Clinical trials: Extubation Failure in Neonates
Neonatal Disease
Neonatologist-performed Lung Ultrasound (NPLUS) to Guide Respiratory Therapy to Prevent Extubation Failure
The objective of the study is to evaluate the role of neonatologist-performed lung ultrasound (NPLUS) after weaning from invasive mechanical ventilation and extubation.
- Trial name
- NCT06469580
- Testing
- NPLUS (neonatologist performed lung ultrasound)
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Neonates
Utility of Spontaneous Breathing Trial (SBT) Using ET-CPAP, in Predicting Extubation Failure in Neonates
Intubation and ventilation are lifesaving interventions in the neonatal intensive care unit (ICU), especially among preterm, low birth weight babies. However, timely extubation is also necessary.
- Trial name
- NCT03091387
- Testing
- Spontaneous Breathing Test
- Volunteers
- 110 people
- Sponsor
- Aga Khan University
Study of Predictors of Successful Extubation in Preterm Infants, Extubation Succeeded
Neonatal Diaphragmatic Activity-Linked Extubation Conditions and Timing
The objective of this study is to evaluate the role of diaphragmatic electrical activity monitoring (collected by esophageal probe) around extubation of preterm patients in order to consider its use as a standardized objective…
- Conditions
- Study of Predictors of Successful Extubation in Preterm Infants, Extubation Succeeded, Extubation Failure, Preterm
- Trial name
- NEODIALECT (NCT07709988)
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Neonatal Respiratory Failure, Invasive Mechanical Ventilation
A Model for Predicting Extubation Success in Premature Babies
Invasive mechanical ventilation is a life-saving treatment in critically ill newborns with respiratory failure. However, continuing this treatment for a long time may have negative consequences, especially bronchopulmonary…
- Conditions
- Neonatal Respiratory Failure, Invasive Mechanical Ventilation, Extubation Failure
- Trial name
- NCT05081973
- Testing
- A model for predicting extubation success based on extubation readiness estimator and lung ultrasonography score
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Marmara University
Intubation Complication, PreTerm Birth
NIPPV Versus Bi-level Nasal Continuous Positive Airway Pressure Following Extubation
Mechanical ventilation is important in the care of preterm infants with respiratory failure, but may be associated with lung injury. Efforts are needed to avoid or minimize the use of mechanical ventilation.
- Trial name
- NCT02842190
- Testing
- NIPPV
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Neonatal Respiratory Failure
Normal Saline Nebulization on Prevention of Extubation Failure in Neonates
this study is about evaluating the effect of using normal saline nebulization in preventing re-intubation in extubated neonates , provided that the cause of intubation is mainly due to respiratory cause
- Trial name
- NCT05194761
- Testing
- Normal saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Weaning Failure
Interest of High Flow Nasal Cannula Oxygen Therapy in Pediatric Intensive Care Unit
monocentric randomized controlled trial starting from Mars 2017, recruitment is still ongoing. Patients aged between 0-45 days needing mechanical ventilation (MV) with tracheal intubation were included random assignation in two…
- Trial name
- NCT03505814
- Testing
- High Flow Nasal Cannula Oxygen therapy (OPTIFLOW®), Conventional oxygen therapy
- Where
- Tunisia
- Volunteers
- 126 people
- Sponsor
- Hôpital d'enfants Béchir-Hamza
Respiratory Distress Syndrome, Bronchopulmonary Dysplasia
Post-extubation Pressures in Preterm Neonates: A CER Study
The optimal post-extubation pressure level on non-invasive respiratory support modes - irrespective of the choice of the specific non-invasive mode - that optimizes extubation success and improves clinical outcomes remains…
- Conditions
- Respiratory Distress Syndrome, Bronchopulmonary Dysplasia, Preterm Birth
- Trial name
- NCT06552455
- Volunteers
- 1,050 people
- Sponsor
- McMaster Children's Hospital
Premature Birth, Respiration Failure
Predictors of Prolonged Mechanical Ventilation in Preterm Infants
This prospective cohort study aims to identify the independent predictors of prolonged mechanical ventilation in preterm infants admitted to the Neonatal Intensive Care Unit of Assiut University Children Hospital.
- Conditions
- Premature Birth, Respiration Failure, Bronchopulmonary Dysplasia
- Trial name
- NCT07821632
- Volunteers
- 100 people
- Sponsor
- Assiut University
Extubation Failure in Neonates
Noninvasive High Frequency Oscillatory Ventilation Versus Nasal Intermittent Mandatory Ventilation After Extubation in Neonates
The goal of this clinical trial is to learn which breathing support works better after removing a newborn's breathing tube. Researchers will study newborns born at 26 weeks of gestation or later.
- Trial name
- NOV-A (NCT07836166)
- Testing
- Noninvasive High Frequency Oscillatory Ventilation, Nasal Intermittent Mandatory Ventilation
- Where
- Pakistan
- Volunteers
- 172 people
- Sponsor
- Aga Khan University
Extubation Failure, Neonates
Predictors of Extubation Failure in Ventilated Neonates
This protocol proposes a prospective observational study to develop and validate such a model, directly addressing a critical evidence gap identified by recent systematic reviews.
- Conditions
- Extubation Failure, Neonates, NICU
- Trial name
- Neonates (NCT07764575)
- Volunteers
- 124 people
- Sponsor
- Assiut University
High-Frequency Ventilation, Intermittent Positive-Pressure Ventilation
Nasal HFOV Versus Nasal SIPPV in Neonate Following Extubation: RCT Crossover Study
Mechanical ventilation was introduced to treat respiratory failure in preterm infants or sick neonates then improvements in survival (1,2).
- Conditions
- High-Frequency Ventilation, Intermittent Positive-Pressure Ventilation, Newborn Morbidity, Noninvasive Ventilation
- Trial name
- nHFOnSIPPV (NCT04323397)
- Testing
- Non-invasive ventilation
- Where
- Thailand
- Volunteers
- 133 people
- Sponsor
- Prince of Songkla University
PreTerm Neonate, Extubation Readiness
Prospective Multicentre Mixed Methods Study to Explore Extubation Practices and Respiratory Outcomes in Extremely Preterm Neonates.
The purpose of this observational study is to learn about neonatologists' perceptions of extubation readiness and extubation and reintubation practices in extremely preterm infants in the first 2 weeks of life using prospective…
- Conditions
- PreTerm Neonate, Extubation Readiness, Extubation Failure, Respiratory Morbidity
- Trial name
- CERAINE (NCT06808997)
- Where
- 31 sites in France
- Volunteers
- 166 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil