Clinical trials: Fertility Preservation
Colorectal (Colon or Rectal) Cancer, Pelvic Malignancies
Utero-ovarian Transposition in Patients With Pelvic Malignancies Undergoing Whole Pelvic Radiotherapy
This study is designed as a Phase I clinical trial enrolling female patients aged 18-40 years who have been diagnosed with pelvic malignancies requiring whole pelvic external radiation therapy (WPXRT) and who express interest in…
- Conditions
- Colorectal (Colon or Rectal) Cancer, Pelvic Malignancies, Oncofertility
- Trial name
- UOT WPXRT (NCT07419490)
- Testing
- Uteroovarian transposition
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of South Florida
Fertility Preservation
Oocyte Cryopreservation
The specific aim of this study is to further develop methods of oocyte cryopreservation and evaluate their impact on reproductive outcomes.
- Trial name
- NCT01696786
- Testing
- Oocyte cryopreservation
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Fertility Preservation
Improving Human Ovarian Transplantation
we will perform xenotransplantation and in vitro culture of ovarian tissue from patients undergoing ovarian cortex cryopreservation.
- Trial name
- NCT00827476
- Testing
- ovarian transplantation
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Infertility, Female
Ovarian Tissue Cryopreservation
Ovarian Tissue Freezing For Fertility Preservation In Girls Facing A Fertility Threatening Medical Diagnosis Or Treatment Regimen
- Trial name
- OTC (NCT06710769)
- Testing
- Ovarian tissue removal will be performed laparoscopically
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Phoenix Children's Hospital
Fertility Preservation, Lymphoma
AMH as a Predictor of Infertility Risk in Children With Cancer (CHANCE)
While most of the children spontaneously recover menstruation or experienced normal puberty after chemotherapy, their ovarian reserve may be impaired by treatment inducing future infertility.
- Conditions
- Fertility Preservation, Lymphoma, Pediatrics Cancer, Gonadotropin-releasing Hormone Agonist
- Trial name
- CHANCE (NCT02595255)
- Testing
- No intervention
- Where
- 8 sites in Belgium, France
- Volunteers
- 275 people
- Sponsor
- Erasme University Hospital
Female Patients Aged 5-35 Prior to Systemic Chemotherapy, With Significant Risk of Ovarian Toxicity
Fertility Preservation by Ovarian and Oocyte Cryopreservation
Success rates of cancer treatment have increased significantly resulting in many girls and young women who are treated now and will be cancer survivors. Nevertheless, cancer treatment may result in long term side effects.
- Trial name
- HFPP (NCT00578500)
- Testing
- ovarian transplantation
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
Fertility, SPERM
Male Fertility and Sperm Cryopreservation
PURPOSE: Primary objective: To assess the feasibility and outcomes of male fertility preservation by sperm freezing prior to starting treatment requiring alkylating agents and/or total body irradiation.
- Conditions
- Fertility, SPERM, Cancer
- Trial name
- NCT02431000
- Testing
- Sperm and blood collected for analysis
- Where
- United States
- Sponsor
- University of Tennessee
Female Infertility
Follow-up of Ovarian Function in Young Women Who Underwent Ovarian Cortex Cryopreservation
Evaluation of ovarian function by a questionnaire and by medical file analysis of women and girls who underwent ovarian cortex cryopreservation for fertility preservation between 1997 an 2013 in the investigators' institution in…
- Trial name
- NCT02454829
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 546 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Fertility Disorders, Childhood Cancer
Cryopreservation of Prepubertal Testicular Tissue for Preservation of Fertility in Young Boys With Cancer
Prepubertal boys treated for cancer are at risk of infertility as a result of their treatment. At present there are no options to preserve fertility in these boys.
- Trial name
- NCT06063551
- Testing
- Testicular Biopsy
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Edinburgh
Minimal Residual Disease, Fertility Preservation
Contamination of Testicle Tissue by RT-PCR in Participants With Solid Tumors
For prepubertal patients, cryopreservation of testicular tissue is the only option available to preserve their fertility before cancer treatment.
