Clinical trials: Endocrine Disorders
Diabetes Mellitus, Type 1
Influence of Vitamin D on Vascular Function in Adolescents and Young Adults With Type 1 Diabetes
The purpose of this study is to study the role of low vitamin D levels on the health of blood vessels or vascular function in adolescents and young adults with type 1 diabetes.
- Trial name
- NCT01103817
- Testing
- Vitamin D
- Where
- Canada
- Volunteers
- 33 people
- Sponsor
- The Hospital for Sick Children
Adult Growth Hormone Deficiency
Metabolic Endocrinology and Growth Hormone in Adults
This is a multicentric, longitudinal, observational study with the prospective follow-up of Adult subjects with Growth Hormone Deficiency (AGHD) being treated with Saizen, every six months in the first year and then annually.
- Trial name
- MEGHA FRANCE (NCT01080755)
- Volunteers
- 90 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Periodontal Diseases, Pregnancy Complications
Oral Health and Adverse Pregnancy Complications
Pregnant women are susceptible to develop periodontitis, but these oral health changes related to pregnancy are often neglected.
- Conditions
- Periodontal Diseases, Pregnancy Complications, Pregnancy Preterm, Gestational Diabetes
- Trial name
- NCT06110143
- Testing
- Periodontal treatment
- Where
- 3 sites in Denmark
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Type 2 Diabetes
Personalized Diabetes Text Messaging (DB-TEXT) Combined With Peer Support Education in Patients With Type 2 Diabetes
The purpose of this study to investigate the effects of personalized diabetes text messaging (DB-TEXT) combined with PSE in patients with type 2 diabetes.
- Trial name
- NCT05629117
- Testing
- Personalized Diabetes Text Messaging (DB-TEXT) combined with Peer Support Education, Personalized Diabetes Text Messaging (DB-TEXT)
- Where
- Taiwan
- Volunteers
- 83 people
- Sponsor
- Taipei Medical University
Childhood Malignant Ovarian Germ Cell Tumor, Childhood Malignant Testicular Germ Cell Tumor
DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
This research trial studies deoxyribonucleic acid (DNA) samples from younger patients with germ cell tumor and their parents or siblings.
- Conditions
- Childhood Malignant Ovarian Germ Cell Tumor, Childhood Malignant Testicular Germ Cell Tumor, Ovarian Choriocarcinoma, Ovarian Embryonal Carcinoma
- Trial name
- NCT01434355
- Testing
- Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- United States
- Volunteers
- 932 people
- Sponsor
- Children's Oncology Group
Dwarfism, Turner's Syndrome
The Effects of Hormones in Growth Hormone-Treated Girls With Turner Syndrome
Turners Syndrome is a genetic condition in females that is a result of abnormal chromosomes. Patients with Turner syndrome are typically short, have abnormal physical features, and lack the physical changes normally associated…
- Trial name
- NCT00001343
- Testing
- Humatrope, Oxandrolone
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pancreas Atrophy, Diabetes
Long-term Health After Severe Acute Malnutrition in Children and Adults: the Role of the Pancreas
Whilst there is an increasing prevalence of overweight and obesity worldwide, malnutrition remains common. In addition, malnutrition, overweight, and infections often interact.
- Conditions
- Pancreas Atrophy, Diabetes, Malnutrition
- Trial name
- SAMPA (NCT05361148)
- Testing
- no interventions will be used
- Where
- 4 sites in India, Philippines and 2 more
- Volunteers
- 2,305 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Thyroid Cancer
The Effect of the Number of Central Lymph Nodes on Changes in Parathyroid Function
This study collected data from patients who underwent thyroidectomy in the Breast and Thyroid Surgery Department of Shandong Provincial Hospital from January 2020 to December 2023 by reviewing medical records.
