Clinical trials: Functional Disabilities
Down Syndrome
Muscle Strength, Physical Work Capacity and Functional Performance in Individuals With Down Syndrome
This project will evaluate muscle strength and its relationship to everyday function in individuals with Down Syndrome.
- Trial name
- NCT00643552
- Volunteers
- 18 people
- Sponsor
- State University of New York - Upstate Medical University
Specific Learning Disability, Mental Health Issue
Biopsychosocial Outcomes of Mindfulness-based Instruction
Over 20% of adolescents living in the United States have a diagnosable psychiatric disorder. However, most adolescents who need mental health services do not receive them due to many reasons, including low resources in families…
- Trial name
- MindUP (NCT05787483)
- Testing
- MindUP group, active control group
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Hemiparetic Cerebral Palsy
Using Neurotechology to Help Children With Physical Disability Due to Cerebral Palsy
Hemiparetic cerebral palsy is a condition in which one side of a child's body becomes weak due to brain injury occurring around birth, often caused by stroke.
- Trial name
- NCT07269353
- Testing
- Brain Computer Interface - Functional Electrical Stimulations
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- University of Alberta
Down Syndrome (DS), Balance Assessment
Effects of a Structured Physical Activity Program on Balance and Functional Performance in Children With Down Syndrome
Children with Down syndrome commonly exhibit hypotonia, impaired balance, and reduced functional mobility. This study aimed to evaluate the effects of a structured yoga-based physical activity program on balance and functional…
- Conditions
- Down Syndrome (DS), Balance Assessment, Physical Activities, Yoga
- Trial name
- DS-YOGA (NCT07534085)
- Testing
- Yoga Program
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Ankara University
Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder
Home Play-based Intervention for Parents and Infants
The goal of this clinical trial is to learn whether a 12-week home-based intervention (Sociometric Play-based Remediation of Individual Neurodevelopmental Trajectories (SPRINT)) helps support parenting and the development of…
- Conditions
- Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder, Premature Birth, Global Developmental Delay
- Trial name
- SPRINT (NCT07716072)
- Testing
- SPRINT Intervention, Waitlist Protocol
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Nanyang Technological University
Down Syndrome
Rebound Therapy on Ventilatory Functions in Down Syndrome
The purpose of this study is to examine the effects of rebound therapy on ventilatory functions in children with Down Syndrome.
- Trial name
- NCT07425353
- Testing
- Chest Physical Therapy Protocol, Rebound Therapy Protocol
- Volunteers
- 40 people
- Sponsor
- Beni-Suef University
Cochlear Impant Children
Implementation of the International Classification of Functioning, Disability and Health Model in Paediatric Cochlear Implant Recipients
The aim of this study is to implement the International Classification of Functioning, disability and health (ICF) in paediatric Cochlear Implant (CI) recipients (<18 years) with prelingual sensorineural hearing loss in a…
- Trial name
- NCT06841900
- Testing
- Cochlear Implantation
- Where
- 6 sites in Australia, Belgium and 4 more
- Volunteers
- 120 people
- Sponsor
- University Hospital, Antwerp
Down Syndrome (DS)
Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool
Epigallocatechin-3-gallate (EGCG), the major catechin in green tea, is postulated to modulate dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) and amyloid beta precursor protein (APP) gene overexpression in…
- Trial name
- NCT01699711
- Testing
- Epigallocatechin-3-gallate (EGCG)
- Where
- Spain
- Volunteers
- 87 people
- Sponsor
- Parc de Salut Mar
Sickle Cell Disease, Pain
Preliminary Feasibility and Efficacy of Behavioral Intervention to Reduce Pain-Related Disability in Pediatric SCD
Pain is the primary complication of sickle cell disease (SCD), including vaso-occlusive crises and more persistent, chronic pain.
- Trial name
- NCT04388241
- Testing
- The Balance Program
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Children's National Research Institute
Down Syndrome, Balance Impairment
Vestibular Stimulation Versus Foot Intrinsic Muscle Exercises in Children With Down Syndrome
This study will compare the effects of vestibular stimulation exercises and foot intrinsic muscle exercises on balance and functional mobility in children with Down syndrome aged 4-15 years.
- Conditions
- Down Syndrome, Balance Impairment, Functional Mobility
- Trial name
- VESTIB-FIME (NCT07778654)
- Testing
- Vestibular Stimulation Exercises, Foot Intrinsic Muscle Exercises
- Volunteers
- 48 people
- Sponsor
- Shalamar Institute of Health Sciences
Fragile X Syndrome
Effect of CANnabidiol on Anxiety and GABAergic Function in Individuals With Fragile-X Syndrome
This study focuses on the therapeutic relevance of the endocannabinoid (eCB) system for the treatment of Fragile-X syndrome (FXS), the primary hereditary cause of autism spectrum disorder (ASD).
