Clinical trials: Functional; Bleeding
Oculocerebrorenal Syndrome
Study of the Pathophysiological Mechanisms Involved in Bleeding Events
Lowe syndrome is associated with mutations in the OCRL1 gene, which encodes OCRL1, a phosphatidylinositol-4, 5-bisphosphate (PtdIns(4, 5)P (2))5-phosphatase.
- Trial name
- LOWE (NCT01314560)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Wiskott-Aldrich Syndrome, Thrombocytopenia
Thrombocytopenia and Bleeding in Wiskott-Aldrich Syndrome (WAS) Patients
The purpose of this project is to describe the pathophysiology of thrombocytopenia and bleeding in patients with Wiskott-Aldrich Syndrome (WAS) and determine the response to thrombopoietic agents in vitro and in vivo.
- Conditions
- Wiskott-Aldrich Syndrome, Thrombocytopenia, Bleeding
- Trial name
- WAS (NCT00909363)
- Testing
- Promacta, blood drawing in patients with WAS, blood drawing in healthy controls
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Immune Thrombocytopenia, Thrombocytopathy
Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies
The purpose of this study is to develop a highly sensitive method for assessing the functional activity of platelets for use in the differential diagnosis of thrombocytopenia and platelet defects.
- Conditions
- Immune Thrombocytopenia, Thrombocytopathy, Acute Leukemia, Hemorrhagic Disorders
- Trial name
- NCT05654766
- Testing
- Flow cytometry, Platelet aggregation and plasma coagulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus