Clinical trials: Extubation
Pediatric Patients After Cardiothoracic Surgery
High Flow Nasal Cannula in Pediatric Patients After Cardiothoracic Surgery
High flow nasal cannula(HFNC) ventilation can provide such effects as wash-out effect of the carbon dioxide inside the anatomical dead space,some level of continuous airway pressure and humidified oxygen gases.
- Trial name
- OSACA CATS (NCT04451057)
- Testing
- high flow nasal cannula therapy, low flow nasal cannula therapy
- Where
- Japan
- Volunteers
- 286 people
- Sponsor
- Osaka University
Pediatric Post Extubation Dysphagia
The Use of PEDI_ EAT 10 Score Versus Nurse Performed Screening in the Assessment of Post Extubation Dysphagia
Invasive mechanical ventilation is one of the most common interventions in critically ill patients, and is invariably characteristic, if not defining, of ICU therapeutic regimen Much attention has been paid to complications…
- Trial name
- NCT05828537
- Testing
- endotracheal tube
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Respiratory Distress of Newborn
Lung Ultrasound - Prospective Study
The goal of this clinical trial is to determine whether lung ultrasound can predict extubation success in neonates with respiratory distress. Participants will undergo a lung ultrasound pre- and post-extubation.
- Trial name
- NCT06140615
- Testing
- Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 71 people
- Sponsor
- University of Wisconsin, Madison
Endotracheal Extubation, Airway Anesthesia
BELUGA: Better to Exchange ETT for LMA Before Extubation in Children Under General Anaesthesia
During surgery, anaesthetists can use an endotracheal tube (ETT) to facilitate ventilation. At emergence from general anaesthesia, there are two techniques for removal of the ETT: (1) the ETT is removed when the child is waking…
- Conditions
- Endotracheal Extubation, Airway Anesthesia, Paediatric
- Trial name
- BELUGA (NCT07204990)
- Testing
- Direct removal of endotracheal tube, Laryngeal mask airway inserted following deep extubation
- Where
- 8 sites in United States, Australia and 4 more
- Volunteers
- 1,400 people
- Sponsor
- Telethon Kids Institute
Congenital Heart Disease
Extubation Times in Postoperative Congenital Cardiovascular Surgeries
Background: Anesthesia management in pediatric cardiac surgeries focuses on reducing morbidity and mortality, early mobilization and discharge, using health resources sparingly and increasing the quality of life of patients.
- Trial name
- NCT05332860
- Testing
- Congenital Cardiovascular Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Apnea of Prematurity, Premature Birth
The Effect of an Additional Pre-extubational Loading Dose of Caffeine-citrate
The goal of this clinical trial is to answer whether the use of a single loading dose (20 mg/kg) of caffeine citrate one hour before extubation has an impact on the success rate of extubation among preterm neonates.
- Conditions
- Apnea of Prematurity, Premature Birth, Respiratory Failure
- Trial name
- NEOKOFF22 (NCT06401083)
- Testing
- Caffeine citrate
- Where
- 2 sites in Hungary
- Volunteers
- 226 people
- Sponsor
- Semmelweis University
Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD)
Measures to Lower the Stress Response in Pediatric Cardiac Surgery
Cardiac surgery induces a measurable stress response in patients which leads to increased morbidity and mortality post-operatively.
- Conditions
- Tetralogy of Fallot (TOF), Ventricular Septal Defects (VSD), Atrioventricular Septal Defects (AVSD)
- Trial name
- NCT00848393
- Testing
- Fentanyl (High Dose), Fentanyl (Low Dose), Fentanyl (Low Dose) + Dexmedetomidine
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Nationwide Children's Hospital
Postoperative Complications
Intratracheal Dexmedetomidine Versus Lidocaine in Eye Surgery
Cough during emergence from general anesthesia is considered a critical event as it may lead to surgical bleeding laryngospasm hemodynamic instability and could be life-threatening in patients who are at risk of complications…
- Trial name
- NCT05291221
- Testing
- intratracheal saline, intratracheal Dexmedetomidine, intratracheal Lidocaine
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Minia University
Extubation Failure
Risk Factors of Extubation Failure in PICU Patients
Up to 20% of MV patients experience EF [10]. EF is defined as the need to reinsert the endotracheal tube to resume MV in patients extubated for less than 48 hours.
- Trial name
- NCT06557941
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Infant, Premature, Diseases, Infant, Newborn, Disease
Noninvasive High Frequency Oscillatory Ventilation as a Post-extubation Respiratory Support in Neonates
A randomized controlled trial comparing Noninvasive high frequency oscillatory ventilation (NHFOV) and Noninvasive positive pressure ventilation (NIPPV) as post-extubation respiratory support in preterm neonates with respiratory…
- Conditions
- Infant, Premature, Diseases, Infant, Newborn, Disease, Respiratory Tract Diseases, RDS
- Trial name
- NCT05493527
- Testing
- noninvasive high frequency oscillatory ventilation, noninvasive positive pressure ventilation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Extubation Failure, Acute Respiratory Failure Post Extubation
Prevention of Reintubation by Using Noninvasive Positive Pressure Ventilation
Child extubation failure range from 4.1% to 19%. Studies in adults and children showed that extubation failure increases mortality mainly in those who need reintubation as this is a invasive procedure associated with many…
- Trial name
- NCT00977002
- Testing
- Positive Pressure Noninvasive ventilation, Inhalatory O2
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
Extubation Failure in Neonates
Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation After Extubation in Neonates
The goal of this clinical trial is to learn which breathing support works better after removing a newborn's breathing tube. Researchers will study newborns born at 26 weeks of gestation or later.
- Trial name
- NOV-A (NCT07836166)
- Testing
- Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation
- Where
- Pakistan
- Volunteers
- 172 people
- Sponsor
- Aga Khan University
Extubation
Total Intravenous Anesthesia (TIVA)/Sevoflurane Initiated Intravenous Anesthesia (SIIVA) in Pediatric Patients
Because Propofol is the primary "anesthetic agent," and inhalational agents remain in trace quantities at the end of the procedure Sevoflurane initiated intravenous anesthesia (SIIVA) or not present at all Total intravenous…
- Trial name
- NCT05837936
- Testing
- Total intravenous anesthesia (TIVA), Sevoflurane initiated intravenous anesthesia (SIIVA)
- Where
- 2 sites in United States, Australia
- Volunteers
- 600 people
- Sponsor
- Wake Forest University Health Sciences
Mechanical Ventilation, Pneumonia
Removal of Endotracheal Tube Secretions Comprehensively Until Extubation
The purpose of this study is to measure secretion accumulation within endotracheal tubes of mechanically ventilated patients and test the efficacy, safety and clinical impact of removing the secretions using novel airway…
- Trial name
- RESCUE (NCT00663637)
- Testing
- CAM (Complete Airway Management) Catheters
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- O. M. Neotech, Inc.
Extreme Prematurity
HFNC and NCPAP in Extremely Preterm Infants
To avoid or decrease the rate of complications in preterm infants after disconnection from a mechanical ventilation (extubation), non-invasive respiratory support is routinely used.
- Trial name
- NCT03649282
- Testing
- HFNC, NCPAP
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Guilherme Sant'Anna, MD
Premature Birth, Respiratory Insufficiency
Comparison of Two Methods of Continuous Positive Airway Pressure (CPAP) to Support Successful Extubation of Infants of Birth Weights ≤ 1500 Grams (C2CPAP)
Continuous positive airway pressure (CPAP) has been used successfully to promote extubation in the premature infant population. The two methods of CPAP to be examined are currently used by many institutions, yet no study has…
- Trial name
- NCT00187434
- Testing
- Infant Flow System, Bubble CPAP
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Sunnybrook Health Sciences Centre
Preterm Birth, Mechanical Ventilation Complication
Optimal High CPAP Pressures in Preterm Neonates Post-extubation
Use of continuous positive airway pressure (CPAP) in preterm neonates has traditionally been limited to between 5-8 cmH2O. In recent years, use of CPAP pressures ≥9 cmH2O is becoming more common in neonates with evolving chronic…
- Conditions
- Preterm Birth, Mechanical Ventilation Complication, Respiratory Distress Syndrome, Newborn
- Trial name
- NCT05230485
- Testing
- CPAP level
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- McMaster Children's Hospital
Pneumothorax, Pulmonary Interstitial Emphysema
Surfactant Administration During Spontaneous Breathing
Spontaneous breathing supported by nasal continuous positive airway pressure (nCPAP) is thought to have some advantages compared with mechanical ventilation in premature infants.
- Conditions
- Pneumothorax, Pulmonary Interstitial Emphysema, Bronchopulmonary Dysplasia
- Trial name
- TAKE CARE (NCT01329432)
- Testing
- Take care, InSurE
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
PreTerm Neonate, Sedation for Invasive Mechanical Ventilation
Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants
Very preterm neonates (born before 32 weeks' gestation) often require invasive mechanical ventilation (IMV) to manage respiratory insufficiency.
- Conditions
- PreTerm Neonate, Sedation for Invasive Mechanical Ventilation, Very Preterm Neonates With Sedation for Invasive Mechanical Ventilation
- Trial name
- DEXPRE (NCT06878703)
- Testing
- Midazolam, Dexmedetomidine
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intubation
Oral Fluid Intake After Extubation
According to the current guidelines the patient is not allowed to drink any fluid at least 2 hours after extubation to prevent complications. However there is no evidence in the literature to support this approach.
- Trial name
- NCT05819645
- Testing
- Fluid intake not as per standard guidlines
- Where
- Czechia
- Volunteers
- 160 people
- Sponsor
- University Hospital, Motol