Clinical trials: Early Caries Lesions
Dental Caries, Early Caries Lesion
Effect of Ozone Therapy on Remineralization of Initial Caries Lesions in Children
Initial caries lesions can be managed using non-invasive treatment approaches that promote remineralization and prevent lesion progression.
- Trial name
- OZONE-CARIES (NCT07671651)
- Testing
- Ozone Therapy, other
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Neslihan Atmaca
Dental Caries, Dental Caries in Children
Atraumatic Versus Silver-Modified Atraumatic Restorative Treatment in Primary Molars
The goal of this clinical trial is to evaluate and compare the short-term effectiveness of two minimally invasive treatments-Atraumatic Restorative Treatment (ART) and Silver-Modified Atraumatic Restorative Treatment (SMART)-in…
- Trial name
- NCT07023939
- Testing
- ART: Atraumatic restorative treatment, SMART: Silver-Modified Atraumatic Restorative Treatment
- Where
- Lebanon
- Volunteers
- 34 people
- Sponsor
- Beirut Arab University
Child, Early Childhood Caries
Evaluation of Remineralizing Efficacy of Combination Varnishes on White Spot Lesions in ECC Children
The remineralizing efficacy of 3 fluoride varnishes were assessed in children with white spot lesion under 6 years of age ( children with early childhood caries)
- Trial name
- NCT03360266
- Testing
- Sodium Fluoride with CPP-ACP varnish, sodium fluoride with ACP varnish, 5% Sodium Fluoride Varnish
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Indira Gandhi Institute of Dental Science
Caries
Effect of CPP-ACP With/Without Fl on White Spot Lesion,Salivary pH and fl Release in High Caries Risk Patients
Effect of CPP-ACP pastes with/without Fluoride on White spot lesion progression, salivary pH and fluoride release in high caries risk Patients, over 3 month period using VistaCam, Digital pH meter and Selective ion electrode.
- Trial name
- NCT03656432
- Testing
- CPP-ACP paste
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesion of Tooth
Efficacy of Different Agents in Treatment of Initial Caries on Smooth Surfaces in Permanent Teeth in Children
White spot lesions (WSL) are characterized by an apparently intact outer surface and a demineralized subsurface, and are considered the first clinical sign of dental caries.
- Trial name
- NCT05206539
- Testing
- Self-assembling peptide (P11-4), CPP-ACFP, Resin infiltration
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Dental Caries
Self Assembling Peptide P11-4 in Patients With Early Occlusal Carious Lesions
Objectives: Occlusal surfaces of erupting permanent molars are highly prone to caries. Self-assembling peptide (P11-4) has proven to enhance biomimetic mineralization of early carious lesions.
- Trial name
- NCT02724592
- Testing
- self assembling peptide P11-4 (Curodont™ Repair), fluoride varnish (Duraphat®)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Clinical Evaluation of the Efficacy of SPR-G Barrier Coat Versus Fluoride Varnish Versus MI Paste in the Treatment of Early White Spot Lesions in Pediatric Patients
In-Vivo randomized clinical trial to compare between the clinical performance of fluoride varnish versus MI paste (CPP_ACP) and the PRG- Barrier coat material concerning enamel remineralization, arrest of active early lesions…
- Trial name
- NCT05202821
- Testing
- PRG Barrier Coat, Fluoride varnish, MI paste
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Tooth Decay
Preventive Treatment Approach of Early Caries Lesions With Contemporary Methods of Remineralization
The purpose of this study is to evaluate 1. the additional therapeutic benefit of Curodont Repair for the treatment early occlusal carious lesions on permanent teeth in children compared fluoride varnish alone 2.
- Trial name
- NCT03780270
- Testing
- Fluoride Varnish, Curodont Repair, Curodont Protect
- Volunteers
- 90 people
- Sponsor
- University Dentistry Clinical Center of Kosovo
Enamel Caries
Medical Treatment of Early-Enamel Carious Lesion Using Different Remeneralizing Agents
Medical Treatment of Early-Enamel Carious Lesion using Different Remeneralizing agents
- Trial name
- NCT05296213
- Testing
- Silver diamine fluoride- potassium iodide, Casein phosphopeptide amorphous calcium phosphate, experimental tricalcium silicate
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mansoura University
White Spot Lesion of Tooth
Effect of Different Pastes on Remineralization of Early Caries Lesions in Primary Teeth
This study is a randomized controlled trial involving 118 children ages between 4 and 5 years to assess the remineralization effect of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions in primary…
- Trial name
- NCT03526276
- Testing
- CPP-ACP paste, Fluoride toothpaste, Both (Fluoride and CPP-ACP)
- Where
- Jordan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Early Caries Lesions
A Prospective, Randomized Clinical Study on the Effects of Casein Phosphopeptide-amorphous Calcium Phosphate (CPP-ACP) Paste on Plaque, Gingivitis and White Spot Lesions in Orthodontic Patients - Part 1
Influence of CPP-ACP paste on the evolution and appearance of white spot lesions in orthodontic patients after removal of the fixed appliances.
