Clinical trials: Embryonic Development
Hepatic Sarcoma
Undifferentiated Embryonal Sarcoma of the Liver: Evaluation of the Relapse Profile According to the Therapies Administered
Undifferentiated embryonal sarcoma of the liver is the 3rd most common malignant liver tumor after hepatoblastoma and hepatocellular carcinoma with a peak incidence between 6 and 10 years of age.
- Trial name
- SARCOM (NCT05640960)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Infertility, Female, Reproductive Techniques, Assisted
SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when…
- Conditions
- Infertility, Female, Reproductive Techniques, Assisted, Fertilization in Vitro
- Trial name
- SISTER (NCT07175571)
- Testing
- Intracytoplasmic Sperm Injection (ICSI), Conventional Insemination (IVF)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Autism Spectrum Disorder, Complication of Prematurity
Correlation of CXCR4 Expression in Premature Infants With a Diagnosis of Autism at 24 Months
Preterm children are at increased risk for autism spectrum disorders, with an estimated rate of 10%. In the US, about 1 in 8 pregnancies ends with a premature birth.
- Trial name
- ASD-CXCR4 (NCT01686685)
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Embryonic Development, Retinal Anomalies
Mapping of the Developmental Atlas of the Visual System and Research on Embryonic Neurogenesis Phenomena
This research studies how nerve cells in the human embryonic retina, visual brain regions, and brain areas responsible for higher cognitive functions grow, develop, and form interconnected functional networks.
- Conditions
- Embryonic Development, Retinal Anomalies, Neural Development
- Trial name
- NCT07688538
- Testing
- Tissue collection and multi-omics sequencing analysis
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sheng Liu
Embryo Development
Impact of Culture Medium on Embryo Quality
The purpose of this study is to compare two culture media.
- Trial name
- NCT01094314
- Testing
- embryo culture medium
- Where
- Belgium
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Infertility (IVF Patients)
Correlation of the Genetic Constitution of the Spent Blastocyst Media
The main objective of this study is to improve niPGT-A (non-invasive Preimplantation Genetic Testing for Aneuploidies) to avoid the need of a biopsy to perform the genetic analysis of the embryo and to help in understanding the…
- Trial name
- CONNECTED (NCT06780605)
- Testing
- niPGT-A, Multifocal TE biopsies and ICM biopsy
- Where
- 2 sites in Cyprus
- Volunteers
- 230 people
- Sponsor
- Igenomix
Embryo Development
The Clinical Outcome of Ultra-low Oxygen Tension on Post Thawed Human Blastocyst
The clinical outcome of Ultra-low oxygen tension on post thawed human blastocyst
- Trial name
- NCT03817671
- Testing
- 5% O2, 2% O2
- Where
- Egypt
- Volunteers
- 168 people
- Sponsor
- Ganin Fertility Center
Thalassemia,Embryonic Development,Reproductive Sterility and Infertility
A Retrospective Study on the Effect of HBA or HBB Genetic Defects on Early Embryonic Development
Thalassemia is an anemia or pathological state caused by compounding absently or inadequately of one or more globin chains of hemoglobin due to the defects of the globin gene,and the carrying rate is high in southern China.
- Trial name
- NCT03687567
- Testing
- Preimplantation genetic diagnosis
- Where
- China
- Volunteers
- 737 people
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Implantation, Embryo
Longitudinal Clinical Observation of a Digital Twin Model for Blastocyst Evaluation in IVF Clinics
This study aims to develop and validate a non-image, multimodal digital twin model of the human blastocyst using fully de-identified clinical, laboratory, molecular, biochemical, and long-term follow-up data obtained during…
- Trial name
- IVFDT (NCT07305480)
- Testing
- Digital Twin Computational Modeling
- Where
- Austria
- Volunteers
- 1 people
- Sponsor
- Ukraine Association of Biobank
Sperm DNA Fragmentation, Male Fertility
Impact of Telomere Biology and Sperm DNA Fragmentation on Embryonic Development
The proposed project we intend to assess the implication of the telomeric pathway in male infertility. To get this, several analyzes will be carried out: 1. Determination of the TL by means of two methods: Q-FISH and PCR. 2.
