Clinical trials: GI Disorders
Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection
The Cohort Study of Early Esophageal Cancer or Precancerous Lesions Treated With Endoscopic Resection
Endoscopic Submucosal Dissection (ESD) is currently the main method of treatment of early esophageal cancer and precancerous lesions.
- Trial name
- NCT03377972
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Small Intestinal Bacterial Overgrowth Syndrome (SIBO), Small Bowel Bacterial Overgrowth Syndrome (SBBOS)
Retrospective Analysis of Treatment Outcomes in Patients With Bacterial Overgrowth Syndrome Diagnosed by D-Xylose Breath Testing
The objective of this study is to compare the efficacy of prokinetics versus antibiotics versus a combination of antibiotics plus prokinetics in the eradication of Small-Intestinal Bacterial Over-Growth Syndrome (SIBO) in those…
- Trial name
- SIBO (NCT01324895)
- Where
- United States
- Volunteers
- 944 people
- Sponsor
- University of Florida
Eosinophilic Esophagitis (EoE)
Dose-Ranging Study of Oral Viscous Budesonide in Pediatrics With Eosinophilic Esophagitis
This is a randomized, placebo-controlled, parallel-arm, dose-ranging study in subjects with eosinophilic esophagitis, 2-18 years of age. Eligible subjects will be randomized into one of four treatment groups.
- Trial name
- NCT00762073
- Testing
- budesonide
- Where
- 20 sites in United States
- Volunteers
- 82 people
- Sponsor
- Shire
HIV, Malnutrition
Breast Milk Composition and HIV-exposed/Unexposed Early Infant Growth and Infectious Disease Events
The purpose of this study is to understand how breast milk may protect infants from infection and promote favorable immunological, growth and development outcomes.
- Conditions
- HIV, Malnutrition, Cryptosporidiosis
- Trial name
- NCT01699841
- Where
- Tanzania
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Cornell University
Pouchitis
A Study to Learn About the Safety of Vedolizumab and How Well it Works in Children and Teenagers With Active Chronic Pouchitis
When some people have their large bowel removed, a surgeon can make a "pouch" from part of the small bowel to connect it to the back passage (anus). Pouchitis is when the pouch becomes inflamed (swollen) or infected.
- Trial name
- NCT06443502
- Testing
- Vedolizumab, Concomitant Antibiotic Therapy
- Where
- 14 sites in Belgium, Croatia and 6 more
- Volunteers
- 30 people
- Sponsor
- Takeda
Pulmonary Aspiration of Gastric Contents
Comparison of Different Preoperative Fasting Times in Pediatric Patients Undergoing Elective General Anaesthesia
Rationale of this study is to provide an evidence on minimal safe clear fluid fasting duration without the risk of aspiration of gastric contents during elective pediatric procedures under general anesthesia.
- Trial name
- NCT05922072
- Testing
- Nasogastric aspiration for measurement of Residual Gastric Volume, Nasogastric Aspiration for Measurement of Gastric pH
- Where
- Pakistan
- Volunteers
- 120 people
- Sponsor
- King Edward Medical University
Appendicitis
Study for a Rational Management of Appendicitis in Children
Despite the fact that appendicitis is one of the most frequent surgical pathology in children, its clinical management is still debated.
- Trial name
- ALGAP (NCT01067937)
- Testing
- appendectomy
- Where
- 8 sites in France
- Volunteers
- 891 people
- Sponsor
- Nantes University Hospital
Colonic Neoplasms
The Influence of Artificial Intelligence (AI )Assisted Polyp Detection (Discovery System) on Visual Gaze Patterns During Real-time Colonoscopy
In this study, the investigators aim to assess the influence of a computer-aided detection (CADe) system on the visual gaze patterns of endoscopists in order to further understand the effect of AI during real-time colonoscopy.
- Trial name
- REVEAL (NCT05619614)
- Testing
- eye-tracking glasses
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- Radboud University Medical Center
Oesophageal Cancer
ROCS (Radiotherapy After Oesophageal Cancer Stenting) Study
The single most distressing symptom for more than 70% of patients with oesophageal cancer is difficulty in swallowing (dysphagia) caused by blockage of the gullet by a tumour.
- Trial name
- ROCS (NCT01915693)
- Testing
- Radiotherapy
- Where
- 17 sites in United Kingdom
- Volunteers
- 220 people
- Sponsor
- Lisette Nixon
Eosinophilic Esophagitis
The Efficacy and Tolerability of 12-weeks Treatment With Almond and Buckwheat Based Formula in Pediatric Patients With Active EoE
Eosinophilic esophagitis (EoE) is a chronic, relapsing, immune-mediated esophageal disease. Clinical manifestations in infants and toddlers generally include vomiting, food refusal, choking with meals and, less commonly, failure…
- Trial name
- NCT05622214
- Testing
- Else nutrition formula
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Ulcerative Colitis
Study to Assess Change in Disease Activity of Risankizumab Treatment in Japanese Participants With Moderate to Severe Ulcerative Colitis
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).
