCT03795454)
- Testing
- Singing
- Volunteers
- 140 people
- Sponsor
- University of Helsinki
Central Precocious Puberty (CPP), Puberty Disorders
Spexin and Phoenixin-20 in Girls With Central Precocious Puberty
Central precocious puberty (CPP) is characterized by the early activation of the hypothalamic-pituitary-gonadal axis in girls and may be difficult to distinguish from benign variants such as premature thelarche.
- Conditions
- Central Precocious Puberty (CPP), Puberty Disorders, Puberty, Hypothalamic-Pituitary-Ovarian Axis Dysfunction (Disorder)
- Trial name
- SPX-PNX-CPP-20 (NCT07359092)
- Where
- Turkey (Türkiye)
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Anxiety, Depression
Evaluation of Different Psychiatric Symptoms in Patients With Thyroid Dysfunction
1. Evaluate psychiatric symptoms in patients with thyroid dysfunction. 2. Investigate effect of treatment on psychiatric symptoms after 2 months.
- Conditions
- Anxiety, Depression, Thyroid Dysfunction
- Trial name
- NCT06185309
- Volunteers
- 85 people
- Sponsor
- Assiut University
Tourette Syndrome
The Pathophysiology of Tourette Syndrome: a Multimodal Study
The purpose of this study is to characterize the functional and anatomical connectivity changes in Tourette syndrome and its relation with iron deficiency.
- Trial name
- PTS (NCT02497807)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine