Clinical trials: Fat Metabolism
Obesity
Efficacy of Increasing Physical Activity to Reduce Children's Visceral Fat
The purpose of this trial is to examine whether adding greater physical activity to standard family-based behavioral pediatric obesity treatment decreases the amount of visceral fat among treated overweight children.
- Trial name
- ADVANCE (NCT00359957)
- Testing
- Pediatric Obesity Intervention (STANDARD), Pediatric Obesity Intervention + High Activity (ADDED)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type 1 Diabetes Mellitus, Adolescent
Effect of High Fat High Protein Meal in Type 1 Diabetes
Aim: Despite optimal glycemic control in individuals with type 1 diabetes, post-meal hyperglycemia remains a clinical challenge, and it has been identified as an independent risk factor for the development of long-term…
- Trial name
- T1DM-HFHP (NCT07158385)
- Testing
- Standard test meal (SM), High fat high protein meal-carbohydrate counting (HFHP), High fat high protein meal-fat counting (HFHP-a)
- Where
- Turkey (Türkiye)
- Volunteers
- 11 people
- Sponsor
- Cumhuriyet University
Hepatic Steatosis, NAFLD
Effect of Amino Acids on Hepatic Fat Content in Adolescents (AMINOS Study)
Participants 13-18 years of age with extra fat stored in the liver will be randomly assigned to a protein supplement or placebo "fake supplement" for 2 months to see if the participants who get the protein supplement have less…
- Conditions
- Hepatic Steatosis, NAFLD, Adolescent Obesity
- Trial name
- AMINOS (NCT05935826)
- Testing
- Essential Amino Acid Supplement by Amino Co
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Colorado, Denver
Steatorrhea, Growth
Tolerance and Digestibility of a New Formula in Healthy Infants
The great majority of infants formula contain fats exclusively from vegetable oil. Nevertheless, the use of both vegetable and dairy lipids is on a real interest to obtain an infant formula closer to the nutritional composition…
- Trial name
- NCT01184378
- Testing
- dairy lipids and soluble milk proteins
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lactalis
Spinal Muscular Atrophy, Merosin Deficient Congenital Muscular Dystrophy
Fat and Glucose Metabolism in Fed and Fasted State in Patients With Low Skeletal Muscle Mass
In a study from 2003 the investigators showed that adult patients with very low skeletal muscle mass (spinal muscular atrophy (SMA) type II, Duchenne muscular dystrophy, congenital muscular dystrophy) are prone to develop…
- Trial name
- NCT03970135
- Testing
- Fasting
- Where
- Denmark
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Generalized Lipodystrophy
Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized Lipodystrophy
This study is researching a new drug called mibavademab (called "study drug"). The study involves participants with a condition called Generalized Lipodystrophy (GLD).
- Trial name
- LAGO (NCT07220785)
- Testing
- Mibavademab
- Where
- 9 sites in United States, Brazil and 1 more
- Volunteers
- 28 people
- Sponsor
- Regeneron Pharmaceuticals
Gestational Diabetes Mellitus
Trial of Diet in Gestational Diabetes Mellitus: Metabolic Consequences to Mother and Offspring
The rapidly rising risk of gestational diabetes pregnant women demands that an effective diet strategy be developed due to the high risk of fetal overgrowth, which places the newborn at increased risk for childhood obesity and…
- Trial name
- CHOICE (NCT02244814)
- Testing
- Low Carbohydrate/Conventional, Choosing Healthy Options in Carbohydrate Energy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Colorado, Denver
Anorexia in Adolescence, Anorexia Nervosa
3-Dimensional Optical Scanning to Assess and Monitor Malnutrition in Eating Disorders (3D-ED) Study
People with anorexia nervosa often become medically unstable because of severe malnutrition and require hospitalization for nutritional rehabilitation.
- Conditions
- Anorexia in Adolescence, Anorexia Nervosa, Anorexia Nervosa, Atypical, Anorexia Nervosa, Binge Eating/Purging Type
- Trial name
- 3D-ED (NCT07726524)
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Francisco
Adolescent Obesity, Eating Behaviors
Mindful Eating Intervention Using EATS UP App: Effects on Body Composition and Insulin Resistance in Obese Adolescents
The goal of this experimental study is to develop and evaluate the effectiveness of a Mindful Eating Intervention (MEI) model integrated with the digital application EatsUp for improving body fat percentage among obese…
- Conditions
- Adolescent Obesity, Eating Behaviors, Nutrition Status, Blood Glucose
- Trial name
- NCT06821555
- Testing
- Nutrition and Physical Activity Education with Mindful Eating Intervention, Nutrition and Physical Activity Education
- Where
- Indonesia
- Volunteers
- 64 people
- Sponsor
- Universitas Indonesia
NAFLD
Healthy Eating Through Reduction Of Excess Sugar
The purpose of the study is to determine the effect of dietary sugar reduction in obese children and examine whether there are differential effects based on genotype of a single amino acid substitution in the PNPLA3 gene that is…
- Trial name
- HEROES (NCT02948647)
- Testing
- Standard of care plus sugar-reduction education
- Where
- 2 sites in United States
- Volunteers
- 113 people
- Sponsor
- University of Southern California
Obesity, Weight Loss
Hormonal Regulation of Body Weight Maintenance
The investigators here propose to perform a collaborative clinical research effort including a randomized controlled trial investigating the mechanisms of weight maintenance and their relation to a lifestyle intervention in…
- Conditions
- Obesity, Weight Loss, Weight Gain, Hormone Disturbance
- Trial name
- NCT00850629
- Testing
- multimodal lifestyle intervention
- Where
- Germany
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Non-alcoholic Fatty Liver Disease
Fructose and Liver Diseases in Youth: Help Them FLY
Obesity has been increasing all over the world. This has lead to a significant increase of a liver disease in children called non-alcoholic fatty liver disease (NAFLD).
- Trial name
- FLY (NCT05528471)
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- University of Alberta
Cardiovascular Diseases, Heart Diseases
Energy Expenditure, Diet and Body Fat in Children
To characterize the pattern of change over a two year period in energy expenditure and energy intake in two cohorts of American Indian (AI) children.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity
- Trial name
- NCT00024817
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Heart Diseases, Diabetes Mellitus
Adiposity and Fat Patterning in Black Americans
To examine the relationships of obesity and fat patterning with morbidity and mortality in Black Americans.
- Conditions
- Heart Diseases, Diabetes Mellitus, Obesity
- Trial name
- NCT00005248
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Type 1 Diabetes Mellitus
Effect of Splitting Mealtime Insulin Doses After Mixed Meals High in Fat and Protein
The current management of type 1 diabetes mellitus (T1DM) depends on the use of intensive insulin therapy - either by insulin pump therapy or multiple daily injection (MDI) therapy - and the use of carbohydrate counting to…
- Trial name
- NCT04783376
- Testing
- : Insulin, lispro and regular insulin
- Where
- Egypt
- Volunteers
- 43 people
- Sponsor
- Sohag University
Hematopoietic Stem Cell Transplantation, Malnutrition
Body Composition Changes During Stem Cell Transplantation: The Case Of Lymphoma Patients
Skeletal Muscle Index (SMI) and Visceral Adipose Ratio (VAR) assess body composition changes and disclose malnutrition risk effectively.
- Conditions
- Hematopoietic Stem Cell Transplantation, Malnutrition, Metabolic Syndrome
- Trial name
- NCT02983643
- Where
- Lebanon
- Volunteers
- 105 people
- Sponsor
- American University of Beirut Medical Center
Cardiac Surgery
Epicardial Fat Immunity extRa Cellular vesicleS HearT
The FIRST study is a monocentric observational pilot study investigating the role of extracellular vesicles (EVs) derived from epicardial adipose tissue (EAT) in cardiovascular complications associated with obesity.
- Trial name
- FIRST (NCT07817667)
- Testing
- Epicardial adipose tissue biopsy, Thoracic subcutaneous adipose tissue biopsy
- Volunteers
- 100 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Obesity, Type 2 Diabetes
Strength and Nutrition Outcomes for Latino Adolescents
We are conducting an intervention study to examine the effects of a 16-week exercise and diet interventions on prevention of disease, specifically type 2 diabetes and heart disease, in Latino youth.
- Conditions
- Obesity, Type 2 Diabetes, Cardiovascular Risk, Cancer
- Trial name
- SANO LA (NCT00697580)
- Testing
- Nutrition, Strength Training & Nutrition, Circuit Training & Nutrition
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Exercise-related Amenorrhea
Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes
One aim of this study is to determine changes in body composition and hormones that differentiate athletes who stop getting their periods versus those who continue to get their periods and non-athletes.
- Trial name
- NCT00946192
- Testing
- Transdermal 17Beta-estradiol, progesterone, Ethinyl Estradiol + Desogestrel
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Obesity, Overweight
Development of Melt Organic Baking Fat for Reducing Child Obesity
The purpose of this study is to compare the effects of a cooking oil on metabolic rate, appetite, and metabolic risk markers.
- Conditions
- Obesity, Overweight, Pediatric Obesity
- Trial name
- NCT02346994
- Testing
- Melt Test Blend 3.2, Corn Oil
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Columbia University