- Trial name
- RISE UP (NCT07136116)
- Where
- 29 sites in Japan
- Volunteers
- 200 people
- Sponsor
- AbbVie
Weaning Failure
Preventing Celiac Disease by Weaning With Mediterranean Diet
Background: The introduction of solid foods in alignment with the Mediterranean Diet (MD) post-exclusive milk feeding has been demonstrated to cultivate a lasting affinity for healthy eating during infancy and childhood.
- Trial name
- PEMED (NCT06184906)
- Testing
- Weaning by Mediterranean Diet
- Volunteers
- 3,200 people
- Sponsor
- University of Naples
Colonic Neoplasms, Colorectal Neoplasms
Performance and Evaluation for CT Colonography Screening
Colorectal cancer (CRC) is an important United Kingdom healthcare issue affecting 1 in 20 individuals, half of whom will die from the disease.
- Trial name
- PERFECTS (NCT02892721)
- Testing
- Training with feedback
- Where
- United Kingdom
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- London North West Healthcare NHS Trust
Hirschsprung Disease, Ganglion
The Association Between Calretinin and the Function of Ganglion Cells in Hirschsprung Disease
This study aims to compare the outcomes of patients with long segment Hirschsprung disease or total colonic aganglionosis who had negative calretinin staining and positive ganglion cells on the proximal resection margins to those…
- Conditions
- Hirschsprung Disease, Ganglion, Hirschsprung Disease, Long-Segment, Hypoganglionosis
- Trial name
- NCT04149093
- Testing
- Calretinin staining
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- St. Justine's Hospital
Mesenteric Ischemia
Registeranalysis for the Examination of NOMI
The registry includes patients undergoing cardiovascular and thoracic surgery at the Saarland University Medical Center, Homburg/Saar, Germany.
- Trial name
- IRRE NOMI (NCT02901808)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Universität des Saarlandes
Perforated Appendicitis
Use of Antibiotic Irrigation to Decrease Wound Infections in Pediatric Perforated Appendicitis
The proposed study will investigate whether antibiotic irrigation using a gentamicin/clindamycin solution during laparoscopic appendectomy is superior in preventing postoperative wound infections and IAA in perforated…
- Trial name
- PA protocol (NCT04039750)
- Testing
- antibiotic rinse with suction, suction only
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Prisma Health-Upstate
Eosinophilic Esophagitis
Inflammatory Mediators as Potential Non-Invasive Biomarkers in Subjects With Eosinophilic Esophagitis
The investigators seek to assess esophageal inflammation or lack of it in response to treatment with a novel non-invasive method that would measure eosinophil-associated inflammatory mediators in the blood and urine to determine…
- Trial name
- NCT03822325
- Where
- 2 sites in United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Crohn's Disease Relapse, Inflammatory Bowel Diseases
Acupuncture Reduces Relapse in Patients With Crohn's Disease: a Superiority Trial
The aim of this study was to further improve the clinical efficacy of acupuncture in delaying the clinical recurrence of CD and to explore the efficacy mechanism of acupuncture efficacy enhancement.
- Trial name
- NCT06553053
- Testing
- "Harmonizing Shaoyang, nourishing spleen and kidney with warmth" Acupuncture Group, "Nourishing spleen and kidney with warmth" Acupuncture Group
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Shanghai Institute of Acupuncture, Moxibustion and Meridian
Colorectal Cancer, Diarrhea
Biomarker-Guided Fluorouracil in Treating Patients With Colorectal Cancer Receiving Combination Chemotherapy
RATIONALE: Drugs used in chemotherapy, such as fluorouracil, oxaliplatin, and leucovorin calcium, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Colorectal Cancer, Diarrhea, Neutropenia
- Trial name
- NCT01164215
- Testing
- fluorouracil, leucovorin, oxaliplatin
- Where
- 5 sites in United States
- Volunteers
- 76 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Crohn's Disease
Top Down Versus Step Up Strategies in Crohn's Disease
The study prospectively compares two treatment algorithms for newly diagnosed Crohn's disease: one 'aggressive' treatment with early introduction of immunomodulators and biologicals and one 'standard treatment' with…
- Trial name
- NCT00554710
- Testing
- infliximab+azathioprine, methylprednisolone or budesonide
- Where
- Belgium
- Volunteers
- 129 people
- Sponsor
- Belgian Inflammatory Bowel Disease Research and Development (BIRD) VZW
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