Clinical trials: Epilepsy Intractable
Refractory Epilepsy, Drug Resistant Epilepsy
Leucine Enriched Essential Amino Acid Powder as an Add-on to a Classic Ketogenic Diet in Refractory Epilepsy
The main purpose of this study is to evaluate the safety and tolerability of a Leucine-Enriched Essential Amino Acid (LEAA) Powder as an add-on to a classic ketogenic diet (KD) in pediatric and adult patients with refractory…
- Trial name
- NCT06387186
- Testing
- Leucine-Enriched Essential Amino Acid powder
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Elizabeth Anne Thiele
Epilepsy
Treatment of Drug Resistant Epilepsy
The main goal of this study is to provide treatment with cannabidiol (CBD) to children with drug resistant epilepsy through a Physician Expanded Access Investigation New Drug protocol.
- Trial name
- Cannabidiol (NCT02461706)
- Testing
- cannabidiol, Blood Test
- Where
- 2 sites in United States
- Sponsor
- University of Florida
Epilepsy
Use of the Atkins Diet for Children With Intractable Epilepsy: A Comparison of Daily Carbohydrate Limits
This study is designed to further investigate the use of a modified Atkins diet for children with intractable, daily seizures. It is a follow-up to a study recently completed by our institution.
- Trial name
- NCT00181090
- Testing
- Modified Atkins diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Epilepsy
RESting-state Functional MRI for Prediction of Post-surgical Prognosis In Pediatric Drug-Resistant Epilepsy
Resting-state functional MRI (r-fMRI) has emerged in recent years to analyze resting networks. It allows, without active participation of the patients, to identify and analyze the different functional brain networks.
- Trial name
- RESPIRE (NCT04451278)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Epilepsy Intractable
5-SENSE Score Validation Study
The purpose of this study is to assess how well a new scoring system called the 5-SENSE score can predict where seizures start in the brain using Stereoelectroencephalography (SEEG).
- Trial name
- NCT06138808
- Testing
- Stereoelectroencephalography (SEEG)
- Where
- 19 sites in United States, Australia and 10 more
- Volunteers
- 400 people
- Sponsor
- Duke University
Drug Resistant Epilepsy, Autism Spectrum Disorder
Effectiveness and Impact on the Quality of Life of Ketogenic Diet in Pediatric Patients
The goal of this observational study is to learn about the clinical and nutritional effectiveness of ketogenic diet (KD) in pediatric patients with genetic, neurological or metabolic conditions requiring KD.
- Conditions
- Drug Resistant Epilepsy, Autism Spectrum Disorder, Chronic Migraine, Brain Tumor, Pediatric
- Trial name
- NCT06309251
- Testing
- ketogenic diet (as per clinical practice)
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Danone Nutricia SpA Società Benefit
Refractory Localization-related Epilepsy
A New Method for Delineation of Epileptic Brian Tissue During Epilepsy Surgery (The HFO Study)
Epilepsy occurs in 0.5-0.7% of the population, of which 25% are children. 30% Of patients with focal epilepsy do not respond well to medication and half of them are eligible for epilepsy surgery.
- Trial name
- NCT02207673
- Testing
- Tailoring of the resection based on biomarker in aEcoG during epilepsy surgery
- Where
- 2 sites in Netherlands
- Volunteers
- 78 people
- Sponsor
- UMC Utrecht
Intractable Epilepsy
Diffusion Tensor and Functional Connectivity Imaging in Pediatric Epilepsy: Imaging/Histology Correlation
To determine the utility of diffusion tensor magnetic resonance imaging in the preoperative workup of children with intractable epilepsy referred for surgery.
- Trial name
- DTI/SEP (NCT02846272)
- Testing
- Observation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- The University of Texas Health Science Center, Houston
Epilepsy, Mental Retardation
Ketogenic Diet vs.Antiepileptic Drug Treatment in Drug Resistant Epilepsy
This is an open randomized controlled study in children with mental retardation and refractory epilepsy in which treatment with ketogenic diet (KD) is compared with treatment with the antiepileptic drug (AED), not tried by the…
- Trial name
- NCT00552526
- Testing
- Ketogenic diet, Antiepileptic drug (AED)
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
SSPE
Role of Ketogenic Diet in SSPE
SSPE is a progressive neurodegenerative disorder occurring after measles infection and is potentially life-threatening.Measles infection remains endemic in Pakistan especially in the lower socioeconomic population where the…
- Trial name
- NCT05152771
- Testing
- KETOGENIC DIET
- Volunteers
- 26 people
- Sponsor
- Aga Khan University
Epilepsies, Partial, Epilepsy, Tonic-Clonic
Microburst Vagus Nerve Stimulator (VNS) Therapy Feasibility Study
Evaluate the initial safety and effectiveness of Microburst VNS stimulation in subjects with refractory epilepsy.
- Trial name
- Microburst (NCT03446664)
- Testing
- Microburst Stimulation
- Where
- 9 sites in United States, Belgium
- Volunteers
- 33 people
- Sponsor
- LivaNova
Epileptic Spasms, Failed Hormonal Therapy
Modified Atkins Diet Versus Topiramate In Children With Epileptic Spasms Refractory To Hormonal Treatment: A Randomized Open-Label Study
This study has been planned to compare the efficacy and tolerability of topiramate, a commonly used second line agent, with modified Atkins diet in children with epileptic spasms refractory to hormonal treatment, in a randomized…
- Trial name
- TOPAMAD (NCT05958160)
- Testing
- Modified Atkins diet, Topiramate
- Where
- India
- Volunteers
- 70 people
- Sponsor
- Lady Hardinge Medical College
Epilepsy
ESIS in Pediatric DRE
The main reason for this research study is to gain information about how the brain makes seizures by causing seizures using very small amounts of current, or electrical stimulation.
- Trial name
- NCT05469373
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Sarah Katie Ihnen
Developmental and Epileptic Encephalopathy, Epilepsy in Children
Developmental and Epileptic Encephalopathies Diagnosed Via Long-read Genome Sequencing
This study focuses on children with Developmental and Epileptic Encephalopathy (DEE), a severe form of epilepsy that often has a genetic origin.
- Trial name
- EEPILOG (NCT07396883)
- Testing
- Long-read Whole Genome Sequencing (lrWGS)
- Where
- 4 sites in France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Drug Resistant Epilepsy, Traumatic Brain Injury Without Open Intracranial Wound
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients
In patients with drug-resistant epilepsy (DRE), there may be changes at the genetic, proteomic, and metabolomic levels when comparing epileptic tissues from DRE to normal tissues in traumatic brain injury (TBI).
- Trial name
- NCT06665880
- Testing
- Routine clinical treatment
- Where
- China
- Volunteers
- 16 people
- Sponsor
- Xuanwu Hospital, Beijing
Refractory Epilepsy
Safety and Therapeutic Measures of Tdcs in Patients With Refractory Focal Epilepsy
This is a single site, non-randomized, prospective, open-label, interventional pilot/feasibility study. Patients recruited will have medically-refractory focal neocortical epilepsy, defined on the basis of presence of focal…
- Trial name
- NCT02866240
- Testing
- Cathodal Transcranial Direct Current Stimulation (tDCS).
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Neuroelectrics Corporation
Epilepsy Intractable, Focal Epilepsy
National Study on the Interest of EEG-fMRI in the Presurgical Evaluation of Partial Epilepsies Drug
The main goal of this study is to evaluate the additional value of EEG-fMRI method in the presurgical evaluation of focal intractable epilepsy.
- Trial name
- ENERGY (NCT03278210)
- Where
- France
- Volunteers
- 102 people
- Sponsor
- University Hospital, Lille
Refractory Epilepsy
Clinical Trial of Vagus Nerve Stimulation for Treatment of Refractory Epilepsy
Evaluate the long-term clinical effectiveness and safety of the PINS vagus nerve stimulator to patients with refractory epilepsy.
- Trial name
- VNSRE (NCT02378792)
- Testing
- Vagus Nerve Stimulation
- Where
- 5 sites in China
- Volunteers
- 300 people
- Sponsor
- Beijing Pins Medical Co., Ltd
Transcranial Electric Stimulation, tDCS
Optimized and Personalized Trans-cranial Brain Stimulation in Partial Refractory Epilepsies
Epilepsy is one of the most common neurological diseases, affecting between 0.5% and 1% of the general population. Therefore, new diagnostic and treatment methods are having a big impact on society.
- Conditions
- Transcranial Electric Stimulation, tDCS, Epilepsy, Pharmacoresistant
- Trial name
- PerEpi2 (NCT06212609)
- Testing
- transcranial electrical stimulation therapy
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Epilepsy, Drug Resistant
Subiculum Electrical Stimulation for Temporal Lobe Epilepsy With Biliteral Hippocampus Sclerosis(SESTB)
The primary objective of this research is to study the efficacy and safety of deep brain stimulation (DBS) of Subiculum as adjunctive therapy for reducing the frequency of seizures in drug-resistant temporal lobe epilepsy with…
- Trial name
- NCT06436547
- Testing
- Subiculum-DBS ON
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Xuanwu Hospital, Beijing