Clinical trials: Endocrine System Disorder
Acute Lymphoblastic Leukemia, Hyperglycemia
Metformin and Transient Hyperglycemia
The purpose of this study is to determine whether metformin is an effective adjunctive treatment for transient hyperglycemia in patients with acute lymphoblastic leukemia (ALL) undergoing induction chemotherapy
- Conditions
- Acute Lymphoblastic Leukemia, Hyperglycemia, Insulin Resistance, Diabetes Mellitus
- Trial name
- NCT01486043
- Testing
- Metformin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Children's Hospital Los Angeles
Children and Adolescent With Type 2 Diabetes
Safety and Efficacy Study of Exenatide Once Weekly in Adolescents With Type 2 Diabetes
The study examines the Safety and efficacy study of exenatide once weekly in children and adolescents with type 2 diabetes
- Trial name
- NCT01554618
- Testing
- Exenatide Once Weekly
- Where
- 35 sites in United States, Bulgaria and 5 more
- Volunteers
- 84 people
- Sponsor
- AstraZeneca
Ovarian Cancer
Prognostic Value of MRD Detection in CA125 Non-sensitive Ovarian Cancer Patients
Ovarian cancer ranks third in the incidence of gynecologic malignancies, while mortality ranks first. The tumor marker CA125 is the most concerned tumor marker in the clinical monitoring prognosis of ovarian cancer, and an…
- Trial name
- NCT06182917
- Where
- China
- Volunteers
- 35 people
- Sponsor
- West China Second University Hospital
Type 1 Diabetes Mellitus
Neuropsychological and Neuroanatomical Studies of Young Children With and Without Type 1 Diabetes Mellitus
This study is being conducted to see if Type 1 diabetes mellitus has any affect on learning, behavior and development in young children and whether there are associated changes on their MRI scan.
- Trial name
- NCT00449891
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity, Type 2 Diabetes Mellitus
Immunometabolism in Pediatric Obesity
This is a study to learn about obesity and how insulin resistance and Type 2 Diabetes develops in children.
- Conditions
- Obesity, Type 2 Diabetes Mellitus, Insulin Resistance
- Trial name
- IPO (NCT03960333)
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Diabetic Foot Ulcers
Efficacy of the Combination of Isosorbide Dinitrate Spray and Chitosan in Diabetic Foot Ulcers
The prevalence of diabetic foot ulceration in the diabetic population is 4-10%; the condition is more frequent in elder patients.
- Trial name
- NCT02789033
- Testing
- Chitosan, Isosorbide dinitrate
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Overall Survival Rates
Malignant Testicular Tumors in Children: A Single Institution's 12-year Experience
Background and Objectives. Testicular neoplasms are not commonly found in children, a formidable threat if treated inappropriately. However, there is no consensus concerning their management.
- Trial name
- NCT04826952
- Testing
- Orchiectomy
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Chang Gung Memorial Hospital
Klinefelter Syndrome, Thyroiditis, Autoimmune
Thyroid Function and Structure in Klinefelter Syndrome
This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.
- Conditions
- Klinefelter Syndrome, Thyroiditis, Autoimmune, Hypothyroidism
- Trial name
- THINKS (NCT05581147)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- University of Roma La Sapienza
Hyponatremia, SIADH
Hyponatraemia and Mortality in Schizophrenic and Bipolar Patients: Protocol for a Bayesian Causal Inference Study
This study seeks to investigate if hyponatraemia be a direct contributor to death in schizophrenic and bipolar patients, and gauge the potential role of somatic comorbidity and psychotropic polypharmacy, with emphasis on…
- Trial name
- NCT04409626
- Testing
- Plasma sodium level (continuous variables)
- Volunteers
- 31,740 people
- Sponsor
- Zealand University Hospital
Diabetes, Diabetes Mellitus, Type 2
Observational Study to Evaluate the Safety of Levemir® in Type 2 Diabetes
This study is conducted in Europe, North America and Asia. The aim of this observational study is to evaluate the safety and effectiveness while using Levemir® once daily in combination with oral antidiabetic drugs in type 2…
- Trial name
- SOLVE™ (NCT00825643)
- Testing
- insulin detemir
- Where
- 9 sites in Canada, China and 7 more
- Volunteers
- 18,481 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes
Simple Meal Management Using Automated Insulin Delivery System
Carbohydrate counting is an essential component of diabetes management in both adults and children, and together with an intensive insulin plan and increased blood glucose monitoring was associated with lower HbA1c.
- Trial name
- SMMAID (NCT06130215)
- Testing
- Simple meal management, Precise meal management
- Where
- Qatar
- Volunteers
- 34 people
- Sponsor
- Sidra Medicine
Type2 Diabetes Mellitus, Cardiovascular Diseases
Mil Familias Cohort Establishment: a Study to Understand Determinants of Diabetes and Its Complications Among US Latinos
The Mil Familias Cohort Establishment involves enrolling 1000 Latino families with at least one member in the family having type 2 diabetes, including children and youth, and measuring the 5 determinants of human health…
- Trial name
- NCT03830840
- Where
- United States
- Volunteers
- 405 people, healthy volunteers welcome
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes
DFMO in Children With Type 1 Diabetes
This study is a multicenter, double-blind, placebo-controlled, 2:1 randomly assigned, phase 1 clinical trial for individuals with type 1 diabetes.
- Trial name
- NCT02384889
- Testing
- Difluoromethylornithine
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Indiana University
Fallopian Tube Cancer, Ovarian Cancer
Liposomal Doxorubicin and Carboplatin in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00006235
- Testing
- carboplatin, pegylated liposomal doxorubicin hydrochloride
- Sponsor
- Gynecologic Oncology Group
Euthyroid Sick Syndromes, Non-thyroidal Illness Syndrome
Approach to a Quantitative Follow-up of Non-thyroidal Illness Syndrome
AQUA FONTIS is a unicentric, multidisciplinary, prospective cross-section and longitudinal study that aims at the development of a more clear-cut diagnostic definition and classification of non-thyroidal illness syndrome (NTIS).
- Conditions
- Euthyroid Sick Syndromes, Non-thyroidal Illness Syndrome, Low T3 Syndrome, TACITUS
- Trial name
- AQUA FONTIS (NCT00591032)
- Where
- 6 sites in Germany
- Volunteers
- 590 people
- Sponsor
- Ruhr University of Bochum
Rare Diseases, X-linked Hypophosphatemia
Burosumab in Children and Adolescents With X-linked Hypophosphatemia
In this prospective longitudinal cohort study we studied the efficacy and safety of burosumab in real-clinical practice for <13- and >13-years old children affected with X-linked hypophosphatemia.
- Trial name
- NCT04419363
- Testing
- Burosumab Injection
- Where
- France
- Volunteers
- 57 people
- Sponsor
- Bicetre Hospital
Type 1 Diabetes
Evaluation of Some Biochemical Markers of Bone Turnover in Childern and Adolescents With Type 1 Diabetes
Type 1 diabetes is associated with many longterm complications as retinopathy,neuropathy and nephropathy. Recently, several studies have linked type 1 diabetes to bone fragility.Studies conducted on patients with type 1 diabetes…
- Trial name
- NCT05892848
- Testing
- serum ostecalcin,serum sclerostin and parathroid profile
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Type1diabetes
Phenotypic and Genotypic Characterization of New-onset Type I Diabetes
The goal of DIATAG study is the identification of biomarkers of T1D evolution in a pediatric cohort.
- Trial name
- DIATAG (NCT04007809)
- Testing
- Glucagon
- Where
- Belgium
- Volunteers
- 98 people
- Sponsor
- Université Catholique de Louvain
Type 2 Diabetes Mellitus
Januvia Re-examination Study (MK-0431-181)
The objectives of this survey are: 1) To examine the safety/efficacy profile of Januvia in Korean participants, and 2) To identify factors that might have an influence on the safety and efficacy profile of Januvia in Korean…
- Trial name
- NCT01062048
- Testing
- Sitagliptin, Sulfonylurea, Insulin
- Volunteers
- 3,483 people
- Sponsor
- Merck Sharp & Dohme LLC
Central Precocious Puberty
Evaluate the Efficacy and Safety of DWJ108J
This study aims to evaluate the efficacy and safety of DWJ108J (Leuprorelin acetate 11.25 mg) in patients with central precocious puberty.
- Trial name
- NCT06025409
- Testing
- Leuprolide Acetate 11.25 MG/ML
- Where
- South Korea
- Volunteers
- 79 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
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