- Trial name
- NCT06432244
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shandong Provincial Hospital
Type 1 Diabetes
Overnight MD-Logic
Study design: Multicenter,randomized, prospective, open label, cross over, six segments, pilot trial to evaluate blood glucose control overnight under closed-loop insulin delivery with MD-Logic Artificial Pancreas (MDLAP) system…
- Trial name
- NCT01238406
- Testing
- MD-logic Artificial Pancreas (MDLAP), Standard treatment with insulin pump
- Where
- 3 sites in Germany, Israel and 1 more
- Volunteers
- 151 people
- Sponsor
- Rabin Medical Center
Childhood-onset Growth Hormone Deficiency, Pituitary Dwarfism
Cool.Click™ Adolescent Transition Study: Study of Saizen® in Subjects With Childhood-onset Growth Hormone Deficiency
The primary objective is to evaluate the efficacy and safety of two different dose regimens of r-hGH (Saizen®) in subjects with childhood-onset growth hormone deficiency (COGHD) during the transition phase from childhood to…
- Trial name
- NCT00109733
- Testing
- recombinant human growth hormone
- Where
- 9 sites in United States
- Volunteers
- 31 people
- Sponsor
- EMD Serono
Type 1 Diabetes
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes
The objective of the proposed research is to evaluate the efficacy and safety of the use of metformin in addition to standard insulin therapy in overweight and obese children and adolescents, age 12-<20 years, with type 1…
- Trial name
- NCT01881828
- Testing
- Metformin (glucophage)
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Jaeb Center for Health Research
ADHD, ADD
ADHD Electrophysiological Subtypes and Implications in Transcranial Direct-current Stimulation
In the present study the aim is to examine whether transcranial direct-current stimulation (tDCS) generated excitability changes and induce modifications of functional cortical architecture in Attention Deficit Hyperactivity…
- Trial name
- tdcs&adhd (NCT01649232)
- Testing
- Active tDCS
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Spanish Foundation for Neurometrics Development
Thyroid Cancer
Selpercatinib and Body Composition
investigation of body composition
- Trial name
- EECRTKI (NCT07543887)
- Testing
- observation in patient under treatment, Selpercatinib
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- University of Pisa
Type 1 Diabetes Mellitus, Dyslipidemia
Clinical Trial of Zocor (Simvastatin) and Vytorin (Ezetimibe/Simvastatin) in Adolescents With Type 1 Diabetes
The purpose of the study is to establish the safety of ezetimibe/simvastatin and simvastatin in adolescents with Type 1 Diabetes and to determine the amount of decrease in LDL-cholesterol.The study hypothesizes that simvastatin…
- Trial name
- NCT00477204
- Testing
- Simvastatin, Ezetimibe/Simvastatin
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Colorado, Denver
Diabetes
Post-marketing Surveillance (Special Use-results Surveillance) on Long-term Use With Ryzodeg®
This trial is conducted in Asia. The aim of this Non-interventional study is to investigate the long-term safety and effectiveness of Ryzodeg® (insulin degludec/insulin aspart) in Japanese patients with diabetes mellitus…
- Trial name
- NCT02821052
- Testing
- insulin degludec/insulin aspart
- Where
- Japan
- Volunteers
- 1,355 people
- Sponsor
- Novo Nordisk A/S
Cardiovascular Diseases, Coronary Heart Disease
Umbrella Review and Updated Systematic Review and Meta-analysis of Pulses/Legumes and Incident Cardiometabolic Diseases
The European Association for the Study of Diabetes (EASD) guidelines have not made any specific recommendations regarding dietary pulses.
- Conditions
- Cardiovascular Diseases, Coronary Heart Disease, Stroke, Diabetes Mellitus, Type 2
- Trial name
- NCT03555734
- Testing
- Dietary pulses or legumes
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes
Production of Stem Cells for the Generation of Pancreatic Cells
The goal of this interventional study is to generate induced pluripotent stem cells (iPSCs) from somatic cells and differentiate them into insulin-producing β cells in patients with metabolic and genetic pancreatic diseases and…
- Trial name
- NCT07479134
- Testing
- Biological - skin biopsy, blood draw, or urine collection for iPSC generation
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ospedale San Raffaele
Diabetes, Alzheimer Disease
The Diabetes Prevention Program Outcomes Study AD/ADRD Project
The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for…
- Conditions
- Diabetes, Alzheimer Disease, Dementia, Vascular, Dementia
- Trial name
- DPPOS-4 (NCT05704309)
- Where
- 27 sites in United States
- Volunteers
- 1,976 people, healthy volunteers welcome
- Sponsor
- Marinella Temprosa
Type 1 Diabetes Mellitus
Glycemic Control and the Brain in Children With Type 1 Diabetes
The purpose of this study is to determine if improving diabetes control by better controlling blood sugars, will help improve or normalize brain function as compared to routine diabetes care.
- Trial name
- NCT03428932
- Testing
- Closed Loop (Medtronic 670G), Standard Care
- Where
- 5 sites in United States
- Volunteers
- 46 people
- Sponsor
- Nemours Children's Clinic
Primary Insulin-like Growth Factor-1 Deficiency
IGFD Registry: A Patient Registry for Monitoring Long-term Safety and Efficacy of Increlex
This project is a retrospective (beginning January 2006) and prospective patient registry program sponsored by Ipsen (formerly Tercica, Inc.).
- Trial name
- NCT00747604
- Testing
- mecasermin [rDNA origin] injection
- Where
- United States
- Volunteers
- 1,378 people
- Sponsor
- Ipsen
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