Clinical trials: Emotional Depression
Depressive Symptoms, Anxiety Disorders and Symptoms
Family Spirit Strengths
This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities.
- Conditions
- Depressive Symptoms, Anxiety Disorders and Symptoms, Substance Use, Mental Health Issue
- Trial name
- FSS (NCT05836090)
- Testing
- Family Spirit Strengths (FSS), Family Spirit Nurture
- Where
- 3 sites in United States
- Volunteers
- 188 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Type 1 Diabetes Mellitus, Depressive Symptoms
Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms in Adolescents With Type 1 Diabetes Mellitus
This study evaluates the use of an established internet-based cognitive behavioral therapy intervention in a group of adolescents with type 1 diabetes and mild to moderate depressive symptoms.
- Trial name
- NCT03655067
- Testing
- CATCH-IT
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Texas Southwestern Medical Center
Prader-Willi Syndrome
Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation
The goal of this study is to help teens with Prader-Willi Syndrome (PWS) and their families learn practical strategies for managing issues like irritability, meltdowns, and anxiety.
- Trial name
- RT-PWS (NCT07607730)
- Testing
- Regulating Together group therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Mercy Hospital Kansas City
Depressive Symptoms
An Evaluation of the Effect of Vitamin D Supplementation on Depressive Symptoms Among Chinese Early Adolescents
The goal of this randomized controlled clinical trial is to investigate the effects of vitamin D3 supplementation on depression in Chinese early adolescents with elevated depressive symptoms and vitamin D deficiency.
- Trial name
- NCT06247930
- Testing
- Vitamin D3, Mental health education
- Where
- 2 sites in China
- Volunteers
- 406 people
- Sponsor
- Anhui Medical University
Adolescent - Emotional Problem, Agent
A Virtual Peer Agent for Counseling Adolescents With Stressful Life Events
This study aims to develop and evaluate a virtual companion agent for providing psychological support to adolescents who have recently experienced stressful life events. This is a single-arm, pre-post pilot trial.
- Conditions
- Adolescent - Emotional Problem, Agent, Psychological, Conversational
- Trial name
- NCT07305064
- Testing
- Virtual Peer Agent Counseling
- Where
- China
- Volunteers
- 55 people
- Sponsor
- Sun Yat-sen University
Depression in Adolescence, Rumination
Mindfulness-Based fMRI Neurofeedback for Depression
In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients.
- Trial name
- mbNF (NCT05617495)
- Testing
- Mindfulness + fMRI Neurofeedback
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Columbia University
Freeman-Sheldon Syndrome, Arthrogryposis Distal Type 2A
Survey Study and Records Review of Treatment Outcomes in Freeman-Sheldon Syndrome
Freeman-Sheldon syndrome (FSS) is a rare muscle disorder present before birth, involving primarily problems of the face and skull and the hands and feet.
- Conditions
- Freeman-Sheldon Syndrome, Arthrogryposis Distal Type 2A, Whistling Face Syndrome, Craniocarpotarsal Dysplasia
- Trial name
- STOP-FSS (NCT01144741)
- Testing
- PTSD Checklist-Civilian (PCL-C), Modified Flanagan Quality of Life Scale, Center for Epidemiologic Studies Depression Scale (CES-D)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Freeman-Sheldon Research Group, Inc.
Attention Deficit Hyperactivity Disorder, Depressive Symptoms
School-Based Depression Prevention for Adolescents With ADHD
The purpose of this study is to develop a modified behavioral activation program in adolescents with ADHD to be implemented by school mental health providers in an urban, low-income school district.
- Trial name
- BEAMS (NCT04104841)
- Testing
- Behaviorally Enhancing Adolescents' Mood in Schools, Usual Care
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Maryland, College Park
Anxiety Disorders, Depressive Disorder
Psychopathology in Adolescence
This observational study aims to evaluate the effectiveness of two different psychotherapy approaches-Cognitive Behavioral Therapy (CBT) and Brief Strategic Therapy (BST)-in treating adolescents with psychological disorders.
- Conditions
- Anxiety Disorders, Depressive Disorder, Obsessive-Compulsive Disorder, Mental Health
- Trial name
- NCT07259109
- Where
- Italy
- Volunteers
- 192 people
- Sponsor
- IRCCS Centro Neurolesi Bonino Pulejo
Type-2 Diabetic Patients
Reiki and Qi-gong Therapy to Improve Negative Emotional States of Anxiety, Depression, and Stress in Type-2 Diabetics
Diabetes is a worldwide chronic disease due to a disorder in the metabolism of blood glucose. It has high prevalence rates especially in developing countries and is associated with 1.5 million deaths per year.
- Trial name
- NCT05704465
- Testing
- Reiki Therapy, Qi-gong Therapy
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Beni-Suef University
BPSD, Expressed Emotion
Intervention for Emotions in Caregivers of Dementia
This study aims to evaluate the effectiveness of a 6-week Caregivers Of dementia Processing Emotions (COPE) program using the integrative therapy to reduce EE (primary outcome) in family caregiver of PLwD to alleviate the…
- Conditions
- BPSD, Expressed Emotion, Depressive Symptoms
- Trial name
- NCT06359704
- Testing
- Caregivers Of dementia Processing Emotions (COPE) program
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Depression, Depressive Disorder
Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation
The patients with depression and obesity will receive add-on metformin with antidepressant therapy, which may result in greater improvement in depressive symptoms and BMI reduction compared to antidepressant monotherapy.
- Conditions
- Depression, Depressive Disorder, Overweight or Obesity, Depressive Symptoms
- Trial name
- NCT07654179
- Testing
- Metformin, Antidepressant Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Treatment Resistant Depression
Deciphering Principles of Network Dynamics Underlying Depression Symptom Severity From Multi-day Intracranial Recordings in Patients With Major Depression
Major depressive disorder (MDD) is common and causes significant disability world-wide. While typically responsive to medications and therapy, there remain a subset of patients who are treatment resistant.
- Trial name
- NCT06953362
- Testing
- Direct Neural Electrical Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Anorexia Nervosa
Metreleptin in Anorexia Nervosa
The treatment of anorexia nervosa often proves to be difficult. There are no drugs that work specifically for the treatment of anorexia nervosa.
- Trial name
- METRAN (NCT06305182)
- Testing
- Metreleptin, Sodium chloride
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Gabriella Milos
Anxiety Disorders, Depressive Disorder
A Prospective Study of Anxiety, Depression, and Bipolar Disorder in People
This study aims to understand how anxiety disorders, depressive disorders, and bipolar disorder change over time and to identify patterns that may help with earlier recognition, diagnosis, and prediction of future symptoms.
- Conditions
- Anxiety Disorders, Depressive Disorder, Bipolar Disorder (BD)
- Trial name
- NCT07903246
- Where
- China
- Volunteers
- 2,690 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Depression, Anxiety
Generative Artificial Intelligence Intervention and Individual Psychological Counseling on Emotional Distress in Young Adults
This randomized controlled trial aims to evaluate the effectiveness of an AI-based mental health chatbot, Emohaa, in reducing symptoms of depression, anxiety, insomnia, and academic burnout among young adults experiencing…
- Trial name
- NCT06992180
- Testing
- Generative Artificial Intelligence Intervention, Individual Psychological Counseling
- Where
- China
- Volunteers
- 222 people
- Sponsor
- Central University of Finance and Economics, China
Mental Health Disorders in Adolescents, Emotional Dysregulation
Dog-Assisted Therapy in Adolescents Attending a Child and Adolescent Mental Health Day Hospital
This study aimed to evaluate the feasibility and effectiveness of a dog-assisted therapy program integrated into a Child and Adolescent Mental Health Day Hospital, as well as to explore participants' subjective experiences.
- Conditions
- Mental Health Disorders in Adolescents, Emotional Dysregulation, Anxiety Disorders, Depressive Disorders
- Trial name
- DAT-MH-DH (NCT07663916)
- Testing
- Experimental: Experimental: Dog-assisted therapy + Treatment as usual, Active Comparator: Treatment as usual
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Clinic of Barcelona
Depression
Study to Compare the Use of a Behavioral Health App Versus Care As Usual for 16-22 Year Olds with Depression
Randomized Controlled Trial comparing a coach-enhanced digital cognitive behavioral intervention (d-CBI) (RxWell) + treatment as usual (TAU) versus TAU alone for moderate depression as determined by Patient Health Questionnaire…
- Trial name
- NCT05159713
- Testing
- dCBI, Treatment as Usual
- Where
- 3 sites in United States
- Volunteers
- 185 people
- Sponsor
- University of Pittsburgh
Depressive Symptoms, Hypomania Nos Single Episode or Unspecified
A Study of Aerobic Exercise for Adolescents With Subthreshold Mood Syndromes
This study will investigate the effects of aerobic exercise on mental states, cognition, and long-term outcomes in adolescents with subthreshold depressive and/or hypomanic syndromes and in non-clinical school children
- Trial name
- NCT03300778
- Testing
- aerobic exercise
- Where
- China
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Guangzhou Psychiatric Hospital
Depressive Symptoms, Happiness
Believing People Can Change: A Randomized Controlled Trial of an Incremental Theory Intervention in Adolescence
This study will test the effectiveness of a brief educational intervention that teaches youth that they can grow and change, known as "growth mindset." Similar growth mindset interventions have improved youths' well-being and…
- Conditions
- Depressive Symptoms, Happiness, Life Satisfaction
- Trial name
- NCT04133389
- Testing
- Growth mindset of personality educational intervention, Growth mindset of athletic ability educational intervention
- Where
- Canada
- Volunteers
- 576 people, healthy volunteers welcome
- Sponsor
- University of Guelph