Clinical trials: Fetal Conditions
Fetal Growth Retardation, Stillbirth
Prediction of Late Fetal Growth Restriction Using Cerebroplacental Ratio
To investigate the screening performance of CPR and biophysical profile score for the prediction of composite of adverse neonatal morbidity and mortality and operative delivery (CS or instrumental) for intrapartum fetal distress…
- Conditions
- Fetal Growth Retardation, Stillbirth, Neonatal Respiratory Failure, Neonatal Death
- Trial name
- NCT04640467
- Testing
- Biophsical profile, Cerebroplacental ratio
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Assiut University
Intrauterine Growth Restriction
Impact of Maternal Pomegranate Juice on Brain Injury in Infants With Intrauterine Growth Restriction (IUGR)
Infants with intrauterine growth restriction are known to be at increased risk for long term neurodevelopmental delay into adulthood.
- Trial name
- POM-1 (NCT00788866)
- Testing
- Pomegranate Juice
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Washington University School of Medicine
Stillbirths and Infant Mortality
Oral Azithromycin to Prevent Stillbirths and Infant Mortality in Mali
The double blind randomized controlled trial will assess the efficacy of oral azithromycin administered to pregnant women and/or infants during routine care in preventing stillbirths and mortality through 6-12 months of age in…
- Trial name
- SANTE (NCT03909737)
- Testing
- Azithromycin to pregnant women, Azithromycin to infants, No intervention to pregnant women
- Where
- Mali
- Volunteers
- 99,700 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Fetal Distress, Fetal Hypoxia
Maternal Oxygen Supplementation for Intrauterine Resuscitation
More than 80% of the 3 million women who labor and deliver each year in the United States undergo continuous electronic fetal monitoring (EFM) during labor in order to fetal hypoxia and prevent the transition to acidemia…
- Conditions
- Fetal Distress, Fetal Hypoxia, Labor and Delivery Complication
- Trial name
- MOXY (NCT05681624)
- Testing
- Maternal oxygen supplementation, Room air
- Where
- United States
- Volunteers
- 2,252 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Birth Weight
Effect of Caffeine on Fetal Growth
The purpose of this study is to determine whether caffeine has any effect on birth weight.
- Trial name
- NCT00131690
- Testing
- Nescafé Gold Blend (exposed), Nescafé Decaffeinated (controls)
- Where
- Denmark
- Volunteers
- 1,200 people
- Sponsor
- The Danish Epdiemiology Science Centre
Pre-Eclampsia, Intrauterine Growth Restriction
Inter- and Multidisciplinary, Cross-sectoral Feto-neonatal Pathway
Due to the fetoneonatal pathway it is possible to identify pregnant women with an increased risk of fetal growth restriction or pre-eclampsia in early stages (from 10th week of pregnancy).
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Maternal Care for Known or Suspected Poor Fetal Growth
- Trial name
- NCT04514276
- Testing
- consecutive fetoneonatal healthcare pathway
- Where
- 2 sites in Germany
- Volunteers
- 828 people
- Sponsor
- Technische Universität Dresden
Pregnancy Complications
Measuring sVAP-1 as a Predictor of Pregnancy Problems
Pre-eclampsia is a common pregnancy disorder defined as high blood pressure and protein in the urine after 20 weeks of pregnancy.
- Trial name
- NCT04891315
- Testing
- Blood test for soluble VAP-1 (sVAP-1).
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Persistent Pulmonary Hypertension of Newborn
Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn
The aim of this study is to evaluate the effectiveness of nebulized magnesium sulfate combined with sildenafil citrate, compared with sildenafil citrate alone, in treating neonates with severe persistent pulmonary hypertension on…
- Trial name
- NCT04898114
- Testing
- Magnesium sulfate, Sildenafil Citrate, Isotonic saline
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Cytomegalovirus Congenital, Hearing Loss
Epidemiology of Congenital Cytomegalovirus in a High HIV Prevalence Setting, South Africa
The aim of this project is to determine the epidemiology of congenital cytomegalovirus (CMV) infection and incidence of subsequent permanent neurological sequelae in a high HIV prevalent setting in Soweto, Johannesburg.
- Conditions
- Cytomegalovirus Congenital, Hearing Loss, Neurodevelopmental Disorders, Immunogenicity
- Trial name
- NCT03722615
- Where
- South Africa
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Fetal Growth Retardation
Day to Day Variation in Fetal Heart Rate Variability
This study evaluates the day-to-day variation in fetal heart rate variability based on non-invasive fetal-ECG (NI-FECG). Furthermore, the effect of fetal movements on fetal heart rate variability will be assessed.
- Trial name
- (FHRV) (NCT04289350)
- Testing
- fetal heart rate variability
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- University of Aarhus
Childhood Obesity
The Healthy Lifestyles Passport Program: a Nutrition Education Program to Prevent Childhood Obesity
The purpose of this study is to evaluate the effectiveness of the Healthy Lifestyles Passport Program (HLPP) in preventing infant and childhood obesity.
