Clinical trials: Effect of Drugs
Asthma
Investigation of Intravenous (IV) Administration of an Approved Drug (MK-0476, Montelukast Sodium) for Acute Asthma (MK-0476-288)
The purpose of this study is to evaluate improved results of treatment for patients entering an emergency department with asthma attacks when given an investigational IV administration of an approved drug (MK-0476, montelukast…
- Trial name
- NCT00092989
- Testing
- montelukast sodium
- Volunteers
- 650 people
- Sponsor
- Organon and Co
Asthma, Chest Syndrome
Azithromycin Treatment for Non-eosinophilic Chest Tightness Variant Asthma
Bronchial asthma (abbr. asthma) is one of common airway chronic inflammatory disease which usually threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tightness and cough, usually…
- Conditions
- Asthma, Chest Syndrome, Azithromycin, Effect of Drug
- Trial name
- NCT05596721
- Testing
- Azithromycin, ICS/LABA
- Where
- 13 sites in China
- Volunteers
- 248 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ventilator Associated Pneumonia, Etiological Organisms
A Clinico-Bacteriological Study and Effect of Stress Ulcer Prophylaxis on Occurrence of Ventilator Associated Pneumonia
Objective of this study was to determine incidence, risk factors, etiological micro-organisms and their antimicrobial susceptibility pattern and outcome of VAP; and to study effect of ranitidine vs.
- Conditions
- Ventilator Associated Pneumonia, Etiological Organisms, Antimicrobial Drug Susceptibility Pattern, Stress Ulcer Prophylaxis
- Trial name
- NCT00702871
- Testing
- Ranitidine, Sucralfate
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Maulana Azad Medical College
Pain, Infant, Newborn, Disease
Effect of Maternal Heart Sound on Crying Time and Pain Level in Newborns During Heel Blood Collection
This study was carried out to determine the effect of maternal heart sound listened to by newborns during heel blood collection on pain level and crying time.
- Trial name
- NCT05520164
- Testing
- Listening the maternal heart sound during the invasive interventions
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Acute Medical Patients Hospitalized in Internal Medicine
Decrease the Frequency of Inappropriate Intravenous Lines in Internal Medicine
Aim: to determine whether a nationwide teaching program delivered to medical doctors can decrease the use of inappropriate intravenous lines in internal medicine
- Trial name
- PERMI (NCT01633307)
- Testing
- Education
- Volunteers
- 59 people
- Sponsor
- Hopital Lariboisière
Nursing Student, Simulation
Drug Administration Competency of Nursing Students
The purpose of this study is to examine the effect of a simulation-based education program designed based on cognitive load theory on the development of medication administration competency of nursing students.
- Conditions
- Nursing Student, Simulation, Cognitive Load, Competence
- Trial name
- NCT05837377
- Testing
- Control- standard medication education, Experiment- cognitive load theory based on medication education
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Overweight, Obesity
Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism
Despite advances in the prevention and treatment of type 2 diabetes, its prevalence continues to rise worldwide. There is a need for new modalities to improve metabolic control in individuals with type 2 diabetes and those who…
- Conditions
- Overweight, Obesity, Dysglycemia, Prediabetes
- Trial name
- NCT02776722
- Testing
- fructose, allulose, tagatose, or sorbose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Congenital Mitral Insufficiency
Study of Innovative Drug Treatment Therapy for Pediatric Mitral Regurgitation
The goal of this observational study is to compare the safety and effectiveness of a modified drug therapy with traditional drug therapy in pediatric patients with mild to moderate mitral valve regurgitation.
- Trial name
- NCT06037434
- Testing
- Captopril Tablets, Metoprolol Oral Tablet, Spironolactone Tablets
- Where
- China
- Volunteers
- 122 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cancer Pain
Effects of Mobile Medicine on Cancer Patients
With the existing medical system and insufficient medical resources in China, we developed a mini program. a pain management mini app can be useful and appreciated by patients and health care professionals, making it a good…
- Trial name
- NCT05049811
- Testing
- mini program, conventional pharmaceutical care
- Volunteers
- 200 people
- Sponsor
- Fujian Cancer Hospital
Cancer, Cardiotoxicity
Role of Aerobic Exercise to Modulate Cardiotoxicity in Long Term Cancer Survivors Exposed to Anthracycline Therapy
Over 50% of the more than 270,000 childhood cancer survivors in the U.S. have been treated with anthracyclines and thus are at risk of developing cardiotoxicity.
