Clinical trials: Fistulizing Crohn's Disease
Perianal Fistula
Phase 1 Crohn's Pediatric Sub-study of MSC AFP
The investigators propose to study the safety of autologous mesenchymal stromal cell transfer using a biomatrix (the Gore Bio-A Fistula Plug) in a Phase I study using a single dose of 20 million cells.
- Trial name
- NCT03014219
- Testing
- Only 1 arm: treatment with MSC-AFP
- Where
- United States
- Sponsor
- William A. Faubion, M.D.
Perianal Fistula Due to Crohn's Disease (Disorder)
Study of Mesenchymal Stem Cells for Pediatric Perianal Fistulizing Crohn's Disease
This study plans to enroll 10 patients aged 13-17 years of age with refractory perianal fistulizing disease. Patients will be treated by direct injection to the fistula tract(s) with 75 million allogeneic bone marrow derived…
- Trial name
- NCT04791878
- Testing
- Mesenchymal stem cells
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Anthony Lembo
Crohn Disease
Treatment and Fate in Fistulizing Crohn's Disease in a Pediatric Population
Crohn's disease is a inflammatory bowel disease evolving towards the destruction of the intestinal wall resulting in stenosing or perforating complications (fistulas, abscesses).
- Trial name
- NCT05759104
- Testing
- Infliximab, Stomy
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Crohn Disease, Perianal Fistula
Risankizumab for Refractory Perianal Fistulizing Crohn's Disease
Crohn's disease is an inflammatory bowel disease characterized by relapses and remissions, causing lesions throughout the digestive tract and accompanied by diarrhea, abdominal pain, and nutritional disorders.
- Conditions
- Crohn Disease, Perianal Fistula, Perianal Fistula Due to Crohn's Disease, Perianal Crohn's Disease
- Trial name
- RIS-PERIANAL (NCT07872449)
- Testing
- Risankizumab
- Where
- 4 sites in Japan
- Volunteers
- 25 people
- Sponsor
- Yuki Horio
Fistula in Ano, Crohn Disease
Pediatric MSC-AFP Sub-study for Crohn's Fistula
The purpose of this study is to determine the safety of using an autologous mesenchymal stromal cell (MSC) coated fistula plug in people with fistulizing Crohn's disease.
- Trial name
- NCT03449069
- Testing
- MSC-AFP
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic