Clinical trials: Fluid Deficit
Hypovolemia, Diuretic Toxicity
Diagnosis Accuracy of Abdominal Compression and Hemoconcentration to Detect Diuretic Induced Fluid Removal Intolerance.
Fluid overload increases morbidity and mortality of pediatrics patients in intensive care unit (ICU). It could be interesting to predict the decrease in stroke volume when diuretics are prescribed.
- Conditions
- Hypovolemia, Diuretic Toxicity, Fluid Overload
- Trial name
- NCT03145935
- Testing
- Abdominal compression (AC), blood sample
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hopital Louis Pradel
Craniosynostoses, Hypovolemia
Hemodynamic Monitoring During Craniosynostosis Surgery: Comparing Traditional and Newer Technology Monitors (CRASY-PRAM)
Hemodynamic evaluation during pediatric anesthesia is essential to care management. Intraoperative cardiovascular instability is frequent in major surgeries, and appropriate monitoring is necessary to ensure safe anesthetic…
- Conditions
- Craniosynostoses, Hypovolemia, Hemorrhage, Hemodynamic Instability
- Trial name
- CRASY-PRAM (NCT06263075)
- Testing
- Intraoperative monitoring
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Fluid Therapy
Crystalloid FLUID Choices for Resuscitation of Hospitalized Patients
The aim of the FLUID Trial is to conduct a pragmatic, multi-centre, open label randomized cluster cross-over trial (RCT) to determine whether fluid administration with 0.9% saline as compared to Ringer's lactate decreases death…
- Trial name
- FLUID (NCT04512950)
- Testing
- Ringer's lactate, 0.9% saline
- Where
- 7 sites in Canada
- Volunteers
- 43,626 people
- Sponsor
- Ottawa Hospital Research Institute
Hypovolemia
Prediction of Fluid Responsiveness in Children With Single Ventricle
The purpose of this study is to evaluate predictability of an abdominal compression-induced change of blood pressure for fluid responsiveness in children with single ventricle (bidirectional cavopulmonary shunt and Fontan tract).
- Trial name
- NCT02826135
- Testing
- abdominal compression
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Seoul National University Hospital
Hypovolemia
Study on Prediction of Fluid Responsiveness Using an Abdominal Compression-induced Change of Blood Pressure in Children
The purpose of this study is to evaluate predictability of an abdominal compression-induced change of blood pressure for fluid responsiveness in children.
- Trial name
- NCT02471534
- Testing
- abdominal compression
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Fluid Therapy, Hemodynamics
Predicting Fluid Responsiveness in Mechanically Ventilated Critically Ill Children Using Transthoracic Echocardiography
Initial fluid resuscitation remains the first treatment step for most children experiencing circulatory failure and/or systemic hypotension.
- Conditions
- Fluid Therapy, Hemodynamics, Hypovolemia, Shock
- Trial name
- PREDIPEN (NCT05054452)
- Testing
- Echocardiographic assessment
- Where
- France
- Volunteers
- 4 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fluid Therapy
Crystalloid FLUID Choices for Resuscitation of Hospital Patients
Salt fluids are used extensively for acutely ill patients who are admitted to hospital. Two salt fluids commonly used are Normal Saline and Ringer's Lactate.
- Trial name
- FLUID (NCT02721485)
- Testing
- Ringer's Lactate, Normal Saline
- Where
- 4 sites in Canada
- Volunteers
- 30,000 people
- Sponsor
- Ottawa Hospital Research Institute
Hypovolemia
Prediction of Fluid Responsiveness in Children Undergoing Major Surgery
The purpose of this study is to evaluate predictability of a respiratory variation in pulse oximeter plethysmography for fluid responsiveness in children undergoing major surgery.
- Trial name
- NCT02952651
- Testing
- Pulse oximeter
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Seoul National University Hospital
Anesthesia Complication, Hypotension on Induction
Ultrasound Assessment of the Subclavian Vein for Predicting Hypotension in Children After Anaesthesia Induction
Intra operative hypotension is a risk factor in pediatric anesthesia (McCann ME et al.Pediatr Anesth 2014; 24: 68-73). In summary, the study aims at examine if ultrasound assessment of the diameter and collapsibility index of the…
- Conditions
- Anesthesia Complication, Hypotension on Induction, Hypovolemia
- Trial name
- NCT04573842
- Testing
- Ultrasound assessment of SCV
- Where
- Sweden
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Hypovolemia
Fluid Responsiveness Using Forehead Sensor in Children
Forehead sensor can predict the more accurate fluid responsiveness than finger sensor in children
- Trial name
- forehead (NCT03132480)
- Testing
- fluid resuscitation
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Hypovolemia, Hemorrhage
Effectiveness of the Pressure Recording Analytical Method in Predicting Fluid Responsiveness in Pediatric Critical Care Patients
The Pressure Recording Analytical Method, invasive hemodynamic monitoring, is an uncalibrated pulse contour analysis, installed in the Mostcare® system that allows a continuous estimation of the stroke volume and thus the cardiac…
- Conditions
- Hypovolemia, Hemorrhage, Fluid Responsiveness
- Trial name
- MOSTCARE-PED (NCT04186416)
- Testing
- Mostcare® device, Transthoracic cardiac ultrasound
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Scoliosis, Spinal Fusion
Is Pleth Variability Index (PVI) a Surrogate for Pulse Pressure Variations (PPV) in Pediatric Spine Fusion (SF) Surgery?
Spine fusion is an involved procedure during which patients are at risk for significant intra-operative blood loss.This study will compare 2 ways of determining fluid status and response to fluid administration.
- Trial name
- NCT00994656
- Testing
- Masimo multi-wavelength pulse co-oximeter
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Children's Hospital of Philadelphia
Plasma Volume Substitution (Hypovolemia) Including Massive Hemorrhage
Study to Obtain Volume Effect and Safety Data on 6 % Hydroxyethyl Starch 130/0.4 in Pediatric and Adult Patients Undergoing Major Elective Surgery
The study shall evaluate the volume effect and safety of 6 % hydroxyethyl starch 130/0.4 for restoration and maintenance of hemodynamics during the investigational period in patients undergoing major elective surgery.
- Trial name
- NCT01127477
- Testing
- 1: Hydroxyethyl starch 130/0.4, 6 %
- Where
- 4 sites in Japan
- Volunteers
- 20 people
- Sponsor
- Fresenius Kabi Japan
Treatment of Hypovolemia and Shock
Gelatines in Pediatric PatientS
The aim of volume replacement is to compensate a reduction in the intravascular volume e.g. during surgery and to counteract hypovolemia in order to maintain hemodynamics and vital functions.
- Trial name
- GPS (NCT02495285)
- Testing
- Gelofusine 4%, Gelaspan 4%
- Where
- 11 sites in Bulgaria, Germany and 3 more
- Volunteers
- 601 people
- Sponsor
- B. Braun Melsungen AG
Hypovolemia, Craniosynostoses
Bedside Resources to Gauge Intravascular Volume Status
The goal if this study is to employ the CardioQ-Esophageal Aortic Doppler probe to define fluid responders from non-responders among infants undergoing cranial vault reconstruction for craniosynostosis.
- Trial name
- NCT03915587
- Testing
- CardioQ-EDM and CipherOx-CRI
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Colorado, Denver
Hypovolemia
Safety Study of Kedbumin 25% Versus Normal Saline in the Treatment of Post-Surgical Hypovolemia in Pediatric Patients
This is a randomized, controlled, open-label clinical trial aimed to evaluate the Safety of Kedbumin 25% Compared to Normal Saline Solution in the Treatment of Post-Surgical Hypovolemia in Pediatric Patients Undergoing Major…
- Trial name
- NCT01531803
- Testing
- Kedbumin 25%, Normal Saline Solution
- Where
- 2 sites in United States
- Volunteers
- 3 people
- Sponsor
- Kedrion S.p.A.
Hypovolemia
Lung Recruitment Maneuver for Predicting Fluid Responsiveness in Children
Lung recruitment maneuver induces a decrease in stroke volume, which is more pronounced in hypovolemic patients. The authors hypothesized that the changes of dynamic variables through lung recruitment maneuver could predict…
- Trial name
- NCT03184961
- Testing
- lung recruitment maneuver
- Where
- South Korea
- Volunteers
- 30 people
- Sponsor
- Seoul National University Hospital
Attention Deficit and Disruptive Behavior Disorder, Attention Deficit Disorder With Hyperactivity
Biological Markers in Attention Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to evaluate individuals with Attention Deficit/Hyperactivity Disorder (ADHD) to learn more about the genetics of the disease. This study is part of other ongoing studies of individuals with ADHD.
- Trial name
- NCT00001206
- Where
- United States
- Volunteers
- 347 people
- Sponsor
- National Institute of Mental Health (NIMH)
Acute Hypovolemia
Esophageal Echo Assessment of LV Function During Acute Normovolemic Hemodilution Using Crystalloid or Hypertonic Saline
The purpose of this study is to examine how the heart functions when a calculated amount of blood is removed and how two fluids, Lactated Ringer's (considered the standard replacement fluid) and Hypertonic Saline, re-expand the…
- Trial name
- NCT00683007
- Testing
- Volume resuscitation (Crystalloid), Volume resuscitation (Hypertonic Saline Solution)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of California, Davis
Congenital Heart Disease (CHD), Univentricular Heart
Fontan Outcomes in Oligemia vs Plethora in Univentricular CHD
This prospective cohort study evaluates differences in clinical outcomes between pulmonary oligemia and pulmonary plethora in patients with cyanotic congenital heart disease and univentricular heart physiology undergoing staged…
- Trial name
- NCT07535203
- Testing
- Fontan Procedure
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Sisca Natalia Siagian