Clinical trials: Feasibility Study, open to volunteers
Keratoconus
Evaluate the Safety and Feasibility of Same-Day Bilateral Epithelium-On Corneal Cross-Linking for Keratoconus
Clinical trial to evaluate the safety and feasibility of corneal cross-linking in both eyes on the same day in subjects with keratoconus.
- Trial name
- NCT07629557
- Testing
- Riboflavin Ophthalmic Solutions, UV-A Irradiation System
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Glaukos Corporation
Healthy Participants Study
ACT-based EMI in College Students
This study aims to evaluate the acceptability and effectiveness of a transdiagnostic, Acceptance and Commitment Therapy (ACT)-based ecological momentary intervention (EMI) among college students.
- Trial name
- NCT06843395
- Testing
- ACT-based ecological momentary intervention, Mood monitoring
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic
Feasibility Study Assessing the Effect of Carbidopa/Levodopa Ratio on Orthostatic Hypotension in Multiple System Atrophy - Parkinsonian Type and Parkinson Disease.
This study is aimed at patients with multi-system atrophy - parkinsonian type (P-MSA) or Parkinson's disease (PD) receiving dopaminergic drugs and suffering from orthostatic hypotension (OH).
- Conditions
- Multi-system Atrophy - Parkinsonian Type, Orthostatic Hypotension, Dysautonomic, Parkinson Disease
- Trial name
- CARBIDOH (NCT06831500)
- Testing
- Administration of Carbidopa/levodopa
- Where
- 2 sites in Switzerland
- Volunteers
- 36 people
- Sponsor
- Julien Bally
Maternal Cardiometabolic Health, Infertility
St Mary's Assisted Reproductive Technology and Cardiometabolic Health: Modifiable Targets for Multimorbidity Prevention (START-HEALThY)
The main causes of death in women are conditions affecting the heart and blood vessels (cardiovascular disease, CVD). Women who have difficulties getting pregnant (infertility) may be at increased risk, but the reasons for this…
- Conditions
- Maternal Cardiometabolic Health, Infertility, Assisted Reproductive Technology, Cardiovascular Health
- Trial name
- START-HEALThY (NCT07173569)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Childhood Obesity Prevention
Digitally Delivered Child Obesity Prevention for Parents in Home Visiting Programs
The goal of this clinical trial is to determine feasibility and acceptability of a digitally-based obesity prevention intervention for mothers of infants participating in a home visitation program.
- Trial name
- NCT07230808
- Testing
- digital intervention + home visiting curriculum, Home visiting curriculum
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida
Extremely Low Birth Weight Infants
Post-Extubation Assessment of Clinical Stability in ELBW Infants
This is an observational, proof-of-concept, feasibility study that aims to evaluate the feasibility of a monitoring system that integrates clinical data, high-resolution waveforms from the bedside monitor, regional oxygenation…
- Trial name
- PEACE (NCT06037083)
- Testing
- Oxygen saturation probe, Near infrared spectroscopy sensors, Electrical impedance tomography
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Obsessive Compulsive Disorder (OCD), CBT
Brief Cognitive Behaviour Therapy (CBT) for Adolescent OCD in Routine Clinical Practice
Obsessive-Compulsive Disorder (OCD) is a common and often disabling condition in young people, characterised by distressing, intrusive thoughts, images or urges, and repetitive behaviours intended to reduce discomfort or prevent…
- Trial name
- NCT06983301
- Testing
- Brief Cognitive Behavioural Therapy (CBT) for OCD
- Where
- 3 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- University of Oxford
Muscle Architecture, Ultrasonic Diagnosis
Feasibility and Preliminary Effects of a Structured Resistance Training Program in Children Aged 10-14 Years
This study is a randomised controlled pilot trial designed to evaluate the feasibility, safety, and preliminary efficacy of a 12-week resistance training intervention in children aged 10-14 years.
- Trial name
- NCT07512570
- Testing
- Progressive Resistance Training Program
- Where
- Czechia
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Examination Phobia
Dogs Offering Guidance: Therapeutic Observation for Reducing Examination Anxiety (DOGTOR).
Physiotherapists work closely with patients to assess, diagnose and treat a variety of conditions. Thus, it is essential that education should assess these key competencies through both written examinations (to measure cognitive…
- Trial name
- NCT07817459
- Testing
- Canine Group
- Where
- Australia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- La Trobe University
Congenital Heart Disease, Cardiac Output
UltraTrac for Cardiac Output Monitoring in Congenital Heart Disease
This pilot feasibility study will evaluate UltraTrac, an investigational noninvasive wearable device for continuous cardiac output monitoring, in patients with congenital heart disease.
- Conditions
- Congenital Heart Disease, Cardiac Output, Hemodynamic Monitoring, Pediatric Heart Disease
- Trial name
- UltraTrac (NCT07866573)
- Testing
- UltraTrac
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Minnesota
Central Nervous System Tumor
Brain Slice Explants to Predict Drug Response in Brain Tumors
This biospecimen collection study will evaluate the feasibility of engrafting and testing resected Central nervous system (CNS) tumors tumor tissue ex vivo to estimate drug response, in pediatric and adult subjects.
