Clinical trials: Functional Disorder
Critical Illness
Neuroendocrine Dysfunction in Critically Ill Pediatric Patients
Research studies in adults have shown that certain hormones may be decreased or may not work normally which contributes to how sick a person becomes. The purpose of this project is to study hormones in children.
- Trial name
- NCT00207896
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Children's Healthcare of Atlanta
Poor Thymic Function, Immunodeficiency
Expanded Access Protocol Thymus Transplantation
The primary purpose is to provide access for patients who have immunodeficiency or severe autoimmune disease related to poor thymic function to cultured thymus tissue for implantation.
- Conditions
- Poor Thymic Function, Immunodeficiency, Athymia, Immunoreconstitution
- Trial name
- NCT02274662
- Testing
- Cultured Thymus Tissue, Blood Draw, Rabbit Anti-Thymocyte Globulin and Cyclosporine or Tacrolimus
- Volunteers
- 11 people
- Sponsor
- Sumitomo Pharma Switzerland GmbH
Congenital Adrenal Hyperplasia
Comparisons of Different Forms of Glucocorticoid on the Recovery of Reproductive Function in Patients With 21α-hydroxylase Deficiency
The purpose of this study is to conduct an open, randomized controlled clinical trial, evaluating the effects of different dosage forms of glucocorticoid on the Recovery of Reproductive Function in Patients With 21α-hydroxylase…
- Trial name
- CGP21 (NCT04536662)
- Testing
- Hydrocortisone, Prednisone, Dexamethasone
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Lower Urinary Tract Symptoms, Neurodevelopmental Disorders
Lower Urinary Tract Symptoms and School Functioning in Children
Children in primary school often suffer from lower urinary tract symptoms (LUTS), which may negatively impact their overall well-being.
- Conditions
- Lower Urinary Tract Symptoms, Neurodevelopmental Disorders, Incontinence, Urinary, ADHD
- Trial name
- NCT06012903
- Testing
- Questionnaire Welbevinden, Questionnaire Vancouver symptom score for dysfunctional elimination syndrome, Developmental Coordination Disorder Questionnaire
- Where
- Belgium
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Cystic Fibrosis (CF), Chronic Kidney Disease(CKD)
Kidney Function in People With Cystic Fibrosis in the Era of HEMT
The purpose of this study is to find out what causes kidney disease in people with CF. The investigators will study biomarkers in the blood and urine that can either predict who is at risk or detect kidney damage early before it…
- Conditions
- Cystic Fibrosis (CF), Chronic Kidney Disease(CKD), Acute Kidney Injury
- Trial name
- NCT06595420
- Where
- 3 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Cystic Fibrosis
Effects of a 6-Months Physical Conditioning Program in Patients With Cystic Fibrosis
The purpose of this randomized, controlled trial was to determine whether a (and if so which) physical conditioning program is effective to improve health status, physical activity, and quality of life in patients with cystic…
- Trial name
- NCT00231686
- Testing
- Supervised aerobic training, Supervised strength training, Unsupervised training
- Where
- 4 sites in Germany, Switzerland
- Volunteers
- 80 people
- Sponsor
- Julius-Maximilians University
Cocaine Dependence, Opioid Dependence
FMRI of Stress and Addictive Disorders
The purpose of this study is to explore whether frontal brain activation in response to stress varies as a function of the presence or extent of early trauma and whether or not this effect is greater in women compared to men.
- Conditions
- Cocaine Dependence, Opioid Dependence, Alcoholism, Pathological Gamblers
- Trial name
- NCT01558973
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Yale University
Congenital Heart Disease
Imaging by 4 DFlow in Patients With Tetralogy of Fallot
Conventionnal cadiac magnetic resonance (CMR) is the reference to assess changes in right heart flow and pulmonary artery hemodynamics in patients with repaired Tetralogy of Fallot.
- Trial name
- 4DFlowFallot (NCT03542968)
- Testing
- magnetic resonance imaging
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Executive Functioning, Pediatric ALL
Effectiveness of EEG Neurofeedback in Pediatric Occupational Therapy to Improve Executive Functioning
EEG Neurofeedback is a noninvasive way that allows the central nervous system to self regulate and the frontal cortex to be accessed through quieting of the limbic system at the subcortical level.
- Trial name
- NCT04221620
- Testing
- Zengar Electroencephalogram (EEG) Neurofeedback device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northern Arizona University
COVID-19, Infant, Newborn, Diseases
Long-term Respiratory Complications in Infants With Perinatal COVID-19
Study outcomes and endpoints: Primary outcome: to assess clinical characteristics of infants with confirmed COVID-19 infection at birth and to evaluate long-term respiratory consequences of neonatal COVID-19 infection.
- Conditions
- COVID-19, Infant, Newborn, Diseases, Respiratory Function Tests
- Trial name
- COLF (NCT05793723)
- Testing
- Pulmonary function testing device
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Diabetic Retinopathy, Macular Degeneration
Diabetic Retinopathy and Visual Function Study
The purpose of this study is to evaluate possible mechanisms of central visual loss in patients with diabetes mellitus. The visual loss of interest to be investigated is that associated with macular edema (prior to and following…
- Conditions
- Diabetic Retinopathy, Macular Degeneration, Vision, Subnormal
- Trial name
- NCT00001346
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Eye Institute (NEI)
Type 1 Diabetes
EMERALD: Effects of Metformin on Cardiovascular Function in Adolescents With Type 1 Diabetes
Diabetes is increasingly common among youth, forecasting early complications. Type 1 (T1D) cause early heart disease, shortening lifespan despite modern improvements in control of blood sugars and other risk factors for heart…
- Trial name
- EMERALD (NCT01808690)
- Testing
- Metformin
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Colorado, Denver
Fabry Disease
Natural History and Structural Functional Relationships in Fabry Renal Disease Treatment Outcomes(Changes)in Fabry Renal Disease Study
The investigators will perform a study with two major components. The first is a natural history study of untreated Fabry patients.
- Trial name
- LDN6702 (NCT01581424)
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- University of Minnesota
Mastication Disorder
Chewing Function in Pediatric Neuromuscular Disorders
We aimed to evaluate chewing function (CF) in children with neuromuscular disorders, and investigate reliability of the Karaduman Chewing Performance Scale (KCPS).
- Trial name
- NCT03116620
- Testing
- Chewing evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Hacettepe University
Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients
Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury
This prospective observational study evaluates the safety profile and patient-reported outcomes associated with MUSE (Multilineage-differentiating Stress-Enduring) stem cell therapy in individuals aged 6 to 75 with chronic…
- Conditions
- Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients, Traumatic Brain Injury (TBI); Concussion, Initial Encounter, Traumatic Brain Injury (TBI); Concussion, Subsequent Encounter
- Trial name
- MUSE-TBI-OBS (NCT07326059)
- Testing
- MUSE Stem Cell Therapy
- Where
- 2 sites in United States, Mexico
- Volunteers
- 10 people
- Sponsor
- Healing Hope International
Immune Deficiency and Early BMF in Childhood
Consequences of DNA Repair and Telomere Defects on the Function of the Immune System: Application to CVID and Immune Deficiencies With Dysmorphic Syndromes
The molecular mechanisms participating in the various aspects of the DNA Damage Response (DDR) are absolutely essential to maintain the genome dynamics essential to all living organisms.
- Trial name
- IMMUNEREP (NCT02556359)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Functional Neurological Symptom Disorder, Neurological Diseases or Conditions
Modulation of Sense of Agency With Non-invasive Brain Stimulation and Mindfulness-based Stress Reduction Therapy
A conversion disorder is a dysfunction of the nervous system in which no structural damage can be demonstrated. However, it must be distinguished from other psychiatric disorders such as psychosis or depression.
- Trial name
- NCT05086380
- Testing
- Mindfulness-based stress reduction therapy, Inhibitory TMS, Psychoeducation
- Where
- Switzerland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University of Fribourg
Schizophrenia
Oculomotor and Spatial Cognition Deficits in Schizophrenia
DESCRIPTION: (Verbatim from the Applicant's Abstract) Abnormalities of eye movement control and spatial cognition are well-established deficits in schizophrenia.
- Trial name
- NCT00931996
- Testing
- Antipsychotic
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Amyotrophic Lateral Sclerosis
Validation of Czech Language Versions of Questionnaires for ALS Patients' Functional Status and Biomarker Long-term Follow-up
Questionnaires and scales used to assess the clinical status and quality of life of patients with amyotrophic lateral sclerosis (ALS) are an important tool to monitor the disease progression and current needs of patients.
- Trial name
- NCT06426030
- Where
- Czechia
- Volunteers
- 100 people
- Sponsor
- Masaryk University
Parkinson's Disease
A Study Assessing Change in Sense of Smell After Rasagiline Use in Parkinson's Patients
A decrease or loss of the sense of smell is very common in patients with Parkinson's Disease even in the earliest stages of the disease.
- Trial name
- PD-SOAR (NCT01007630)
- Testing
- Rasagiline
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- The Parkinson's Institute
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