Clinical trials: Ejection Fraction
Heart Failure, Heart Failure With Reduced Ejection Fraction
Efficacy of AI EF Screening by Using Smartphone Application Recorded PLAX View Cardiac Ultrasound Video Clips
Assessing the Efficacy of Artificial Intelligence in Left Ventricular Function Screening Using Parasternal Long Axis View Cardiac Ultrasound Video Clips ABSTRACT BACKGROUND: Echocardiography serves as a fundamental diagnostic…
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Cardiac Failure, Echocardiography
- Trial name
- NCT06330103
- Testing
- Easy EF
- Where
- Thailand
- Volunteers
- 923 people, healthy volunteers welcome
- Sponsor
- Rayong Hospital
Pediatric Heart Failure
Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LCZ696 Followed by a 52-week, Double-blind Study of LCZ696 Compared With Enalapril in Pediatric Patients With Heart Failure
This study consists of two parts (Part 1 and Part 2). The purpose of Part 1 is to evaluate the way the body absorbs, distributes, metabolizes and removes the drug LCZ696.
- Trial name
- NCT02678312
- Testing
- LCZ696, Enalapril
- Where
- 98 sites in United States, Argentina and 27 more
- Volunteers
- 393 people
- Sponsor
- Novartis Pharmaceuticals
Heart Failure With Reduced Ejection Fraction (HFrEF), Hospitalization
Intravenous Iron Sucrose for Acute Decompensated Heart Failure Patients With Reduced Ejection Fraction and Iron Deficiency
Iron deficiency (ID) affects about 25% of the global population, presenting with symptoms of fatigue, weakness, and impaired cognitive function.
- Conditions
- Heart Failure With Reduced Ejection Fraction (HFrEF), Hospitalization, Iron Deficiency
- Trial name
- IronSucroseHF (NCT06703411)
- Testing
- Iron Sucrose IV, Standard Medical Therapy
- Where
- Taiwan
- Volunteers
- 76 people
- Sponsor
- Cheng-Hsin General Hospital
Heart Failure
BAROSTIM THERAPY™ In Heart Failure With Preserved Ejection Fraction
The purpose of this registry (NCT02876042) is to evaluate the effect of BAROSTIM THERAPY with the BAROSTIM NEO system in the commercial setting in subjects recently implanted under the CE-Marked indication for resistant…
- Trial name
- HFpEF (NCT02876042)
- Testing
- BAROSTIM NEO™ System
- Where
- 13 sites in Germany
- Volunteers
- 11 people
- Sponsor
- CVRx, Inc.
Right Bundle-Branch Block, Heart Failure With Reduced Ejection Fraction
Bifocal Right Ventricular PAcing in Right Bundle Branch blocK and Heart Failure With Reduced Ejection Fraction. The Study Tests the Superiority of Right Ventricular Bifocal Stimulation Over VVI Implantable Defibrillator in Right Bundle Branch Block and Heart Failure.
RATIONALE: Cardiac resynchronization therapy (CRT) is known to improve cardiac performance and to reduce morbidity and mortality in reduced-ejection fraction heart failure (HFrEF) despite optimal medical therapy (OMT).
- Conditions
- Right Bundle-Branch Block, Heart Failure With Reduced Ejection Fraction, Bifocal Stimulation
- Trial name
- BiPARK-HF (NCT03524001)
- Testing
- Compare VVi mode versus DDD bifocal stimulation through crossover randomization
- Where
- Italy
- Volunteers
- 13 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Functional Mitral Regurgitation
Plasty or Prosthesis to Treat Functional Mitral Regurgitation
Functional Mitral regurgitation is a now well known entity due to tethering of the valve either mono-lateral, as happens in lateral myocardial infarction, or bilateral as happens in dilated cardiomyopathy.
- Trial name
- POP (NCT00947921)
- Testing
- Plasty, Prosthesis
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Cardiochirurgia E.H.
Functional Mitral Regurgitation, Heart Failure
Evaluation of Outcomes of CRT and MitraClip for Treatment of Low Ejection Fraction and Functional Mitral Regurgitation in HF
At present, the optimal treatment strategy for heart failure patients and moderate-to-severe (3+) or severe (4+) mitral regurgitation with a class IIa recommendation for CRT is uncertain.Whether these patents should also be…
- Trial name
- EVOLVE-HF (NCT02985268)
- Testing
- MitraClip, Optimal Medical Therapy, CRT-D
- Sponsor
- Montreal Heart Institute
Left Ventricular Ejection Fraction, Heart Failure (HF)
REsynchronization Comparison In LBBB and Normal or Mildly Reduced VENTricular Function With CRT (REINVENT-CRT)
Primary Objective - To determine if implantation of a permanent CRT pacing device (with LB-CRT, or conventional BiV-CRT with a coronary sinus LV lead) can improve electromechanical function, HF symptoms, and natriuretic peptide…
- Conditions
- Left Ventricular Ejection Fraction, Heart Failure (HF), Left Bundle-Branch Block
- Trial name
- REINVENT (NCT05652218)
- Testing
- LB-CRT, BIV-CRT
- Where
- 2 sites in United States
- Volunteers
- 21 people
- Sponsor
- Inova Health Care Services
Heart Failure With Mid Range Ejection Fraction
Outcome of Discharged HFmrEF Patients
This study aimed to define the independent risk factors related cardiac events (cardiac death or heart failure-related hospitalization) among heart failure with mildly reduced ejection fraction (HFmrEF) patients who discharged…
- Trial name
- OUDI-HF (NCT05240118)
- Volunteers
- 1,693 people
- Sponsor
- Xiangtan Central Hospital
Heart Failure With Preserved Ejection Fraction
Cardiac Magnetic Resonance Assessment for Heart Failure With Preserved Ejection Fraction
This is a prospective study that aims to define the utility of cardiac magnetic resonance feature tracking (CMR-FT) as a non-invasive quantification tool to assess diastolic functionality in patients with Heart Failure with…
- Trial name
- NCT04063579
- Testing
- Cardiac Magnetic Resonance, Echocardiogram, Blood investigation (NT-proBNP), cardiac catheterization, Cardiac Magnetic Resonance, Echocardiogram, Blood investigation (NT-proBNP)
- Where
- Hong Kong
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Heart Failure
The Effects of Inspiratory Muscle Training in Patients With Heart Failure With Preserved Ejection Fraction
Previous studies have evaluated the effects of inspiratory muscle training in patiens with heart failure and reduced ejection fraction; nevertheless,no evidence endorse the therapeutic role of inspiratory muscle training in…
- Trial name
- NCT01707277
- Testing
- Inspiratory muscle training, Usual care
- Where
- Spain
- Volunteers
- 26 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Strength Training Effects, HFrEF - Heart Failure With Reduced Ejection Fraction
Eccentric Muscle Training in Cardiac Rehabilitation
The goal of this interventional study is to assess the training effects in a training schedule in which eccentric overload training and eccentric cycle training are used.
- Trial name
- NCT07636343
- Testing
- eccentric bike training, eccentric overload training, aerobic treadmill training
- Where
- Belgium
- Volunteers
- 3 people
- Sponsor
- University Hospital, Antwerp
Acute Myocardial Infarction, Heart Failure With Preserved Ejection Fraction
Predictors and Outcomes of In-hospital HFpEF in AMI Patients
This retrospective observation is to investigate the incidence,clinical outcomes and prognosis of hospitalized heart failure with preserved ejection fraction (HFpEF) in patients with acute myocardial infarction(AMI).
- Conditions
- Acute Myocardial Infarction, Heart Failure With Preserved Ejection Fraction, Predictor, Prognosis
- Trial name
- NCT03351179
- Testing
- clinical characteristics, previous history, laboratory bio-markers, echocardiographic measurements, angiographic findings,clinical outcomes
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xiangjun Yang
Heart Failure With Preserved Ejection Fraction
Optimising Management of Patients With Heart Failure With Preserved Ejection Fraction in Primary Care
Heart failure (HF) accounts for 2% of National Health Service (NHS) expenditure, and 5% of emergency hospitalisations. Patients with HF with preserved ejection fraction (HFpEF) are older, have more comorbidities, have similarly…
- Trial name
- OPTIMISEHFpEF (NCT03617848)
- Where
- United Kingdom
- Volunteers
- 153 people
- Sponsor
- Professor Christi Deaton
Heart Failure, Diastolic
Exercise Training in Heart Failure With Preserved Ejection Fraction - a Long-term Follow-up
Exercise training is an effective therapy for patients with heart failure with preserved ejection fraction. However, it is unclear, whether a one-year intervention has a sustainable effect beyond the active study phase.
- Trial name
- NCT05162859
- Where
- Germany
- Volunteers
- 74 people
- Sponsor
- Technical University of Munich
Cardiac Arrest, Long QT Syndrome
Registry of Unexplained Cardiac Arrest
The CASPER will collect systematic clinical assessments of patients and families within the multicenter Canadian Inherited Heart Rhythm Research Network.
- Conditions
- Cardiac Arrest, Long QT Syndrome, Brugada Syndrome, Catecholaminergi Polymorphic Ventricular Tachycardia
- Trial name
- NCT00292032
- Where
- Canada
- Volunteers
- 1,529 people
- Sponsor
- University of British Columbia
Heart Failure, Diastolic (HFpEF)
Pogejiuxin Decoction Combination of Conventional Western Medicine for the Treatment of Heart Failure With Preserved Ejection Fraction
The objective of this study is to investigate the potential of Pogejiuxin Decoction to enhance the efficacy and mitigate the adverse effects associated with conventional treatment in patients with heart failure and preserved…
- Trial name
- NCT06629246
- Testing
- Conventional heart failure treatment, Pogejiuxin decoction combined with conventional heart failure treatment
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chongqing Traditional Chinese Medicine Hospital
Heart Failure With Reduced Ejection Fraction, Pediatric HD, Stage IV
Pumps for Kids, Infants and Neonates (PumpKIN): The Jarvik 2015 Pivotal Trial
This is a 22-subject prospective, multicenter, single-arm clinical trial to evaluate the safety and effectiveness of the Jarvik 2015 left ventricular assist device (LVAD) as a bridge to heart transplant in children weighing 8 to…
- Conditions
- Heart Failure With Reduced Ejection Fraction, Pediatric HD, Stage IV, LVAD
- Trial name
- PumpKIN (NCT06348043)
- Testing
- Jarvik 2015 LVAD
- Volunteers
- 22 people
- Sponsor
- Stanford University
Cto, Acef Score
Prognostic Value of The Age, Creatinine, and Ejection Fraction Score for Non-infarct-related Chronic Total Occlusion Revascularization After Primary Percutaneous Intervention in Acute ST-elevation Myocardial Infarction Patients: A Retrospective Study
The age, creatinine, and ejection fraction (ACEF) score has been used to evaluate the clinical prognostic to patients who underwent PCI.
- Trial name
- NCT02833636
- Testing
- ACEF score
- Volunteers
- 2,952 people
- Sponsor
- Xibei Hospital
Cardiomyopathy, Dilated
Variability of Ventricular Mass, Volume, & Ejection Fraction in Pediatric Cardiomyopathy Patients-Pediatric Heart Network
This observational study will provide data (variations in ventricular size and function) that are essential to designing and conducting clinical trials.
- Trial name
- VVV (NCT00123071)
- Where
- 8 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- Carelon Research