Clinical trials: Exacerbations
Asthma, Vitamin D Deficiency
Rapid vs Maintenance Vitamin D Supplementation in Deficient Children With Asthma to Prevent Exacerbations.
The role of vitamin D in respiratory health remains uncertain. Whether vitamin D reduces clinically important exacerbations of childhood asthma remains uncertain.
- Trial name
- NCT01395589
- Testing
- Vitamin D
- Where
- Qatar
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- Hamad Medical Corporation
Cystic Fibrosis, Cystic Fibrosis Pulmonary Exacerbation
Study to Determine the Efficacy&Safety of ARV-1801(ACG-701) for the Treatment of Cystic Fibrosis Pulmonary Exacerbations
This study will evaluate the efficacy and safety of an oral ARV-1801(ACG-701) plus optimized background therapy (OBT) compared to oral placebo plus OBT, each administered for 14 days, in the treatment of participants with Cystic…
- Trial name
- REPRIEVE (NCT05641298)
- Testing
- Sodium Fusidate
- Where
- 25 sites in United States
- Sponsor
- Aceragen
Asthma, Heart Failure
The General Breathing Record Study
This study will test the use of a new handheld device (called the N-Tidal C), that measures a person's tidal breath carbon dioxide, in diagnosing the cause of someone's breathlessness.
- Conditions
- Asthma, Heart Failure, Pneumonia, Motor Neuron Disease
- Trial name
- GBRS (NCT03356288)
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- TidalSense
Cystic Fibrosis
Pressure Support Ventilation During CF Exacerbations
Chest physiotherapy is recognized as a mainstay of cystic fibrosis therapy, and is particularly important during treatment of pulmonary exacerbations.
- Trial name
- NCT00008775
- Testing
- Pressure support ventilation
- Where
- United States
- Sponsor
- National Center for Research Resources (NCRR)
Eosinophilic Asthma
A Study to Evaluate the Efficacy and Safety of Reslizumab (3.0 mg/kg) in the Reduction of Clinical Asthma Exacerbations in Patients (12-75 Years of Age) With Eosinophilic Asthma
This is a Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy, safety, and immunogenicity of treatment with reslizumab in patients with eosinophilic asthma.
- Trial name
- NCT01287039
- Testing
- Reslizumab
- Where
- 128 sites in United States, Australia and 15 more
- Volunteers
- 489 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Asthma
A Trial of Mepolizumab Adjunctive Therapy for the Prevention of Asthma Exacerbations in Urban Children
The purpose of this study is to see if treatment with a medication called Nucala® (mepolizumab), given along with standard asthma care, makes children less likely to have asthma attacks.
- Trial name
- MUPPITS-2 (NCT03292588)
- Testing
- Mepolizumab
- Where
- 9 sites in United States
- Volunteers
- 335 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cystic Fibrosis
Outpatient Antibiotic Treatment for a Cystic Fibrosis Pulmonary Exacerbation
This study plans to learn more about the effect of oral antibiotics for an outpatient pulmonary exacerbation (respiratory illness) on sputum (mucus) bacterial infections, lung function, airway inflammation and quality of life.
- Trial name
- NCT02480270
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- University of Colorado, Denver
Asthma
Noninvasive Positive Airway Pressure in the Pediatric Emergency Department for the Treatment of Acute Asthma Exacerbations
Previous investigations and anecdotal experience have shown safety and utility of Noninvasive Positive Pressure Ventilation/Bilevel Positive Airway Pressure (NIPPV/BiPAP) for the treatment of asthma in children.
- Trial name
- RCT BiPAP (NCT01497691)
- Testing
- NIPPV (PALMtop PTV), Volumetric CO2 (NM3), USCOM
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Asthma, Asthma Exacerbations
Vitamin D In the Prevention of Viral-induced Asthma in Preschoolers
In this 7-month randomized controlled trial, children aged 1 to less than 6 years, with recurrent asthma attacks triggered mostly by colds, will receive a high dose of vitamin D or a placebo every 3.5 months during their usual…
- Conditions
- Asthma, Asthma Exacerbations, Preschool Child, Vitamin D
- Trial name
- DIVA (NCT03365687)
- Testing
- Vitamin D
- Where
- 9 sites in Canada
- Volunteers
- 323 people
- Sponsor
- Professor Francine Ducharme
Asthma
Effectiveness of a School-Based Hand Sanitizer Program on Reducing Asthma Exacerbations
Asthma is a common, serious illness among children in the United States. Improving hand cleanliness and hygiene may prevent the spread of viruses that can cause asthma exacerbations.