- Trial name
- TESTIMAR (NCT02400970)
- Testing
- malignant cells
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Gender Dysphoria, Transgender
Ovarian Tissue Cryopreservation in the Setting of Gender-affirming Therapy
The goal of this study is to learn about fertility preservation in the gender-diverse community. The main objectives it aims to understand are to: 1.
- Trial name
- NCT05863676
- Testing
- Oophorectomy, Infectious Disease Testing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pittsburgh
Infertility
Efficacy and Safety of Fertility Treatments and Fertility Preservation
This study analyses clinical data prospectively collected for over a decade in several clinical databases. Electronic medical records are available since 1998.
- Trial name
- NCT04602962
- Testing
- fertility preservation, several methods
- Where
- Sweden
- Volunteers
- 50,000 people
- Sponsor
- Karolinska Institutet
Amenorrhea, Premature Ovarian Failure
GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patients
Primary Objectives: To determine the effectiveness of the 3-month depot leuprolide in inducing and maintaining secondary amenorrhea in patients undergo hematopoietic stem cell transplantation.
- Conditions
- Amenorrhea, Premature Ovarian Failure, Ovarian Function Insufficiency
- Trial name
- NCT00429494
- Testing
- Leuprolide Acetate, Questionnaire, Hematopoietic Stem Cell Transplantation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Ovarian Cancer
Gonadal Dysgenesis Tissue Cryopreservation for Fertility Preservation
The "Gonadal Dysgenesis Tissue Cryopreservation for Fertility Preservation" study is open to a subset of patients with disorders of sex development (DSD) which is associated with the risk of malignancy and a high risk of…
- Trial name
- NCT06518746
- Testing
- Cryopreservation of gonadal tissue
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Cancer, Hematologic Disorder
Fertility Preservation With Ovarian Tissue Freezing
The purpose of this study is to obtain ovarian tissue from female patients undergoing gonadotoxic treatments or gonadal ablating surgery, and that in consequence may see their future fertility impaired.
- Conditions
- Cancer, Hematologic Disorder, Infertility, Ovarian Failure
- Trial name
- PTO (NCT03674164)
- Testing
- Ovarian Cryopreservation
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- St. Justine's Hospital
Infertility, Male
Fertility Preservation in Male AYA With Cancer
Very little is known about how medical providers can help adolescent and young adults (AYAs) and their caregivers make decisions about fertility preservation (sperm banking) before beginning cancer treatment.
- Trial name
- NCT04268004
- Testing
- FP Decision Tool and Discussion
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Leena Nahata
Oncology [See Also, Affected System]
Fertility Preservation in Prepubertal Boys: An Experimental Approach
Due to remarkable advances in cancer treatments, the investigators are witnessing a growing population of long-term survivors of childhood malignancies.
- Trial name
- NCT02529826
- Testing
- Testicular Biopsy
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Cancer in Pregnancy, Fertility Preservation
Advisory Board on Cancer, Infertility and Pregnancy
The Advisory Board on Cancer, Infertility and Pregnancy provides a platform where physicians from all over the world can request recommendations regarding the medical care of pregnant women diagnosed with cancer or regarding…
- Conditions
- Cancer in Pregnancy, Fertility Preservation, Cancer, Pregnancy
- Trial name
- ABCIP (NCT04904263)
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Gasthuisberg
Effects of Chemotherapy, Premature Ovarian Failure
Ovarian Reserve After Cancer: Longitudinal Effects
Women of reproductive age who will receive treatment for cancer that includes chemotherapy may participate in a study measuring ovarian function over time.
- Trial name
- ORACLE (NCT02467231)
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cancer, Autoimmune Disorders
Testicular Tissue Cryopreservation for Fertility Preservation
Testicular tissue cryopreservation is an experimental procedure where a young boy's testicular tissue is retrieved and frozen. This technique is reserved for young male patients who are not yet producing mature sperm, with the…
- Trial name
- NCT02972801
- Testing
- Testicular biopsy
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- University of Pittsburgh