Clinical trials: Functional Neuroimaging
Major Depressive Episode
Personalized Repetitive Transcranial Magnetic Stimulation Treatment for Major Depressive Episode
Adolescents and young adults with mood disorders experiencing major depressive episode have poor efficacy of medication treatment.
- Trial name
- PRTMSTMDEAYA (NCT05465928)
- Testing
- Active rTMS
- Where
- China
- Volunteers
- 219 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Functional Abdominal Pain Syndrome, Anxiety
Neural Mechanisms of Treatment Response to ADAPT
Complex functional abdominal pain disorders (FAPD) with co-occurring anxiety are highly prevalent in children, can be very disabling, and are not responsive to currently available treatments.
- Trial name
- NCT03518216
- Testing
- ADAPT
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Michigan State University
Healthy
Imaging Study of Automatic Movements
This study uses magnetic resonance imaging (MRI) to explore the brain activities involved in performing learned automatic movements. Automatic movements are performed without concentrating on the details of the movement.
- Trial name
- NCT00031382
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Functional Gastrointestinal Disorders
Defining Adolescent Nausea Through Brain Imaging and Neurostimulation Response
This study evaluates the efficacy of auricular neurostimulation via an non-invasive percutaneous electrical nerve field stimulator (PENFS) in adolescents with functional nausea.
- Trial name
- NCT03675321
- Testing
- Active Auricular Neurostimulation
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Healthy
Magnetic Resonance Imaging of Calculus Problem Solving
This study will use magnetic resonance imaging (MRI) to identify brain regions involved in solving algebraic math problems. It will examine brain activation according to the level of difficulty and the number of steps required to…
- Trial name
- NCT00060658
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Attention Deficit Hyperactivity Disorder, ADHD
Imaging Stimulant and Non Stimulant Treatments for ADHD: A Network Based Approach
The growing number of medications used to treat attention-deficit/hyperactivity disorder (ADHD) raises important questions about whether different medications have similar or different therapeutic mechanisms of action.
- Trial name
- NCT01678209
- Testing
- fMRI scans, Atomoxetine arm, Methylphenidate arm
- Where
- United States
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Mood Disorder
Studies of Brain Function and Course of Illness in Pediatric Bipolar Disorder
This study seeks to learn more about the symptoms of severe mood dysregulation in children and adolescents ages 7-17. Children and adolescents with severe mood dysregulation (SMD) display chronic anger, sadness, or irritability…
- Trial name
- NCT00025935
- Testing
- Lithium
- Where
- United States
- Volunteers
- 2,350 people
- Sponsor
- National Institute of Mental Health (NIMH)
Executive Dysfunction, Autism Spectrum Disorder
Intervention-Induced Plasticity of Flexibility and Learning Mechanisms in ASD
This project explores the association between learning and cognitive flexibility by testing whether a cognitive behavioral intervention designed to improve flexibility in ASD changes learning and associated neural activation…
- Conditions
- Executive Dysfunction, Autism Spectrum Disorder, Adolescent Behavior
- Trial name
- NCT05131659
- Testing
- Executive function group therapy
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- Children's National Research Institute
Glioma
fMRI Study of Functional Reorganization in Glioma Patients
Glioma is an invasive growth, easy to relapse, poor prognosis, great harm to human and society. Studies have shown that gliomas can cause the dynamic reorganization of brain functional areas, affecting the accuracy of surgical…
- Trial name
- NCT05019196
- Testing
- GE 3.0T MRI
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Attention Deficit Disorder With Hyperactivity
Neuroimaging of Diet in ADHD: Phase I
Children with Attention Deficit Hyperactivity Disorder (ADHD) aged 9-12 years of age will be placed on a restriction diet for a 5 week period.
