Clinical trials: Fertility Disorders
Infertility
Single-center Prospective Cumulus Cell Test Study in rFSH Patients
Performing an additional non-invasive oocyte diagnostic test based on cumulus cell gene expression could improve the outcome of the ART cycle for rFSH stimulated patients
- Trial name
- NCT03663868
- Testing
- CC-Test
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Universitair Ziekenhuis Brussel
Stem Cell Transplant, Stem Cell Transplantation
Fertility Protection for Children, Adolescents and Young Adults
This study focuses on improving fertility preservation and long-term care for children, adolescents, and young adults (CAYA) undergoing cancer treatments or stem cell transplantation.
- Conditions
- Stem Cell Transplant, Stem Cell Transplantation, Oncological Outcomes, Oncological Patients
- Trial name
- FeProCAYA (NCT06692868)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Ulm
Fertility Preservation, Ovarian Tissue Cryopreservation
Preservation of Ovarian Cortex Tissue in Girls With Turner Syndrome
Rationale: Infertility due is a major concern for girls with Turner syndrome (TS) and their parents. Physicians are often asked about possible options to preserve their fertility.
- Conditions
- Fertility Preservation, Ovarian Tissue Cryopreservation, Turner Syndrome, Live Birth
- Trial name
- NCT03381300
- Testing
- Ovarian tissue cryopreservation
- Where
- Netherlands
- Volunteers
- 106 people
- Sponsor
- Radboud University Medical Center
Morbid Obesity
Bariatric Surgery Outcomes
The UCLA Metabolic and Bariatric Surgery Program (adult program) and the UCLA Fit for Healthy Weight Program (adolescent program) are committed to the care of morbidly obese patients. This study is observational.
- Trial name
- NCT01057784
- Testing
- Bariatric surgery.
- Where
- 2 sites in United States
- Sponsor
- University of California, Los Angeles
Cancer, Fertility Issues
Intervening on Women's Health for Rural Young Cancer Survivors
The purpose of this pilot study is to evaluate the feasibility of a multi-component intervention to improve young female cancer survivors' engagement in goal-concordant reproductive health care.
- Conditions
- Cancer, Fertility Issues, Contraception
- Trial name
- NCT06664034
- Testing
- Multi-component reproductive health care intervention
- Where
- 4 sites in United States
- Volunteers
- 42 people
- Sponsor
- University of California, San Diego
Klinefelter Syndrome
Fertility Preservation in Cases of Klinefelter Syndrome.
Klinefelter Syndrome (KS) is the most common sex chromosomal abnormalities (1/600 newborn males), and is characterized by a hypergonadism hypogonadism.
- Trial name
- FERTIPRESERVE (NCT01918280)
- Testing
- Seminal analyses and testicular biopsy
- Where
- 4 sites in France
- Volunteers
- 141 people
- Sponsor
- Hospices Civils de Lyon
Minimal Residual Disease, Fertility Preservation
Contamination of Ovarian Tissue by RT-PCR in Participants With Solid Tumors
For prepubertal patients, cryopreservation of ovarian tissue is the only option available to preserve their fertility before cancer treatment.
- Trial name
- OVAMAR (NCT02400827)
- Testing
- malignant cells
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Klinefelter Syndrome
Klinefelter Fertility Preservation
Klinefelter syndrome occurs in 1 in 600 males and is a common cause of infertility in men. It appears scar tissue forms in these boys' testicles, leading to progressive destruction over their lifetimes.
- Trial name
- NCT01817296
- Testing
- Testicular Biopsy
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Boston Children's Hospital
Abnormal Fertilization, Infertility
Outcomes of Embryos Created From Abnormally Fertilized Oocytes
The purpose of this study is to retrospectively analyze data from multiple clinics in a fertility network on embryos that were created from abnormally fertilized oocytes (AFO) including the rate of transfers and any clinical…
- Trial name
- NCT07666243
- Volunteers
- 92 people
- Sponsor
- Inception Fertility Research Institute, LLC
Colorectal (Colon or Rectal) Cancer, Pelvic Malignancies
Utero-ovarian Transposition in Patients With Pelvic Malignancies Undergoing Whole Pelvic Radiotherapy
This study is designed as a Phase I clinical trial enrolling female patients aged 18-40 years who have been diagnosed with pelvic malignancies requiring whole pelvic external radiation therapy (WPXRT) and who express interest in…
- Conditions
- Colorectal (Colon or Rectal) Cancer, Pelvic Malignancies, Oncofertility
- Trial name
- UOT WPXRT (NCT07419490)
- Testing
- Uteroovarian transposition
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of South Florida
Infertility Unexplained, Fertility Disorders
Hypnofertility for Women Undergoing In Vitro Fertilization (HWUIVF)
This randomized controlled study aimed to specify whether the interventions based on Hypnofertility would lead to increased fertility preparedness and pregnancy outcomes, decreased cortisol levels of women undergoing In Vitro…
- Trial name
- NCT04141436
- Testing
- Interventions Based on Hypnofertility, Routine clinical procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Dokuz Eylul University
Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract
Data Collection Study of Pediatric and Adolescent Gynecology Conditions
Background: Gynecologic conditions are those that are related to the reproductive system. They can be reproductive gland disorders or reproductive system tumors. They can also be inborn anomalies of the reproductive tract.
