Clinical trials: Endocrine Disorders
Hyperglycemia
Resistant Starch on Glucose and Insulin Sensitivity in Individuals With Type 2 Diabetes
This study will test the effects of resistant starch type 4 on blood sugar and hunger in adults with Type 2 diabetes.
- Trial name
- NCT00691249
- Testing
- Resistant Starch Type 4-Raw, Resistant Starch Type 4-Cooked, Shredded Wheat
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Kansas State University
Thyroid, Cardiac Remodeling, Ventricular
Effect of Thyroid Hormone on Post-Myocardial Infarction Remodeling and Prognosis in STEMI Patients
This study aims to determine whether thyroid hormone levels are predictive of cardiac remodeling following myocardial infarction and the prognosis in patients with STEMI receiving primary percutaneous coronary intervention.
- Conditions
- Thyroid, Cardiac Remodeling, Ventricular, STEMI
- Trial name
- ThyREST (NCT03933358)
- Testing
- Thyroid hormone levels
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Beijing Friendship Hospital
Type 1 Diabetes Mellitus
Diabetes Control and Complications Trial (DCCT)
Background. Long-term microvascular and neurologic complications cause major morbidity and mortality in patients with insulin-dependent diabetes mellitus (IDDM).
- Trial name
- NCT00360815
- Testing
- Insulin
- Where
- 38 sites in United States, Canada
- Volunteers
- 1,441 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
SEDC, Hypochondrogenesis
A Natural History Study in Children With a Type II Collagen Disorder With Short Stature
There are relatively few data available on type II collagen disorders, and evidence is lacking on the disease course in relation to symptoms and development of complications, the level of actual disease burden over time as well…
- Conditions
- SEDC, Hypochondrogenesis, Semd, Strudwick Type, Kniest Dysplasia
- Trial name
- ROCKET (NCT05408715)
- Testing
- Natural History Study
- Where
- 2 sites in France, Spain
- Volunteers
- 60 people
- Sponsor
- Innoskel
Pancreatic Exocrine Insufficiency
The Development of a Metabolomic Test to Diagnose and Quantify Pancreatic Exocrine Insufficiency (The DETECTION Study)
DETECTION. The development of a metabolomic test to diagnose and quantify pancreatic exocrine insufficiency.
- Trial name
- DETECTION (NCT05980221)
- Testing
- Metabolomics, 13C MTGT
- Where
- United Kingdom
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Germ Cell Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow patients to tolerate higher doses…
- Conditions
- Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Ovarian Cancer, Testicular Germ Cell Tumor
- Trial name
- NCT00003852
- Testing
- filgrastim, carboplatin, cyclophosphamide
- Where
- 18 sites in France
- Volunteers
- 45 people
- Sponsor
- UNICANCER
Diabetes Mellitus, Type 1
Automated Insulin Delivery for Type 1 Diabetes - Beyond Glucose Metrics
The goal of this clinical trial is to determine if transitioning to automated insulin delivery (AID) systems, can improve objectively measured sleep quality and quantity and alleviate cardiovascular risk factors in both children…
- Trial name
- AID-BEYOND (NCT06469593)
- Testing
- Automated insuling delivery system
- Where
- 3 sites in Denmark
- Volunteers
- 200 people
- Sponsor
- Steno Diabetes Center Copenhagen
Cryptorchidism
Role of the Environment and Endocrine Disruptors in Child Cryptorchidism
Cryptorchidism is the most frequent congenital defect of the male newborn. It requires surgery in childhood, increases the risk of fertility disorders and cancer.
- Trial name
- CRYPTENV (NCT04342026)
- Testing
- Measure of the exposure of parent of male with /without cryptorchidism to endocrine disruptors
- Where
- France
- Volunteers
- 1,452 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes
Investigation of the Skin Barrier in Patients With Type 1 Diabetes
This study is a case-control study comparing the skin barrier between 50 T1D patients with healthy controls in 3 age-strata including both pediatric and adult patients.
- Trial name
- NCT04280315
- Where
- 2 sites in Denmark
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Jannet Svensson
Type 1 Diabetes
Simple Meal Management Using Automated Insulin Delivery System
Carbohydrate counting is an essential component of diabetes management in both adults and children, and together with an intensive insulin plan and increased blood glucose monitoring was associated with lower HbA1c.
