Clinical trials: Extracorporeal Life Support
Kidney Diseases, Acute Injury of Kidney
Hemofilter Life Span, ECLS And/or CRRT
The goal of this project to better understand the immune-modulatory effects of continuous renal replacement therapy (CRRT) in neonatal and pediatric patients, particularly those receiving extracorporeal life support (ECLS).
- Conditions
- Kidney Diseases, Acute Injury of Kidney, Renal Failure, Renal Insufficiency
- Trial name
- NCT04193865
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Medical University of South Carolina
Venovenous Extracorporeal Membrane Oxygenation, Recirculation
Measurement of Recirculation During Venovenous Extracorporeal Membrane Oxygenation (VV ECMO)
This study is to test the usefulness of ultrasound dilution recirculation measurements in patients receiving venovenous extracorporeal membrane oxygenation as therapy.
- Trial name
- NCT00920062
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Transonic Systems Inc.
Persistent Fetal Circulation Syndrome, Diaphragmatic Hernia
Antibody Secreting Cell and Cyotokine Profiles in Neonates on ECMO
Infants are placed on ECMO for correction of reversible respiratory failure. Often, because a few of the reasons for respiratory failure show us similar things in the baby, it is difficult to determine exactly which is causing…
- Conditions
- Persistent Fetal Circulation Syndrome, Diaphragmatic Hernia, Meconium Aspiration, Sepsis
- Trial name
- NCT00371241
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- The University of Texas Health Science Center, Houston
ARDS
Establishment of a Early Risk Model of ECMO in Children With ARDS
The key problem in the treatment of ARDS is refractory hypoxemia. Extracorporeal Membrane Oxygenation (ECMO) is an extracorporeal oxygenation of venous blood to eliminate carbon dioxide and return to the body.
- Trial name
- NCT04710173
- Testing
- ECMO
- Where
- 3 sites in China
- Volunteers
- 95 people
- Sponsor
- Children's Hospital of Fudan University
Out-of-Hospital Cardiac Arrest
Induced Hypothermia in Cardiac Arrest Patients Rescued by Extracorporeal Cardiopulmonary Resuscitation.
Background： Cardiopulmonary resuscitation (CPR) with closed-chest cardiac massage has been shown that survival to discharge rate is poor.
- Trial name
- NCT00965016
- Testing
- hypothermia
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Min-Sheng General Hospital
Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion
Trial of Indication-Based Transfusion of Red Blood Cells in ECMO
TITRE - Trial of Indication-based Transfusion of Red Blood Cells in ECMO, is a multicenter, prospective, randomized clinical trial.
- Conditions
- Extracorporeal Membrane Oxygenation, Red Blood Cell Transfusion, Organ Failure, Multiple
- Trial name
- TITRE (NCT05405426)
- Testing
- Red blood cell transfusion
- Where
- 22 sites in United States, Australia and 1 more
- Volunteers
- 228 people
- Sponsor
- Boston Children's Hospital
Extracorporeal Circulation; Complications, Extracorporeal Membrane Oxygenation Complication
DIC Markers and Thrombin Generation Parameters in Patients on ECMO Support: a Pilot Study
To study the correlation between novel DIC markers and thrombin generation parameters with thrombotic and hemorrhagic complications of patients on ECMO support.
- Trial name
- DIC-ECMO (NCT06095518)
- Testing
- DIC markers and Thrombin Generation Parameters
- Where
- Hong Kong
- Volunteers
- 49 people
- Sponsor
- Queen Mary Hospital, Hong Kong
Cardiogenic Shock, Cardiac Arrest
Outcome of Patients Treated With ECLS
Extracorporeal life support (ECLS), also called extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique of providing effective circulatory and (or) respiratory failure, with a growing number of critically ill…
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Heart Failure, Acute Respiratory Failure
- Trial name
- NCT04405817
- Testing
- ECMO
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Extracorporeal Membrane Oxygenation Complication
Transplantation of Autologously Derived Mitochondria Following Ischemia
The investigators propose a robust therapeutic intervention to ameliorate myocardial ischemia/ reperfusion injury and significantly decrease morbidity and mortality in patients requiring extracorporeal membrane oxygenation…
- Trial name
- NCT02851758
- Testing
- autologous mitochondria transplantation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Boston Children's Hospital
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Cardiac Failure, Extracorporeal Membrane Oxygenation Complication
Echocardiographic Assessment of Function During ECMO Support
The purpose of this study is to evaluate echocardiographic markers of cardiac function to assess the ability of patients to successfully end VA-ECMO support.
- Trial name
- NCT01551849
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Nationwide Children's Hospital
Cardiogenic Shock, Cardiac Arrest
Outcomes of Patients With Venoarterial Extracorporeal Membrane Oxygenation
Venoarterial extracorporeal membrane oxygenation (VA ECMO)-also referred to as extracorporeal life support-is a form of temporary mechanical circulatory support and simultaneous extracorporeal gas exchange.
- Trial name
- NCT04039594
- Testing
- VA ECMO
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Anzhen Hospital
Sepsis, Critical Illness
Exploring and Establishment of Combined Extracorporeal Life Support(CELS) in Critically Ill Children
Multiple organ failure (MODS) is still the leading cause of death in children in ICU. The treatment of MODS is mainly organ function monitoring and organ replacement therapy.
- Conditions
- Sepsis, Critical Illness, MODS
- Trial name
- CELS (NCT03654287)
- Testing
- Treatment
- Where
- China
- Sponsor
- Guoping Lu
Neonates on ECMO
Pharmacokinetic Study of Recombinant AT III in Neonates Undergoing ECMO
Maintenance of adequate anticoagulation or blood thinning is of critical importance when patients are placed on extracorporeal life support, such as extracorporeal membrane oxygenation (ECMO).
- Trial name
- NCT01913444
- Testing
- Recombinant Antithrombin
- Where
- United States
- Sponsor
- Children's Hospital Los Angeles
Respiratory Failure
Lung Transplantation in Respiratory Failure Patients
Survival after cadaveric lung transplantation in recipients depended on ventilation support prior to transplantation has been reported to have relative high surgical mortality and morbidity rate.
- Trial name
- NCT00854165
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Respiratory Failure
PCO2 ELSO (Extracorporeal Life Support Organization)
Investigation of the association between PaCO2 change after extra corporeal membrane oxygenation (ECMO) initiation and neurological outcome and mortality in neonates treated by ECMO for respiratory failure.
- Trial name
- NCT04798794
- Testing
- ECMO for neonates
- Where
- France
- Volunteers
- 4,072 people
- Sponsor
- Nantes University Hospital
Extracorporeal Membrane Oxygenation Complication, Critical Care
Evaluation of Long-term Quality of Life in Children Supported with ExtraCorporeal Membrane Oxygenation (ECMO)
The main objective of this prospective transversal comparative study is to describe the quality of life of children supported by ECMO.
- Trial name
- ECMOQoL (NCT05721105)
- Testing
- Quality of life assessment using questionnaires
- Where
- France
- Volunteers
- 84 people
- Sponsor
- Nantes University Hospital
Brain Injuries, Congenital Heart Disease
Protecting Brains and Saving Futures - the PBSF Protocol
Background: Multiple neonatal disorders are associated with risks of neurological injury. Thus, management of these infants should involve a coordinated approach to permit early diagnosis with improved clinical care.
- Conditions
- Brain Injuries, Congenital Heart Disease, Newborn Morbidity, Intraventricular Hemorrhage
- Trial name
- PBSF (NCT03786497)
- Where
- 2 sites in Brazil
- Volunteers
- 2,268 people
- Sponsor
- Protecting Brains Saving Futures
Drug Effect
Pharmacokinetics of Sedatives and Analgesics During Extracorporeal Membrane Oxygenation (ECMO) Support
This study will measure plasma concentrations of dexmedetomidine, fentanyl, morphine and midazolam in pediatric patients supported with extracorporeal membrane oxygenation (ECMO) aiming to understand the pharmacokinetics of these…
- Trial name
- NCT03593408
- Testing
- Dexmedetomidine, Fentanyl, Midazolam
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Boston Children's Hospital
Feasibility and Safety of a Low-field MRI, Acute Brain Injury
Low-Field Bedside Brain Magnetic Resonance Imaging in Pediatric Extracorporeal Membrane Oxygenation
The primary object of the study is to further characterize safety and feasibility of low-field bedside MRI in pediatric and neonatal ECMO patients.
- Conditions
- Feasibility and Safety of a Low-field MRI, Acute Brain Injury, Extracorporeal Membrane Oxygenation Complication
- Trial name
- NCT06074406
- Testing
- Hyperfine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Mercy Hospital Kansas City