- Trial name
- NCT00528814
- Testing
- Active Hand Sanitizer
- Where
- United States
- Volunteers
- 527 people
- Sponsor
- University of Alabama at Birmingham
Asthma
Montelukast Added to Standard Therapy for Acute Asthma in Children Age 6-14 Years
Oral montelukast is helpful in chronic asthma. The purpose of this pediatric study was to investigate whether the addition of oral montelukast to standard therapy for acute asthma exacerbations results in further improvement in…
- Trial name
- NCT00353184
- Testing
- Montelukast 5-mg orally added to standard therapy
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Washington University School of Medicine
Asthma
Exacerbations in Severe Asthma Patients: Mechanisms and Biomarkers
The purpose of this study is to investigate exacerbations in severe asthma with regard to symptoms, lung function, aetiology and biomarkers.
- Trial name
- NCT02660853
- Testing
- FEV1
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Imperial College London
Chronic Obstructive Pulmonary Disease
Effect of Tiotropium on Inflammation and Exacerbations in COPD
Patients with COPD experience exacerbations that are a major cause of morbidity. Exacerbations are associated with increased airway and systemic inflammation and those experiencing frequent exacerbations demonstrate increased…
- Trial name
- NCT00405236
- Testing
- tiotropium
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- Royal Free and University College Medical School
Cystic Fibrosis
Effectiveness of Respiratory Physiotherapy on Frequency of Exacerbations, Lung Function and Quality of Life After 6 Months in Children With Cystic Fibrosis
Daily respiratory physiotherapy is a fundamental part of cystic fibrosis treatment, however, patients adherence is low. Thus, there is a need for studies that evaluate the impact of physiotherapy supervision in patients with…
- Trial name
- NCT07088614
- Testing
- Remote respiratory physiotherapy
- Where
- Chile
- Volunteers
- 9 people
- Sponsor
- University of Americas - Chili
Acute Asthma
Optimal Albuterol Regimens for Acute Asthma Exacerbations: DBRCT Pilot Study
Our overall objective is to model a pediatric Acute Asthma Clinical Decision Rule (ADR) for personalized medicine by identification of treatment-response phenotypes that are important determinants of outcome.
- Trial name
- OARS (NCT01196377)
- Testing
- Albuterol
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University Medical Center
Cystic Fibrosis
The Infective Pulmonary Exacerbations in Cystic Fibrosis - an Ecological Perspective
Given the treatment burden and excess morbidity and mortality associated with acute infective exacerbations in cystic fibrosis, a clear understanding of the mechanisms involved in the origins of an infective exacerbation and the…
- Trial name
- NCT01306279
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Acute Exacerbation Copd
Impact of Air Quality on Exacerbations of COPD in the Somme
All COPD patients with a diagnosis of acute exacerbation in emergency room in University Hospital of Amiens-Picardie between 01/01/2017 and 31/12/2017.
- Trial name
- PolluBPCO (NCT03079661)
- Where
- France
- Volunteers
- 179 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Asthma
Predictors of Asthma Exacerbations in Children
The purpose of this study is to determine whether parameters of the pulmonary function tests and the bronchial hyperresponsiveness to methacholine are predictors of asthma exacerbations.
- Trial name
- NCT01449435
- Testing
- Methacholine challenge testing
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cystic Fibrosis, Pneumonia, Bacterial
Imipenem/Cilastatin/Relebactam Pharmacokinetics, Safety, and Outcomes in Adults and Adolescents With Cystic Fibrosis
There is established evidence that patients with Cystic Fibrosis (CF) may have altered antibiotic pharmacokinetics compared with non-CF patients.
- Trial name
- NCT05561764
- Testing
- Imipenem/Cilastatin/Relebactam
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- Hartford Hospital
Cystic Fibrosis
Hyperpolarized Xenon MRI in Cystic Fibrosis Pulmonary Exacerbations
The investigators aim to assess whether pulmonary MRI (hyperpolarised 129Xe ventilation imaging [Xe-MRI]) can detect changes in ventilation defects in patients with CF before and after treatment for a pulmonary exacerbation.
- Trial name
- NCT02606487
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- The Hospital for Sick Children