Clinical trials: Early Detection
Moyamoya Disease
Family-Based Moyamoya Susceptibility and Early Detection
This single-center, prospective, family-based observational cohort study aims to investigate susceptibility to moyamoya disease (MMD) and to develop strategies for early screening in individuals at increased familial risk.
- Trial name
- FAMES (NCT07517354)
- Testing
- 5T High-Resolution MRI
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
HIV
Evaluation of Use of Clinical Decision Support System in HIV Care in Resource Constrained Settings
The purpose of this study is to determine whether the use of a Computerized Decision Support System (CDSS) in form of alerts to clinicians enhances early detection of immunological treatment failure in HIV patients.
- Trial name
- CDSS (NCT01634802)
- Testing
- EMR Only, EMR+CDSS
- Where
- Kenya
- Volunteers
- 1,460 people
- Sponsor
- Kenya Medical Research Institute
Dementia
Implementation Study of Dementia Guidelines in Primary Care
The purpose of this study is to determine whether a specially developed Dementia Training Program for duos of general practitioners and primary care nurses is able to increase the number dementia diagnoses in elderly people…
- Trial name
- NCT00459784
- Testing
- Dementia Training Program
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Bipolar Disorder, Depression
Early Detection and Prevention of Mood Disorders in Children of Parents With Bipolar Disorder
This study will develop strategies for early detection and prevention of mood disorders and associated impairment in adolescent children of parents with bipolar disorder.
- Trial name
- NCT00338806
- Testing
- Interpersonal psychotherapy for prevention with adolescents, Educational clinical monitoring
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- New York State Psychiatric Institute
Language Disorders in Children, Learning; Developmental Disorder
Impact of Teacher Training and the Introduction of Early Adjustments on the Developmental Trajectory of Children at Risk of SLLD in Pre-school.
The high incidence of neurodevelopmental disorders, including specific language and learning disorders, and their profund impact on the schooling of the children concerned remains a major public health concern.
- Trial name
- PRISME-TSLA (NCT06062147)
- Testing
- Teacher training
- Where
- Reunion
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Liver Fibrosis
T1rho Imaging of Liver in Presence of Iron
Liver T1rho is elevated in response to accumulation of extracellular matrix proteins during fibrosis. The presence of hepatic iron overload; however, can shorten the T1rho value.
- Trial name
- NCT05154643
- Where
- Hong Kong
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Adolescent Idiopathic Scoliosis (AIS)
Detection of Scoliosis
This study aims to evaluate whether plantar pressure data collected during standing and walking can be used with machine learning to support early detection of scoliosis in young people.
- Trial name
- NCT07581015
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University College, London
Dental Caries, Detection
Comparing Fluorescent Starch Nanoparticles Rinse with ICDAS for Early Caries Detection in Children
The present study aims to evaluate the diagnostic accuracy of fluorescent starch nanoparticles caries detection rinse versus the International Caries Detection and Assessment System (ICDAS) in identifying early dental caries…
- Conditions
- Dental Caries, Detection, Fluorescence, Diagnostic Accuracy
- Trial name
- FSNCDR-ICDAS (NCT06761248)
- Testing
- Fluorescent Starch Nanoparticles Caries Detection Rinse
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Cairo University
Gastrointestinal Stromal Tumor
A Study on Non-invasive Early Diagnosis of Gastrointestinal Stromal Tumors and Differentiation of Benign and Malignant Nodules
Gastrointestinal Stromal Tumors (GIST) is the most common mesenchymal tumor of the gastrointestinal tract, and the incidence rate in China has increased year by year in recent years.Gastrointestinal stromal tumors are not…
- Trial name
- NCT04143048
- Testing
- DNA extraction of tumer tissue samples and high-throughput sequencing of small panels, DNA extraction of tumer tissue samples and blood sample and high-throughput sequencing of small panels
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
5 Year Old Children Born Prematurely
Early Detection of Developmental Abnormalities of Preterm Infants at 5 Years of Age
The project is a national, prospective, multicenter, interventional pilot project focused on the follow up of 5 year old children that were born prematurely.
- Trial name
- NCT07391527
- Testing
- Pediatric check-up
- Where
- 4 sites in Czechia
- Volunteers
- 210 people
- Sponsor
- Institute of Health Information and Statistics of the Czech Republic
Obesity Prevention, Pediatric Obesity
Relationship Between Eating Patterns, Body Composition and the Detection of Fatty Liver in Children and Adolescents With Trisomy 21: LiverTy Project
Childhood obesity is a growing public health issue affecting millions of children worldwide, increasing the risk of metabolic and cardiovascular diseases in adulthood.
