Clinical trials: Eye--Refractive Errors
Myopia
Microdosed Atropine 0.1% and 0.01% Ophthalmic Solutions for Reduction of Pediatric Myopia Progression
This study evaluates the progression of myopia in participants using microdosed atropine 0.01%, atropine 0.1%, or placebo ophthalmic solution. Eligible subjects will administer study medication daily in each eye for 48 months.
- Trial name
- NCT03942419
- Testing
- Atropine 0.1% Ophthalmic Solution, Atropine 0.01% Ophthalmic Solution
- Where
- 18 sites in United States
- Volunteers
- 438 people
- Sponsor
- Eyenovia Inc.
Myopia, Hyperopia
Corneal Asphericity Adjustment (Q Adjustment) in Myopic and Hyperopic Patients Undergoing Refractive Correction With Excimer Laser
To study the postoperative results in myopic and hyperopic eyes treated with two different laser ablation algorithms (STD and F-CAT), both FDA approved.
- Trial name
- NCT01296867
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Myopia, Mental Health
Intervention for Preventing Myopia and Multimorbidity in Children
This study aims to develop and evaluate a scalable, hybrid intervention model for the co-prevention of myopia, obesity, and mental health issues among children.
- Conditions
- Myopia, Mental Health, Cardiovascular Health Status
- Trial name
- NCT07294222
- Testing
- Standard School Health Education, Multi-component Health Promotion Package
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Myopia, Progressive
Crossover RCT of TAMER Lenses in Myopia Control
This study is a prospective, randomized, crossover clinical trial with a planned proposed enrollment of 120 Chinese male and female subjects aged 6-12 years without systemic or ocular diseases to follow up their cycloplegic…
- Trial name
- NCT06329986
- Testing
- TAMER Lens Spectacle, SV lenses
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia
Clinical Evaluation of a Myopia Control Lens in Slowing Myopia Progression.
This is a mono-centre, prospective, one-arm, unmask clinical trial to evaluate the effectiveness of test lens in slowing myopia progression with respect to axial length elongation compared to a single vision spectacle lens from…
- Trial name
- NCT05534022
- Testing
- Test myopia control lenses (BSL)
- Where
- Singapore
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Essilor International
Myopia
Influence of Rodenstock Spectacle Lenses on Myopia Progression.
The prevalence of myopia in Singapore is among the highest in the world, with 65 percent of our children being myopic by Primary 6, and 83 percent of young adults being myopic.
- Trial name
- NCT06816446
- Testing
- Myopia control spectacle lens, Single-vision lens
- Where
- Singapore
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Rodenstock GmbH
Myopia, Myopia, Progressive
Multicenter RCT: LED Red Light Dose-Response in Myopia Progression Control
The goal of this clinical trial is to verify the effectiveness and safety of non-laser LED red light combined with defocus lens therapy for controlling myopia progression and evaluate the impact of different intervention…
- Trial name
- NCT07330180
- Testing
- Yingtong Vision Rehabilitation Instrument, Hoya DIMS multi-point myopia defocus lens
- Where
- 7 sites in China
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Myopia, Repeated Low-level Red Light
Real-world Registry Study of Red Light Treatment on Myopia Control: a Focus on Non-responders to Conventional Treatments
This real-world observational registry study aims to assess the effectiveness of Repeated Low-Level Red Light (RLRL) therapy in controlling myopia progression among children aged 8 to 16 who have not responded to conventional…
- Trial name
- NCT06569810
- Testing
- Repeated Low-Level Red Light (RLRL) therapy
- Volunteers
- 2,500 people
- Sponsor
- The Hong Kong Polytechnic University
Anisometropic Amblyopia, Strabismic Amblyopia
3D Movie Viewing vs Occlusion for Treating Amblyopia in Children
Amblyopia is a common childhood visual disorder that affects vision in one eye and can also impair depth perception (stereopsis).
- Trial name
- VISTA3D (NCT07563946)
- Testing
- 3D Movie Viewing, Occlusion Therapy
- Volunteers
- 56 people
- Sponsor
- Universitat Politècnica de Catalunya
Hyperopia
Investigation of the Effect of Different Eye Exercises on Hypermetropia in School-age Children
Hypermetropia in school-aged children is a pathology which is very common and responds to treatments early. No studies have been found in the literature on the efficancy of the hypermetropia treatments with physiotherapy methods.
