Clinical trials: Exanimation
Brain Dead Organ Donors
Evaluation of the Efficacy and Safety of Levothyroxine in Brain Death Organ Donors: a Randomized Controled Trial
The primary objective of this study is to evaluate the feasibility of a randomized controlled trial comparing levothyroxine to placebo in neurologically deceased donors
- Trial name
- ECHOT4 (NCT02211053)
- Testing
- Levothyroxine
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Impaired Consciousness
FOUR Score in Children With Non-traumatic Impairment of Consciousness
Hypothesis: FOUR score is a better predictor of outcome (in hospital mortality and functional outcome at discharge) than GCS in children 5- 18 years age admitted in pediatric ward/ ICU with non-traumatic impaired consciousness.
- Trial name
- NCT01537913
- Volunteers
- 70 people
- Sponsor
- All India Institute of Medical Sciences
Impaired Consciousness
Outcome Predictors of Non Traumatic Coma in Children
To catch the high risk comatosed child to improve service and direct the limited resources to those children in countries with limited resources .
- Trial name
- NCT03618745
- Testing
- CT brain
- Volunteers
- 50 people
- Sponsor
- Assiut University
Infant, Extremely Premature, Brain Injuries
Safeguarding the Brain of Our Smallest Infants Phase III
the SafeBoosC-III trial investigates the benefit and harms of treatment based on near-infrared spectroscopy monitoring compared with treatment as usual.
- Conditions
- Infant, Extremely Premature, Brain Injuries, Death, Brain, Death; Neonatal
- Trial name
- SafeBoosC (NCT03770741)
- Testing
- Modify cardio-respiratory support to avoid cerebral hypoxia, Treatment as usual
- Where
- Denmark
- Volunteers
- 1,601 people
- Sponsor
- Gorm Greisen
Cardiac Arrest, Post-Anoxic Coma
QUality Of Life and surviVAl in carDIac arreSt Patients
QUO VADIS is a national observational study with the aim to describe clinical intervention and utilization of neuroprognostication tools in the management of patients admitted to ICU following cardiac arrest
- Conditions
- Cardiac Arrest, Post-Anoxic Coma, Central Nervous System Diseases
- Trial name
- QUOVADIS (NCT04129073)
- Testing
- Intensive care treatment
- Volunteers
- 1,600 people
- Sponsor
- Gruppo Italiano per la Valutazione degli Interventi in Terapia Intensiva
Unallocated Pancreas Organs
Expanding Pancreas Donor Pool by Evaluation of Unallocated Organs After Brain Death - The EXPLORE Study
Pancreas graft quality directly affects morbidity and mortality rates after pancreas transplantation (PTx). The criteria for pancreas graft allocation are restricted, which has decreased the number of available organs.
- Trial name
- NCT04127266
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Dr. A. Mehrabi
Malaria, Seizures
Aggressive Antipyretics for Fever Reduction in CNS Malaria
The study will examine whether prophylactic and scheduled treatment with acetaminophen and ibuprofen can decrease the maximum temperature experienced during the acute illness in children with CNS malaria.
- Conditions
- Malaria, Seizures, Coma, Parasitemia
- Trial name
- NCT03399318
- Testing
- Acetaminophen, Ibuprofen
- Where
- 3 sites in Malawi, Zambia
- Volunteers
- 256 people
- Sponsor
- University of Rochester
Coma
Optic Nerve Sheath Diameter as a Screening Test for Increased Intracranial Pressure
Patients admitted to the ICU may have delayed awakening after their critical illness has resolved. Though most either are due to metabolic causes or delayed elimination of sedative medications, more serious pathologies such as…
- Trial name
- NCT02338284
- Testing
- ultrasound of globe
- Where
- Saudi Arabia
- Volunteers
- 100 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Consciousness Disorders, Brain Injuries
tDCS in Patients With Disorder of Consciousness Due to Severe Acquired Brain Injury
The present observational study is aimed at reporting the short-, mid- and long-term outcomes of patients with Disorder of Consciousness (DOC), in Vegetative State (VS) or Minimally Conscious State (MCS), due to a severe Acquired…
- Conditions
- Consciousness Disorders, Brain Injuries, Vegetative State, Minimally Conscious State
- Trial name
- NCT03367078
- Testing
- Anodal tDCS, Usual care
- Where
- Italy
- Volunteers
- 1 people
- Sponsor
- Montecatone Rehabilitation Institute S.p.A.
Organ Donation
Organ Procurement : Usefulness of a Guide for Meeting With the Next of Kin
A dedicated guide for physicians and organ procurement nurses meeting with the next of kin could be associated with a reduction in organ donation refusal rate, and in anxiety of professionals involved in such meetings
- Trial name
- CANEVAS (NCT02854267)
- Where
- France
- Volunteers
- 322 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury
Comparison of Effectiveness of Pentobarbital and Thiopental in Patients With Refractory Intracranial Hypertension
Objective: to assess the effectiveness of pentobarbital and thiopental to control raised intracranial pressure (ICP), refractory to first level measures, in patients with severe traumatic brain injury.
- Trial name
- NCT00622570
- Testing
- Pentobarbital, thiopental
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Universitari Son Dureta
Brain Death, Respiration, Artificial
Miniature In-line Respirator
This first-in-human pilot study will test an investigational miniature breathing device called the Hope inVent. The device is a small, single-use, in-line respirator that connects to a breathing tube and uses compressed oxygen to…
- Trial name
- NCT07768215
- Testing
- Hope inVent
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Sequelae of; Complications Surgical and Medical Care
The Effect of Listening to the Holy Quran on Vital Signs in Coma Patients
The aim of this study is to examine the effect of the Holy Quran listened to to coma patients on their vital signs. Does listening to the Holy Quran have a positive effect on the life values of coma patients?
- Trial name
- NCT06326541
- Testing
- music therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Bitlis Eren University
Status Epilepticus
Treatment of Refractory Status Epilepticus
The purpose of this study is to determine whether propofol or barbiturates should be preferred in the treatment of status epilepticus (continuous seizure activity) refractory to 2 standard antiepileptic agents.
- Trial name
- NCT00265616
- Testing
- propofol, thiopental/pentobarbital
- Where
- 5 sites in United States, Switzerland
- Volunteers
- 23 people
- Sponsor
- Brigham and Women's Hospital
Acute Brain Injury Coma
Circadian Rhythmicity During Coma Awakening
Acute brain injury is a major cause of admission to intensive care units, as well as of mortality and morbidity, worldwide and for all age groups.
- Trial name
- COMARHYTHM (NCT06245434)
- Testing
- Repeated behavioural assessment, Act-Pass paradigm, Biological measures of circadian and monoamines biomarkers
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Hospices Civils de Lyon
Status Epilepticus, Coma
Rapid-Response EEG in Children With Suspected Status Epilepticus
Seizures are common in children (~350 per 100,000 patients per year) and require immediate medical attention. If the seizure is prolonged (> 5 minutes) it is called status epilepticus and delayed treatment leads to higher risk in…
- Trial name
- RECS (NCT06564662)
- Testing
- Rapid Response EEG
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital at Montefiore
Brain Death, Organ Donors
Naloxone for Optimizing Hypoxemia Of Lung Donors
Brain-dead patients who provide authorization for organ donation will be randomized to naloxone or placebo if baseline arterial blood gas (ABG) after initiation of OPO (Organ Procurement Organization) management reveals…
- Conditions
- Brain Death, Organ Donors, Lung Transplantation
- Trial name
- NO-HOLDS (NCT02581111)
- Testing
- Naloxone, Normal saline
- Where
- 4 sites in United States
- Volunteers
- 199 people
- Sponsor
- Washington University School of Medicine
Coma
Comprehensive Observations and Multidisciplinary Approaches in the Management of Unconscious Patients
This prospective observational high-fidelity simulation study aims to observe and better understand how physicians from different disciplines differentiate in the management of a comatose patient and how their diagnostic and…
- Trial name
- COMA (NCT06265168)
- Testing
- Simulation
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Basel, Switzerland
Brain Death
Nutritional Status and Enteral Absorption Capability After Brain Death
The investigators propose to assess 36 donors' nutritional status using accepted parameters (prealbumin, resting energy expenditure); to assess nutrient intestinal absorption through 13Curacil breath tests; and to evaluate serum…
- Trial name
- HRSA Nutrition (NCT00858390)
- Testing
- enteral feeding with Oxepa® and Glutasolve®
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- The University of Texas Health Science Center, Houston
Brain Death, Organ Donation
Goal of Open Lung Ventilation in Donors
The primary goal of this study is to assess whether ventilation of deceased organ donors with an open lung protective ventilatory strategy will improve donor lung utilization rates and donor oxygenation compared to a conventional…
- Conditions
- Brain Death, Organ Donation, Organ Transplant Failure or Rejection
- Trial name
- GOLD (NCT03439995)
- Testing
- Open lung protective ventilation, Conventional ventilation
- Where
- 4 sites in United States
- Volunteers
- 154 people
- Sponsor
- Vanderbilt University Medical Center