Clinical trials: Functional Disorder of Intestine
Irritable Bowel Syndrome (IBS)
Microbiome Fructan Metabolism and Symptoms in Childhood IBS
This study evaluates whether the gut microbiome is involved in determining whether children with irritable bowel syndrome (IBS) develop worsening GI symptoms (e.g. pain) when given fructans (a sugar often found in wheat).
- Trial name
- NCT02842281
- Testing
- Fructan, Maltodextrin
- Where
- 2 sites in United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Autism Spectrum Disorder
Effects of Hippotherapy in Children With Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in social communication and interaction, as well as impairments in physical function domains such as postural control, balance…
- Trial name
- NCT07739693
- Testing
- Hippotherapy Program, Special Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Fenerbahce University
Irritable Bowel Syndrome
Use of Functional Magnetic Resonance Imaging (fMRI) to Study Brain Activation in Children With Irritable Bowel Syndrome
The purpose of the study is to map regions of brain activation following rectal stimulation in children with irritable bowel syndrome (IBS) and healthy controls.
- Trial name
- fMRI (NCT00677976)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Constipation, Children
Comparison of Anorectal Manometry and 3D Manometry in Diagnosis of Functional Disorders in Children
Pressures measured by manometric solid-state catheters may differ according to the type of the catheter and specific anatomy and physiology of anorectum.
- Conditions
- Constipation, Children, Fecal Incontinence
- Trial name
- NCT02812823
- Testing
- High-resolution anorectal manometry
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
Functional Gastrointestinal Disorders, Irritable Bowel Syndrome
ICBT for Pain-predominant FGIDs in Children and Adolescents: an Implementation Study.
This open trial aims to evaluate feasibility and preliminary effectiveness of an internet-delivered CBT-program for children and adolescents with functional gastrointestinal disorders when implemented in regular care.
- Conditions
- Functional Gastrointestinal Disorders, Irritable Bowel Syndrome, Dyspepsia, Functional Abdominal Pain
- Trial name
- NCT03252743
- Testing
- Exposure-based internet-delivered CBT
- Where
- Sweden
- Volunteers
- 68 people
- Sponsor
- Karolinska Institutet
Self-hypnosis, Functional Bowel Disorder
Hypnotherapy With Audiofiles for Children and Adolescents With Disorders of Gut-brain Interactions in Sweden -a Feasibility Study
This study aims at testing the effect and feasibility of a new treatment strategy - hypnotherapy mediated with audio files - for children and adolescents with disorders of gut-brain-interaction (DGBI) in Sweden.
- Conditions
- Self-hypnosis, Functional Bowel Disorder, Functional Abdominal Pain Syndrome
- Trial name
- NCT06493097
- Testing
- Gut-directed hypnotherapy via audio files
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Karolinska Institutet
Constipation, Fecal Incontinence
Diagnosis of Functional Defecation Disorders in Childhood
Purpose To compare different kinds of diagnostic investigations in order to identify the most sensitive and least invasive when diagnosing constipation.
- Trial name
- NCT00230360
- Where
- Denmark
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Chronic Constipation (CC) (Excluding Constipation Due to Organic Diseases), Irritable Bowel Syndrome With Constipation (IBS-C)
Post-marketing Surveillance of Linaclotide Tablet in Patients With Irritable Bowel Syndrome With Constipation or Chronic Constipation (Excluding Constipation Due to Organic Diseases)
The objective of this study is to evaluate the long-term safety and efficacy of linaclotide in post-marketing use.
- Trial name
- NCT03471728
- Testing
- linaclotide
- Where
- 47 sites in Japan
- Volunteers
- 2,475 people
- Sponsor
- Astellas Pharma Inc
Irritable Bowel Syndrome
Clinical Effectiveness of Exposure Based Cognitive Behavioral Group Therapy for IBS
The aim of the study is to evaluate the effects of a specific Cognitive Behavioral treatment protocol for patients with IBS used in routine care at a gastroenterology unit in Stockholm.
- Trial name
- NCT04756414
- Testing
- Exposure based face-to-face Cognitive Behavior Group Therapy
- Volunteers
- 143 people
- Sponsor
- Karolinska Institutet
Autism Spectrum Disorder, Functional Gastrointestinal Disorders
Combined Gut-brain Therapy for Children With Autism
CLINICAL ISSUE: Children with Autism Spectrum Disorder (ASD) are four times more likely to suffer with functional gastrointestinal disorders (FGIDs) than their neurotypical peers.