- Trial name
- NCT03347734
- Testing
- Eye exercises group, Convergence exercise group, Oculomotor Exercise Group (OMEG)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medipol University
Myopia
Study of Safety and Effectiveness of the Boston Orthokeratology Shaping Lens in the Arise Orthokeratology Lens
The objective of this orthokeratology study is to evaluate the safety and effectiveness of the Arise Orthokeratology Lens with non-spherical posterior peripheral curves
- Trial name
- NCT05984290
- Testing
- orthokeratology lens
- Where
- 6 sites in United States
- Volunteers
- 90 people
- Sponsor
- Bausch & Lomb Incorporated
Myopia, Hyperopia
Corneal and Conjunctival Sensitivity and Staining Study
The primary objective of this study is to compare subjective symptoms and ocular health in a group of individuals who are currently wearing soft contact lenses on a daily wear basis, after a short period of no lens wear and…
- Trial name
- NCT00455455
- Testing
- Optifree RepleniSH Multipurpose Disinfecting Solution, ReNu Multiplus Multipurpose Solution
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Myopia
Myopia Intervention in Children and Adolescents and Establishment of a Precise Intervention Model
Investigators are going to conduct a multi-centered randomized clinical trial that myopic children are randomly allocated into three groups: 0.01% atropine， 0.04% atropine and orthokeratology in order to evaluate the efficacy and…
- Trial name
- NCT05357326
- Testing
- Atropine Sulfate 0.01% Eye Drop, Orthokeratology, Atropine Sulfate 0.04% Eye Drop
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia, Refractive Error
Comparative Study of Cycloplegic Refraction and Subjective Refraction With Fogging in School Age Children
A thorough ophthalmic examination of a child must include a refraction and this is often done with cycloplegia. In our study, we aim to determine at which age group a non-cycloplegic refraction technique closely correlates with a…
- Trial name
- NCT00347347
- Where
- Singapore
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Singapore National Eye Centre
Myopia, Myopia; Refractive Error
Peripheral Relative Refractive Power of Orthokeratology Lenses
Orthokeratology (OK) has been demonstrated to be an effective intervention for slowing axial elongation in children with myopia.
- Trial name
- NCT07294404
- Testing
- orthokeratology
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Tianjin Eye Hospital
Myopia Progressing
3D Designed Defocus Lenses on Myopia Control in Children and Adolescents
This study aims to evaluate the effectiveness of lenses with 3D Designed Defocus in controlling the progression of myopia in children and adolescents, and to explore the feasibility of effective design, and apply personalized…
- Trial name
- NCT07284147
- Testing
- Defocus Lenses
- Where
- China
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Myopia
Low-dose Atropine for the Prevention of Myopia Progression in Danish Children
Myopia (nearsightedness) is increasing in prevalence throughout the world. It is associated with a risk of potentially blinding complications such as retinal detachment and myopic maculopathy.
- Trial name
- APP (NCT03911271)
- Testing
- 0.1% atropine and 0.01% atropine, 0.01% atropine, 0.9% Sodium-chloride
- Where
- 3 sites in Denmark
- Volunteers
- 97 people
- Sponsor
- Line Kessel
Myopia
Investigation of Multi-Purpose Solution-Based Corneal Staining and Ocular Comfort
The primary objective of this study is to compare subjective ocular symptoms and corneal staining over time in a group of individuals who wear soft contact lenses on a daily wear basis, whilst they sequentially use two different…
- Trial name
- NCT00349843
- Testing
- Soft contact lens, Marketed soft lens multipurpose disinfection regimen
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Axial Length, Myopia
Study of the Intervention Effect of Outdoor Activity Period Patterns in Promoting Myopia Among Preschool Children
This study is a randomized controlled trial based on outdoor activity interventions at specific time periods, involving preschool children aged 4 to 5 years.
- Trial name
- NCT06607640
- Testing
- Increase outdoor activity time during specific time periods
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Fangbiao Tao
Myopia, Hyperopia
High Refractive Index Material 510(k)
The purpose of this study is to establish the substantial equivalence of the HDS HI 1.54™ to the paflufocon C material control lenses to correct myopia and hyperopia with and without astigmatism.
- Trial name
- PVS-07-07 (NCT00766168)
- Testing
- HDS HI 1.54; pahrifocon A, FluoroPerm 30 RGP; paflufocon C
- Where
- 8 sites in United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- CooperVision International Limited (CVIL)