Clinical trials: Febrile Illness
Malaria
Impact of Enhanced Health Facility Care in Uganda
The investigators propose to assess whether an intervention to build capacity and improve delivery of drugs and diagnostics at government-run health facilities improves the health of children and quality of care delivered, as…
- Trial name
- NCT01024426
- Testing
- Enhanced health facility-based care, Standard care
- Where
- Uganda
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Uganda Malaria Surveillance Project
Acute Febrile Illness
Evaluation of the DPP II Assay in Laos
Fever is the most frequent symptom in patients seeking care globally. Several causative agents of febrile illness have been described with a high prevalence in South East Asia.
- Trial name
- NCT04299607
- Testing
- DPP Fever Panel II assay and DPP Micro Readers
- Where
- Laos
- Volunteers
- 300 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Febrile Illness
Timmy3 Module Clinical Accuracy ISO 80601-2-56:2017 + A1 2018
The purpose of this document is to validate the clinical accuracy of the TIMMY3 thermometry module, integrated into host device CVSM, according to ISO 80601-2-56:2017 + A1 2018.
- Trial name
- NCT06056011
- Testing
- Connex CVSM with Timmy3 module
- Where
- 5 sites in United States
- Volunteers
- 373 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Fever, Febrile Illness
Fever and Febrile Support for Parents and Carers of Children 2016
To assess the suitability and user-friendliness of an information leaflet for parents on management of fever and febrile illness in children.
- Trial name
- NCT02903342
- Testing
- Leaflet
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University College Cork
Dengue Fever, Fever
Prospective Surveillance of Febrile Illness for Dengue-Endemic Areas in Asia
The purpose of this study is to detect acute febrile episodes and dengue infection in five Asian countries, to assess dengue seroprevalence, and to assess surveillance infrastructure at investigational sites in anticipation of a…
- Trial name
- NCT01218906
- Where
- 11 sites in Indonesia, Malaysia and 3 more
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Sanofi
Febrile Illness, Acute Cardiovascular Disease
Medication List in and Out of Hospital
30 patients acute hospitalized to medical ward and their medication records are examined. It is to be recorded how the investigators find information about medicine use by the reception when they do not follow the patient.
- Conditions
- Febrile Illness, Acute Cardiovascular Disease, Acute Respiratory Disease
- Trial name
- NCT01288846
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University of Oslo
Fever
Biomarkers of Mortality and Morbidity in Children Hospitalized With Fever
The objective of this study is to identify clinically informative biomarkers of host defense pathways with potential utility as diagnostic and prognostic tools among children hospitalized with acute febrile illness in a…
- Trial name
- NCT04726826
- Testing
- Diagnostic and prognostic biomarkers
- Where
- Uganda
- Volunteers
- 2,500 people
- Sponsor
- University of Alberta
Antimicrobial Resistance
Algorithm Using a Rapid Diagnostic Test for the Management of Childhood Febrile Diseases.
In Sub-Saharan Africa (SSA), fever remains a major public health problem in children. The introduction of malaria rapid diagnostic tests (RDTs) in routine healthcare has greatly improved the management of malaria.
- Trial name
- e-MANIC (NCT05285657)
- Testing
- Two-step malaria RDT detecting PfHRP2/pLDH (SD Ag Bioline Malaria Ag P.f/Pan: Standard Diagnostics, Hagal-Dong, Korea)
- Where
- 2 sites in Burkina Faso
- Volunteers
- 1,176 people
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Sepsis
Prediction of Disease Severity in Young Children Presenting With Acute Febrile Illness in Resource-limited Settings
Note that this is a study that is co-sponsored by Medecins Sans Frontieres, Spain, and the University of Oxford. The primary objective is to develop a risk prediction algorithm, combining measurements of host biomarkers and…
- Trial name
- SPOT-SEPSIS (NCT04285021)
- Where
- 6 sites in Bangladesh, Cambodia and 3 more
- Volunteers
- 3,433 people
- Sponsor
- Medecins Sans Frontieres, Spain
Fever, Infection
Personalised Risk Assessment in Febrile Illness to Optimise Real-life Management Across the European Union (PERFORM)
Childhood fever is a prevalent problem. Most febrile children who visit hospital improve without treatment, but a minority require treatment, and a few will have severe disease.
- Conditions
- Fever, Infection, Inflammation
- Trial name
- PERFORM (NCT03502993)
- Testing
- Validation of biomarker
- Where
- United Kingdom
- Volunteers
- 7,247 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Dengue, Dengue Vaccines
This Study Will Describe the Burden of DENgue Fever Virus (DENV) Illness Among Household Members Aged 6 Months to 50 Years of Selected Communities in Latin America and Southeast Asia
The purpose of this study is to describe the burden of DENV illness among household members aged 6 months to 50 years of selected communities in Latin America and Southeast Asia.
- Trial name
- NCT02766088
- Testing
- Blood sample collection
- Where
- 2 sites in Mexico, Philippines
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Infectious Disease, Febrile Illness
A Rapid Triage Test to Improve Risk-stratification of Febrile Children (EChiLiBRiST, Clinical Trial 1, Outpatients)
The overall aim of the study is to provide evidence that introducing novel biomarkers evaluation at triaging (first clinical assessment), in combination with IMCI-based guidelines (SoC), is a viable strategy to enhance rapid and…
- Conditions
- Infectious Disease, Febrile Illness, Child, Only
- Trial name
- NCT06422338
- Testing
- IMCI-enhanced by suPAR levels (SoC + suPAR POC)
- Where
- 2 sites in Gabon, Mozambique
- Volunteers
- 5,212 people
- Sponsor
- Barcelona Institute for Global Health
Acute Febrile Illnesses
Validation of Promising Biomarker Assays to Assess Their Diagnostic Performance Characteristics
This project aims to evaluate the performance characteristics of rapid tests to differentiate bacterial from non-bacterial infection in febrile adults and children presenting at OPDs (outpatient departments) i.e.("fever triage…
- Trial name
- NCT03047642
- Testing
- Biomarker assay
- Where
- 3 sites in Brazil, Gabon and 1 more
- Volunteers
- 2,000 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Acute Febrile Illness
Causes and Outcomes of Febrile Illness in Health Facilities in Rural South and Southeast Asia
This prospective multi-site observational study aims to describe causes and clinical outcomes of acute febrile illness as well as host biomarkers in patients aged >28 days residing in rural areas in Laos, Myanmar, Thailand, the…
- Trial name
- SEACTN-WP-B (NCT04629053)
- Where
- 4 sites in Bangladesh, Laos and 1 more
- Volunteers
- 7,200 people
- Sponsor
- University of Oxford
Acute Febrile Illness
Clinical Study of Transcriptome-based Diagnostic Biomarker for Acute Febrile Illness
Acute febrile illness is the main cause of outpatient visits，and bacterial and viral infections remains the most common cause. The diagnosis of infection is still based on symptoms and traditional techniques, resulting in overuse…
- Trial name
- NCT06552975
- Testing
- Infection
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University
Febrile Illness Acute
Treatment of Febrile Infectious Disease Among Children in Hadera District Given the Final Diagnosis. Descriptive Study
Study goal - to describe pediatric patients with febrile disease that administered to the emergency department (ED) of hillel-yaffe hospital, according to arrival diagnosis, ED diagnosis, given therapy, and therapy concordance…
- Trial name
- NCT02313532
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Hillel Yaffe Medical Center
Bloodstream Infection, Salmonella Bacteremia
Clinical Decision Support in Non-typhoidal Salmonella Bloodstream Infections in Children
In sub-Saharan Africa, non-typhoidal Salmonella (NTS) are a frequent cause of bloodstream infection, display high levels of antibiotic resistance and have a high case fatality rate (15%).
- Conditions
- Bloodstream Infection, Salmonella Bacteremia, Malaria,Falciparum, Severe Malaria
- Trial name
- DeNTS (NCT04473768)
- Where
- Belgium
- Volunteers
- 1,880 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Healthy, Febrile Illness
Comparison of Thermometry in Canada for Pediatrics
Compare and assess the accuracy and reliability of the InstaTemp MD® device to techniques presently in use for measuring temperature in infants and children in a Canadian clinical setting.
- Trial name
- CIT-CRCP (NCT03147534)
- Testing
- InstaTemp MD, "Welch Allyn", rectal, "Welch Allyn", oral
- Where
- 2 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- ARC Devices
Dengue
A Cohort Study to Determine the Incidence of Dengue Fever and to Build Capacity for Dengue Vaccine Trials in Dengue-endemic Regions of South Asia
The purpose of this study is to determine the incidence of dengue fever and to build capacity for dengue vaccine trials in dengue-endemic regions of South Asia.
- Trial name
- NCT02570152
- Testing
- Blood sample collection
- Where
- Sri Lanka
- Volunteers
- 2,004 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Febrile Illness, Healthy
NC Thermometer (Gen 3) ISO 80601-2-56 Validation
The purpose of this clinical validation is to evaluate the the clinical bias, the limits of agreement, and the clinical repeatability of measuring oral temperature using a new thermometer, NC° Thermometer (Gen 3), compared to a…
- Conditions
- Febrile Illness, Healthy, Fever
- Trial name
- NCT05721131
- Testing
- NC° Thermometer (Gen 3)
- Where
- 2 sites in United States
- Volunteers
- 105 people
- Sponsor
- Natural Cycles