Clinical trials: Folate
Analgesia, Post Operative Pain
The Analgesic Efficacy of Vitamin B Complex in Critically Ill Obstetrics After Caesarean Section
We aim to investigate the value of vitamin B (B1, B6, B9, B12) on post-cesarean section analgesia in addition to the standard opioid-sparing multimodal regimen to achieve more robust analgesia with minimal side effects.
- Conditions
- Analgesia, Post Operative Pain, Cesarean Section
- Trial name
- NCT06446830
- Testing
- multimodal analgesia and vitamin B, standard multimodal analgesia
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Inflammatory Bowel Diseases
Folic Acid in Pediatric Inflammatory Bowel Disease
Inflammatory bowel disease often requires immunomodulators, such as methotrexate, to maintain disease remission. This medication is administered as one dose weekly.
- Trial name
- NCT03860012
- Testing
- Folic Acid
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Le Bonheur Children's Hospital
Iron Deficiency, Vitamin A Deficiency
Nutritional Status and Bouillon Use in Northern Ghana
This pilot aims to generate data that are critical for informing the design of a planned, more detailed study to evaluate the effect of multiple micronutrient (MN)-fortified bouillon cube on biomarkers of nutrient status of women…
- Conditions
- Iron Deficiency, Vitamin A Deficiency, Vitamin B 12 Deficiency, Folate Deficiency
- Trial name
- NCT04632771
- Testing
- N/A (observational study)
- Where
- Ghana
- Volunteers
- 995 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Autism Spectrum Disorder
Role of Folinic Acid in Improving the Adaptive Skills and Language Impairment in Children With Autism Spectrum Disorder
No such study has been conducted in Pakistan so the primary objective of this study was to determine the role of folinic acid in improving the speech and adaptive skills while secondary objective was improvement of stereotype…
- Trial name
- NCT05013164
- Testing
- Folinic Acid
- Where
- Pakistan
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Nishtar Medical University
Methylation, Body Composition
Diet and Nutrition Pilot Study for Chinese Adolescents and Their Mothers
Background: Researchers want to collect information on diet, physical activity, and sun exposure in children and young adults. The data can provide information on the effect these factors might have on the development of cancer…
- Conditions
- Methylation, Body Composition, Physical Activity, Puberty
- Trial name
- NCT01517139
- Where
- China
- Volunteers
- 278 people
- Sponsor
- National Cancer Institute (NCI)
Autism Spectrum Disorder
A Placebo-controlled Trial of Folinic Acid in Children With ASD
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulties in social communication and the presence of restricted or repetitive behaviors.
- Trial name
- AFAT (NCT07642661)
- Testing
- Folinic Acid
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Prof. Adi Aran
Oral Ulcer
Therapeutic Effect of Folic Acid in Healing of Oral Ulcers
patients reporting at the department of oral medicine with the complain of oral ulceration will be asked to participate in this study.
- Trial name
- NCT04989049
- Testing
- Folic Acid 5 MG
- Volunteers
- 75 people
- Sponsor
- Dow University of Health Sciences
Autoimmune Disease, Lymphatic Disease
Pyrimethamine to Treat Autoimmune Lymphoproliferative Syndrome
This study will examine whether the drug pyrimethamine can shrink lymph nodes and spleen in patients with autoimmune lymphoproliferative syndrome (ALPS).
- Conditions
- Autoimmune Disease, Lymphatic Disease, Lymphoproliferative Disorder
- Trial name
- NCT00065390
- Testing
- Pyrimethamine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Pregnant Women, Pregnant Women and Their Offspring
Effectiveness of MMS Compared With IFS Among Pregnant Women in Bangladesh: an Experimental Study
Background Maternal undernutrition and micronutrient deficiencies remain highly prevalent in Bangladesh and contribute to maternal anaemia, low birth weight, preterm birth, and adverse neonatal outcomes.
- Trial name
- NCT07540130
- Testing
- Multiple micronutrient supplementation
- Where
- Bangladesh
- Volunteers
- 667 people
- Sponsor
- National Institute of Neurosciences and Hospital, Dhaka
Folate Deficiency, Vitamin B 12 Deficiency
Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls
Folic acid and vitamin B12 play an interdependent role in key cellular processes, namely deoxyribonucleic acid synthesis, cell division, red blood cell formation, and nervous system myelination.
- Conditions
- Folate Deficiency, Vitamin B 12 Deficiency, Anemia, Megaloblastic, Cognitive Development
- Trial name
- NCT06100146
- Testing
- Folic acid and vitamin B12 fortified flour, Unfortified cereal flour
- Where
- 2 sites in Ethiopia
- Volunteers
- 472 people, healthy volunteers welcome
- Sponsor
- University Ghent
Depression, Bipolar Disorder
Prevention of Mood Disorders by Folic Acid Supplementation
The purpose of this study is to determine whether daily folic acid supplements can prevent new episodes of mood disorder in young people (aged 14-24 years) of biological parents with current or past history of depression or…
- Trial name
- PRE-EMPT (NCT00459264)
- Testing
- Folic Acid
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Ovarian Cancer
The Development of Human Immunologic Assays Specific to Folate Receptor Antigen
Ovarian cancer has the highest mortality rate of gynecologic malignancies and the overall 5-year survival rate of ovarian cancer is only 20-30%.
- Trial name
- NCT00155935
- Testing
- venous puncture
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Childhood Leukemia Survivors
N-PhenoGENICS: Neurocognitive-Phenome, Genome, Epigenome and Nutriome In Childhood Leukemia Survivors
To find possible therapeutic targets to help prevent long-term brain and behavioural side effects in survivors of childhood leukemia that may have been caused by chemotherapy (Treatment-Related late Adverse Neuro-Cognitive…
- Trial name
- NPG (NCT01913093)
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- The Hospital for Sick Children
Cervical Cancer
Folate and Protection Against Cervical Cancer
This is a randomised double-blind placebo-controlled trial to see whether giving a low dose of the vitamins folic acid and riboflavin is beneficial to women who have very low grade abnormalities of the cervical cells.
- Trial name
- NCT00220532
- Testing
- Folic acid with riboflavin
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Vitamin B-12 Deficiency
THE B-BABIES STUDY: An Observational Study of Group B Vitamins in Preterm Infants
Infancy may be associated with a risk of micronutrient depletion due to the high demands of rapid growth. This is particularly true when preterm birth occurs, as the period before term exhibits the highest rate of bodily growth…
- Trial name
- B-BABIES (NCT07163962)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Norfolk and Norwich University Hospitals NHS Foundation Trust
Ovarian Cancer
FR in Stored Plasma
The folate receptor (FR) is a cell over expressed on the surface of certain cancers, this occurs most frequently in ovarian cancers.
- Trial name
- NCT00787514
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Pediatric Leukemia, Other Pediatric Cancers
Follow-up Study of Late Effects of Periconceptional Folic Acid in Mothers and Offspring in the Community Intervention Program Population: The Chinese Children and Families Study
Periconceptional folic acid supplements of 400 (Micro) daily prevent neural tube defects (NTD) in offspring. Some data suggest that periconceptional folic acid supplements, folate levels during pregnancy, and/or certain variants…
- Trial name
- NCT01365975
- Where
- United States
- Volunteers
- 1,382 people
- Sponsor
- National Cancer Institute (NCI)
Healthy Infants
Influence of Inflammation on Micronutrient Status Assessment
Inflammation can influence several biochemical measurements those commonly used to interpret micronutrient status in children. Our primary objective is to investigate the effects of inflammation on several biochemical…
- Trial name
- NCT03801161
- Testing
- Pentavalent vaccine. It is a combination of five different antigens (Hepatitis B (HBV)/ Haemophilus influenzae type b (HiB) / Tetanus-Diphtheria-whole cell Pertussis (TDwP)).
- Where
- 2 sites in Bangladesh
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Malaria
Folic Acid Supplementation in Gambian Primigravidae
Supplementation with folic acid and iron is recommended for pregnant women in order to prevent them from developing anemia. In malaria endemic areas of Africa, the World Health Organization (WHO) now recommends that pregnant…
- Trial name
- NCT00120822
- Testing
- Folic acid
- Where
- The Gambia
- Volunteers
- 1,000 people
- Sponsor
- London School of Hygiene and Tropical Medicine
HIV Infections
Vitamin B Therapy for Hyperlactatemia
The purpose of this study is to see if vitamin B can treat mild hyperlactatemia (a higher than normal level of lactate in the blood) in patients who take nucleoside reverse transcriptase inhibitors (NRTIs).
- Trial name
- NCT00031057
- Testing
- Thiamine hydrochloride, Riboflavin
- Where
- 3 sites in United States
- Volunteers
- 225 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)