- Conditions
- Sperm DNA Fragmentation, Male Fertility, Telomeres, Sperm
- Trial name
- NCT05508217
- Where
- Spain
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- IVI Madrid
Pregnancy
Vitrification Versus Spontaneous Conception and Slow- Rate Freezing
Great scientific effort has been made to improve practical as well as economical procedures of modern assisted reproduction. In the last years a shift from the well established method of slow-rate freezing to vitrification of 2PN…
- Trial name
- NCT01088425
- Testing
- Observation
- Where
- Germany
- Volunteers
- 850 people
- Sponsor
- University of Luebeck
Infertility
A Study Using Recombinant Human Chorionic Gonadotrophin (rhCG, Ovidrel®) in the Induction of Final Follicle Maturation and Early Luteinization in Chinese Women Undergoing in Vitro Fertilization and Embryo Transfer (IVF/ET)
This was an open, randomized, comparative study using rhCG (Ovidrel) in the induction of final follicle maturation and early luteinization in Chinese female subjects undergoing IVF or ET.
- Trial name
- NCT01081756
- Testing
- r-hCG, Urinary-hCG
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Reduced Sperm Motility, IVF
Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods Sperm Selection and Embryo Development: Comparison of the Density Gradient Centrifugation and Microfluidic Chip Sperm Preparation Methods
Purpose: To compare the effects of the density gradient centrifugation and microfluidic chip sperm preparation methods on embryo development in a study population with astheno-teratozoospermia.
- Conditions
- Reduced Sperm Motility, IVF, ICSI, Astheno Teratozoospermia
- Trial name
- NCT04962074
- Testing
- Microfluidic sperm sorting chip, Density gradient
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Maltepe University
Child Development, Endometrial Preparation
Development of IVF/ICSI Children Born From Different Endometrial Preparation Protocols
The efficacy and safety of endometrial preparation regimens remain controversial. In the most recent meta-analysis, using natural and modified natural cycle protocol to prepare the endometrium in frozen embryo transfer resulted…
- Trial name
- MONARTBABIES (NCT05502770)
- Testing
- Developmental score according to The Ages & Stages Questionnaires®, Third Edition - ASQ®-3, Physical development and General Health, Developmental Red flags
- Where
- Vietnam
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
Infertility
Human MATER and Idiopathic Infertility
Approximately 15 percent of couples experience infertility, yet no abnormalities can be detected in the man or the woman. In a number of couples, their embryos unexpectedly slow down growth or stop growth completely.
- Trial name
- NCT00361816
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility
Development of a Screening Tool for Difficult Embryo Transfers
This study aims to investigate the accuracy of a proposed screening tool in identifying difficult embryo transfers (ETs) without doing a mock ET.
- Trial name
- NCT05701072
- Testing
- Oocyte Pick Up, Embryo Transfer
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 200 people
- Sponsor
- ART Fertility Clinics LLC
Embryo Hypoxia
The Effect of Low Oxygen Tension on the Early Development of Human Embryo in IVF/ICSI
To investigate the effect of low oxygen tension during in vitro culture in terms of embryo quality and outcomes of pregnancy in vitro fertilization/ Intracytoplasmic sperm injection
- Trial name
- NCT01983696
- Testing
- 5% oxygen concentration
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanxi Provincial Maternity and Children's Hospital
Anophthalmos
Molecular Analysis of Microphthalmia/Anophthalmia
This study will try to learn more about the genetic cause and symptoms of microphthalmia (small eyes) or anophthalmia (absence of one or both eyes).
- Trial name
- NCT00011843
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Preimplantation Genetic Testing (PGT), Frozen Embryo Transfer Cycle
Effects of Trophectoderm (TE) Biopsy on the Health and Development of Children Born After Preimplantation Genetic Testing (PGT) Cycles.
This study aims to investigate the effects of trophectoderm (TE) biopsy on the health and development of children born after preimplantation genetic testing (PGT) cycles.
- Conditions
- Preimplantation Genetic Testing (PGT), Frozen Embryo Transfer Cycle, Assisted Reproduction Technologies, Postnatal Health
- Trial name
- NCT07349966
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Polycystic Ovary Syndrome, IVF
Follicular Fluid Raman Shifts and IVF Outcomes
This study intends to collect about 150 cases of follicular fluid samples from PCOS and non-PCOS infertility patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles (in clinical…
- Trial name
- NCT04838535
- Testing
- Raman spectrum
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute