Clinical trials: Emergency Department Patient
Sickle Cell Anemia Crisis
Does IV Acetaminophen Reduce Opioid Requirement in Pediatric Patients With Acute Sickle Cell Crises?
The purpose of this study is to determine whether IV acetaminophen can decrease the need for subsequent opioid administration in the acute management of sickle cell crisis pain in the pediatric emergency room.
- Trial name
- NCT03541980
- Testing
- Acetaminophen, Normal saline
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Newark Beth Israel Medical Center
Benzodiazepine Refractory Status Epilepticus
Established Status Epilepticus Treatment Trial
The primary objective is to determine the most effective and/or the least effective treatment of benzodiazepine-refractory status epilepticus (SE) among patients older than 2 years.
- Trial name
- ESETT (NCT01960075)
- Testing
- Fosphenytoin, Levetiracetam, Valproic acid
- Where
- 65 sites in United States
- Volunteers
- 478 people
- Sponsor
- University of Virginia
Respiratory Tract Infections, Influenza, Human
Rapid Diagnostics for Upper Respiratory Infections in the Emergency Department
This is a randomized clinical trial to assess the effect of rapid, near point-of-care testing for multiple common respiratory viruses and bacteria on antibiotic and anti-influenza medication use in emergency department (ED)…
- Conditions
- Respiratory Tract Infections, Influenza, Human, Common Cold
- Trial name
- URIDxED (NCT02957136)
- Testing
- Rapid respiratory pathogen nucleic acid amplification test
- Where
- United States
- Volunteers
- 194 people
- Sponsor
- University of California, Davis
Abscess
The Effect of Wound Irrigation With Irrisept on Abscess Healing (Irrisept UF Study)
The purpose of this study was to evaluate the safety and effectiveness of Irrisept compared to standard of care treatment of skin and soft tissue infections in the form of abscesses.
- Trial name
- NCT04957732
- Testing
- Standard of Care (SoC), Irrisept Delivery System
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Irrimax Corporation
Abscess
Management of Skin and Soft Tissue Abscesses in Pediatric Patients After Incision and Drainage
The purpose of the study is to compare rates of cure of abscesses with and without antibiotic treatment after incision and drainage.
- Trial name
- NCT00691600
- Testing
- oral trimethoprim/sulfamethoxazole
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Baylor College of Medicine
Alzheimer Disease or Associated Disorder
Coordinated Emergency Department Transitions
The goal of this observational study is to learn the feasibility, acceptability, appropriateness, and adherence to a case management intervention.
- Trial name
- NCT06933849
- Testing
- Structured case management
- Where
- United States
- Volunteers
- 1,376 people
- Sponsor
- Brown University
Carbon Monoxide Poisoning, Anemia
Utility of Non-invasive Carboxyhemoglobin and Total Hemoglobin Measurement in the Emergency Department
The purpose of this study is to determine the clinical utility of triage screening for anemia and carbon monoxide poisoning (COP) in the ED setting.This is a prospective, nonrandomized, multi-center study of the performance of…
- Trial name
- NCT03017742
- Testing
- Pulse Oximeter
- Where
- Turkey (Türkiye)
- Volunteers
- 813 people
- Sponsor
- Masimo Corporation
Asthma
Effect of Nebulized Budesonide and Oral Corticosteroids on Wheezing Episode Relapse in Children
Subjects aged 1-8 years who have been discharged from the emergency department/outpatient care facility with a diagnosis of asthma/bronchospasm/wheezing after usual standard care will be enrolled into this open-label, randomized…
- Trial name
- BudER (NCT00189436)
- Testing
- Nebulized Budesonide, Usual care (albuterol with or without oral steroid)
- Where
- 2 sites in United States
- Volunteers
- 61 people
- Sponsor
- Deborah Gentile
Cellulitis
Study of New Antibiotic Regimen for the Treatment of Uncomplicated Cellulitis in Emergency Department Patients
The primary aim of this study is to quantify the effectiveness of Bactrim as additional therapy for the treatment of uncomplicated cellulitis in adults, by comparing: standard therapy plus Bactrim, versus standard therapy plus…
- Trial name
- NCT00676130
- Testing
- trimethoprim-sulfamethoxazole, Cephalexin
- Where
- 3 sites in United States
- Volunteers
- 153 people
- Sponsor
- Brigham and Women's Hospital
External Causes of Morbidity and Mortality
Comparative Analysis of APACHE II and P-POSSUM
To compare APACHE II and P-POSSUM scoring system in emergency laparotomy.
- Trial name
- NCT02471612
- Where
- India
- Volunteers
- 159 people
- Sponsor
- Tata Main Hospital
Advanced Cancers, Pain
Compare Fentanyl Nasal Spray With Intravenous Opioids to Treat Severe Pain
The goal of this clinical research study is to compare fentanyl nasal spray with a standard drug given by vein (hydromorphone hydrochloride) to help reduce pain related to cancer in patients coming to the emergency department.
- Trial name
- NCT02459964
- Testing
- Fentanyl Nasal Spray, Hydromorphone Hydrochloride, Phone Call
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- M.D. Anderson Cancer Center
Syncope
Diagnostic Yield of an Ambulatory Patch Monitor in Unexplained Emergency Department Syncope: A Pilot Study (PATCH-ED)
Syncope is a common Emergency Department (ED) presentation but the underlying diagnosis is not apparent in 60% of patients after assessment and serious adverse event rate is 7% at one month with most having acute cardiovascular…
- Trial name
- PATCH-ED (NCT02683174)
- Testing
- Novel ambulatory patch (ZIO® XT Patch), BNP and hs-troponin I at 0 and 3 hours post ED attendance
- Where
- United Kingdom
- Volunteers
- 86 people
- Sponsor
- NHS Lothian
Aging
Reducing Potentially Inappropriate Medication Prescribing for Older Patients in the ED
This research is being conducted to learn which implementation strategy of EQUIPPED is most effective to improve prescribing practices of ED providers toward older Veterans and determine the factors influencing implementation of…
- Trial name
- EQUIPPED (NCT04004936)
- Testing
- EQUIPPED with Active Feedback, EQUIPPED with Passive Feedback
- Where
- 4 sites in United States
- Volunteers
- 74 people
- Sponsor
- VA Office of Research and Development
Migraine
Oral Dexamethasone for the Treatment of Acute Migraine Recurrence in the Pediatric Emergency Department
Migraine recurrence is common amongst pediatric patients being discharged from the emergency department after treatment for migraine.
- Trial name
- NCT02794441
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Children's Hospital of Eastern Ontario
One-year Outcome After Prehospital Intubation
One-year Outcome After Prehospital Intubation
The primary aim of this study was to describe the long-term outcome of critically ill or severely injured patients not in cardiac arrest treated by an EMS physician.
- Trial name
- NCT02307123
- Testing
- Intubation
- Volunteers
- 483 people
- Sponsor
- Tampere University Hospital
Presyncope, Arrhythmias, Cardiac
The IPED (Investigation of Palpitations in the ED) Study
Palpitations (noticeable pounding, fluttering or irregular heart beat) and pre-syncope (near blackout) are common ED problems sometimes due to an abnormal cardiac rhythm.
- Conditions
- Presyncope, Arrhythmias, Cardiac, Tachycardia, Supraventricular, Atrial Fibrillation
- Trial name
- IPED (NCT02783898)
- Testing
- AliveCor Heart Monitor
- Where
- 10 sites in United Kingdom
- Volunteers
- 243 people
- Sponsor
- NHS Lothian
Abscess
The Effect Of Wound Irrigation With Irrisept™ Delivery System On Abscess Healing In Patients Presenting To The Emergency Department
The purpose of this study is to determine if wound cleansing and irrigation using the IRRISEPT Chlorhexidine Gluconate(CHG)solution, applying a given volume with a pressurized stream, will improve the outcome for infected…
- Trial name
- NCT01302548
- Testing
- IRRISEPT, Usual Care
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Florida
Smoking Cessation
An Intervention to Reduce Second Hand Smoke Exposure Among Pediatric Emergency Patients
This study will test the efficacy of a cessation intervention for caregivers in a large, inner-city Pediatric Emergency Department.
- Trial name
- NCT02531594
- Testing
- SBIRT, HHC
- Where
- United States
- Volunteers
- 770 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Asthma
Comparison of Nebulizers in ED in Pediatric Asthma Patients
The primary objective will be, in an open-label randomized trial, a comparison of emergency department (ED) length of stay (LOS) between children experiencing acute asthma treated with two different nebulizers.
- Trial name
- NCT01951378
- Testing
- Hudson RCI® nebulizer, NebuTech® HDN® nebulizer, Albuterol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seton Healthcare Family
Cardiac Arrest
Comparing Vasopressin and Adrenaline in Patients With Cardiac Arrest
The effectiveness of medications in cardiac arrest has been greatly debated and questioned. Historically intravenous adrenaline has been the drug of choice since 1906.
- Trial name
- PIVOT (NCT00358579)
- Testing
- Adrenaline, Vasopressin
- Where
- 4 sites in Singapore
- Volunteers
- 727 people
- Sponsor
- Singapore General Hospital