Clinical trials: Functional Disorder
Gastroschisis
Evaluation of Glycerin Suppositories to Improve Bowel Function in Gastroschisis
Gastroschisis is a congenital defect of the abdominal wall that leads to evisceration of various amounts of the abdominal organs.
- Trial name
- NCT03355326
- Testing
- Glycerin Suppository
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Indiana University
Asthma, Allergic Rhinitis
Fractional Exhaled Nitric Oxide (FeNO) Result Prediction Factors in Children With Allergic Diseases
In about 800 children with allergic diseases (asthma, allergic rhinitis, atopic dermatitis) the investigators will retrospectively and cross-sectionally analyze the influence/correlation of diagnosis, treatment methods, allergy…
- Conditions
- Asthma, Allergic Rhinitis, Atopic Dermatitis
- Trial name
- NCT00815984
- Testing
- measurements of lung function tests
- Where
- Poland
- Volunteers
- 800 people
- Sponsor
- Medical University of Lodz
Cytomegalovirus Infections
Letermovir Treatment for Refractory or Resistant Cytomegalovirus Infection
The trial will evaluate the safety and efficacy of letermovir antiviral treatment of active cytomegalovirus infection or cytomegalovirus disease in patients with infections that are refractory or resistant to available treatments…
- Trial name
- NCT03728426
- Testing
- Letermovir
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Amy C. Sherman, MD
Severe Malaria, Thrombocytopenia
Platelet-Directed Whole Blood Transfusion Strategy for Malaria
Open-label randomized controlled trial to test the effectiveness of whole blood transfusion for improving survival in children with severe malaria complicated by thrombocytopenia.
- Trial name
- PLATFORM (NCT05711485)
- Testing
- Whole blood transfusion
- Where
- 2 sites in United States, Zambia
- Volunteers
- 132 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Lupus Erythematosus, Scleroderma
Clinico-biological Collection to Investigate the Physiopathology of Systemic Autoimmune Diseases
The aim of this project is to start a biological and clinical collection of patients presenting systemic autoimmune disease. This collection will provide appropriate biological samples to identify new biomarkers and to be…
- Conditions
- Lupus Erythematosus, Scleroderma, Myositis, Vasculitis
- Trial name
- ESSAi (NCT05251415)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Toulouse
Irritable Bowel Syndrome, Food Allergy
Endomicroscopic Evaluation of Food-induced Gastrointestinal Mucosal Alteration
The overarching goal of this study is to establish a first ever registry in the U.S. to collect outcomes data to evaluate changes in the gastrointestinal (GI) mucosa following direct food application utilizing Confocal Laser…
- Trial name
- NCT06792838
- Testing
- Confocal Laser Endomicroscopy
- Volunteers
- 200 people
- Sponsor
- Cook Children's Health Care System
Hemiplegic Cerebral Palsy, Mirror Hands
Mirror Therapy in Children With Hemiparetic Cerebral Palsy
Cerebral palsy (CP) is a neurodevelopmental disorder that frequently impairs upper extremity motor control and hand function, resulting in limitations in daily activities.
- Conditions
- Hemiplegic Cerebral Palsy, Mirror Hands, Upper Extremity Dysfunction, Motor Activity
- Trial name
- NCT07734376
- Testing
- Mirror Therapy, Conventional Physiotherapy
- Volunteers
- 26 people
- Sponsor
- Marmara University
Erectile Dysfunction, Peyronie' Disease
Management of Peyronie's Disease With Adipose Tissue Stem Cell
Erectile dysfunction is growing in prevalence all over the world and one of the most existing disease in old age patients There is many lines of treatment concerning the status of patient like psychosexual, medical, and surgical…
- Trial name
- NCT02414308
- Testing
- Adipose tissue stem cell injection
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Man Clinic for Andrology, Male Infertility and Sexual Dysfunction
Atopic Dermatitis
Dupilumab Skin Barrier Function Study in Atopic Dermatitis
Primary Objective: Evaluate changes in skin barrier function with transepidermal water loss (TEWL) assessed after skin tape stripping (STS) in pre-defined lesional skin in participants with moderate to severe atopic dermatitis…
- Trial name
- BALISTAD (NCT04447417)
- Testing
- Dupilumab SAR231893
- Where
- 2 sites in United States, Canada
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Sanofi
Chronic Granulomatous Disease
Role of Interferon-gamma 1-b (IFN-γ) on Cells of the Innate Immune System: Functional, Biochemical and Gene Expression Studies in Patients With Chronic Granulomatous Disease
The overall goal of the study is to investigate the functional, biochemical, and gene expression effects of Interferon-gamma 1-b (IFN-γ) on the neutrophils of patients with Chronic Granulomatous Disease (CGD).
