Clinical trials: Early Developmental Impairment
Development, Infant, Development, Language
Early Neurophysiological Markers of Language Impairments
The present project aims at identifying very early electrophysiological risk markers for language impairments. The long-term goals of the study include the characterization of learning developmental trajectories in children at…
- Conditions
- Development, Infant, Development, Language, Developmental Language Disorder, Learning Disabilities
- Trial name
- NCT05767242
- Testing
- Electrophysiological recording, Behavioral assessment
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Autism Spectrum Disorder, Language Disorders
Early Treatment of Language Impairment in Young Children With Autism Spectrum Disorder With Leucovorin Calcium
The primary objective of this study is to evaluate the cognitive and behavioral effects of liquid leucovorin calcium on young children with autism spectrum disorder (ASD) and determine whether it improves language as well as the…
- Trial name
- NCT04060017
- Testing
- Levoleucovorin Calcium
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Southwest Autism Research & Resource Center
Autism Spectrum Disorder, Social Communication Disorder
Virtual Group Social ABCs - Multi-site Randomized Controlled Trial
The goal of this randomized control trial is to test the efficacy of the Social ABCs 6 week, group-based model using a virtual delivery platform.
- Conditions
- Autism Spectrum Disorder, Social Communication Disorder, Autism or Autistic Traits, Autism Spectrum Disorder With Impaired Functional Language
- Trial name
- NCT05663970
- Testing
- VG Social ABCs
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Language Impairment
Feasibility of Omega-3 Supplementation for Children With Language Impairments
The primary objective of this study is to obtain preliminary (pilot) data regarding the feasibility of using dietary omega-3 supplementation in children with significant delays in language skills; a related secondary objective is…
- Trial name
- NCT01640106
- Testing
- Omega-3
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Shuvo Ghosh
Pectus Excavatum, Cryo Analgesia
Phrenic Infiltration as Cryoanalgesia Adjuvant for Early Postoperative Pain Following the Nuss Procedure
The goal of this observational ambispective study is to compare the effectiveness of two pain management strategies in pediatric patients undergoing the Nuss procedure for pectus excavatum.
- Conditions
- Pectus Excavatum, Cryo Analgesia, Phrenic Nerve-related Diaphragmatic Impairment
- Trial name
- PHABULA (NCT07290582)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Papa Giovanni XXIII Hospital
Early Childhood Developmental Disability (Disorder)
Enhancing Social Communication and Emotional Development in Under 5 Children
In the United Nation's Sustainable Development Goals (SDGs), the conversation has shifted from the complexity of ensuring decrease in infant mortality to that of holistic wellbeing of children from conception onwards by ensuring…
- Trial name
- NCT04541069
- Testing
- Social Communication and Emotional Skill Development (SCESD) module
- Volunteers
- 2,004 people, healthy volunteers welcome
- Sponsor
- Centre for Injury Prevention and Research Bangladesh
Autism Spectrum Disorder (ASD), Central Auditory Processing Disorder
Mental And Speech Developmental Delay Autism Spectrum-Type Behavioral Disorder
FAMILY SYSTEM CITADEL 2060.METHODOLOGY "VOICE OF SLEEP MAMABEE 2026-2085 Systemic work with brain neurons through training modules at the border of sleep in clinical, psychological and strategic logic.
- Conditions
- Autism Spectrum Disorder (ASD), Central Auditory Processing Disorder, Nervous System Disorder, Neurological Disorder
- Trial name
- NCT07670000
- Testing
- Audio fairy tales
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Natalia Poluektova
Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD)
Intensive Multimodal Neurorehabilitation Targeting Neuroplasticity in Pediatric Neurodevelopmental and Chromosomal Disorders
This observational study evaluates functional and developmental outcomes in pediatric participants undergoing a two week intensive multimodal neurorehabilitation program.
- Conditions
- Neurodevelopmental Disorders, Neurodevelopmental Disorders (NDD), Neurodevelopmental Disorders and Developmental Abnormalities, Developmental Delay (Disorder)
- Trial name
- GEN-HOPE (NCT07493096)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Healing Hope International
Cerebral Palsy, Pediatric Neurological Disorder
Lung Ultrasound for Infants' Swallowing Disorders
The aim is to test the effectiveness of lung ultrasound (LUS) in the dynamic assessment of aspiration related to abnormal swallowing in infants and young children with neurological impairment (cerebral palsy/developmental…
- Conditions
- Cerebral Palsy, Pediatric Neurological Disorder, Developmental Disability
- Trial name
- LUNCH (NCT04253951)
- Testing
- Lung Ultrasound (LUS)-monitored feeding trial
- Where
- 2 sites in Italy
- Volunteers
- 150 people
- Sponsor
- IRCCS Fondazione Stella Maris
Obesity, Childhood, Hyperphagia
Early Genetic Identification of Obesity
TITLE: Whole genetic approach in Early Genetic Identification of Obesity (WEGIO) DESIGN: Multicenter epidemiological study STUDY POPULATION: Participants at risk for a syndromic or a monogenic genetic obesity, incl.