- Trial name
- HLPP (NCT01649115)
- Testing
- Healthy Lifestyles Passport
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Bronx-Lebanon Hospital Center Health Care System
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development
Maternal Adversity, Vulnerability and Neurodevelopment
Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) project is a prospective community-based, pregnancy and birth cohort of Canadian mother-child dyads.
- Conditions
- Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development, Infant Behavior
- Trial name
- MAVAN (NCT03434457)
- Where
- Canada
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Microbial Colonization
Shaping Microbiome in the First 1,000 Days of Life
Events occurring in the early stages of life play an important role in the development of chronic diseases; diet and lifestyle during pregnancy are recognized to be crucial determinants in modulating offspring microbiota…
- Trial name
- AMAMI (NCT04122612)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Pregnancy Complications, Preterm Birth
Group Antenatal/Postnatal Care in Rwanda
The focus of this work is to improve antenatal care (ANC) and postnatal care (PNC) at the health center level in five districts in Rwanda (Bugesera, Burera, Nyamasheke, Nyarugenge, and Rubavu).
- Conditions
- Pregnancy Complications, Preterm Birth, Preterm Labor, Stillbirth
- Trial name
- PTBi Rwanda (NCT03154177)
- Testing
- Group ANC/PNC, Ultrasound+Pregnancy Testing
- Where
- 2 sites in Rwanda
- Volunteers
- 26,381 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Meconium Aspiration Syndrome
Lung Lavage With Dilute Poractant Alfa for Meconium Aspiration Syndrome
Meconium aspiration syndrome (MAS) is an important cause of severe respiratory failure in newborn infants. Treatment for MAS is mainly supportive but surfactant therapy might change the course of the disease.
- Trial name
- NCT02041546
- Testing
- Lung lavage with surfactant, Bolus surfactant
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Down Syndrome, Aneuploidy
Noninvasive Screening for Affected Pregnancies: Assay Development & Optimization in Affected Pregnancies
To collect samples for the purpose of developing and optimizing an in vitro noninvasive prenatal diagnostic (NIPD) test. The NIPD test employs circulating cell free (ccff) DNA extracted from whole blood samples collected from…
- Trial name
- CHARMM-AP (NCT01052688)
- Testing
- Maternal blood draw of 30 to 50ml
- Where
- 10 sites in United States
- Volunteers
- 150 people
- Sponsor
- Sequenom, Inc.
ABO Incompatibility, Hemolytic Disease of Newborn
Measurement of Carboxyhemoglobin by Gas Chromatography as an Index of Hemolysis
The purpose of this research study is to more accurately measure the amount of true red blood cell breakdown (hemolysis) in newborn babies with potentially problematic blood type mismatch with their mothers (ABO incompatibility)…
- Conditions
- ABO Incompatibility, Hemolytic Disease of Newborn, Neonatal Jaundice, Neonatal Hyperbilirubinemia
- Trial name
- NCT00917007
- Where
- 2 sites in United States
- Sponsor
- State University of New York - Upstate Medical University
Developmental Delay
Improving Neurodevelopmental ouTcomes After Prenatal Cannabinoid in uTero Exposure
The INTACT trial is a multisite pilot feasibility study aimed at testing the effectiveness of the INTACT Intervention program in improving neurodevelopmental outcomes in infants prenatally exposed to cannabinoids.
- Trial name
- INTACT (NCT06423664)
- Testing
- Play and Learn Strategies (PALS) Program
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IDeA States Pediatric Clinical Trials Network
Transient Tachypnea of Newborn and Fetal Acidosis
Impact Of Maternal Spinal Anesthesia-Induced Hypotension At Scheduled Cesarean Delivery On Risk Development Of Transient Tachypnea Of Newborn And Fetal Acidosis
We will evaluate the association between transient tachypnea of newborns and fetal acidosis development to the degree and duration of maternal hypotension and anesthesia to delivery time during spinal anesthesia at scheduled…
- Trial name
- NCT06383624
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Benha University
Pregnant Individuals, Aneuploidy
The ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) Study is the Largest U.S.-Based Prospective Study Demonstrating a Circulating Fetal Cell (CFC) Based Approach to Non-invasive Fetal Risk Assessment
The goal of the ADVANCE (Assay Development and Validation for Pre-Natal and Obstetric Conditions) study is to compare the concordance of results of a novel non-invasive circulating fetal cell (CFC) assay to the results of…
- Conditions
- Pregnant Individuals, Aneuploidy, Down Syndrome (Trisomy 21), 22q11.2 Deletion Syndrome
- Trial name
- ADVANCE (NCT07643896)
- Where
- 9 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- BillionToOne Inc.