Clinical trials: Endocrine Female Infertility
Polycystic Ovary Syndrome, Infertility
New Application of Sequential in Vitro Muturation System for Infertility Patients With Polycystic Ovary Syndrome
Oocyte in vitro maturation (IVM) is an artificial reproductive technologies (ART) in which cumulus-oocyte complex (COC) are collected at the immature germinal vesicle (GV) stage from unstimulated or FSH-primed ovaries and matured…
- Trial name
- NCT03773263
- Testing
- sequential IVM system, intracytoplasmic sperm injection (ICSI), Thawed embryo transfer (TET)
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Sun Yat-sen University
Healthy, PCOS
In Vitro Maturation of Human Eggs
CCRM Fertility, a global pioneer in fertility treatment, research and science, is seeking participants for a new study on in vitro maturation (IVM).
- Conditions
- Healthy, PCOS, PCOS (Polycystic Ovary Syndrome), Ovarian Reserve
- Trial name
- NCT06633120
- Testing
- IVM
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Colorado Center for Reproductive Medicine
Infertility and at High Risk of OHSS
Repeated Injection of GnRH Agonist to Reduce Ovarian Hyperstimulation Syndrome
Gonadotropin releasing hormone (GnRH) agonist is sufficient for triggering final oocyte maturation in GnRH antagonist protocol and can significantly reduce incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk…
- Trial name
- NCT02022241
- Testing
- triptorelin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chenshiling
Cryopreservation, Ovary Injury
Improving the Quality of Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma
The study is aimed to evaluate the effects of intraovarian injection of autologous Platelet-enriched Autologous Plasma on the outcomes of orthotopic transplantation of cryopreserved ovarian tissue.
- Conditions
- Cryopreservation, Ovary Injury, Infertility, Female, Menopause Ovarian Failure
- Trial name
- TESOVA2022 (NCT06261658)
- Testing
- Cryopreserved Ovarian Tissue Reimplantation
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
PCOS, Myo-inositol-resistance
Myo-inositol Plus Alpha-lactalbumin in PCOS Myo-inositol-resistant Patients
The investigator's aim is to evaluate if the combination of myo-inositol and alpha-lactalbumin can overcome the resistance to myo-inositol in PCOS patients
- Trial name
- NCT03667443
- Testing
- Myo-inositol + folic a. + α-lactalbumin, Myo-inositol + folic a.
- Where
- Bulgaria
- Volunteers
- 50 people
- Sponsor
- Lo.Li.Pharma s.r.l
Endocrine Disease, Infertility
Evaluation of Women With Endocrine and Reproductive-Related Conditions
This study was designed to allow inpatient and outpatient evaluation of women with a variety of reproductive and endocrine-related disorders for purposes of research and physician education.
- Conditions
- Endocrine Disease, Infertility, Leiomyoma, Endometriosis
- Trial name
- NCT00001850
- Where
- United States
- Volunteers
- 833 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Klinefelter Syndrome, Infertility, Male
Unraveling the Klinefelter's Disease Physiopathology
Organoid Model to unravel Klinefelter Syndrome infertility Klinefelter Syndrome (KS) is characterized by the presence of an extra chromosome X in male (47,XXY), it is the most frequent genetic cause of azoospermia in adult men.
- Trial name
- KLINEFELTER (NCT05997706)
- Testing
- Testicular biopsy
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Anti-Müllerian Hormone, Polycystic Ovarian Syndrome
Clinical Application of Serum Anti-Müllerian Hormone (AMH) Measurements
This study aims to assess the association of Anti-Müllerian hormone (AMH) with polycystic ovarian syndrome, premature ovarian insufficiency and fertility. The main objectives include the following: 1.
- Conditions
- Anti-Müllerian Hormone, Polycystic Ovarian Syndrome, Premature Ovarian Insufficiency, Fertility Issues
- Trial name
- NCT05858307
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Hypothyroidism
Clinical Efficacy of Darqeen Capsule for the Management of Hypothyroidism Associated with Female Reproductive Hormonal Imbalance
STUDY OBJECTIVES 1. To assess the safety of Darqeen capsule for the management of Hypothyroidism 2. Evaluate the efficacy of Darqeen capsule for the management of Hypothyroidism 3.
- Trial name
- NCT06826248
- Testing
- Darqeen Capsule
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Hamdard University
Polycystic Ovary Syndrome, Endometriosis
Mathematical Model for the Human Menstrual Cycle, Endocrinological Diseases and Fertility Treatment-PAEON
Development of a bio-mathematical model of the human female cycle
- Conditions
- Polycystic Ovary Syndrome, Endometriosis, Hyperprolactinemia
- Trial name
- PAEON (NCT02098668)
- Testing
- Fertility treatment
- Where
- Switzerland
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Polycystic Ovary Syndrome (PCOS)
Blood Vessel Function in Adolescents and Women With Polycystic Ovary Syndrome
The purpose of this study is to determine if changes in blood vessel health lead to the menstrual irregularities that women with PCOS experience.
- Trial name
- NCT01615562
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Turner Syndrome, Ovarian Insufficiency
Cryopreservation of Ovarian Cortex in Girls With Turner Syndrome
Ovarian insufficiency is common in Turner syndrome related to premature and rapid follicular apoptosis and spontaneous pregnancies are rare in this population.
- Trial name
- CRYO-X0 (NCT01410045)
- Testing
- Ovariectomy
- Where
- France
- Volunteers
- 47 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Klinefelter Syndrome
Fertility Preservation in Cases of Klinefelter Syndrome.
Klinefelter Syndrome (KS) is the most common sex chromosomal abnormalities (1/600 newborn males), and is characterized by a hypergonadism hypogonadism.
- Trial name
- FERTIPRESERVE (NCT01918280)
- Testing
- Seminal analyses and testicular biopsy
- Where
- 4 sites in France
- Volunteers
- 141 people
- Sponsor
- Hospices Civils de Lyon
Ovulation Induction
A Prospective, Multi-centric Observational Study to Determine the Mono-bifollicular Development in Infertile Women Subjected to Ovulation Induction With Follitropin α
This is a prospective and multicentric observational study to determine the real mono-bifollicular development rate that is obtained under normal care conditions following ovulation induction (OI) treatment with follitropin-alpha…
- Trial name
- P450 (NCT01111084)
- Testing
- Follitropin alpha (r-FSH)
- Where
- Spain
- Volunteers
- 410 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility and at High Risk of OHSS
Dual Trigger to Reduce Ovarian Hyperstimulation Syndrome
Gonadotropin releasing hormone (GnRH) agonist is sufficient for triggering final oocyte maturation in GnRH antagonist protocol and can significantly reduce incidence of ovarian hyperstimulation syndrome (OHSS) in high-risk…
- Trial name
- NCT02022228
- Testing
- triptorelin, hCG
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chenshiling
Turner Syndrome, Infertility, Female
Turner Syndrome Minipuberty Study
Rationale: Due to accelerated germ cell loss, infertility is a major problem in girls with Turner syndrome (TS). Therefore, cryopreservation of ovarian tissue or oocytes before exhaustion of the ovarian reserve may preserve…
- Conditions
- Turner Syndrome, Infertility, Female, Premature Ovarian Failure, Gonadal Dysgenesis
- Trial name
- Minipuberty (NCT04189406)
- Testing
- Venapunction
- Where
- 13 sites in Denmark, Germany and 3 more
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Klinefelter Syndrome
Sex Steroids Balance for Metabolic and Reproductive Health in Klinefelter Syndrome
The study seeks primarily to determine whether modulation of systemic and testicular sex steroids balance by aromatase inhibitors will positively affect the metabolic health and spermatogenesis of men with Klinefelter syndrome…
- Trial name
- KLIN-HEALTH (NCT05586802)
- Testing
- Anastrozole, Semaglutide, human chorionic gonadotropin
- Where
- Switzerland
- Volunteers
- 150 people
- Sponsor
- Georgios Papadakis
Ovarian Diseases, Fertility Issues
A Novel Ovarian Reserve Monitoring Algorithm for Patients at Risk of Ovarian Injury From Gonadotoxic Therapy
This is an observational cohort study to examine the use of a novel proposed ovarian reserve monitoring algorithm to (1) identify patients who are at risk of DOR and POI from gonadotoxic therapy, (2) minimize time from treatment…
- Conditions
- Ovarian Diseases, Fertility Issues, Gonadal Disorders
- Trial name
- MA (NCT05048654)
- Sponsor
- University of Colorado, Denver
Thyroid, Infertility
Thyroid Autoimmunity and Reproductive Failure in Danish Women
The present Ph.D.-study investigates the mechanisms behind the association between thyroid autoimmunity and reproductive failure.
- Conditions
- Thyroid, Infertility, Autoantibodies, Autoimmunity
- Trial name
- NCT02912442
- Where
- Denmark
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor
Treatment Outcome and Quality of Life in Patients With Pediatric Extra-Cranial Germ Cell Tumors Previously Treated on Clinical Trial CCLG-GC-1979-01 or CCLG-GC-1989-01
RATIONALE: Treatment for pediatric extracranial germ cell tumors may cause side effects and secondary cancers later in life. A study that evaluates patients after receiving combination chemotherapy or surgery may help doctors…
- Conditions
- Childhood Germ Cell Tumor, Extragonadal Germ Cell Tumor, Gastrointestinal Complications, Infertility
- Trial name
- NCT00436774
- Testing
- assessment of therapy complications, quality-of-life assessment
- Where
- 13 sites in Ireland, United Kingdom
- Volunteers
- 60 people
- Sponsor
- Children's Cancer and Leukaemia Group