Clinical trials: Fetal Anomaly
Mullerian Anomaly of Uterus, Nec, Mullerian Anomaly of Vagina
Diagnostic, Therapeutic and Reproductive Aspects of Patients With Mullerian Anomalies
The purpose of this study is to get a better understanding of the clinical implications (including reproductive problems and obstetric complications), appropriate diagnostic tools and correct surgical treatment of Mullerian…
- Conditions
- Mullerian Anomaly of Uterus, Nec, Mullerian Anomaly of Vagina, Mullerian Anomaly of Cervix
- Trial name
- MULAN (NCT04627818)
- Where
- Belgium
- Volunteers
- 1,500 people
- Sponsor
- University Hospital, Ghent
Gorham Disease, Lymphatic Diseases
Imaging of Lymphatic Anomalies
Lymphatic Anomalies (LA) is characterized by proliferation of lymphatic tissue causing deterioration of pulmonary function. Understanding changes in lymphatic anatomy in these patients is hindered by the difficulty of imaging the…
- Conditions
- Gorham Disease, Lymphatic Diseases, Lymphangiomatosis
- Trial name
- NCT02744027
- Testing
- Dynamic Contrast Enhanced Magnetic Resonance Lymphangiography (DCMRL), Heavy Weighted T2 Imaging (T2W), Lymph Node Access
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Hospital of Philadelphia
Pregnancy Related, Fetal; Circulation
Doppler Ultrasonographic Assessment of Fetal Internal Thoracic Artery Indexes
The aim of this study is to assess the feasibility of visualizing the internal thoracic artery (ITA), establishing the normogram for ITA pulsatility index (PI), resistance index (RI) and acceleration/ejection time (AT/ET) at…
- Trial name
- NCT04686240
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Osteogenesis Imperfecta
Boost Brittle Bones Before Birth
An exploratory, open label, multiple dose, multicentre phase I/II trial evaluating safety and efficacy of postnatal or prenatal and postnatal administration of allogeneic expanded fetal mesenchymal stem cells for the treatment of…
- Trial name
- BOOSTB4 (NCT03706482)
- Testing
- BOOST cells
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Karolinska Institutet
Stillbirth, Intrauterine Growth Retardation
Antenatal Detection of Fetal Growth Restriction and Stillbirths Rate.
The main objective is to assess the role of antenatal detection of fetal growth restriction (FGR) on stillbirth, by a case-control study in a population-based sample of small for gestational age (SGA) livebirths and stillbirths…
- Conditions
- Stillbirth, Intrauterine Growth Retardation, Infant, Small for Gestational Age
- Trial name
- REPERE (NCT01995968)
- Testing
- Antenatal identification of fetal growth restriction
- Where
- 21 sites in France
- Volunteers
- 480 people
- Sponsor
- University Hospital, Grenoble
Preterm Infant, Placental Insufficiency
Effect of Delayed Cord Clamping in Preterm Neonates With Placental Insufficiency
To investigate the effect of delayed cord clamping (DCC) on hematopoietic progenitor cells (HPCs), hematological parameters including haemoglobin concentration and hematocrit value in premature infants (34 weeks gestational age…
- Conditions
- Preterm Infant, Placental Insufficiency, Placental Transfusion
- Trial name
- NCT03731546
- Testing
- Delayed cord clamping
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University Children Hospital
Infant, Newborn, Diseases, Fetus or Neonate Affected by Cesarean Section
HeartLight: Heart Rate Monitoring for Newborn Resuscitation
This study will compare a newborn heart rate sensor (HeartLight) that is integrated into a hat with other common forms of heart rate monitoring such as electrocardiography (ECG), stethoscope and pulse oximetry (PO) in newborn…
- Conditions
- Infant, Newborn, Diseases, Fetus or Neonate Affected by Cesarean Section, Infant, Premature, Diseases
- Trial name
- HeartLight (NCT02701920)
- Testing
- HeartLight hat, The HeartLight hat with in-built sensor, HeartLight
- Where
- United Kingdom
- Volunteers
- 184 people
- Sponsor
- University of Nottingham
Malaria in Pregnancy, Pregnancy Related
MiMBa Pregnancy Registry
The MiMBa (Malaria in Mothers and Babies) Pregnancy Registry aims to generate robust evidence on the safety of a range of antimalarials when used in pregnancy, particularly in the first trimester.
- Conditions
- Malaria in Pregnancy, Pregnancy Related, Congenital Anomaly
- Trial name
- NCT04825782
- Where
- 2 sites in Burkina Faso, Kenya
- Volunteers
- 15,391 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Congenital Heart Disease in Children, Hypoxia
Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior
Determine 1) the impact of abnormal fetal cerebrovascular physiology with neurodevelopmental delay (ND) outcomes and 2) how this relationship is modified by patient and environmental factors such as chronic congenital heart…
- Conditions
- Congenital Heart Disease in Children, Hypoxia, Neurodevelopmental Disorders, Complex Congenital Heart Disease
- Trial name
- NCT05767385
- Testing
- Single Arm, Neonatal Neurobehavioral Scale
- Where
- 5 sites in United States
- Volunteers
- 104 people
- Sponsor
- University of Utah
IUGR, Fetal Growth Retardation
Cardiac Displacement From Third Trimester to Early Childhood
The aim is to increase awareness of the relationship between (IUGR) and cardiac function in the foetus, the development of cardiac function over time after delivery and what significance a possible early disturbed myocardial…
- Conditions
- IUGR, Fetal Growth Retardation, Intrauterine Growth Restriction
- Trial name
- CADETTE (NCT02583763)
- Testing
- Echocardiography, Blood sample
- Where
- 2 sites in Sweden
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Persistent Pulmonary Hypertension of Newborn
Treprostinil in Newborns With Pulmonary Hypertension; a Non-Interventional Study to Collect Data on Drug Utilization, Safety, and Effectiveness
This observational study will seek to describe the uses and safety and efficacy outcomes of treprostinil in clinical practice in patients with persistent pulmonary hypertension (PPHN).
- Trial name
- NEPHY (NCT06499363)
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Ferrer Internacional S.A.
Renal Failure Congenital, Congenital Renal Anomaly Nos
Serial Amnioinfusions as Regenerative Therapy for Pulmonary Hypoplasia
Congenital lower urinary tract obstruction (LUTO) is a heterogeneous group of congenital anomalies that lead bladder outlet obstruction.
- Conditions
- Renal Failure Congenital, Congenital Renal Anomaly Nos, Renal Agenesis and Dysgenesis, Lower Urinary Tract Obstructive Syndrome
- Trial name
- NCT03723564
- Testing
- Lactated Ringers Solution for Injection
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Fetal Alcohol Spectrum Disorders
Dissecting the Genetics of Fetal Alcohol Spectrum Disorders
The purpose of this study is to help scientists understand why some people who were exposed to alcohol in the womb have special facial features but other people do not.
- Trial name
- DiGFASD (NCT04072809)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 751 people, healthy volunteers welcome
- Sponsor
- Indiana University
Dissociation, Depersonalization
Dissociation CBT Studies
Dissociation involves distressing feelings of unreality and disconnection. Evidence suggests it is particularly common amongst people with existing mental health difficulties, where it has been linked with greater clinical…
- Conditions
- Dissociation, Depersonalization, Dissociative Disorder
- Trial name
- DisCS (NCT06054009)
- Testing
- Brief CBT
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Birmingham
Clubfoot
Children Born With Club Feet
Clubfoot is one of the most common birth defects, with a prevalence in Europe estimated between 1 and 4.5 for 1000 live birth. It is useful to distinguish the forms of isolated clubfoot, and the forms related to others…
- Trial name
- CBCF (NCT03671863)
- Testing
- Invasive analysis (caryotype, CGH array), Prenatal management
- Where
- France
- Volunteers
- 219 people
- Sponsor
- University Hospital, Montpellier
Kernicterus
Does Maternal Instruction Prevent Kernicterus in Nigeria?
This study examines (a) whether introduction of public, health provider, and maternal education about risks of jaundice will decrease the occurrence of ABE compared with baseline prevalence (before-after design) or (b) whether…
- Trial name
- NCT02713464
- Testing
- maternal education
- Volunteers
- 1,765 people
- Sponsor
- Bilimetrix s.r.l.
Persistent Pulmonary Hypertension of Newborn
N-Terminal Pro-brain Natriuretic Peptide Hormone and Persistent Pulmonary Hypertension
Babies who are suspected of having persistent pulmonary hypertension (PPHN) will be included in this study. PPHN is a condition in which the blood is restricted from flowing to the lungs in a normal way making it hard for babies…
- Trial name
- NCT00443859
- Where
- 2 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Stillbirth, Neonatal Death
Intermittent Auscultation Using Handheld Doppler: a Randomized Controlled Trial Comparing Perinatal Outcomes in Uganda
A novel handheld Doppler has been developed which is rugged and is powered only by a hand crank. This study aims to test the use of this Doppler versus the Pinard horn to monitor the fetal heart rate in labour in a hospital…
- Trial name
- NCT02273037
- Testing
- Fetal heart rate Doppler, Partograph
- Where
- 2 sites in Canada, Uganda
- Volunteers
- 1,987 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Intrauterine Growth Retardation (IUGR), Lung Function Tests
Early Lung Function Trajectories: Comparison Between Infants With and Without Intrauterine Growth Restriction.
During intrauterine life, some babies are smaller or grow less than expected. This fetal growth abnormality, called fetal growth restriction (FGR), can be diagnosed by ultrasound.
- Conditions
- Intrauterine Growth Retardation (IUGR), Lung Function Tests, Preterm Infant, Respiratory Monitoring
- Trial name
- ELFIGO (NCT06919757)
- Testing
- fetal ultrasound to assess lungs, heart and diaphragm
- Where
- Italy
- Volunteers
- 54 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Comparative Genomic Hybridization
Evaluation of the Relevance of Comparative Genomic Hybridization in Prenatal Diagnosis
Pre-natal diagnosis is developing nowadays thanks to the improvement of ultrasound performances but also of genetic analysis techniques. The karyotype was previously the reference technique for genetic analysis.
- Trial name
- NCT04814563
- Where
- France
- Volunteers
- 830 people
- Sponsor
- Central Hospital, Nancy, France