Clinical trials: Elevated Intracranial Pressure
Traumatic Brain Injury
Measurement of Optic Nerve Sheath in Traumatic Raised Intracranial Pressure
Trauma patients are at risk for serious head trauma. The consequences of serious head trauma are often life altering. Currently, the only method available to rapidly assess the severity of head injury and need for neurosurgical…
- Trial name
- MOONSTRIP (NCT00783809)
- Where
- Canada
- Volunteers
- 560 people
- Sponsor
- McMaster University
Prospective Study , Questionaires
Neurocognitive Outcome in Children Who Suffered From Idiopathic Increased Intracranial Hypertension (IIH)
15 patients, Ages 8-17 who were diagnosed in the recent years with Idiopathic increased intracarnial hypertension (IIH) went through a battery of neurocognitive tests to establish whether there was any affect of the disease on…
- Trial name
- NCT02857335
- Testing
- neurocognitive tests
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Intracranial Hypertension
A Novel Non-invasive Technique of Cerebral Compliance and Auto-regulation Assessment
Introduction: Intracranial pressure (ICP) monitoring is essential in several medical situations, however, currently there is an invasive technique, costly, not widely available and sometimes contraindicated.
- Trial name
- NCT03144219
- Testing
- Transcranial Doppler (TCD) ultrasound monitoring, Non invasive intracranial compliance monitoring
- Where
- Brazil
- Volunteers
- 133 people
- Sponsor
- University of Sao Paulo
Intracranial Hypertension
Non-invasive Intracranial Pressure (ICP) Monitoring in Pediatric Patients
The purpose of this study is to prospectively evaluate the accuracy and safety of non-invasive intracranial pressure (ICP) measurements using the HeadSense-1000 (HS-1000) device compared to the current invasive external…
- Trial name
- NCT02695264
- Testing
- HS-1000 recording
- Where
- United States
- Sponsor
- HeadSense Medical
Brain Injury Traumatic Severe, Intracranial Hemorrhage, Hypertensive
Multiomic Analysis of Traumatic Brain Injury and Hypertension Intracranial Hemorrhage Lesion Tissue
The goal of this experimental observation study is to figure out differently expressed biomarkers in lesion tissues in traumatic brain injury or hypertension intracranial hemorrhage patients.
- Trial name
- MOSS-THINK (NCT05778110)
- Testing
- Type of disease
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Posterior Reversible Encephalopathy Syndrome
Prognostic Observation of Posterior Reversible Encephalopathy Syndrome
Posterior Reversible Encephalopathy Syndrome (PRES) is a clinical-radiological entity, which is associated with a variety of clinical conditions.
- Trial name
- POPRES (NCT02665598)
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Yantai Yuhuangding Hospital
Pediatric Critical Illness, Brain Injuries, Traumatic
Tissue Penetration of Paracetamol in Pediatric Intensive Care Patients
TIPPIC was a single-centre, prospective, observational pharmacokinetic study in critically ill children aged 1 month to 15 years who were admitted to the paediatric intensive care unit (PICU) of Ghent University Hospital with an…
- Conditions
- Pediatric Critical Illness, Brain Injuries, Traumatic, Brain Neoplasms, Intracranial Hypertension
- Trial name
- TIPPIC (NCT07916831)
- Testing
- Paracetamol, Pharmacokinetic sampling (blood and CSF microsampling)
- Where
- Belgium
- Volunteers
- 31 people
- Sponsor
- University Hospital, Ghent
Optic Nerve Sheath Neoplasm, Intracranial Pressure Increase
Optic Nerve Sheath Diameter in Pediatric Patients
Endotracheal intubation and laryngeal mask are generally applied to secure the airway during general anesthesia. There is a widespread opinion among anesthesiologists that endotracheal intubation increases intracranial pressure.
- Conditions
- Optic Nerve Sheath Neoplasm, Intracranial Pressure Increase, Intubation Complication, Airway Complication of Anesthesia
- Trial name
- NCT05445271
- Testing
- Optic nerve sheath diameter measurement with linear ultrasound
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
Severe Traumatic Brain Injury
Approaches and Decisions for Acute Pediatric TBI Trial
Approaches and Decisions in Acute Pediatric TBI Trial (ADAPT) is an international research study designed to evaluate the impact of interventions on the outcomes of children with severe traumatic brain injury.
- Trial name
- ADAPT (NCT04077411)
- Testing
- Observational
- Where
- 48 sites in United States, Australia and 6 more
- Volunteers
- 1,000 people
- Sponsor
- University of Pittsburgh
Intracranial Pressure Increase
Non-invasive Diagnostic for Assessing Elevated Intracranial Pressure
The study is a prospective, multi-center, non-randomized, open label observational study. The objective of this study is to compare the accuracy of the EyeBOX to a clinical diagnosis of abnormal ICP as determined by an external…
- Trial name
- NCT03418753
- Testing
- EyeBOX for ICP
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Oculogica, Inc.
Head Injury
Effects of Head Elevation on Intracranial Pressure in Children
Head injury is the most common cause of mortality and acquired disability in childhood. It is common to elevate the head of patients at risk for increased intracranial pressure, although it is not clear if it is always…
- Trial name
- NCT00636376
- Testing
- Place HOB in alternate positions from 0-50 degrees.
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Children's Hospital of Philadelphia
Neuroimaging, Cognitive Dysfunction
Long-term Consequences of Neuroimaging and Perceived Cognitive Dysfunction in oPRES
The purpose of this study is to explore the long-term consequences of neuroimaging and perceived cognitive dysfunction in obstetrics posterior reversible encephalopathy syndrome.
- Conditions
- Neuroimaging, Cognitive Dysfunction, Posterior Reversible Encephalopathy Syndrome
- Trial name
- NCT05140850
- Testing
- neuroimaging examination,neuro-cognitive test,blood pressure,blood sample
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Dunjin Chen
Craniosynostosis, Strabismus
Ocular Characteristics in Patients With Craniosynostosis
Craniosynostosis are cranial deformations due to the premature closure of one or more cranial sutures. These deformations affect approximately one in 2.500 births.
- Conditions
- Craniosynostosis, Strabismus, Intracranial Hypertension, Amblyopia
- Trial name
- COPACA (NCT06928727)
- Where
- France
- Volunteers
- 65 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Traumatic Brain Injury, Subarachnoid Hemorrhage
Comparison of Narcotrend and Cerebral Function Analysing Monitor in Intensive Care to Monitor Seizures and Deep Sedation
A study in the use of the Narcotrend depth of anaesthesia monitor to record a) seizures, and b) monitor a level of sedation referred to as 'burst suppression', in sedated patients in the adult and paediatric intensive care.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Haemorrhage, Encephalitis
- Trial name
- NCT06067750
- Testing
- Narcotrend compared to Cerebral Function Analysing Monitor (CFAM)
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Intracranial Hypertension
CSF Biomarkers in Idiopathic Intracranial Hypertension
Aim of the study is to high lighten the rule of CSF biomarkers in early diagnosis of IIH and in follow up to reach to a definite clinically based decision if this patient will improved on medical treatment or that patient is in…
- Trial name
- NCT05647837
- Testing
- lumper puncture
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Intracranial Pressure Increase
Ocular Screening in Children and Young Adults at Risk for Increased Intracranial Pressure
The purpose of this study is to evaluate the vision and posterior segment of eyes in children and young adults less than 22 years of age with risk, suspicion, or past medical history significant for elevated intracranial pressure…
- Trial name
- ICP (NCT03286426)
- Testing
- Pictor
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Duke University