- Trial name
- NCT04036032
- Testing
- Exercise program
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Connecticut Children's Medical Center
PCOS
Effects of Triple Drug Cocktail Therapy on Metabolic, Endocrine Alterations and Perceived Stress in Patients With Poly Cystic Ovary Syndrome
The investigators aim is to conduct a double blind randomized clinical trial, to study the effects of triple drug cocktail (metformin, pioglitazone and acetyl L-Carnitine) therapy on metabolic, endocrine alterations and perceived…
- Trial name
- PCOS (NCT04113889)
- Testing
- Metformin (1000 mg daily), Pioglitazone (30 mg daily), Acetyl-L-carnitine (3 gm daily)
- Where
- Pakistan
- Volunteers
- 147 people
- Sponsor
- Khyber Medical University Peshawar
HIV Infections
Effects of Two Anti-HIV Drug Regimens on HIV Transmission Risk Behavior Among SMART Study Participants
The purpose of this study is to compare the effects of two different anti-HIV drug regimens on HIV transmission risk behavior among SMART study participants.
- Trial name
- NCT00386035
- Testing
- Delayed ART, Continuous ART
- Where
- 58 sites in United States
- Volunteers
- 883 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Adverse Drug Reaction (ADR)
National Active Surveillance Network and Pharmacogenomics of Adverse Drug Reactions in Children
The purpose of the study is (1) to identify and collect samples from children and adults who take drugs and have adverse drug reactions AND children and adults who take drugs and do not experience any adverse drug effects; (2) to…
- Trial name
- NCT00414115
- Where
- Canada
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Anesthesia, Electroencephalography/ Drug Effect
Detection of Consciousness by EEG and Auditory Evoked Potentials
The objective of the present investigation is to analyze EEG and auditory evoked potentials at the transition from consciousness to unconsciousness and vice versa.
- Trial name
- NCT01720615
- Testing
- Propofol / Remifentanil, Sevoflurane / Remifentanil
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Technical University of Munich
Health Literacy Level
The Effect of Health Literacy Based Practices
It is important to adopt healthy lifestyle behaviors such as nutrition and physical activity in adolescence. Health literacy, which is the competence of adolescents to participate in their own health decisions and takes…
- Trial name
- NCT05677854
- Testing
- Health literacy based motivaonal interview, Health literacy based health education
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Ayşegül Akca
HIV Infections
The Effects of Zidovudine on the Blood of HIV-Infected Patients
To define the pharmacokinetic parameters (blood levels) of total phosphorylated zidovudine (AZT) in peripheral blood mononuclear cells (PBMC) from HIV-infected patients.
- Trial name
- NCT00000965
- Testing
- Zidovudine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malaria
Parasite Clearance and Protection From Infection (PCPI) in Cameroon
The Cameroon PCPI study will measure the effect of the parasite genotypes associated with SP resistance on parasite clearance and protection from infection when exposed to SP.
- Trial name
- NCT06173206
- Testing
- SP (Macleods Pharmaceuticals Ltd), SPAQ (Guilin Pharmaceuticals), AS (Guilin Pharmaceuticals)
- Where
- Cameroon
- Volunteers
- 902 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections
Effects of Two Anti-HIV Drug Regimens on Quality of Life and Health Care Use Among SMART Study Participants
The purpose of this study is to compare the effects of two different anti-HIV drug regimens on quality of life and health care utilization among SMART study participants.
- Trial name
- NCT00385632
- Testing
- Antiretroviral Regimens
- Where
- 67 sites in United States
- Volunteers
- 1,224 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Musculoskeletal Pain, Postural; Defect
Posture Training for Middle Schoolers
The goal of this clinical trial is to investigate if posture training can improve back pain and posture in middle school students.
- Trial name
- NCT06909747
- Testing
- Posture Training
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Amasya University
Fatigue, Sleep Deprivation
Effect and Utilization of Protected Time Among Interns on Extended Duty-Hour Call Shifts
This study will test the feasibility and effectiveness of protected time for physicians in training during 30 hour shifts in a medical intensive care unit. The primary outcome will be fatigue.
- Conditions
- Fatigue, Sleep Deprivation, Depression
- Trial name
- NCT00983008
- Testing
- Protected time and Dedicated time
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Providence Health & Services