- Trial name
- CANAX (NCT06261502)
- Testing
- CBD Oral Solution
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Université de Sherbrooke
Intellectual Disability, Mild
Effects of a 12-Week Pickleball Training Program on Cognitive and Motor Skills in Adolescents With Mild Intellectual Disability
This study aims to investigate the effects of a 12-week pickleball training program on cognitive and motor outcomes in adolescents with mild intellectual disability.
- Trial name
- PBID-12 (NCT07586722)
- Testing
- Pickleball Training Intervention Group, Standard Special Education Curriculum
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Elif Top
Development Coordination Disorder, Motor Coordination or Function; Developmental Disorder
The Effects of Yoga on Sensory, Motor, Cognitive Skills, and Perceived Stress in Children With Developmental Coordination Disorder
This clinical study aims to investigate the effects of yoga on children with Developmental Coordination Disorder (DCD). DCD is a condition that can make it difficult for children to perform everyday activities, as it affects…
- Conditions
- Development Coordination Disorder, Motor Coordination or Function; Developmental Disorder, Sensory Integration Disorder, Perceived Stres Level
- Trial name
- NCT07547514
- Testing
- Yoga intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Fenerbahce University
Children, Only, Vestibular Disorder
Vestibular and Postural Function in Children Suspected of Balance Disorders
The goal of this prospective cohort study is to investigate the vestibular function in children suspected of balance disorders, and to follow up on their balance progressions after rehabilitation.
- Conditions
- Children, Only, Vestibular Disorder, Vestibular Function Disorder, Development Delay
- Trial name
- VASIC (NCT06229704)
- Testing
- video Head Impulse Test, Cervical Vestibular Evoked Myogenic Potential, Ocular Vestibular Evoked Myogenic Potential
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Gødstrup Hospital
Down S Syndrome
Manual Ankle Rocking Training on Postural Control and Foot Function in Children With Down Syndrome
Down syndrome occurs due to abnormal cell division of extra chromosome 21. It is a genetic disorder that causes postural un stability, leads to poor foot function and causes them difficulty that they can't fulfill their daily…
- Trial name
- NCT05392309
- Testing
- Manual ankle rocking training, Conventional
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Riphah International University
Disabilities Multiple
Investigation of the Relationship Between Pulmonary Function and Muscle Strength in Athletes With Disability
To investigate the relationship between respiratory function and core muscles strength in athletes with disabilities and compare with healthy athletes.
- Trial name
- NCT03769480
- Testing
- Muscle strength evaluation and Respiratory function Tests
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II
Effects of Adalimumab in Mucopolysaccharidosis Types I, II and VI
The purpose of the study is to collect preliminary data on whether the drug adalimumab (also called Humira) can decrease pain and stiffness, improve quality of life, and is safe in people with mucopolysaccharidosis type I, II, or…
- Conditions
- Mucopolysaccharidosis Type I, Mucopolysaccharidosis Type II, Mucopolysaccharidosis Type VI
- Trial name
- NCT02437253
- Testing
- Adalimumab
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Down Syndrome
Role of Sleep Apnea in the Neuropsychological Function in Down Syndrome People
This is the first study about Neuropsychological function and OSAS in Taiwan. Although the correlation between OSAS and neuropsychological abnormalities had been reported, it is worth to understand more about the detailed domains…
- Trial name
- NCT03267602
- Testing
- CPAP
- Volunteers
- 45 people
- Sponsor
- National Taiwan University Hospital
Fragile X Syndrome
Optical Imaging as a Tool for Monitoring Brain Function in Fragile X Syndrome
The objective of this project is to explore the potential of functional near- infrared spectroscopy (fNIRS) as innovative functional biomarker for clinical trial readiness in Fragile X Syndrome (FXS) that is still without cure.
- Trial name
- NCT06293027
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- IRCCS Fondazione Stella Maris
Executive Function, Social Interaction
Study: Effects of a Collaborative Occupational Therapy Interactive Vaulting
Occupational therapy services will be integrated into an interactive vaulting program which is an equine assisted activity. Children with disabilities ages 5-17 will participate.
- Conditions
- Executive Function, Social Interaction, Disability, Developmental
- Trial name
- NCT04481334
- Testing
- Collaborative occupational therapy interactive vaulting group
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- East Carolina University