Clinical trials: Fluid Management
Circulatory Failure / Shock State, Fluid Therapy
Metabolic Fluid Responsiveness in Children
The investigators aim to validate markers of metabolic fluid-responsiveness in children with acute circulatory failure following cardiac surgery.
- Trial name
- METAFRIC (NCT07255469)
- Where
- 8 sites in France
- Volunteers
- 110 people
- Sponsor
- University Hospital, Bordeaux
Cruciate Ligament Reconstruction Infection, Septic Arthritis
A Metagenomic Next-generation Sequencing (mNGS)-Guided Sequential Culture Strategy for Postoperative Cruciate Ligament Reconstruction Infection (CLRI): a Retrospective Cohort Study
This retrospective cohort study evaluates a sequential diagnostic strategy for patients with postoperative cruciate ligament reconstruction infection (CLRI).
- Conditions
- Cruciate Ligament Reconstruction Infection, Septic Arthritis, Surgical Wound Infection, Joint Infection
- Trial name
- NCT07852598
- Testing
- Metagenomic next-generation sequencing (mNGS), mNGS-guided modified culture, Conventional microbiological culture
- Where
- China
- Volunteers
- 80 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Circulatory Failure, Shock State
Fluid-responsiveness Assessment Simplified by Electric Cardiometry in Children
In this study of diagnostic accuracy, the investigators aim to validate a faster, simpler, and noninvasive test of fluid-responsiveness in critically ill children.
- Conditions
- Circulatory Failure, Shock State, Fluid Therapy
- Trial name
- FAST (NCT07522580)
- Testing
- validation a test of fluid-responsiveness in critically ill children
- Where
- 4 sites in France
- Volunteers
- 42 people
- Sponsor
- University Hospital, Bordeaux
Transient Tachypnea of the Newborn
Fluid Management in Transient Tachypnea of the Newborn
Transient tachypnea of the newborn (TTN) is a diagnosis given to infants born between 34 and 42 weeks gestation who develop difficulty breathing during the first days of life when no specific cause of the breathing difficulty can…
- Trial name
- NCT01225029
- Testing
- Amount of total fluids
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Critical Illness, Sepsis
Role of Active Deresuscitation After Resuscitation-2
RADAR-2 will be a randomised, open-label, allocation concealed, pilot trial of conservative fluid administration and deresuscitation compared with usual care in patients who are critically ill.
- Conditions
- Critical Illness, Sepsis, Trauma
- Trial name
- RADAR-2 (NCT03512392)
- Testing
- Conservative fluid and deresuscitation strategy, Usual care strategy
- Where
- 8 sites in United Kingdom
- Volunteers
- 180 people
- Sponsor
- Belfast Health and Social Care Trust
Circulatory Failure (Shock)
Fluid-responsiveness in Children Ventilated With LOW Tidal Volume - The FLOW Study.
In this study of diagnostic accuracy, the investigators aim to validate a fluid-responsiveness test in critically ill children mechanically ventilated with low tidal volume.
- Trial name
- FLOW (NCT07494643)
- Testing
- Echocardiographic
- Where
- 6 sites in France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Bordeaux
Shock, Critical Illness
Chloride High Level Of Resuscitation Infusion Chloride High Level Of Resuscitation Infusion Delivered Evaluation
The purpose of this study is to determine whether intravenous fluid management using lower chloride solutions (Hartmann's solutions and Plasmalyte®) will result in better outcome when compared to management using high chloride…
- Trial name
- CHLORIDE (NCT00885404)
- Testing
- Lower chloride fluids (Hartmann's solution and Plasmalyte®)
- Where
- Australia
- Volunteers
- 7,000 people
- Sponsor
- Austin Health
Circulatory Failure (Shock)
Fluid Responsiveness Evaluation by a Non-invasive Method in CHildren
In this study, the investigators aim to validate a non-invasive marker of fluid-responsiveness in children with acute circulatory failure based on standardized abdominal compression.
- Trial name
- FRENCH (NCT05919719)
- Testing
- Non interventional study (study of diagnostic accuracy with an extra echocardiographic assessment).
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Bordeaux
USCOM, Echocardiography
Comparison of the Ultrasonic Cardiac Output Monitor and Echocardiography for Hemodynamic Assessment in Pediatric Anesthesia
This prospective observational pilot study evaluates agreement between Ultrasound Cardiac Output Monitor (USCOM) measurements and transthoracic echocardiography-derived hemodynamic parameters in pediatric patients under…
- Conditions
- USCOM, Echocardiography, Echocardiography Guided Fluid Management
- Trial name
- NCT07342842
- Testing
- USCOM, Echocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 57 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Rh Isoimmunization
Doppler or Amniocentesis to Predict Fetal Anemia
In pregnancies complicated by Rhesus disease, the mother has developed antibodies which cross the placenta and can cause anemia and death of the fetus.
