Clinical trials: Endocrine Cancer
Neoplasms Pancreatic
PRIMUS 001: A Study Looking at Two Different Chemotherapy Regimens in Patients With Metastatic Pancreatic Cancer
This study is comparing two combinations of chemotherapy treatments in patients with metastatic pancreatic cancer. Half the participants will receive FOLFOX-A and the other half will receive AG.
- Trial name
- NCT04151277
- Testing
- FOLFOX-A, Gemcitabe and Abraxane, G-CSF
- Where
- 30 sites in United Kingdom
- Volunteers
- 500 people
- Sponsor
- Judith Dixon-Hughes
Ovarian Sex Cord Stromal Tumor, Ovarian Neoplasms
TC or BEP in Treating Patients With Ovarian Malignant Sex Cord-Stromal Tumors
Investigators will conduct the trial to determine whether paclitaxel and cisplatin (PT) has the same curative effects and less adverse effects than bleomycin, etoposide and cisplatin(BEP) among newly diagnosed ovarian malignant…
- Conditions
- Ovarian Sex Cord Stromal Tumor, Ovarian Neoplasms, Ovarian Cancer
- Trial name
- SCST-01 (NCT02429700)
- Testing
- Paclitaxel, Carboplatin, Bleomycin
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Beihua Kong
Childhood Germ Cell Tumor, Leydig Cell Tumor
Studying Genes in Samples From Younger Patients With Ovarian or Testicular Sex Cord Stromal Tumors
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors identify biomarkers related to cancer.
- Conditions
- Childhood Germ Cell Tumor, Leydig Cell Tumor, Ovarian Cancer
- Trial name
- NCT01572467
- Testing
- RNA analysis, gene expression analysis, mutation analysis
- Volunteers
- 50 people
- Sponsor
- Children's Oncology Group
Cancer
Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to chronic graft-versus-host disease in patients who…
- Trial name
- NCT00957736
- Testing
- polymorphism analysis, laboratory biomarker analysis
- Where
- 3 sites in United States
- Volunteers
- 252 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Pancreatic Cancer
Comparison Between Base and Cover Slide From Endoscopic Ultrasound Guided Fine Needle Aspiration for Pancreatic Cancer
The purpose of this study is to determine whether there is a difference of diagnostic accuracy between cover slides and base slides from EUS-FNA cytopathologic sample in patients who were previously suspected of pancreatic cancer…
- Trial name
- EUS-FNA (NCT02190071)
- Where
- South Korea
- Volunteers
- 73 people
- Sponsor
- Seoul National University Hospital
Thyroid Cancer, Thyroid Nodule
Surgical Competency for Robot-Assisted Thyroidectomy: Construction and Validation of a Robotic Thyroidectomy Assessment Score (RTAS)
To develop and validate a structured scoring tool (robotic thyroidectomy assessment score, RTAS) for assessing and quantifying surgical performance in robotic thyroidectomy (RT).
- Conditions
- Thyroid Cancer, Thyroid Nodule, Thyroid Diseases, Thyroid Cancer, Papillary
- Trial name
- NCT06730321
- Testing
- Observations on clinicopathological factors influencing the assessment score of surgery
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanghai 6th People's Hospital
Polycystic Ovary Syndrome, Abnormal Weight Gain
Go Girls! Fitness Support Group Intervention Effectiveness Study
The main purpose of this study is to determine if the Go Girls! program to take place at the Kluge Children's Rehabilitation Center Therapeutic Recreation Gymnasium, intended to introduce girls to a fun, non-threatening…
- Conditions
- Polycystic Ovary Syndrome, Abnormal Weight Gain, Excess Weight, Insulin Resistance
- Trial name
- CBS002 (NCT02117063)
- Testing
- Go Girls! Fitness Support Group
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- University of Virginia
Breast Cancer, Bladder Cancer
Germline Alterations of Tumor Susceptibility Genes in New York Cancer Patients
The basic premise of this research proposal is to determine whether there is any significant association between germline polymorphisms and cancers of colon, bladder, breast, testicular, prostate, ovaries, kidney, lung, lymphoid…
- Conditions
- Breast Cancer, Bladder Cancer, Kidney Cancer, Colon Cancer
- Trial name
- NCT00579514
- Testing
- PCR/PCR/LDR Strategy
- Where
- United States
- Volunteers
- 21,081 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Thyroid Cancer, Thyroid Neoplasms
Response to Neoadjuvant Treatment in Locally Advanced Thyroid Cancer
This multicenter observational study aims to evaluate the safety and efficacy of neoadjuvant therapy in patients with locally advanced thyroid cancer, focusing on imaging, biochemical, and pathological responses, as well as…
- Trial name
- NeoLATC (NCT07419932)
- Testing
- Multitarget Tyrosine Kinase Inhibitors, BRAF inhibitor dabrafenib and MEK inhibitor trametinib, RET Inhibitor
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University
Thyroid Cancer
RET Inhibitor for Neoadjuvant Therapy in Locally Advanced RET-altered Thyroid Cancer
This study is a multicenter observational study. Patients receive neoadjuvant therapy with RET inhibitors in the real world, and those who can undergo surgery after neoadjuvant therapy receive surgical treatment.