- Conditions
- Disorders of Sex Development (DSD), Pediatric and Adolescent Cancers of the Genital Tract, Reproductive Endocrine Conditions in Puberty, Structural Gynecologic Conditions Including Vulvar and Vaginal Conditions
- Trial name
- NCT04717349
- Where
- United States
- Volunteers
- 11,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Sickle Cell Anemia
Serial Assessment of Fertility Experiences
The SAFE study is a long-term research project that watches people with sickle cell anemia (SCA) over time. The main goal is to see how a medicine called hydroxyurea affects their growth, puberty, and ability to have children.
- Trial name
- SAFE (NCT07116772)
- Where
- 3 sites in Dominican Republic, Jamaica and 1 more
- Volunteers
- 250 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Infertility, Female
Ovarian Tissue Cryopreservation
Ovarian Tissue Freezing For Fertility Preservation In Girls Facing A Fertility Threatening Medical Diagnosis Or Treatment Regimen
- Trial name
- OTC (NCT06710769)
- Testing
- Ovarian tissue removal will be performed laparoscopically
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Phoenix Children's Hospital
Fertility Preservation, Lymphoma
AMH as a Predictor of Infertility Risk in Children With Cancer (CHANCE)
While most of the children spontaneously recover menstruation or experienced normal puberty after chemotherapy, their ovarian reserve may be impaired by treatment inducing future infertility.
- Conditions
- Fertility Preservation, Lymphoma, Pediatrics Cancer, Gonadotropin-releasing Hormone Agonist
- Trial name
- CHANCE (NCT02595255)
- Testing
- No intervention
- Where
- 8 sites in Belgium, France
- Volunteers
- 275 people
- Sponsor
- Erasme University Hospital
Fertility Disorders, Turner Syndrome
The Danish TURNER Cryopreservation Study
The goal of this clinical trial is to investigate if cryopreservation of ovarian tissue in girls with Turner syndrome can improve their fertility and lead to increased number of liveborn babies of Turner syndrome mothers.
- Conditions
- Fertility Disorders, Turner Syndrome, Premature Ovarian Failure
- Trial name
- DANTE (NCT05740579)
- Testing
- laparoscopic cryopreservation of one ovary
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Infertility
Influence of Ethnical Differences on the Egg Cell Collected in Patients Undergoing Fertility Treatment
Investigators wants to analyze the differences considering the country of origin, ethnicity, characteristics, reproductive history and habits of participants undergoing in vitro fertilization (IVF) / intracytoplasmic sperm…
- Trial name
- NCT03927417
- Where
- United Arab Emirates
- Volunteers
- 1,117 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Ovarian Diseases, Fertility Issues
A Novel Ovarian Reserve Monitoring Algorithm for Patients at Risk of Ovarian Injury From Gonadotoxic Therapy
This is an observational cohort study to examine the use of a novel proposed ovarian reserve monitoring algorithm to (1) identify patients who are at risk of DOR and POI from gonadotoxic therapy, (2) minimize time from treatment…
- Conditions
- Ovarian Diseases, Fertility Issues, Gonadal Disorders
- Trial name
- MA (NCT05048654)
- Sponsor
- University of Colorado, Denver
Fertility Issues
Correlation of Urinary and Serum Hormone Levels in Natural Cycle Frozen Embryo Transfer Cycles
To evaluate whether the measurement of urinary estrone glucuronide and luteinizing hormone (LH) concentrations with an at-home device is correlated with serum hormone levels within a natural cycle frozen embryo transfer protocol.
- Trial name
- MIRA (NCT06410170)
- Testing
- MIRA Device
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ottawa Fertility Centre
Fertility Disorders
Natural Frozen Embryo Transfer (FET) vs Substituted Frozen Embryo Transfer (FET)
In frozen embryo transfer substituted cycles, patients are treated with progesterone and estrogen in an attempt to mimic the natural cycle and a transfer is planned whenever the endometrium is ready.
- Trial name
- NCT06053827
- Testing
- Frozen embryo transfer
- Where
- Canada
- Volunteers
- 1,207 people
- Sponsor
- Clinique Ovo