- Conditions
- Autism Spectrum Disorder, Functional Gastrointestinal Disorders, Neurodevelopmental Disorders, Anxiety
- Trial name
- NCT04639141
- Testing
- Synbiotic, Gut-directed Hypnotherapy
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- The University of Queensland
Irritable Bowel Syndrome (IBS), Pediatrics
Pentabiocel in Pediatric IBS
Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder characterized by chronic abdominal pain and altered bowel habits, including diarrhea, constipation, or a combination of both.
- Trial name
- NCT06720805
- Testing
- Pentabiocel
- Where
- 4 sites in Italy
- Volunteers
- 56 people
- Sponsor
- University of Roma La Sapienza
Autism
Therapeutic Intervention Effects of rTMS on Children With Autism Spectrum Disorder
Autism spectrum disorder (ASD) is a common and complex neurodevelopmental disorder, which is characterized by impairments of social communication, social reciprocity, as well as restricted and repetitive behaviors (RRB).
- Trial name
- NCT05140356
- Testing
- Applied high amplitude repeated transcranial magnetic stimulation, Applied low amplitude repeated transcranial magnetic stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- University of Electronic Science and Technology of China
Autism Spectrum Disorder
Gut Microbiome Characteristics and Neurodevelopmental Functioning in Children With Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition that affects communication, behavior, sensory processing, and daily functioning.
- Trial name
- GAIN-ASD (NCT07646808)
- Where
- India
- Volunteers
- 600 people
- Sponsor
- Saveetha University
Bladder Cancer
The Impact of Intrathecal Morphine Versus Continuous Epidural Analgesia on Return of Bowel Function in Patients Undergoing Laparoscopic Ileal Conduit
This study aims to compare the effects of intrathecal morphine (ITM) and continuous epidural analgesia (CEA) on bowel function recovery after Bricker surgery.This study was a prospective, randomized controlled trial that included…
- Trial name
- NCT06688643
- Testing
- ITM group, EA group
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Xiaguang Duan
Ogilvie Syndrome
Neostigmine Route for Acute Colonic Pseudo Obstruction
Neostigmine is commonly used for medical treatment of acute colonic pseudo obstruction, however, the ideal route of administration has not been determined.
- Trial name
- NCT04951726
- Testing
- Neostigmine
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Southern California
Fertility Disorders, Ovarian Reserve Function
Fertility and Ovarian Reserve Function in the Patient With Inflammatory Bowel Disease
ECCO consensus, the fertility would decline in activity inflammatory bowel disease(IBD), because of anus lesions and pelvic abscess, or who underwent surgery, especially in patients with ileal pouch anal anastomosis (IPAA)…
- Conditions
- Fertility Disorders, Ovarian Reserve Function, Pregnancy Outcomes
- Trial name
- NCT03269916
- Testing
- Anti Mueller hormone, Estrogen, Follicle-Stimulating Hormone
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Crohn Disease, Recurrence
Comparison of Two Stapled Antimesenteric Anastomosis for CD: a Randomized Control Trial Study
The postoperative recurrence of Crohn's diseases (CD) remains high. Stapled anti-mesenteric functional end-to-end anastomosis was safe for CD patients. Its impact on the postoperative recurrence of CD was unknown.
- Trial name
- NCT05658081
- Testing
- Kono-S group, Side-to-side group
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Jinling Hospital, China
Hypermobile Ehlers-Danlos Syndrome, Irritable Bowel Syndrome
Comprehensive Assessment of Nutrition and Dietary Intervention in Hypermobile Ehlers Danlos Syndrome
This study involves a comprehensive nutritional assessment of hEDS participants who have functional gastrointestinal disorders and dietary intervention to broaden their food choices and nutritional intake.
- Conditions
- Hypermobile Ehlers-Danlos Syndrome, Irritable Bowel Syndrome, Functional Gastrointestinal Disorders
- Trial name
- CANDI-hEDS2 (NCT05148039)
- Testing
- Dietician advice
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Queen Mary University of London
Fecal Incontinence
Transcutaneous Posterior Nerve Stimulation inTreatment of Fecal Incontience
Shafik and colleagues were the first to report the use of posterior tibial nerve stimulation (PTNS) for FI, and they documented improved continence after 4 weeks course.
- Trial name
- NCT04478799
- Testing
- Transcutanous Posterior Tibial Nerve Stimulation
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Batterjee Medical College
Celiac Disease in Children, Celiac Disease in Adolescents
Effect of Adherence to a Gluten-Free Diet on Cognitive and Motor Dual-Task Performance in Adolescents Diagnosed With Celiac Disease
The aim of this cross-sectional observational study is to comprehensively examine the effects of adherence to a gluten-free diet on cognitive, motor, and psychosocial functions in adolescents aged 8-18 years diagnosed with celiac…
- Trial name
- NCT07382999
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Inonu University