- Trial name
- FTF (NCT01862484)
- Testing
- Restricted Diet, Ruse Diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Ornithine Transcarbamylase Deficiency
Investigation of Brain Nitrogen in Partial Ornithine Transcarbamylase Deficiency (OTCD) Using 1 H MRS, DTI, and fMRI
The purpose of this study is to use various types of MRI and cognitive testing to evaluate changes in the brain and cognitive function that occur in subjects with ornithine transcarbamylase deficiency (OTCD) relative to healthy…
- Trial name
- NCT01569568
- Testing
- MRI scanning, Cognitive testing
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Andrea Gropman
Hearing Loss
fNIRS in Pediatric Hearing Aids
Pilot phase. Monocentric, non-controlled, non-randomized, open-label study evaluating the capacity of the functional near-infrared functional neuroimaging (fNIRS) technique to translate temporal cortical activity in response to a…
- Trial name
- FNIRS (NCT04696835)
- Testing
- speech audiometry
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Post Concussive Syndrome, Chronic, Post Concussion Symptoms
Accelerated Transcranial Magnetic Stimulation Intervention for Post-Concussion Syndrome
This study looks at the effects of accelerated intermittent theta burst stimulation (aiTBS) on patients with chronic and acute post-concussion syndrome.
- Conditions
- Post Concussive Syndrome, Chronic, Post Concussion Symptoms, Post Concussive Syndrome, Post Concussion Syndrome
- Trial name
- NCT07211919
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Cognitive FX
Poor Feeding, Infant Development
taVNS Paired With Bottle Feeding in Infants Failing Oral Feeds
Oromotor dysfunction and poor feeding is common after premature birth and hypoxic ischemic encephalopathy (HIE). Pairing vagus nerve stimulation (VNS) with motor activity accelerates functional improvements after stroke.
- Conditions
- Poor Feeding, Infant Development, Vagus Nerve Stimulation
- Trial name
- NCT04643808
- Testing
- transcutaneous auricular vagus nerve stimulation
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Medical University of South Carolina
Cerebral Palsy, Brachial Plexus; Injury, Newborn
Multi-modal Neuroimaging in Children With Cerebral Palsy or Brachial Plexus Birth Palsy
The main goal of this study is to identify abnormal functional and anatomical brain reorganization associated with hand, foot, and shoulder function in children (0-18 years old) with cerebral palsy (CP) due to periventricular…
- Trial name
- NCT03712072
- Testing
- Magnetoencephalography (MEG), Electroencephalography (EEG), Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Gender Identity, Gender Dysphoria in Adolescents and Adults
Puberty, Testosterone, and Brain Development
Transmasculine youth (female sex assigned at birth, male gender identity) who begin clinical gender affirming hormone therapy (GAHT) with testosterone (T) may experience changes in headache.
- Conditions
- Gender Identity, Gender Dysphoria in Adolescents and Adults, Headache, Transgender
- Trial name
- NCT06670053
- Testing
- Testosterone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
Neurological Disorders, Neuroscience
Advanced Space-time Resolved Techniques for Functional Neuroimaging at 7 Tesla MRI
In recent years, the in vivo study of the central nervous system has undergone significant advancement through the implementation of magnetic resonance imaging (MRI)-based neuroimaging techniques.
- Conditions
- Neurological Disorders, Neuroscience, Epilepsy, Brain Injuries, Focal
- Trial name
- AURORA (NCT07865546)
- Testing
- Functional neuroimaging
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Imago 7 Fondazione di Ricerca onlus
Alzheimer's Disease, Healthy
The Effect of Acetylcholine on Memory and Attention
This study will examine whether enhancing the chemical acetylcholine in the brain can improve memory and attention. It will identify changes in brain function that occur during these cognitive tasks.
- Trial name
- NCT00001977
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Cerebral Palsy
Cognitive Training Cerebral Palsy
This study aims to conduct a single-blind randomized controlled trial with sixty children with Cerebral Palsy (CP) to explore if a home-based computerized multi-modal executive training is effective improving infants' executive…
- Trial name
- ETCONNECT (NCT04025749)
- Testing
- Computerized Executive Functions training, Care as usual
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Barcelona
Juvenile Neuronal Ceroid Lipofuscinosis, Smith-Lemli-Opitz Syndrome
Functional Near-Infrared Spectroscopy (fNIRS) Combined With Diffuse Correlation Spectroscopy (DCS) in Neurocognitive Disease as Compared to Healthy Neurotypical Controls
Background: Neurocognitive disorders affect how the brain uses oxygen. They may affect mental development in children. These disorders can be studied with imaging scans that use radiation; however, these methods are not ideal for…
- Conditions
- Juvenile Neuronal Ceroid Lipofuscinosis, Smith-Lemli-Opitz Syndrome, Creatine Transporter Deficiency, Niemann-Pick Disease Type C1
- Trial name
- NCT05642221
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)