Clinical trials: Fulminant Liver Failure
Acute Liver Failure
Plasma Exchange for Amanita Toxin-induced Acute Liver Failure
Retrospective evaluation of the value of additive therapeutic plasma exchange (PEX) compared to standard medical therapy (SMT) in Amanita toxin-associated acute liver failure in children and adolescents within the last 10 years…
- Trial name
- Amanita-Pex (NCT06187220)
- Testing
- Therapeutic Plasma Exchange (PEX)
- Where
- 6 sites in Germany, Italy and 3 more
- Volunteers
- 111 people
- Sponsor
- Hannover Medical School
Acute Liver Failure
High Volume Plasma Exchange in Children With Acute Liver Failure and Acute on Chronic Liver Failure
All the children with acute liver failure who are candidates for transplant but have constraints for transplant will be randomized either to receive standard medical therapy or high volume plasma exchange along with standard…
- Trial name
- NCT02719210
- Testing
- High Volume Plasma Exchange, Hypertonic 3% saline, Mannitol
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Failure, Acute
Efficacy of L-ornithine L-aspartate and Therapeutic Plasma Exchange Versus Plasma Exchange Alone in Lowering Ammonia and Improving Outcomes in Pediatric Acute Liver Failure.
Pediatric acute liver failure (PALF) is associated with very high mortality and morbidity with native liver survival varying between 21 to 75%.Hyperammonemia manifesting as hepatic encephalopathy and causing cerebral edema…
- Trial name
- NCT05778461
- Testing
- L-ornithine L-Aspartate
- Where
- India
- Volunteers
- 32 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Diseases, Liver Cirrhosis
Better Diagnostic Tools for Children and Adolescents With Acute Liver Failure and Chronic Liver Insufficiency
The aim of this study is to validate and develop a new diagnostic and prognostic approach for assessment of liver function in children and adolescents with acute liver failure and chronic liver insufficiency.
- Conditions
- Liver Diseases, Liver Cirrhosis, Pediatric Disorder
- Trial name
- DAKL (NCT03509194)
- Where
- Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Acute Liver Failure, Mitochondrial Diseases
Longitudinal Study of Mitochondrial Hepatopathies
The specific aims of this study are (1) to determine the clinical phenotypes and natural history of hepatic RC and FAO disorders, (2) to determine the correlation between genotype and phenotype, (3) to determine if circulating…
- Conditions
- Acute Liver Failure, Mitochondrial Diseases, End Stage Liver Disease, Respiratory Chain Deficiencies, Mitochondrial
- Trial name
- MITOHEP (NCT01148550)
- Where
- 16 sites in United States, Canada
- Volunteers
- 90 people
- Sponsor
- Arbor Research Collaborative for Health
Fulminant Liver Failure
Hepatocyte Transplantation as a Life Support Bridge
The purpose of this study is to gain knowledge about the result of infusing liver cells, carefully matched to blood type, into a subject's body.
- Trial name
- NCT00282542
- Testing
- Hepatocyte Infusion
- Sponsor
- Virginia Commonwealth University
Acute Liver Failure
Etiology and Prognostic Analysis of Acute Liver Failure in Chinese Children
Research Background: Pediatric acute liver failure (PALF) refers to the sudden onset of severe liver injury in children without known chronic liver disease, leading to multi-system organ dysfunction, with a mortality rate as high…
- Trial name
- EPOCH-ALF (NCT06778941)
- Volunteers
- 400 people
- Sponsor
- liyumei
Acute Liver Failure
Hepatocyte Microbeads for Acute Liver Failure
Acute Liver Failure in children is associated with high mortality without liver transplantation. In addition, donor organ shortage makes it difficult to provide this treatment to every potential patient.
- Trial name
- HELP (NCT05491135)
- Testing
- HMB002
- Volunteers
- 17 people
- Sponsor
- King's College Hospital NHS Trust
Acute Liver Failure
Clinical Study of Pediatric Acute Liver Failure
The goal of this observational study is to understand the etiology, prognosis and influencing factors of acute liver failure in children, evaluate the predictive value of children's SOFA score, PELD score and LIU score for the…
- Trial name
- NCT06893042
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Fansen Zeng
Acute Liver Failure, Wilson Disease
Daily Versus Alternate Day Plasma Exchange in Wilson Disease With Acute Liver Failure in Children
Wilson disease in children has a varied presentation. Wilson disease with acute liver failure is associated with very high mortality and morbidity.
