Clinical trials: Fatty Acids
Cognitive Function, Academic Performance
Effect of Omega-3 LCPUFA Intervention on Learning, Cognition, Behaviour and Visual Processing.
The brain is primarily developed in the third trimester of pregnancy, but continues maturing through the late twenties, especially the prefrontal cortex.
- Conditions
- Cognitive Function, Academic Performance, Mental Health
- Trial name
- NCT02240264
- Testing
- Krill oil capsules
- Where
- 17 sites in Netherlands
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Open University
Bipolar Disorder
Omega-3 Fatty Acids in Children and Adolescents With Bipolar Disorder
The purpose of this study is to test the hypothesis that flax oil, as an omega-3 fatty acid, will be superior to placebo in the maintenance treatment of bipolar disorder in children and adolescents.
- Trial name
- NCT00252486
- Testing
- Flax oil
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Rochester
Infant Nutrition
Essential Fatty Acid Nutrition For 1-2 Yr-Olds
This is a prospective longitudinal study that will involve 200 infants enrolled at 12-13 months of age. The study will use a classic nutrition design to assess if infants' feeding practices in Canada place infants 1-2 years of…
- Trial name
- NCT01263912
- Testing
- LCPUFA Supplement
- Where
- Canada
- Volunteers
- 133 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Cystic Fibrosis in Children
Effect of Antioxidant Docosahexaenoic Acid (DHA) in Cystic Fibrosis Patients
This study evaluates the effect of antioxidant docosahexaenoic acid (DHA) in patients with cystic fibrosis. Half of participants will receive DHA, while the other half will receive placebo.
- Trial name
- NCT04987567
- Testing
- ANTIOXIDANT DHA TRIGLYCERIDE (TRIDOCOSAHEXAENOINE-AOX®)
- Where
- Spain
- Volunteers
- 22 people
- Sponsor
- Corporacion Parc Tauli
Usher Syndrome, Retinitis Pigmentosa
Study of Dietary N-3 Fatty Acids in Patients With Retinitis Pigmentosa and Usher Syndrome
OBJECTIVES: I. Examine the concentration of docosahexanoic acid (DHA) and other n-3 fatty acids in plasma, erythrocyte, and adipose tissue in patients with various forms of retinitis pigmentosa and Usher syndrome. II.
- Trial name
- NCT00004345
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Autism Spectrum Disorders, Hyperactivity
Omega-3 Fatty Acids for Hyperactivity Treatment in Autism Spectrum Disorder
The proposed study is an internet-based, randomized, double-blind, placebo-controlled trial which will assess changes in hyperactivity in children ages five through eight with an autism spectrum disorders (ASD) and elevated…
- Trial name
- NCT01694667
- Testing
- Omega-3 Fatty Acids
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Hugo W. Moser Research Institute at Kennedy Krieger, Inc.
NASH - Nonalcoholic Steatohepatitis
Dietary Modulation of Intestinal Microbiota as Trigger of Liver Health: Role of Bile Acids - "A Diet for Liver Health"
Studies in recent years have demonstrated that the commensal intestinal flora (microbiome) plays a key role in the development of nonalcoholic steatohepatitis (NASH).
- Trial name
- ADLH (NCT03897218)
- Testing
- oatmeal flakes with prebiotic food supplements, millet flakes
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 84 people
- Sponsor
- RWTH Aachen University
Preterm Infant
Effects of Parenteral Nutrition With Different Lipid Emulsions in Preterm Infants
Previous studies have suggested that olive oil-based emulsion is safe and well tolerated in preterm infants, a showed efficacy and a good clinical and biological safety profile.
- Trial name
- NCT01683162
- Testing
- ClinOleic, Lipofundin, Intralipid
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Wei Cai
Acute Lymphoblastic Leukemia
Effect of Omega-3 Fatty Acids on Methotrexate Induced Hepatotoxicity in Children With Acute Lymphoblastic Leukemia
Study the role of oxidative stress in methotrexate induced hepatic damage, and the possible protective effect of OMEGA-3 fatty acids against methotrexate hepatotoxicity using clinical and biochemical parameters.
- Trial name
- NCT02373579
- Testing
- Omega-3 Fatty Acids, Methotrexate
- Volunteers
- 70 people
- Sponsor
- Nancy Samir Elbarbary
Schizophrenia
Omega-3 Fatty Acids Efficacy in First-episode of Schizophrenia
There is accumulating experimental evidence to suggest the role of essential fatty acids (EFA) in neuronal migration, pruning and synaptic plasticity.
