Clinical trials: GI Disorders
Gastric Cancer
Questionnaire Survey of the Advanced Training Program for Laparoscopic Radical Gastrectomy
This study aims to evaluate the outcomes of the advanced training program for laparoscopic radical gastrectomy (ATP-LRG). The research subjects are the trainees who participated in this training program.
- Trial name
- ATP-LRG-1 (NCT05219539)
- Where
- China
- Volunteers
- 1,355 people, healthy volunteers welcome
- Sponsor
- Fujian Medical University
Cancer, All Types, Cancer of Liver
The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)
The PIONEER Initiative stands for Precision Insights On N-of-1 Ex vivo Effectiveness Research. The PIONEER Initiative is designed to provide access to functional precision medicine to any cancer patient with any tumor at any…
- Conditions
- Cancer, All Types, Cancer of Liver, Cancer of Stomach, Cancer of Head and Neck
- Trial name
- PIONEER (NCT03896958)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- SpeciCare
Lymphatic Disorders, Plastic Bronchitis
European Registry Study on Lymphatic Interventions
This European multicenter observational study aims to evaluate the real-world use, timing, and outcomes of lymphatic interventions in patients with congenital heart disease and/or primary lymphatic disorders.
- Conditions
- Lymphatic Disorders, Plastic Bronchitis, Protein Losing Enteropathy, Chylothorax
- Trial name
- EURO-LYMPH (NCT07131293)
- Testing
- Lymphatic intervention
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Functional Gastrointestinal Disorders
Study to Learn More About the Stomach and Intestine Complaints of Children Aged From 3 to 14 Years
In this observational study, researchers want to gain more information on children suffering from abnormal stomach and intestine function (based on the Rome criteria) and treated Iberogast.
- Trial name
- NCT04029376
- Testing
- Iberogast®
- Where
- Germany
- Volunteers
- 1,032 people
- Sponsor
- Bayer
Crohn's Disease
A Study of Ustekinumab Treatment in Children With Crohn's Disease
The purpose of this study is to evaluate the effectiveness of ustekinumab in achieving clinical remission in pediatric participants (greater than or equal to [>=] 2 to less than [<] 18 years and weight >= 40 kilograms [kg] at…
- Trial name
- REALITI (NCT05242458)
- Testing
- Ustekinumab
- Where
- United States
- Volunteers
- 545 people
- Sponsor
- Janssen Research & Development, LLC
Asthma
A Randomized, Double-Blind, Placebo-Controlled Study of Gastroesophageal Reflux Disease Therapy.
Asthma and gastroesophageal reflux disease (GERD) are common disorders, which although are not usually lethal, both have high morbidity, and high healthcare costs.
- Trial name
- NCT00237068
- Testing
- Lansoprazole; Solutab
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Emory University
Gastritis
Clinical Effect of Rebamipide on Chronic Gastritis
To investigate the clinical effect of rebamipide in chronic gastritis patients. Patients with chronic gastritis were randomly divided into the experimental group and the control group.
- Trial name
- NCT02393430
- Testing
- Rebamipide, optimization of life style
- Volunteers
- 180 people
- Sponsor
- BangMao Wang
UC - Ulcerative Colitis
To Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of LYNC-101 for Injection in Healthy Adult Participants
This Phase I study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), immunogenicity, and cytokine profiles of LYNC-101 for Injection in healthy adult participants.
- Trial name
- NCT07505030
- Testing
- LYNC-101
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- LyncBio Therapeutics Co., Ltd.
Dysphagia
The Effects of Cold Liquids on the Swallowing Mechanism in Preterm Infants
The purpose of this study is to see if cold liquids improve the swallowing mechanisms in premature infants with swallowing difficulties (dysphagia).
- Trial name
- NCT01863264
- Testing
- Cold Thin Liquid Barium
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NYU Langone Health
Appendicitis, Hernia
Aromatherapy Versus Acupressure: Impact on Postoperative Pain and Sleep Quality in Pediatric Abdominal Surgery Patients
The study's aim is to examine the effect of using aromatherapy versus acupressure on pain intensity and sleep pattern for children undergoing abdominal surgeries.
- Conditions
- Appendicitis, Hernia, Abdominal Exploration, Splenectomy
- Trial name
- NCT07157501
- Testing
- Accupressure, Aromatherapy inhaler
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Gastric Cancer
Hematological Dynamic Scores for Predicting Survival and Treatment Response for Advanced Gastric Cancer After Neoadjuvant Therapy
HMDLS, based on hematological markers, could effectively distinguish the long-term efficacy of AGC patients after NAT. The predictive performance of nomogram-HMDLS was better than ypTNM stage, achieving better prognostic…
- Trial name
- NCT06573307
- Where
- China
- Volunteers
- 442 people
- Sponsor
- Chang-Ming Huang, Prof.
Infection, Enterocolitis, Necrotizing
Oropharyngeal Administration of Mother's Colostrum for Premature Infants (NS-72393-360)
Extremely premature (BW<1250g) infants are at high risk for morbidity and mortality. Own mother's colostrum (OMC) and milk (OMM) protect against neonatal morbidity and are rich in immune factors which may provide…
- Conditions
- Infection, Enterocolitis, Necrotizing, Ventilator-associated Pneumonia
- Trial name
- NCT02116699
- Testing
- oropharyngeal mother's milk, oropharyngeal sterile water
- Where
- 5 sites in United States
- Volunteers
- 260 people
- Sponsor
- Endeavor Health
Colorectal Cancer, Surgery
Incremental Cost-Utility Study on Prehabilitation Among Older Patients With Colorectal Cancer Undergoing Surgery
A prospective multicenter observational cost-utility study following older or high-risk patients with colorectal cancer with and without prehabilitation before surgery.
- Trial name
- PreColo CU (NCT04097795)
- Testing
- Prehabilitation
- Where
- 5 sites in Netherlands
- Volunteers
- 72 people
- Sponsor
- Radboud University Medical Center
Primary Sclerosing Cholangitis, Inflammatory Bowel Disease
NPDT Evaluation in Children With CFTR and (PSC)
The investigators hypothesize that PSC in children is associated with mutations and functional changes of the cystic fibrosis (CF) gene.
- Trial name
- NPD (NCT00179439)
- Testing
- nasal potential difference testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Beth Israel Deaconess Medical Center
Children, Only, Physical Activity
Turkish Cultural Adaptation, Validity and Reliability of the "Physical Activity-Specific Rumination Scale for Children"
Anxiety that turns into an over-generalized and repetitive form is called rumination. When the literature was reviewed, rumination was found to be associated with depression and anxiety, but its applicability to physical activity…
- Conditions
- Children, Only, Physical Activity, Rumination
- Trial name
- NCT04933734
- Where
- Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Fecal Incontinence, Urinary Incontinence
Safety and Efficacy of Concurrent MACE and Mitrofanoff Procedures
This was a prospective study. The study period was from January 2022 to July 2025. The study included 30 patients suffering from combined fecal and urinary incontinence submitted for concurrent Malone Antigrade continent Enema…
- Trial name
- MitroMACE (NCT07206719)
- Testing
- Malone Antegrade Continent Enema (MACE) and Mitrofanoff procedures
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mohammad Daboos
Functional Abdominal Pain, Irritable Bowel Syndrome
Efficacy of Combination Therapy vs Placebo for Pediatric Functional Abdominal Pain
IND application was submitted to FDA on November 17th.
- Conditions
- Functional Abdominal Pain, Irritable Bowel Syndrome, Functional Dyspepsia
- Trial name
- FAP (NCT01269671)
- Testing
- Melatonin, Peppermint Oil (mentharil), and Simethicone, Sugar pill
- Where
- United States
- Sponsor
- Medical College of Wisconsin
Late Onset Neonatal Sepsis, Necrotising Enterocolitis
Lactoferrin Prophylaxis in VLBW and Regulator T-cells
The aim of the study is to evaluate whether oral administration of 200 mg/day lactoferrin (LF) to very low birth weight infants reduces late onset sepsis and necrotising enterocolitis and the effect of LF on regulatory T cells.
- Conditions
- Late Onset Neonatal Sepsis, Necrotising Enterocolitis, Very Low Birth Weight Infants
- Trial name
- NCT01287507
- Testing
- Lactoferrin (bovine origin)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Ankara University
Rett Syndrome
Treatment of Mitochondrial Dysfunction in Rett Syndrome With Triheptanoin
The aim of this study is to evaluate the safety and tolerability of triheptanoin in participants with Rett syndrome using laboratory values, electrocardiogram, rate of adverse events (AE), and physical exam.This study also seeks…
- Trial name
- NCT02696044
- Testing
- triheptanoin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Center for Rare Neurological Diseases, Norcross, GA
Colorectal Neoplasm, Hereditary Nonpolyposis
Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and Carriers
This is a randomized, placebo-controlled Phase I/II multi-center trial, of the safety and efficacy of Celecoxib in a cohort of 81 HNPCC subjects and gene carriers.
- Trial name
- NCT00001693
- Testing
- Celecoxib (SC-58635)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Cancer Institute (NCI)
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