- Trial name
- NCT06698991
- Testing
- Plasma Exchange, Standard Medical Treatment
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Biliary Atresia, Metabolic Disorders
Clinical and Basic Study for Pediatric Liver Transplantation
Background: In mainland China, the development of pediatric liver transplantation (LT) has lagged behind that of adult LT during the past two decades, but it has been progressing immensely in recent years.
- Conditions
- Biliary Atresia, Metabolic Disorders, Fulminant Liver Failure, Hepatic Tumors
- Trial name
- CBSPLT (NCT02503384)
- Where
- China
- Volunteers
- 180 people
- Sponsor
- RenJi Hospital
Acute Liver Failure
Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure
The purpose of the study is to determine whether L-Ornithine L-Aspartate infusion improves the survival of patients with acute liver failure.
- Trial name
- NCT00470314
- Testing
- L-Ornithine L-Aspartate
- Where
- India
- Volunteers
- 150 people
- Sponsor
- All India Institute of Medical Sciences
Acute Liver Failure, Acute Liver Injury
Biomarkers in Liver Failure
Acute liver injury (ALI) and acute liver failure (ALF) are rare clinical conditions, the latter often associated with a poor outcome.
- Conditions
- Acute Liver Failure, Acute Liver Injury, Acute on Chronic Hepatic Failure
- Trial name
- NCT02833064
- Testing
- Non-contrast magnetic resonance imaging, Biological sampling
- Volunteers
- 200 people
- Sponsor
- University of Edinburgh
Liver Failure Acute
Hepatocyte Transplantation for Acute Decompensated Liver Failure
The purpose of this research study is to determine whether liver cell transplantation can provide help for patients with liver failure who are unlikely to survive without some form of liver support.
- Trial name
- NCT01345565
- Testing
- human hepatocytes
- Where
- United States
- Sponsor
- Ira Fox
Acute Liver Failure
Emergency Use of OCR-002 in Acute Liver Failure (ALF)
This study provides emergency use of the unapproved study medication in ALF patients with acute liver failure who are not responding to standard of care.
- Trial name
- NCT01634230
- Testing
- OCR-002
- Where
- United States
- Sponsor
- Ocera Therapeutics, Inc.
End Stage Liver Disease, Acute Liver Failure
Robotic vs. Laparoscopic vs. Open Living Donor Hepatectomy
This will be a study to examine the outcomes of open, laparoscopic, and robotic Living Donor Liver Transplantation (LDLT) procedures.
- Conditions
- End Stage Liver Disease, Acute Liver Failure, Acute-On-Chronic Liver Failure, Hepatocellular Carcinoma
- Trial name
- NCT06062706
- Testing
- Donor hepatectomy
- Where
- Saudi Arabia
- Volunteers
- 3,448 people
- Sponsor
- King Faisal Specialist Hospital & Research Center
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Acute Liver Failure, Hepatic Encephalopathy
N-acetylcysteine in Non-Acetaminophen Pediatric Acute Liver Failure
We have completed patient enrollment in the the double blind, randomized, placebo-controlled trial of intravenous (IV) N-acetylcysteine (NAC) vs. placebo for the treatment of non-acetaminophen ALF.
- Trial name
- NCT00248625
- Testing
- N-acetylcysteine
- Where
- 20 sites in United States, Canada and 1 more
- Volunteers
- 184 people
- Sponsor
- University of Pittsburgh
Acute Liver Failure
Standard Volume vs. High Volume Plasma Exchange in Pediatric Acute Liver Failure
Acute liver failure is a multisystem disorder characterized by a syndrome of jaundice, coagulopathy, and encephalopathy with high mortality in the absence of liver transplantation.
- Trial name
- NCT06831643
- Testing
- Standard Medical treatment, Therapeutic Plasma Excahnge
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Liver Failure
High-Volume Plasma Exchange Versus Standard Medical Treatment in Patients With Acute Liver Failure
The study will be conducted on patients admitted to Department of Hepatology from Jan 2016 to Jan 2018 at Institute of Liver \& Biliary Sciences, New Delhi.
- Trial name
- NCT02718079
- Testing
- Plasma Exchange, Management of cerebral edema/intracranial hypertension:, Transfer to Intensive Care Unit
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Institute of Liver and Biliary Sciences, India