Clinical trials: Frail Elderly, open to volunteers
CLL (Chronic Lymphocytic Leukemia)
A Trial to Evaluate the Efficacy and Safety of a Fitness-adapted Thera-py Approach With Either Continuous Zanubrutinib Monotherapy or Time-limited Zanubrutinib + Sonrotoclax in Older and/or Frail Patients With Treatment-naïve CLL
The CLL-Frail2 trial will be a prospective, open-label, multicentre phase-II-trial to evaluate the efficacy and safety of a fitness-adapted therapy approach with either con-tinuous zanubrutinib (BGB-3111) monotherapy or…
- Trial name
- NCT07899398
- Testing
- Zanubrutinib, Sonrotoclax
- Volunteers
- 80 people
- Sponsor
- German CLL Study Group
Plasma Cell Myeloma
Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
This phase III trial compares three-drug induction regimens followed by double-or single-drug maintenance therapy for the treatment of newly diagnosed multiple myeloma in patients who are not receiving a stem cell transplant and…
- Trial name
- NCT05561387
- Testing
- Bortezomib, Daratumumab and Hyaluronidase-fihj, Dexamethasone
- Where
- 397 sites in United States
- Volunteers
- 510 people
- Sponsor
- SWOG Cancer Research Network
Frail Elderly, Frailty
Frailty Training for Emergency Nurses: A Cluster RCT in Morocco
This study tests whether a training program helps nurses better recognize and care for older adults with frailty in hospital emergency departments.
- Trial name
- NCT07892612
- Testing
- Structured Educational Program on Geriatric Frailty
- Where
- Morocco
- Volunteers
- 144 people
- Sponsor
- Cadi Ayyad University
DLBCL
A Real-world Data and Sample Compendium of Frail and/or Multiply Treated Large B-cell Lymphoma
LBCL is a cancer of the lymphatic system where B-cells (a type of white blood cell) experience uncontrolled growth. The standard treatment for LBCL is a combination of chemotherapy and immunotherapy, referred to as…
- Trial name
- ALMANAC (NCT07335120)
- Where
- United Kingdom
- Volunteers
- 800 people
- Sponsor
- The Clatterbridge Cancer Centre NHS Foundation Trust
Immunocompromised Patients
Immunogenicity, Efficacy and Safety of Recombinant Herpes Zoster Vaccine in Frail Patients
Herpes zoster (HZ) is a serious health problem whose incidence and severity increase with the decline of cell-mediated immunity (CMI) because of age and immunocompromised (IC) status.
- Trial name
- AID4FRAIL_RZV (NCT07321808)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia