Clinical trials: Dysmotility
Motility Disorder of Intestine
Magnetic Resonance Imaging Assessment of Small Bowel Motility
This project involves the development, validation and application of a novel test using MRI to assess gastrointestinal motility a vital process that mixes the contents of our digestive tract.
- Trial name
- NCT02754869
- Where
- United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University College, London
Cerebral Palsy, Gastric Dysmotility
Effect of Protein Composition on Gastric Emptying
The protein composition of nutrition may affect the rate of gastric emptying and gastric fysiology. This is espesially important in children with neurologic impariment, who commonly rely on tube feedings, have feeding problems…
- Conditions
- Cerebral Palsy, Gastric Dysmotility, Enteral Feeding
- Trial name
- NCT00345566
- Testing
- Nutrition composition
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Ullevaal University Hospital
Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD)
Indiana University Gastrointestinal Motility Diagnosis Registry
Develop a registry (list of patients) with accurate clinical motility diagnosis. This registry will help the doctors to identify the patients with specific disease conditions.
- Conditions
- Eosinophilic Esophagitis, Gastroesophageal Reflux Disease (GERD), Gastroparesis, Functional Vomiting
- Trial name
- NCT04506593
- Testing
- no intervention
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Indiana University
Gastrointestinal Motility Disorder, Gastroparesis
IVIG for Drug and Device Refractory Gastrointestinal Auto-Immune Neuropathy
Patients with the symptoms of generalized GI dysmotility, including gastroparesis, are sometimes refractory to available medications, devices and other interventions/ Some of these patients have serologic and/or endo organ…
- Conditions
- Gastrointestinal Motility Disorder, Gastroparesis, Neuropathy
- Trial name
- GAIN (NCT04208828)
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Louisville
Oesophageal Motility Disorder
Correlation Between Clinical Signs and High-resolution Manometry Data in Children
High resolution oesophageal manometry (HRM) is the gold standard for the diagnosis of oesophageal motility disorder. Standard esophageal manometry has been replaced since 2000 by high resolution manometry.
- Trial name
- NCT03662490
- Testing
- High resolution oesophageal manometry
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Oesophageal Atresia, Dumping Syndrome
Dumping Syndrome and Esophageal Atresia
Dumping syndrome (DS) is frequent in oesophageal atresia (29%). In causing hypoglycaemia, it can be dangerous for neonates. Mechanisms of DS are actually partialy understood.
- Trial name
- DUMTORING (NCT04522193)
- Testing
- Glycemic Holter, gastric emptying scintigraphy, Holter ECG
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Lille
Preterm Infant, Feeding Disorder Neonatal
Oropharyngeal Administration of Mother's Milk in Preterm Infants and Gastrointestinal Motility
Mother's milk does not come in contact with the oropharyngeal pouch of preterm infants during gavage feeding. We hypothesized that stimulation of the oropharyngeal pouch using small amount of the mother's milk 5 minutes before…
- Conditions
- Preterm Infant, Feeding Disorder Neonatal, Gastrointestinal Motility Disorder
- Trial name
- OPAMM (NCT03552510)
- Testing
- Oro-pharyngeal Administration of Mother's Milk
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mansoura University Children Hospital
Motility Disorder of Small Intestine (Disorder)
Intestinal Dysmotility: Minute Rythm
Introduction: Intestinal manometry may detect phasic pressure patterns that suggest small bowel obstruction. The most common is the "clustered contractions pattern", characterized by repetitive short spouts of intestinal…
- Trial name
- NCT05230121
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Hirschsprung's Disease
Effects of Butyrate Enemas on Postoperative Intestinal Motility Disorders in Hirschsprung's Disease
Hirschsprung's disease (HD) is a rare congenital disorder (1/5000) defined by the absence of ganglion cells in the submucosal and myenteric plexuses along a variable length of the digestive tract.
- Trial name
- Buty-Hirsch (NCT03660176)
- Testing
- Sodium Butyrate, routine management
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Prader-Willi Syndrome
Effect of Intranasal Oxytocin on Dysphagia in Children and Adolescents With Prader-Willi Syndrome
This phase 2B is designed to test the effectiveness of intranasal Oxytocin on Prader Willi Syndrome (PWS). This is a prospective, multicentre, randomised, double-blind, Phase 2B clinical study planned to include around 24 PWS…
- Trial name
- DYSMOT (NCT05298085)
- Testing
- Oxytocin nasal spray
- Where
- 4 sites in France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Toulouse
Motility Disorder
The Relationship Between Body Surface Gastric Mapping and Gastric Emptying Rate
Currently, a new generation of high-resolution electrogastrograms recording technology with 64-channel electrode array is being developed by Alimetry Limited.