- Trial name
- OFFER (NCT02210962)
- Testing
- essential fatty acids, olive oil
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Medical University of Lodz
NAFLD, Non Alcoholic Steatohepatitis (NASH)
DHA and Vitamin D in Children With Biopsy-proven NAFLD
Non-alcoholic fatty liver disease (NAFLD) has reached epidemic proportions and is rapidly becoming the one of most common causes of chronic liver disease in children.
- Trial name
- VitD_DHA (NCT02098317)
- Testing
- DHA plus Vitamin D
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Acute Liver Failure, Mitochondrial Diseases
Longitudinal Study of Mitochondrial Hepatopathies
The specific aims of this study are (1) to determine the clinical phenotypes and natural history of hepatic RC and FAO disorders, (2) to determine the correlation between genotype and phenotype, (3) to determine if circulating…
- Conditions
- Acute Liver Failure, Mitochondrial Diseases, End Stage Liver Disease, Respiratory Chain Deficiencies, Mitochondrial
- Trial name
- MITOHEP (NCT01148550)
- Where
- 16 sites in United States, Canada
- Volunteers
- 90 people
- Sponsor
- Arbor Research Collaborative for Health
Inborn Errors of Metabolism
Nutritional Therapy of the Deficits of Oxidation Mitochondrial of the Fatty Acids
Usual dietary therapies of mitochondrial fatty acid oxidation disorders (FAO) are based on 3 strategies: limitation of lipid intake in the diet; supplementation of the diet with medium-chain triglycerides (MCT) for patients…
- Trial name
- NCT00328159
- Testing
- Oil special 107 and MYGLIOL 810
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ADHD
Omega-3 Fatty Acids, Inflammation, Gut Microbiota in Youth With Depression
This is a 12 week double blind RCT aimed to investigate the role of omega-3 fatty acids in patients with major depressive disorder
- Trial name
- OMIMYDep (NCT07363551)
- Testing
- Omega-3 fatty acids
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- China Medical University Hospital
Urea Cycle Disorders, Organic Acidemias
At Home Ammonia Monitoring of Inborn Errors of Ammonia Metabolism
The goal of this observational study is to learn if people with certain ammonia metabolism disorders will measure their ammonia levels at home.
- Conditions
- Urea Cycle Disorders, Organic Acidemias, Fatty Acid Oxidation Disorder, Ammonia; Metabolic Disorder
- Trial name
- NCT06953505
- Testing
- Ammonia Study Device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Sequitur Health Corp.
Oligospermia
A Preliminary Study on Effect of Omega-3 on Human Sperm
The phospholipids of mammalian spermatozoa possess a distinctive fatty acid composition with high proportion of long chain polyunsaturated fatty acids.
- Trial name
- NCT00479960
- Testing
- commercially available omega-3 fatty acids supplementation
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Asthma, Obesity
Obesity and Asthma: Nutrigenetic Response to Omega-3 Fatty Acids
This project will assess the effectiveness of omega-3 fatty acid supplementation in controlling asthma symptoms among obese asthmatics, and will assess if a person's genes influence response to treatment (personalized medicine).
- Trial name
- NOOA (NCT01027143)
- Testing
- omega-3 polyunsaturated fatty acids, Omega-3 Fatty Acid
- Where
- 3 sites in United States
- Volunteers
- 143 people
- Sponsor
- Nemours Children's Clinic
Klinefelter Syndrome
Interrogating Fatty Acid Metabolism Impairment and Clinical Correlates in Males with Klinefelter Syndrome
This study will learn more about how the body uses energy. Usually, the body uses sugars as energy first and then fats are used when the sugar stores are gone. Some people have trouble using fats as energy.
- Trial name
- NCT05498090
- Testing
- Fenofibrate 145 mg
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Cow's Milk Allergy, Intolerance to Extensively Hydrolyzed Formulas
Evaluation of Fatty Acid Levels and Growth in Infants Fed Amino Acid Based (AA) Formulas
This clinical trial will compare the amount of fatty acids in whole blood of babies fed one of two study formulas for 4 months.
- Conditions
- Cow's Milk Allergy, Intolerance to Extensively Hydrolyzed Formulas, Intolerance to Breast Milk
- Trial name
- NCT01470768
- Testing
- Amino Acid-based Formula with high DHA and ARA, Amino Acid-based Formula with lower DHA and ARA
- Where
- United Kingdom
- Sponsor
- Mead Johnson Nutrition
Vitamin/Nutritional Deficiency, Neurobehavioral Manifestations
Walnuts, Long-Chain Polyunsaturated Fatty Acids and Adolescent Brain Development
Background: Adolescence is an important period for brain development as a result of increased synaptic plasticity. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are essential nutrients for brain development and protection…
- Trial name
- WALNUTs (NCT02590848)
- Testing
- Walnut intake
- Where
- Spain
- Volunteers
- 730 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health