Clinical trials: Exudative Macular Degeneration
Wet AMD
Genetics Study of Wet Age-Related Macular Degeneration (AMD) Non-Responders to Vascular Endothelial Growth Factor (VEGF) Therapy
To obtain a genotypic analysis of patients with chronic exudative age-related macular degeneration noted to have subretinal or intraretinal edema despite continuous monthly Anti-VEGF therapy.
- Trial name
- NCT01310686
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- West Coast Retina Medical Group, Inc.
Exudative Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy
Effect of Intravitreal VEGF-Trap Eye on Polypoidal Choroidal Vasculopathy
Effects of VEGF Trap-Eye (aflibercept) in treatment-naive polypoidal choroidal vasculopathy (PCV) will be evaluated.
- Trial name
- VAULT (NCT01950741)
- Testing
- aflibercept
- Where
- 8 sites in South Korea
- Volunteers
- 48 people
- Sponsor
- Pusan National University Hospital
Exudative Age-Related Macular Degeneration
Monocentric Retrospective Observational Study on Patients With Macular Degeneration
Main Objective: The main objective of this retrospective observational study was to describe the evolution of visual acuity measured on ETDRS (Early Treatment Diabetic Retinopathy Study) scale, for patients with exudative…
- Trial name
- ELOUAN (NCT02089503)
- Testing
- intravitreal injections of Lucentis
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Hospital St. Joseph, Marseille, France
Age-Related Macular Degeneration
Beovu Experience UZ Leuven
Reporting early real-world clinical data of consecutive patients on the use of Beovu® (brolucizumab) intravitreal injections in patients with neovascular age-related macular degeneration.
- Trial name
- BEL (NCT05220085)
- Testing
- Brolucizumab Ophthalmic Dbll 6 Mg/0.05 mL Intravitreal Solution
- Where
- Belgium
- Volunteers
- 17 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Exudative Age-related Macular Degeneration
Blood-aqueous Barrier Integrity in Eyes Undergoing Intravitreal Bevacizumab Therapy to Treat Neovascular AMD
The aim of this study is to evaluate the effect of repeated intravitreal bevacizumab injections on blood-aqueous barrier permeability in eyes with neovascular age-related macular degeneration (AMD).
- Trial name
- NCT03744806
- Testing
- Bevacizumab Injection
- Volunteers
- 48 people
- Sponsor
- Medical University of Lublin
Wet Macular Degeneration
Efficacy of Fixed Monthly Dosing of Ranibizumab in Neovascular Age-related Macular Degeneration
The objective of this pilot study is to evaluate the efficacy of intensive fixed monthly dosing of intravitreal Lucentis® (Ranibizumab) for the treatment of SRF and PED in neovascular AMD which is persistent to anti-VEGF…
- Trial name
- NCT02944227
- Testing
- Lucentis
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Seoul National University Hospital
Wet Macular Degeneration
The Impact of Baseline Visual Acuity on the Treatment Outcomes in Patients Treated With AflIbercept in Real-life Clinical Setting
The study will assess the mean change in Visual Acuity (VA) (overall and stratified by baseline VA) at year 1 and 2 of treatment with Aflibercept in real-life setting.
- Trial name
- INSIGHT (NCT03278262)
- Testing
- Aflibercept (Eylea, BAY86-5321)
- Where
- Sweden
- Volunteers
- 2,312 people
- Sponsor
- Bayer
Exudative Age-related Macular Degeneration
Treat and Extend Therapy Study Using Intravitreal Aflibercept for Patients Exited From Protocol VGFT-OD 0910
The purpose of this research study is to determine if a "Treat and Extend" regimen (increasing the time between visits when the disease is stable and not getting worse) of aflibercept 2.0mg injections inside the eye for treating…
- Trial name
- RANGE (NCT01961414)
- Testing
- Aflibercept
- Where
- 6 sites in United States
- Volunteers
- 45 people
- Sponsor
- Palmetto Retina Center, LLC
Dry Macular Degeneration
Non Exudative AMD Imaged With SS-OCT- Extension
The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and…
- Trial name
- BIRC-02 (NCT04469140)
- Testing
- SS-OCT imaging
- Where
- 5 sites in United States, Australia
- Volunteers
- 450 people
- Sponsor
- Boston Image Reading Center
Wet Macular Degeneration
Caregiver Burden of Wet Age-related Macular Degeneration (wAMD) in Japan
This study aims at investigation of the caregiver burden of Wet Age-related Macular Degeneration (wAMD) patients and at the assessment of how much of caregiver burden could be reduced in transitioning from Pro Re Nata to…
- Trial name
- NCT02541084
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
- Where
- Japan
- Volunteers
- 72 people
- Sponsor
- Bayer
Age-related Macular Degeneration
Tools to Optimize Patient Presentation After Onset of Exudative Age-Related Macular Degeneration (AMD)
Exudative age-related macular degeneration ("wet" AMD) continues to be a leading cause of central vision loss in the US for those over fifty years of age, despite the availability of several effective interventions to contain…
- Trial name
- NCT01337414
- Testing
- VMS diary booklet, Standard of Care
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- Johns Hopkins University
Wet Macular Degeneration, Diabetic Macular Edema
Artificial Intelligence Diagnostic Aid
The investigators have worked with software designers to develop a software that allows us to analyse current adherence to guidelines on Ophthalmic conditions such as Age related Macular Degeneration (AMD), Diabetic Macular Edema…
- Conditions
- Wet Macular Degeneration, Diabetic Macular Edema, Retinal Vein Occlusion
- Trial name
- AID (NCT05675540)
- Testing
- Macusense Assessment Software
- Where
- United Kingdom
- Volunteers
- 422 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Macular Degeneration
Long-Term Efficacy in AMD of Rheopheresis in North America
The purpose of these studies are to evaluate the effect on vision in subjects with AMD who received active and placebo treatment in the MIRA-1 study.
- Trial name
- NCT00380172
- Testing
- Rheopheresis blood filtration
- Where
- 9 sites in United States, Canada
- Volunteers
- 120 people
- Sponsor
- OccuLogix
Wet Macular Degeneration
Aflibercept (Eylea) in roUtine Clinical Practice in patientS With Wet Age-related Macular Degeneration in Italy
The main objectives of this non-interventional cohort field study are to evaluate effectiveness of Eylea and to describe follow-up as well as treatment patterns in patients with wAMD (wet age-related macular degeneration) in…
- Trial name
- PERSEUS-IT (NCT02289924)
- Testing
- Aflibercept (Eylea, VEGF Trap-Eye, BAY86-5321)
- Where
- Italy
- Volunteers
- 912 people
- Sponsor
- Bayer