- Trial name
- NCT05093010
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Dysmotility Syndrome, Autoimmunity
Autoimmune Gastrointestinal Dysmotility: Symptoms, Pathogenesis and Treatment
Autoimmune gastrointestinal dysmotility syndromes are poorly understood, and often difficult to treat because the underlying pathogenesis is unclear. Refractory symptoms result in an impaired quality of life.
- Trial name
- NCT04859829
- Testing
- Current Intravenous Immunoglobulin (IVIG) treatment, No Intravenous Immunoglobulin (IVIG) treatment
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Johns Hopkins University
Bowel Dysfunction, Dysmotility
Comparison of a New Non-invasive Device With the Invasive Gold-standard Investigation to Assess Function of the Large Bowel in Children
The goal of this clinical trial is to learn if the new non-invasive device (Body Surface Colonic Mapping) works to accurately assess colonic movement and function in children.The main questions it aims to answer are: Are Body…
- Conditions
- Bowel Dysfunction, Dysmotility, Hirschsprung Disease, Anorectal Malformations
- Trial name
- NCT07789782
- Testing
- Body Surface Colonic Mapping
- Where
- Australia
- Volunteers
- 50 people
- Sponsor
- Murdoch Childrens Research Institute
Pediatric ALL, Motility Disorder
Feasibility and Efficacy of Physical Literacy Screening Integration Into Pediatric Clinical Settings
The proposed research will be the first study to investigate the feasibility of incorporating physical literacy screening into primary care clinical settings, while determining the efficacy of integration on physical literacy.
- Trial name
- PLAY II (NCT04950777)
- Testing
- patient education document
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Ocular Motility Disorder
Evaluation and Treatment of Pediatric Eye Diseases
This study offers evaluation and treatment for patients with pediatric eye diseases, particularly amblyopia and strabismus. The protocol is not designed to test new treatments; rather, patients will receive current standard of…
- Trial name
- NCT00006422
- Testing
- current standard of care treatments
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Eye Institute (NEI)
Short Bowel Syndrome, Intestinal Failure
Can SMOFlipid®, A Composite Parenteral Nutrition Lipid Emulsion, Prevent Progression Of Parenteral Nutrition Associated Liver Disease In Infants?
The aim of this study is to determine the feasibility of conducting a trial to examine the efficacy of an ω3FA (Omega-3 fatty acid) containing balanced lipid emulsion in the prevention of progression of PNALD in infants with…
- Conditions
- Short Bowel Syndrome, Intestinal Failure, Gastrointestinal Motility Disorder, Mucosal Enteropathy
- Trial name
- NCT00793195
- Testing
- Intralipid 20%, SMOFlipid 20%
- Where
- 5 sites in Canada
- Volunteers
- 24 people
- Sponsor
- The Hospital for Sick Children
Autoimmune Gastrointestinal Dysmotility
Novel Antineuronal Antibodies in Gastrointestinal Motility Disorders
Gastrointestinal motility disorders represent a heterogeneous group of neuromuscular diseases of the enteric nervous systems. While autoimmune neuromuscular diseases of the central nervous system (CNS) are well described, the…
- Trial name
- NCT04872439
- Testing
- Blood sample collection
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Johns Hopkins University
Dysautonomia
Temporary Celiac Ganglion Block as a Test Before Celiac Ganglion Resection for Dysautonomia-Related Bowel Dysmotility
Dysautonomia is malfunction of the autonomic nervous system. It usually results from overactivity of the sympathetic portion and over-secretion of acetylcholine.
- Trial name
- NCT04121338
- Testing
- Celiac ganglion block, Liposomal bupivacaine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Johns Hopkins University
Hemorrhagic Shock, Pediatric Trauma
Effect of Resuscitation on Gastric Emptying Using POCUS in Pediatric Trauma Patients
Pediatric trauma often leads to hemorrhagic shock, which reduces blood flow to the digestive tract and delays gastric emptying. This delay can cause fluid and food to remain in the stomach, increasing the risk of pulmonary…
- Conditions
- Hemorrhagic Shock, Pediatric Trauma, Delayed Gastric Emptying, Gastric Dysmotility
- Trial name
- NCT07810907
- Volunteers
- 50 people
- Sponsor
- Assiut University
Upper Gastrointestinal Motility Disorders
Use of an Ambulatory Capsule to Characterize Gastrointestinal Pressure Patterns in Children
This study will test a new medical device called the SmartPill GI Monitoring System, which is now used to diagnose gastric motility disorders in adults, in children.
- Trial name
- NCT01026922
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Nationwide Children's Hospital