- Trial name
- SMMAID (NCT06130215)
- Testing
- Simple meal management, Precise meal management
- Where
- Qatar
- Volunteers
- 34 people
- Sponsor
- Sidra Medicine
COVID19- Infection with SARS-CoV-2 Virus
Impact of the COVID-19 Pandemic on Central Precocious Puberty: a Retrospective Cohort Study from Turkey
Objective: This study investigates the clinical and demographic characteristics of girls diagnosed with central precocious puberty (CPP) in the pre-pandemic and pandemic periods to assess potential changes during the COVID-19…
- Trial name
- COVID-19-PP (NCT06823076)
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Umraniye Education and Research Hospital
Type 1 Diabetes Mellitus
Effect of Splitting Mealtime Insulin Doses After Mixed Meals High in Fat and Protein
The current management of type 1 diabetes mellitus (T1DM) depends on the use of intensive insulin therapy - either by insulin pump therapy or multiple daily injection (MDI) therapy - and the use of carbohydrate counting to…
- Trial name
- NCT04783376
- Testing
- : Insulin, lispro and regular insulin
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Sohag University
Health Attitude, Diabetes type1
Oral Health Awareness and Oral Hygiene in Insulin Dependent Diabetes Mellitus
This study is designed to evaluate the effect of oral health educational program on the awareness and oral health status of children with Insulin Dependent Diabetes Mellitus.
- Trial name
- NCT03170089
- Testing
- Oral Health Educational Program
- Volunteers
- 44 people
- Sponsor
- Cairo University
Diabetes, Diabetes Mellitus, Type 1
Paediatric Subjects - Special Survey
This study is conducted in Japan. The aim of this study is to collect safety and efficacy data when using insulin aspart in children with diabetes under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT01538576
- Testing
- insulin aspart
- Where
- Japan
- Volunteers
- 71 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus
Computer-Assisted Access to Specialist Expertise
The goal of this research was to determine if providing specialist input to primary care providers (PCPs) by means of informal consultation could improve the process and outcomes of care for diabetes.
- Trial name
- NCT00013117
- Testing
- Telephone specialist consultation
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- US Department of Veterans Affairs
Cystic Fibrosis, Prediabetes
Prevention of Cystic Fibrosis Diabetes
Acute systemic hyperglycemia causes oxidative stress and a pro-inflammatory response. The pro-inflammatory cytokines induced by hyperglycemia are toxic to islet insulin producing cells, and thus worsen glucose intolerance.
- Trial name
- Prevent (NCT00967798)
- Testing
- Sitagliptin
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Emory University
Pheochromocytoma, Endocrine Disease
Diagnosis of Pheochromocytoma
The goal of this study is to develop better methods of diagnosis, localization, and treatment for pheochromocytomas. These tumors, which usually arise from the adrenal glands, are often difficult to detect with current methods.
- Conditions
- Pheochromocytoma, Endocrine Disease, Endocrine Diseases
- Trial name
- NCT00004847
- Testing
- ([18F]-DOPA), ([18F]-6F-DA)
- Where
- United States
- Volunteers
- 3,000 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Type 1 Diabetes
BeAT1D: Benign Autoimmunity and Type 1 Diabetes
National multi-center non-interventional case-control cohort study with collection of biological samples to characterize the autoimmune T and B lymphocytes involved in the development of type 1 diabetes.
- Trial name
- BeAT1D (NCT05139784)
- Testing
- Biosampling
- Where
- 17 sites in France
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Diabetes Mellitus, Type 1
Type 1 Diabetes Aerobic and Resistance Exercise (T1-DARE)
This is a randomized controlled trial evaluating different exercise modalities in previously inactive subjects with type 1 diabetes.
- Trial name
- NCT00148538
- Testing
- Resistance and/or Aerobic Exercise
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Ottawa Hospital Research Institute
Diabetes Mellitus
Defining the Molecular and Physiological Mechanisms of Pancreatic Islet Cell Dysfunction Which Lead to Type 2 Diabetes
Defects in insulin secretion are central to the pathogenesis of type 2 diabetes (T2D) but the molecular basis and physiological consequences of those defects are poorly understood, impeding efforts to develop novel therapeutic…
- Trial name
- DIVA-Exeter (NCT02505308)
- Testing
- Glucose-Potentiated Arginine-Induced Insulin Secretion
- Where
- 2 sites in United Kingdom
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
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