- Trial name
- NCT06530316
- Testing
- RET Inhibitor, Surgery
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Fudan University
Polycystic Ovary Syndrome
The Influence Factors of Ovarian Response in PCOS Patients With IVF-ET Treatment
The purpose of this study is to explore the factors which affect ovarian response of PCOS patients with IVF-ET treatment, in order to provide predictive clinical index for the outcome of IVF-ET treatment in PCOS patients.
- Trial name
- NCT02331758
- Testing
- Lifestyle Counseling
- Volunteers
- 1,000 people
- Sponsor
- Peking University Third Hospital
Parathyroid Adenomas
Expanded Access:18F-Fluorocholine for the Detection of Parathyroid Adenomas
This expanded access protocol is proposed to allow University of California San Francisco (UCSF) patients additional access to 18F-fluorocholine (FCH) Positron Emission Tomography (PET) imaging for localization of parathyroid…
- Trial name
- NCT07218224
- Testing
- 18F-Fluorocholine (FCH), Positron emission tomography (PET)
- Sponsor
- Thomas Hope
HIV Infections, Sexually Transmitted Infections
HIV Prevention Program for African American Teen Males
The purpose of this study is to test if sexual health interventions can reduce the incidence of STIs among African American teens (15 to 21 years old).
- Trial name
- NCT00849823
- Testing
- Male Sexual Health Program, Focus on the Future Program
- Where
- United States
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Richard Crosby
Breast Neoplasms
Antiestrogen vs Aromatase Inhibitor After Adjuvant Chemotherapy for Breast Cancer
To investigate the benefit of postoperative adjuvant therapy using sequential administration of the hormone, toremifene citrate (TOR) or anastrozole (ANA), after chemotherapy in breast cancer.
- Trial name
- NCT00437359
- Testing
- Toremifene citrate, Anastrozole
- Where
- 7 sites in Japan
- Volunteers
- 240 people
- Sponsor
- Japan Breast Cancer Research Network
Ovarian Cancer
Adjuvant Chemotherapy Compared With Observation in Treating Patients With Resected Early Stage Ovarian Epithelial Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00002477
- Testing
- carboplatin, cisplatin, cyclophosphamide
- Where
- United Kingdom
- Sponsor
- Medical Research Council
Advanced Solid Tumor, Advanced Malignant Neoplasm
The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
The Phase 2 monotherapy portion of this study is currently enrolling and will evaluate the efficacy and safety of PC14586 (INN rezatapopt) in participants with locally advanced or metastatic solid tumors harboring a TP53 Y220C…
- Conditions
- Advanced Solid Tumor, Advanced Malignant Neoplasm, Metastatic Cancer, Metastatic Solid Tumor
- Trial name
- NCT04585750
- Testing
- rezatapopt, pembrolizumab
- Where
- 76 sites in United States, Australia and 7 more
- Volunteers
- 300 people
- Sponsor
- PMV Pharmaceuticals, Inc
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Treatment Outcome and Quality of Life in Patients With Pediatric Extra-Cranial Germ Cell Tumors Previously Treated on Clinical Trial CCLG-GC-1979-01 or CCLG-GC-1989-01
RATIONALE: Treatment for pediatric extracranial germ cell tumors may cause side effects and secondary cancers later in life. A study that evaluates patients after receiving combination chemotherapy or surgery may help doctors…
- Conditions
- Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Gastrointestinal Complications, Infertility
- Trial name
- NCT00436774
- Testing
- assessment of therapy complications, quality-of-life assessment
- Where
- 13 sites in Ireland, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Children's Cancer and Leukaemia Group
Thyroid Neoplasms, Thyroid Nodules
Is the Routine Pressure Dressing After Thyroidectomy Necessary?
Thyroidectomy is an operation that is commonly performed. After an operation a pressure dressing by Hypafix is usually used due to the belief that it will help to reduce complications such as post-operative bleeding or haematoma.
- Conditions
- Thyroid Neoplasms, Thyroid Nodules, Graves Disease, Goiter
- Trial name
- NCT00400465
- Testing
- Normal dressing, Pressure dressing
- Where
- Thailand
- Volunteers
- 116 people
- Sponsor
- Khon Kaen University
Thyroid Cancer
Assessment of CA 19-9 in Patients' With Thyroid Malignancies
Thyroid cancer is a rare disease that represents approximately 3.8% of all new cancer cases.Incidence of thyroid cancer in north Africa about 2.8% of all new cancer cases with mortality rate about 0.73%.Thyroid malignancies are…
- Trial name
- NCT05124938
- Testing
- Laboratory investigations for control: a-Complete blood count. b-Liver function test. c-kidney function test. d-thyroid-stimulating hormone,T3 and T4. e-Assessment of levels of CA19-9.
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sohag University
Stroke, Transient Ischemic Attack
The "COSMOS"-Study (Copeptin in Osmoregulation and Stress Assessment)
Sodium imbalance is common and an adverse prognostic factor in hospitalized patients. However, identifying the causes of sodium imbalance is challenging in clinical practice.
- Trial name
- NCT00390962
- Where
- Switzerland
- Volunteers
- 469 people
- Sponsor
- University Hospital, Basel, Switzerland
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