- Trial name
- NCT00670670
- Testing
- CPP-ACP (GC Tooth Mousse), CPP-ACP (GC MI Paste Plus)
- Where
- Belgium
- Volunteers
- 325 people
- Sponsor
- University Hospital, Ghent
Early Childhood Caries
A Clinical Trial of Silver Diamine Fluoride to Arrest Early Childhood Caries in Young Children
Silver diamine fluoride (SDF) is an antibiotic liquid that has the potential to arrest Early Childhood Caries in young children and delay treatment until children can be seen in outpatient settings.
- Trial name
- NCT04054635
- Testing
- Silver diamine fluoride
- Where
- Canada
- Volunteers
- 84 people
- Sponsor
- University of Manitoba
Dental Caries, Early Caries Lesions
A Randomized Split-Mouth Clinical Trial Comparing Resin Infiltration and Microabrasion for Early Caries Lesions
This study aims to evaluate and compare the clinical characteristics and treatment outcomes of early caries lesions using resin infiltration (Icon) and microabrasion (Opalustre).
- Conditions
- Dental Caries, Early Caries Lesions, White Spot Lesions[Initial Caries]on Smooth Surface of Tooth
- Trial name
- ICON-CTU (NCT07544849)
- Testing
- Resin Infiltration, Microabrasion
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Can Tho University of Medicine and Pharmacy
White Spot Lesions, Caries
Randomized Trial on Resin Infiltration in Deciduous Teeth
It was hypothesized that resin infiltration in conjunction with fluoride varnish treatment of smooth-surface caries lesions in deciduous teeth reduce considerably the progression of treated caries lesions, compared to fluoride…
- Trial name
- infiltration (NCT01881100)
- Testing
- resin infiltration, fluoride varnish
- Where
- Poland
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Early Caries Lesions
A Prospective, Randomized Clinical Study on the Effects of Casein Phosphopeptide-amorphous Calcium Phosphate (CPP-ACP) Paste on Plaque, Gingivitis and White Spot Lesions in Orthodontic Patients - Part 2
Influence of CPP-ACP paste and Elmex Medical Gel on the prevention of white spot lesions in orthodontic patients during fixed appliances.
- Trial name
- NCT00670618
- Testing
- CPP-ACP (GC Tooth Mousse), CPP-ACP (GC MI Paste Plus), Fluoride (Elmex Medical Gel)
- Where
- Belgium
- Volunteers
- 325 people
- Sponsor
- University Hospital, Ghent
Tooth; Lesion, White Spot Lesions
Resin Infiltratration on the Sealing of Proximal Early Caries
Material for caries prevention dont have better results compared with non-operatory interventions.
- Trial name
- NCT01659463
- Testing
- ICON, instruction oral hygiene
- Where
- Brazil
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Enamel Lesions, Caries
Enamel Lesion Detection With New DX Tool
The primary objective of this 12-week study is to test BlueCheck's ability to identify enamel lesions consistently, and its ability to track changes in these lesions over time.
- Trial name
- NCT07819370
- Testing
- BlueCheck, Prevident 5000ppm Booster Plus Toothpaste
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Colgate Palmolive
Caries; Initial, Occlusal Caries
Early Treatments for Preventing Occlusal Caries Lesions
Sealants effectively arrest non-cavitated caries lesions on the fully erupted occlusal surface of permanent teeth. However, the clinical effectiveness of sealants is uncertain in preventing occlusal caries lesions in partially…
- Conditions
- Caries; Initial, Occlusal Caries, Caries,Dental
- Trial name
- NCT05969756
- Testing
- Fluoride varnish, Conventional etch and rinse sealant, Self-etch sealant
- Where
- 2 sites in Vietnam
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hue University of Medicine and Pharmacy
Remineralization Effect of the Varnish on White Spot Lesions
Remineralization Potential of MI Varnish Versus Fluoride Varnish on White Spot Lesions in Maxillary Primary Incisors
Remineralization effect of CPP-ACP and Fluoride (MI varnish) versus Fluoride varnish on white spot lesions in maxillary primary incisors
- Trial name
- NCT03731403
- Testing
- MI varnish
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Remineralization of White Spot Lesions Using Self-Assembling Peptide P11-4 in Primary Anterior Teeth A Randomized Clinical Trial
This study is a randomized controlled clinical trial on primary anterior teeth of 3-5 year-old patients suffering from white spot lesions (ICDAS system II scores 1-2).
- Trial name
- NCT03927794
- Testing
- Self-Assembling Peptide P11-4
- Where
- Egypt
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Ain Shams University