- Conditions
- Obesity Prevention, Pediatric Obesity, Trisomy 21, Down Syndrome (Trisomy 21)
- Trial name
- LiverTy (NCT06888570)
- Testing
- To evaluate fat liver content in the cases/controls population.
- Where
- Spain
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- IMDEA Food
Surgical Wound Infection, Heart; Surgery, Heart, Functional Disturbance as Result
Early Detection of Surgical Wound Infections Using Sensor Technology
Infections that are caused by surgical incision are commonly known as surgical site infections (SSI). A surgical wound infection can develop at any time after surgery until the wound has healed (usually two to three weeks after…
- Trial name
- SSI-Sensor (NCT03401658)
- Testing
- Sensor light detector
- Where
- United Kingdom
- Sponsor
- Liverpool Heart and Chest Hospital NHS Foundation Trust
Inherited Retinal Degeneration Associated With RPGR Mutations, Inherited Retinal Degeneration Associated With Biallelic RPE65 Mutations
Monitoring and Early Detection of Treatable Inherited RETinal Disease in Children and Adolescents
The goals of this observational study are to develop and train artificial intelligence (AI) algorithms using multimodal imaging to identify patients with inherited retinal degeneration (IRD) caused by Retinal Pigment Epithelium…
- Trial name
- MEDIRET (NCT07901907)
- Where
- 3 sites in United States, Germany and 1 more
- Volunteers
- 4,887 people, healthy volunteers welcome
- Sponsor
- University College, London
Melanoma
War on Melanoma™ Public Health & Education Campaign
This trial studies how well a health educational campaign works in increasing early detection of melanoma in Oregon. The health educational campaign may provide information to help people learn about the early signs of melanoma.
- Trial name
- NCT04611568
- Testing
- Educational Intervention, Health Education, Media Campaign
- Where
- United States
- Volunteers
- 75,000 people, healthy volunteers welcome
- Sponsor
- OHSU Knight Cancer Institute
Pre-eclampsia, Pregnancy
IMproved PRegnancy Outcome by Early Detection
The overall objective of the IMPROvED project is to develop a sensitive, specific, high-throughput and economically viable early pregnancy screening test for preeclampsia.
- Conditions
- Pre-eclampsia, Pregnancy, Pregnancy, High-risk, Pregnancy Complications
- Trial name
- IMPROvED (NCT01891240)
- Where
- 6 sites in Ireland, Netherlands and 2 more
- Volunteers
- 5,000 people
- Sponsor
- Louise Kenny
Autism Spectrum Disorder, Neurodevelopmental Disorders
A Smart Toy for Motor Function and Early Assessment of Children With Possible Autism
Autism diagnostic referrals across the UK have doubled within the last five years. Covid-19 has further delayed diagnostic pathways, while innovation has not kept pace in assisting clinical teams with low cost, fast, and…
- Trial name
- Tangiball (NCT04980677)
- Testing
- Tangiball
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Sussex Community NHS Foundation Trust
Down Syndrome, Obstructive Sleep Apnea of Newborn
Early Detection and Treatment of Obstructive Sleep Apnoea in Infants With Down Syndrome
Interventional, comparative, open-label, single-center study to demonstrate that early (from 6 months of age) and systematic (every 6 months) screening for Obstructive Sleep Apnoea (OSA) by polysomnography (PSG) in infants with…
- Trial name
- RESPIRE21 (NCT03210675)
- Testing
- Polysomnography (PSG)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Institut Jerome Lejeune
Blood Disease
Cystatin c and Beta 2 Microglobulin in Thalassemic Children.
Beta thalassemia has many complications on many systems as the renal system.So early detection of renal impairment is required in those children to decrease complications of this nephropathy.
- Trial name
- NCT03881917
- Testing
- Cystatin c and beta 2 microglobulin kits
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rare Diseases
Children Affected by Rare Disease and Their Families Network
Families of children with rare diseases (i.e., not more than 5 out of 10.000 people are affected) are often highly burdened with fears, insecurities and concerns regarding the affected child and his/her siblings.
- Trial name
- CARE-FAM-NET (NCT04339465)
- Testing
- CARE-FAM, WEP-CARE
- Where
- 17 sites in Germany
- Volunteers
- 687 people
- Sponsor
- Silke Wiegand-Grefe, Prof. Dr.
Danon Disease, Fabry Disease
Precision Diagnosis and Risk Stratification of Rare Cardiomyopathies Based on Novel Cardiac Magnetic Resonance Techniques
What is this study about? This research is focused on improving the care for people with rare heart muscle diseases, known as rare cardiomyopathies.
- Conditions
- Danon Disease, Fabry Disease, Cardiac Amyloidosis, Noonan Syndrome
- Trial name
- NCT07336394
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital