Clinical trials: Emergency Treatment
Anxiety, Lacerations
Intranasal Midazolam for Treatment of Anxiety in Children Undergoing Suturing in the Pediatric Emergency Department
Laceration repair can cause significant anxiety in children. As open wounds account for 21-25% of injuries in children presenting to the emergency department, the management of anxiety is of great importance.
- Trial name
- NCT02618772
- Testing
- Midazolam, Saline
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Benzodiazepine Refractory Status Epilepticus
Established Status Epilepticus Treatment Trial
The primary objective is to determine the most effective and/or the least effective treatment of benzodiazepine-refractory status epilepticus (SE) among patients older than 2 years.
- Trial name
- ESETT (NCT01960075)
- Testing
- Fosphenytoin, Levetiracetam, Valproic acid
- Where
- 65 sites in United States
- Volunteers
- 478 people
- Sponsor
- University of Virginia
Headache, Pregnancy Related
Acute Headache Treatment in Pregnancy: Occipital Nerve Block vs PO Acetaminophen With Caffeine
This is an open label randomized controlled trial evaluating response to bupivacaine occipital nerve block compared to Tylenol/Caffeine cocktail in treatment of pregnant patients seeking care of headache.
- Conditions
- Headache, Pregnancy Related, Occipital Nerve Block
- Trial name
- NCT03951649
- Testing
- Occipital Nerve Block
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gastroenteritis
Impact of Emergency Department Probiotic (LGG) Treatment of Pediatric Gastroenteritis
The investigators will study the efficacy and side effect profile of LGG, a probiotic, in pediatric patients with acute gastroenteritis.
- Trial name
- NCT01773967
- Testing
- LGG, micro-crystalline cellulose
- Where
- 10 sites in United States
- Volunteers
- 971 people
- Sponsor
- Washington University School of Medicine
Cellulitis
Study of New Antibiotic Regimen for the Treatment of Uncomplicated Cellulitis in Emergency Department Patients
The primary aim of this study is to quantify the effectiveness of Bactrim as additional therapy for the treatment of uncomplicated cellulitis in adults, by comparing: standard therapy plus Bactrim, versus standard therapy plus…
- Trial name
- NCT00676130
- Testing
- trimethoprim-sulfamethoxazole, Cephalexin
- Where
- 3 sites in United States
- Volunteers
- 153 people
- Sponsor
- Brigham and Women's Hospital
Advanced Cancers, Pain
Compare Fentanyl Nasal Spray With Intravenous Opioids to Treat Severe Pain
The goal of this clinical research study is to compare fentanyl nasal spray with a standard drug given by vein (hydromorphone hydrochloride) to help reduce pain related to cancer in patients coming to the emergency department.
- Trial name
- NCT02459964
- Testing
- Fentanyl Nasal Spray, Hydromorphone Hydrochloride, Phone Call
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- M.D. Anderson Cancer Center
Asthma in Children
Treating Respiratory Emergencies in Children Study
Over 200,000 children have a 911 Emergency Medical Services (EMS) activation for respiratory distress each year, most of whom have acute wheezing.
- Trial name
- T-RECS (NCT06074185)
- Testing
- Ipratropium Bromide
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Oregon Health and Science University
Dyspepsia, Emergency
Symptomatic Relief of Acute Dyspeptic Pain in Emergency Department With Pantoprazole
The purpose of this study is to evaluate the immediate synergistic effect on the relief of severe acid-related dyspeptic pain by adding intravenous pantoprazole to the combination of oral antacid and antispasmodic agent (the…
- Conditions
- Dyspepsia, Emergency, Pain
- Trial name
- NCT01281501
- Testing
- Normal saline, Pantoprazole, Oral antacid
- Where
- Thailand
- Volunteers
- 87 people
- Sponsor
- Chulalongkorn University
Asthma
Trial of One Versus Two Doses of Dexamethasone for Pediatric Asthma Exacerbation
Comparing one versus two doses of oral dexamethasone for the treatment of asthma in the pediatric emergency department.
- Trial name
- R2D2 (NCT02725008)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Geoffrey W Jara-Almonte
Pain
PREMIX vs PREMED Intranasal Lidocaine and Midazolam
Intranasal (IN) midazolam is an anxiolytic that is commonly used in the pediatric population for procedural anxiolysis in the emergency department (ED) setting to facilitate painful and distressing procedures, such as laceration…
- Trial name
- NCT03054844
- Testing
- Lidocaine, Lidocaine and midazolam (PREMIX), Midazolam
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Columbia University
Asthma
Albuterol Versus Xopenex in Treatment of Acute Asthma in the Emergency Department (ED)
The purpose of this study is to determine in a large, double-blind, randomized, prospective pediatric clinical trial whether the use of continuous levalbuterol (Xopenex) in addition to standard emergency department treatment for…
- Trial name
- Xopenex (NCT00585039)
- Testing
- xopenex
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Phoenix Children's Hospital
Migraine
Oral Dexamethasone for the Treatment of Acute Migraine Recurrence in the Pediatric Emergency Department
Migraine recurrence is common amongst pediatric patients being discharged from the emergency department after treatment for migraine.
- Trial name
- NCT02794441
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Children's Hospital of Eastern Ontario
One-year Outcome After Prehospital Intubation
One-year Outcome After Prehospital Intubation
The primary aim of this study was to describe the long-term outcome of critically ill or severely injured patients not in cardiac arrest treated by an EMS physician.
- Trial name
- NCT02307123
- Testing
- Intubation
- Volunteers
- 483 people
- Sponsor
- Tampere University Hospital
Pediatric Emergency Care
PECARN Emergency Care Registry
The objectives of this study are to: develop an emergency care visit registry for pediatric patients for Quality Improvement purposes and to support future research; to use the emergency care visit registry to collect…
- Trial name
- NCT01657344
- Where
- 5 sites in United States
- Volunteers
- 2,019,461 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Asthma
Comparison of Nebulizers in ED in Pediatric Asthma Patients
The primary objective will be, in an open-label randomized trial, a comparison of emergency department (ED) length of stay (LOS) between children experiencing acute asthma treated with two different nebulizers.
- Trial name
- NCT01951378
- Testing
- Hudson RCI® nebulizer, NebuTech® HDN® nebulizer, Albuterol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Seton Healthcare Family
Status Asthmaticus
The Use of Inhaled Corticosteroids in the Treatment of Asthma is Children in the Emergency Room
Asthma is the most common chronic illness of childhood. About 10% of children are affected. Not surprisingly, acute asthma exacerbations are one of the common reasons to visit pediatric emergency rooms (ER).
- Trial name
- NCT01524198
- Testing
- Budesonide, Normal saline
- Where
- Saudi Arabia
- Volunteers
- 945 people
- Sponsor
- King Saud University
Coral Snake Bite, Toxic Effect of Coral Snake Venom
Emergency Treatment of Coral Snake Envenomation With Antivenom
The purpose of this study is to see whether a new F(ab')2 antivenom will prevent injury and death from the bite of a coral snake. Funding Source - FDA OOPD.
- Trial name
- NCT01337245
- Testing
- Snake (Micrurus) North American immune F(ab')2 Equine
- Where
- 5 sites in United States
- Volunteers
- 26 people
- Sponsor
- University of Arizona
Procedural Sedation and Analgesia
Ketamine Versus Co-administration of Ketamine and Propofol for Procedural Sedation in a Pediatric Emergency Department
The purpose of this study is to compare the effectiveness of the co-administration of intravenous ketamine and propofol to intravenous ketamine as a single agent for procedural sedation in the pediatric emergency department.
- Trial name
- NCT01387139
- Testing
- Ketamine, Ketamine Co-administered with Propofol
- Where
- United States
- Volunteers
- 183 people
- Sponsor
- University of Colorado, Denver
Headache, Migraine
Study of Intramuscular Ropivacaine Injections for Treatment of Pediatric Headache
Objective: To determine if lower paracervical intramuscular ropivacaine injection is an effective treatment for pediatric headache in an emergency department setting.
- Trial name
- NCT00680823
- Testing
- Ropivacaine, Normal saline
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Robert Hickey
Abscess
Antibiotics Versus Placebo in the Treatment of Abscesses in the Emergency Department
The purpose of this study is to determine if there is a difference between an antibiotic, trimethoprim-sulfamethoxazole versus placebo in healing outcomes of soft tissue abscesses following incision and drainage.
- Trial name
- NCT00867789
- Testing
- Trimethoprim-sulfamethoxazole, Sugar pill
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City