- Conditions
- Obesity, Childhood, Hyperphagia, Retinopathy, Syndactyly
- Trial name
- WEGIO (NCT06239064)
- Testing
- Genetic testing via blood collection
- Where
- 37 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Rolfs Consulting und Verwaltungs-GmbH (RCV)
Math Learning Disability, Child Development
Interventions in Mathematics and Cognitive Skills
The purpose of this study is to investigate neurocognitive mechanisms underlying response to intervention aimed at enhancing, and remediating weaknesses in, numerical skills in children, including those with mathematical learning…
- Conditions
- Math Learning Disability, Child Development, Developmental Disability, Learning Disabilities
- Trial name
- NCT05201534
- Testing
- Interventions in Mathematics and Cognitive Skills - Experimental, Interventions in Mathematics and Cognitive Skills - Active Comparator
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Stanford University
Neurological Impairments, Genetic Syndrome
Speech Therapy and Parenting for Early Socio-communicAtive sKills
Every year, millions of children are diagnosed with neurodevelopmental disabilities. This term covers a wide range of conditions, from genetic syndromes to brain injuries such as cerebral palsy.
- Conditions
- Neurological Impairments, Genetic Syndrome, Neurodevelopmental Disability, Developmental Delays
- Trial name
- SPEAK (NCT06666777)
- Testing
- Intervention focused on intersubjective prelinguistic and socio-communicative skills, Standard speech therapy intervention
- Where
- 9 sites in Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Eugenio Medea
Cerebral Visual Impairment, Refractive and Accommodative Disorders
Babies in Glasses; a Feasibility Study.
This is a feasibility study to begin investigating the possibility that early use of near vision glasses will improve vision in infants at risk of Cerebral Visual Impairment (CVI), leading to further improvement in other areas of…
- Conditions
- Cerebral Visual Impairment, Refractive and Accommodative Disorders, Hypoxic-Ischemic Encephalopathy, Premature Birth
- Trial name
- BiG (NCT05048550)
- Testing
- Near vision spectacles
- Where
- United Kingdom
- Volunteers
- 55 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Language Development, Language Development Disorders
Efficacy of an Early Rhythmic Intervention in Infancy
The present project develops from a wide research line aiming at identifying very early electrophysiological risk markers for neurodevelopmental disorders.
- Conditions
- Language Development, Language Development Disorders, Infant Development, Intervention
- Trial name
- NCT04755309
- Testing
- Rhythmic intervention, Passive auditory stimulation
- Where
- Italy
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Autism Spectrum Disorder, Early Developmental Impairment
Multicenter Validation Study on Autism Screening Using a Machine-assisted System
The goal of this observational study is to assess the effectiveness of a machine-assisted system for early screening of autism. The main questions it aims to answer are: Does the machine-assisted system including 5 main…
- Conditions
- Autism Spectrum Disorder, Early Developmental Impairment, Language Development Disorders
- Trial name
- NCT07006948
- Testing
- Autism Diagnostic Observation Schedule, the 2nd edition(ADOS-2), Griffiths Developmental Scales, Chinese edition(GDS-C)
- Where
- 10 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Developmental Language Disorder, Language Disorders in Children
The Influence of Immersive Virtual Field Trips on Academic Vocabulary
The purpose of this study is to investigate an immersive virtual field trip (iVFT) on topic specific academic vocabulary for students with developmental language disorder (DLD).
- Trial name
- NCT05242575
- Testing
- The information provided in the iVFT and control book parallel one another.
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Salus University
Cerebral Palsy, Cerebral Palsy (CP)
Assessing Intellectual and Motor Outcomes in High-risk Infants
Cerebral palsy (CP) is a condition when a baby has a brain injury that affects their movement and muscle tone. Some people with CP can have other developmental issues, like learning impairments, but many do not and have isolated…
- Conditions
- Cerebral Palsy, Cerebral Palsy (CP), Cerebral Palsy Children, High-risk Infants
- Trial name
- AIM-High (NCT06857539)
- Where
- 4 sites in Ireland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University College Cork
Cerebral Palsy, Child, Preschool
Effect of Power Wheelchairs on the Development and Function of Young Children With Severe Physical Disabilities
Self-produced locomotion often is limited in children with cerebral palsy and other conditions that cause severe motor impairments.
- Trial name
- NCT01115998
- Testing
- Power wheelchair, No power wheelchairs
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Oklahoma
Autism Spectrum Disorder With Impaired Functional Language
Pivotal Response Intervention Minimal Responders Study
Early intervention (EI) using naturalistic behavioural methods have shown benefits for the development of communication and other skills for young children with autism spectrum disorder.
- Trial name
- PRIMeR (NCT05511220)
- Testing
- PRIMeR, PRT
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- IWK Health Centre