- Trial name
- NCT05978557
- Testing
- Biospecimen collection
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
PANS, PANDAS
PEDI Pediatric Autoimmune Neuropsychiatric Disorder Associated With Streptococcus Study
The objective of the Pediatric Epidemiological Data and Incidence (PEDI) PANDAS study is to demonstrate the feasibility of enrollment and retention of subjects in a study to determine the incidence and natural history of children…
- Trial name
- PANDAS (NCT06811935)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Wisconsin, Madison
Anorexia Nervosa, Atypical Anorexia Nervosa
Feasibility and Acceptability of Metacognitive Training for Eating Disorders in Adolescents With Anorexia Nervosa
This study aims to assess the feasibility and acceptability of Metacognitive Training for Eating Disorders (MCT-ED) in adolescents with anorexia nervosa and atypical anorexia nervosa.
- Trial name
- MCT-ED (NCT07435818)
- Testing
- Metacognitive Training for Eating Disorders
- Where
- Portugal
- Volunteers
- 14 people
- Sponsor
- University of Évora
Cerebral Palsy (CP), Unilateral Cerebral Palsy
tDCS and Bi-manual Training in Cerebral Palsy
Unilateral spastic cerebral palsy (USCP) is the most common subtype of cerebral palsy and significantly limits upper limb function.
- Conditions
- Cerebral Palsy (CP), Unilateral Cerebral Palsy, Spastic Cerebral Palsy (sCP)
- Trial name
- NCT07573865
- Testing
- Anodal tDCS
- Where
- Pakistan
- Volunteers
- 15 people
- Sponsor
- Riphah International University
To Assess the Feasibility, Visualization Capability, and Optimal Dosing of ICG Fluorescence Imaging for Intraoperative Assessment of Knee Tissue Perfusion
ICG Fluorescence in Knee Arthroscopy Study
The purpose of this study is to first evaluate whether ICG fluorescence angiography can be used to evaluate blood flow of the anterior cruciate ligament (ACL), tendons, and knee structures during an arthroscopic surgery.
- Trial name
- NCT07793266
- Testing
- Intravenous administration of indocyanine green (SPY Agent Green) 2 mL of SPY Agent Green (5.0 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 3 mL of SPY Agent Green (7.5 mg dose), Intravenous administration of indocyanine green (SPY Agent Green) 4 mL of SPY Agent Green (10 mg dose)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Henry Ford Health System
Feasibility Studies, Acceptability
Feasibility Study of a Relaxation and Guided Imagery Intervention Research Protocol for Use in School Settings.
The goal of this study is to gather information that (1) will be used to determine whether or not a research protocol for investigating the efficacy of a relaxation and guided imagery intervention for improving K-12 students'…
- Conditions
- Feasibility Studies, Acceptability, Pilot Study
- Trial name
- NCT07910695
- Testing
- Relaxation and Guided Imagery, Progressive Muscle Relaxation
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Pace University
Leukemia, Lymphoma
The PACMAN-Hu19 Trial: a Study of the Safety and Feasibility of Locally Produced, CD19-targeted and Human CAR T-cell Therapy in Children and Young Adults With Relapsed or Refractory B-cell Malignancies
PACMAN is a phase I/II single arm, open-label, multi-center study evaluating the safety of human CD19 CAR-T (huCAR19) produced locally using the Miltenyi Prodigy in children, adolescents and young adults with relapsed/refractory…
- Trial name
- PACMAN (NCT07020260)
- Testing
- CAR T-cell and Cellular Therapies
- Where
- 2 sites in Netherlands
- Volunteers
- 18 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Diffuse Midline Glioma, H3 K27-Altered
Focused Ultrasound Blood-Brain Barrier Opening in Pontine Diffuse Midline Glioma to Enhance Temozolomide Therapy: Pilot Feasibility Study (FIDES)
This study is for people (children and adults) with a rare and aggressive brain tumor called H3K27-altered diffuse midline glioma (DMG) located in the pons, a deep part of the brainstem.
- Trial name
- FIDES (NCT07562971)
- Testing
- Focused Ultrasound (FUS) Blood-Brain Barrier Opening, Temozolomide (TMZ)
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- UMC Utrecht
Urinary Tract Infection, Cellulitis
Perspectives on Antibiotics and Tracking Symptoms in Children
The study will assess families' perspectives and decision-making regarding the duration of oral antibiotic courses prescribed to children (4-17 years) who present with uncomplicated bacterial infections at the Royal Children's…
- Conditions
- Urinary Tract Infection, Cellulitis, Impetigo, Pharyngitis
- Trial name
- PATSy (NCT07093749)
- Testing
- Garmin Smartwatch
- Where
- Australia
- Volunteers
- 300 people
- Sponsor
- Murdoch Childrens Research Institute
Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
FUS Etoposide for DMG
The blood brain barrier (BBB) prevents some drugs from successfully reaching the target tumor. Focused Ultrasound (FUS) using microbubbles and neuro-navigator controlled sonication is a non-invasive method of temporarily opening…
- Trial name
- NCT05762419
- Testing
- Etoposide; Oral, 50 Mg, Focused ultrasound with neuro-navigator-controlled sonication
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University