- Trial name
- NCT03548818
- Testing
- Interferon Gamma-1B
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Colorado, Denver
Respiratory Function, Pediatric Anesthesia
Effects of Different Inspiratory:Expiratory Ratios on Respiratory and Recovery Outcomes During Dental Procedures Under General Anesthesia in Pediatric Patients
This observational study aims to evaluate the effects of different inspiratory to expiratory (I:E) ratios (1:2 vs. 1:3) during mechanical ventilation in pediatric patients undergoing dental procedures under general anesthesia.
- Conditions
- Respiratory Function, Pediatric Anesthesia, General Anesthesia
- Trial name
- NCT07323420
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Cerebral Palsy
The Effect of Botox on Children With Cerebral Palsy
Botulinum toxin injections are a common form of treatment for children with cerebral palsy to help reduce muscle tightness and help them walk without resorting to surgery.
- Trial name
- NCT00503620
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Functional Gastrointestinal Disorders
Internet-delivered CBT for Children With Functional Gastrointestinal Disorders - an Open Pilot Study
This pilot-study aims to evaluate the effect size and feasibility of internet-delivered cognitive behavior therapy (ICBT) for children (age 8-12 years) with pain-predominant functional gastrointestinal disorders (e.g.
- Trial name
- NCT02475096
- Testing
- Internet-delivered CBT
- Where
- 2 sites in Sweden
- Volunteers
- 31 people
- Sponsor
- Karolinska Institutet
Mild Persistent Asthma
Response of FeNO, Small Airway Dysfunction and Lung Heterogeneity to 2-week Montelukast Treatment in Asthmatic Children.
This study aims to identify markers to prove rapid improvement of lung function, airway inflammation and bronchodilator response after 2-week LTRA administration.
- Trial name
- NCT01581710
- Volunteers
- 32 people
- Sponsor
- CHA University
Executive Dysfunction, Autism Spectrum Disorder
Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD
This project explores the association between learning and cognitive flexibility by testing whether a cognitive behavioral intervention designed to improve flexibility in ASD changes learning and associated neural activation…
- Conditions
- Executive Dysfunction, Autism Spectrum Disorder, Adolescent Behavior
- Trial name
- NCT05131659
- Testing
- Executive function group therapy
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Children's National Research Institute
Transient Hypothyroxinemia of Prematurity
EEG Alterations in Preterm Infants With Thyroid Dysfunction
The aim of this study is to investigate differences in electroencephalography (EEG) evolution between preterm infants with and without transient hypothyroxinemia of prematurity (THOP) in order to find differences in the…
- Trial name
- EEG-THOP (NCT03493113)
- Testing
- EEG
- Where
- Belgium
- Volunteers
- 87 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Contraception, Female Sexual Function
The Effect of Sexual Education-Counseling According to PLISSIT in Solving Sexual Problems in Women Using Contraceptive Methods: One Year Follow-up Results
Sexuality is a universal part of human life and is a process in which two people share their emotions, body, soul and pleasures. Although it is a natural part of life, sexuality can be affected by many factors.
- Conditions
- Contraception, Female Sexual Function, Sexual Dysfunction, PLISSIT
- Trial name
- NCT06772883
- Testing
- sexual education and counseling, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 352 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Cerebral Palsy Spastic Diplegia
FES Assisted Cycling in Children With CP
This project proposes to assess if Functional Electrical Stimulation (FES) assisted cycling can improve the cycling ability, muscle strength, cardiovascular health, quality of life, self perception and functional mobility of…
- Trial name
- CP FES Cycling (NCT04688424)
- Testing
- FES, Cycling
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Acute Renal Failure, Gastroenteritis
Cystatin C as a Marker for Detecting Early Renal Dysfunction in a Pediatric Emergency Department
Acute renal failure (ARF) is a rare but serious complication of gastroenteritis and dehydration, the most common reason for pediatric emergency visits. Renal function is determined by the glomerular filtration rate (GFR).
- Conditions
- Acute Renal Failure, Gastroenteritis, Dehydration
- Trial name
- CARING (NCT00462527)
- Where
- Canada
- Volunteers
- 464 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
End-Stage Renal Disease (ESRD) Chronic Kidney Disease, Stage 5 Renal Regeneration Anuria Diabetic Nephropathy, Anuria
Clinical Observation of Renal Function Reactivation Following a GRAS-Based Protocol in Patients With Chronic Kidney Disease and Long-Term Renal Arrest.
This observational study documents the impact of a specific oral protocol (based on FDA-GRAS ingredients) on patients with Stage 5 Chronic Kidney Disease (CKD).
- Conditions
- End-Stage Renal Disease (ESRD) Chronic Kidney Disease, Stage 5 Renal Regeneration Anuria Diabetic Nephropathy, Anuria, End-Stage Renal Disease (ESRD), Chronic Kidney Disease, Stage 5
- Trial name
- NCT07555327
- Testing
- CSR-CKD Oral Protocol
- Where
- Algeria
- Volunteers
- 8 people
- Sponsor
- Amar h Zireg
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