- Trial name
- NCT00295516
- Testing
- Fetal Middle Cerebral Artery Doppler measurement
- Where
- Canada
- Volunteers
- 157 people
- Sponsor
- University of Toronto
Septic Shock, Echocardiography Guided Fluid Management
Prediction of Fluid Responsiveness in Paediatric Patients With Septic Shock Using Carotid Doppler Ultrasonography and Echocardiography
The goal of this study is to evaluate the role of carotid Doppler and Echocardiography as a predictor of fluid responsiveness in paediatric patients with septic shock.
- Trial name
- NCT07136532
- Testing
- echocardiography
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Cesarean Section Complications, Anesthesia Complication
Prophylactic Phenylephrine Co-administration During Caesarean Section
This single centre prospective alternating intervention study will aim to compare prophylactic phenylephrine given in the first litre of Ringers lactate as co-load in healthy patients having an elective caesarean section under…
- Trial name
- NCT04005664
- Testing
- Phenylephrine
- Where
- South Africa
- Volunteers
- 300 people
- Sponsor
- University of KwaZulu
Migraine, Headache
Intravenous Fluid for Pediatric Migraine in the Emergency Department
The purpose of this study is to evaluate the effect of intravenous fluid (0.9% sodium chloride and water) alone on headache pain in children with migraine visiting the Emergency Department.
- Trial name
- EDMigraine3 (NCT01073787)
- Testing
- Normal saline
- Where
- Canada
- Volunteers
- 46 people
- Sponsor
- University of Alberta
Diabetic Ketoacidosis
Double Blinded Randomized Control Trial of Types of IVF in Children With DKA
Objectives: Intravenous (IV) fluid administration is a fundamental component of diabetic ketoacidosis (DKA) treatment. Normal saline (NS), the most common IV fluid used in DKA management, contains more chloride than human blood.
- Trial name
- NCT03066440
- Testing
- Normal saline, Lactated Ringers
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- State University of New York at Buffalo
Respiratory Distress Syndrome, Newborn
Fluid Restriction in Respiratory Distress of the Newborn
The object of this study is to determine the best way to care for infants with respiratory distress. The investigators are testing a method of feeding fluids to infants with respiratory distress in amounts similar to what healthy…
- Trial name
- NCT03120585
- Testing
- Fluid Management Intervention
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- University of Oklahoma
Colectomy, Pancreatectomy
Implementation of a GDT Algorithm for Major Surgery Patients
This study examines the effect of an algorithm for GDT for patients undergoing major surgery under routine conditions.
- Conditions
- Colectomy, Pancreatectomy, Fluid Therapy
- Trial name
- NCT02509910
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Philipps University Marburg
Volume Overload
Perioperative Fluid Therapy in Pediatric Patients Undergoing Penile Hypospadias Repair
Optimization of perioperative fluid management is important for preventing adverse events, such as hypovolemia, cardiogenic shock, volume overload, and pulmonary edema, in both adult and pediatric patients.
- Trial name
- NCT04444089
- Testing
- lung ultrasound
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Premature Baby 26 to 32 Weeks, Premature Baby 33 to 36 Weeks
Fluid Responsiveness Evaluation by a Non-invasive Method in Children, Extended to PREterm Infants - FRENCH-PREMA
In this study, the investigators aim to validate a non-invasive marker of fluid-responsiveness in preterm infants (term below 37 gestational week) with acute circulatory failure based on standardized abdominal compression.
- Trial name
- FRENCH-PREMA (NCT06287710)
- Testing
- Non interventional study (study of diagnostic accuracy with an extra echocardiographic assessment).
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Bordeaux
Primary Immunodeficiency Diseases (PID)
Gammagard Liquid and rHuPH20 in PID
The purpose of the study is to develop a subcutaneous treatment option for participants with Primary Immunodeficiency Diseases (PID) that allows an administration of Immune Globulin Intravenous (Human), 10% at the same frequency…
- Trial name
- NCT00814320
- Testing
- Recombinant human hyaluronidase (rHuPH20)+ immune globulin intravenous (IGIV)
- Where
- 14 sites in United States, Canada
- Volunteers
- 89 people
- Sponsor
- Baxalta now part of Shire
Sepsis, Systemic Inflammatory Response Syndrome
PPV to Guide Fluid Management in the PICU
Children who are critically ill often require large amounts of fluid during their acute illness. It has been shown in multiple studies that appropriate administration of fluid decreases morbidity and mortality, but giving too…
- Trial name
- PPV (NCT02308371)
- Testing
- Automated Pulse Pressure Variation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill